Thyroid hormone stimulates phosphoglycerate mutase activity and isozyme transition in rat muscle tissues.

abstract：:The effect of triiodothyronine (T3) on Na+,K(+)-ATPase activity of K562 human erythroleukemic cell was studied to understand why the erythrocyte sodium pump activity is decreased in hyperthyroidism. Na+,K(+)-ATPase activity of K562 cell lysates was assayed by measuring the release of inorganic phosphate (Pi) from ATP....

journal_title：Life sciences

authors： Arumanayagam M,Swaminathan R

更新日期：1992-01-01 00:00:00

abstract：AIMS:Hypoxia-inducible factor-1α (HIF-1α) is a transcriptional regulator of cellular responses to hypoxic stress. MicroRNAs (miRNAs) play an essential role in hypoxia-mediated cellular responses. Previous studies have identified some let-7 family members as hypoxia-regulated miRNAs (HRMs). In the present study, we aime...

journal_title：Life sciences

authors： Huang CX,Chen N,Wu XJ,He Y,Huang CH,Liu H,Wang WM,Wang HL

更新日期：2017-02-15 00:00:00

abstract：:The effect of chronic cigarette smoke exposure on the activity of rat trachea and lung ornithine decarboxylase (ODC) and s-adenosyl-methionine decarboxylase (AdoMet-DC) was determined. Male rats were exposed once daily for 10 min to mainstream (MS) or different sidestream (SS) dilutions of fresh Kentucky 2R1 cigarette...

journal_title：Life sciences

authors： Olson JW

更新日期：1985-12-09 00:00:00

abstract：:This study examines the effects of prenatal cocaine administration on the development of vascular sympathetic innervation and contractile responsiveness. Rabbits received cocaine (4 mg/kg, iv, bid) or saline during gestational days 8 to 29. Aortas were obtained on postnatal days 10, 20, 30 and 50. Vascular smooth musc...

journal_title：Life sciences

authors： Johnson MD,Gurdal H,Cai G,Snyder DL,Roberts J

更新日期：1994-01-01 00:00:00

abstract：:miRNAs are a group of non-coding RNAs that have regulatory functions in post-transcriptional gene expression. These molecules play a fundamental role in cellular processes, for instance cell proliferation, apoptosis, migration, and invasion. Scientific investigations have previously established that miRNAs can either ...

journal_title：Life sciences

authors： Khalili N,Nouri-Vaskeh M,Hasanpour Segherlou Z,Baghbanzadeh A,Halimi M,Rezaee H,Baradaran B

更新日期：2020-09-01 00:00:00

abstract：:We investigated the role of sensory nerves in glucose tolerance in conscious Wistar rats neonatally treated with neurotoxin capsaicin or vehicle. Intravenous glucose tolerance tests (IVGTT, 150, 300 and 450 mg in 30 min) were performed to measure glucose tolerance, and glucose, insulin and glucagon levels were measure...

journal_title：Life sciences

authors： van de Wall EH,Gram DX,Strubbe JH,Scheurink AJ,Koolhaas JM

更新日期：2005-07-29 00:00:00

abstract：AIMS:In animal models of neuropathic pain, the noradrenergic descending pain inhibitory pathways from the locus coeruleus (LC) may be suppressed. However, no study has investigated the correlation between noradrenaline (NA) release in the LC and efficacy of analgesics in rats with painful diabetic neuropathy. Using mic...

journal_title：Life sciences

authors： Suehiro K,Funao T,Fujimoto Y,Yamada T,Mori T,Nishikawa K

更新日期：2013-06-21 00:00:00

abstract：:We studied the incorporation of 14C-formate into uric acid and allantoin in different organs (liver, lung, kidney, spleen), isolated hepatocytes, perfused liver and urine of the rat. Allantoin had a higher specific radioactivity than uric acid after 14C-formate load in the liver in vivo. This was found to be a strictl...

journal_title：Life sciences

authors： Pizzichini M,Pandolfi ML,Arezzini L,Terzuoli L,Fe L,Bontemps F,Van den Berghe G,Marinello E

更新日期：1996-01-01 00:00:00

abstract：:Since somatostatin inhibits basal and stimulated gastric acid secretion and gastrin release, it is conceivable that decreased gastric somatostatin concentration may be one of the factors responsible for gastric hypersecretion found in patients who have undergone long-term pylorotomy for hypertrophic pyloric stenosis. ...

journal_title：Life sciences

authors： Barrios V,Urrutia MJ,Hernández M,Lama R,García-Novo MD,Hernanz A,Arilla E

更新日期：1994-01-01 00:00:00

abstract：:Treatment of primary cultured chondrocytes from rabbit articular cartilage with interleukin-1 (IL-1)alpha and plasminogen induced the production of pro-matrix metalloproteinase 1 (proMMP-1/interstitial collagenase), proMMP-3 (stromelysin 1) and proMMP-9 (gelatinase B), as well as their active forms. Human urinary tryp...

journal_title：Life sciences

authors： Hashimoto K,Nagao Y,Kato K,Mori Y,Ito A

更新日期：1998-01-01 00:00:00

abstract：:Multidrug resistance-associated proteins (Mrps) are ATP-dependent transporters which transport a wide variety of anionic and cationic compounds. The purpose of this study was to determine the tissue distribution of Mrp5 and 6 in male and female Sprague-Dawley rats in various tissues, and to investigate whether the exp...

journal_title：Life sciences

authors： Maher JM,Cherrington NJ,Slitt AL,Klaassen CD

更新日期：2006-04-04 00:00:00

abstract：:Although exogenous cannabinoid ligands such as delta9-tetrahydrocannabinol (THC) have been implicated in reward-related learning and aversion, the hedonic effects of the endogenous cannabinoid agonist anandamide (arachidonylethanolamide) have never been assessed. Thus, the effects of anandamide were tested in a place ...

journal_title：Life sciences

authors： Mallet PE,Beninger RJ

更新日期：1998-01-01 00:00:00

abstract：AIM:The objective of this study was to investigate the potential of aerobic exercise training (AET) to prevent kidney lipid accumulation and the contribution of renal metabolism to mediate this response. MAIN METHODS:Male C57BL/6J mice were assigned into groups CHOW-SED (chow diet, sedentary; n = 13), CHOW-TR (chow di...

journal_title：Life sciences

authors： Muller CR,Américo ALV,Fiorino P,Evangelista FS

更新日期：2018-10-15 00:00:00

abstract：:Renal failure (RF) has been shown to alter intestinal transport of a number of nutrients. We studied jejunal absorption of pyridoxine (B6) in rats rendered azotemic by subtotal nephrectomy (RF group) and compared the results with those obtained in normal rats subjected to sham operation (controls) and animals pair-fed...

journal_title：Life sciences

authors： Barbari A,Vaziri ND,Benavides I,Chen YT,Said H,Pahl MV

更新日期：1989-01-01 00:00:00

abstract：:Mutations that increase constitutive activity and alter ligand binding have been used to investigate the structure and mechanism of activation of muscarinic receptors. These data are reviewed with reference to the recently published three-dimensional structure of rhodopsin. Residues in TM3 and TM6 where amino acid sub...

journal_title：Life sciences

authors： Spalding TA,Burstein ES

更新日期：2001-04-27 00:00:00

abstract：:A radioimmunoassay for orexin A has been developed. Anti-orexin A antiserum was raised in New Zealand white rabbits immunized with a conjugate of synthetic orexin A with bovine serum albumin. This antibody did not crossreact with orexin B, hypothalamic hormones, pituitary hormones, neuropeptides or gut hormones. Radio...

journal_title：Life sciences

authors： Mitsuma T,Hirooka Y,Kayama M,Mori Y,Yokoi Y,Rhue N,Ping J,Izumi M,Ikai R,Adachi K,Nogimori T

更新日期：2000-01-01 00:00:00

abstract：:The effect of local pH on the in vivo efflux of endogenous dopamine (DA) and 3,4-dihydroxyphenylacetic acid (DOPAC) following administration of d-amphetamine (AMPH) was examined in the striatum of the anesthetized rat using two bilaterally placed push-pull cannulae. At both pH 7.3 and 6.4, the baseline efflux values f...

journal_title：Life sciences

authors： Guan XM,McBride WJ

更新日期：1988-01-01 00:00:00

abstract：:Chymase is an important enzyme for the generation of angiotensin (Ang) II and in the activation of transforming growth factor (TGF)-beta1. Therefore, chymase may be involved in the hemodialysis access dysfunction, which is caused by intimal hyperplasia that occurs after polytetrafluoroethylene (PTFE) graft implantatio...

journal_title：Life sciences

authors： Jin D,Ueda H,Takai S,Muramatsu M,Furubayashi K,Ibaraki T,Kishi K,Katsuoka Y,Miyazaki M

更新日期：2007-09-29 00:00:00

abstract：:The present study is undertaken to investigate whether the phospholipase A(2) (PLA(2)) influences mRNA nucleocytoplasmic transport evaluated by nucleoside triphosphatase (NTPase) activity and mRNA export in isolated hepatic nuclear envelope. Isolated hepatic nuclei from rat liver were exposed to PLA(2) (10(-5) approxi...

journal_title：Life sciences

authors： Li JX,Li ZQ,Pang YZ,Tang CS

更新日期：2003-07-11 00:00:00

abstract：:The process of synaptogenesis has been studied by many investigators to determine the factors which regulate synapse formation. We have used neonatal rabbit retina to investigate the role of the gamma-aminobutyric acid (GABA) neurotransmitter system during development. By utilizing an in vitro incubation treatment of ...

journal_title：Life sciences

authors： Madtes P Jr,Redburn DA

更新日期：1983-09-05 00:00:00

abstract：AIMS:This study analyzed in pithed rats the effect of several acute and prophylactic antimigraine drugs on the CGRPergic vasodepressor sensory outflow, in an attempt to investigate systemic cardiovascular effects in a model unrelated to migraine. MAIN METHODS:Male Wistar pithed rats were pretreated with continuous i.v...

journal_title：Life sciences

authors： Lozano-Cuenca J,González-Hernández A,Muñoz-Islas E,Sánchez-López A,Centurión D,Cobos-Puc LE,Villalón CM

更新日期：2009-01-30 00:00:00

abstract：:We examined, in young adult women, the association between current low dose oral contraceptive (OC) use and plasma levels of C-reactive protein (CRP), an acute phase reactant predictive of cardiovascular disease risk. We conducted a cross-sectional analysis of 30 healthy, non-smoking, non-obese women (18 OC users and ...

journal_title：Life sciences

authors： Dreon DM,Slavin JL,Phinney SD

更新日期：2003-07-25 00:00:00

abstract：:Seasonal and diurnal variations in tonic pain reactions were examined in female and male CBA/J mice maintained in a 12/12 dark/light cycle, at controlled temperature and humidity conditions. Animals were injected into the dorsum of one hindpaw with a dilute (20 microl, 1%) formalin solution. Pain-related behaviors wer...

journal_title：Life sciences

authors： Perissin L,Facchin P,Porro CA

更新日期：2003-01-10 00:00:00

abstract：:This study was designed to investigate the effect of diabetic duration on serum concentrations of endogenous inhibitor of nitric oxide synthase N(G), N(G)-asymmetric dimethylarginine (ADMA) in patients and rats with diabetes, and to determine whether elevated endogenous ADMA is implicated in endothelial dysfunction or...

journal_title：Life sciences

authors： Xiong Y,Lei M,Fu S,Fu Y

更新日期：2005-05-27 00:00:00

abstract：:Neuroblastoma x glioma hybrid cells NG 108-15 were chronically treated with opioid agonists and tested for their development of "tolerance" as evaluated by the loss of inhibitory activity of opioids upon cAMP-accumulation. Desensitization was dose-dependent and non-competitive and highly selective, since the activity ...

journal_title：Life sciences

authors： Wüster M,Costa T,Gramsch C

更新日期：1983-01-01 00:00:00

abstract：:It has been reported that naloxone, an opioid antagonist, has antiarrhythmic activity in vivo. In Langendorff perfused rat hearts, we found that ischemia-reperfusion-induced ventricular tachyarrhythmia reverted to normal sinus rhythm after the treatment with naloxone (3 approximately 10 microM). The method of voltage ...

journal_title：Life sciences

authors： Hung CF,Wu MH,Tsai CH,Chu SH,Chi JF,Su MJ

更新日期：1998-01-01 00:00:00

abstract：:The enkephalin analogs, [D-Pen2,L-Cys5]- and [D-Pen2,D-Cys5]-enkephalin are cyclic compounds, conformationally constrained by virtue of their 14-membered, disulfide containing rings and by the rigidizing effect of the beta, beta dimethyl substituents of the penicillamine side chain. The analogs exhibit profound delta ...

journal_title：Life sciences

authors： Mosberg HI,Hurst R,Hruby VJ,Galligan JJ,Burks TF,Gee K,Yamamura HI

更新日期：1983-05-30 00:00:00

abstract：:Kinin release and its involvement in inflammatory exudation were assessed by immuno-blot analysis of the kinin-precursor protein, high molecular weight kininogen (HK). HK consists of heavy (H) chain, bradykinin and light (L) chain. After bradykinin was released by plasma kallikrein, HK remains two-chain-kinin-free for...

journal_title：Life sciences

authors： Fujie H,Hayashi I,Oh-ishi S

更新日期：1993-01-01 00:00:00

abstract：:Protein binding determination in post heparin plasma samples is complicated by the continued post heparin lipase activity, in vitro, during the binding analysis. The decomposition of lipoproteins and accumulation of nonesterified fatty acids (NEFA) results in artifically elevated free fractions of many drugs. This art...

journal_title：Life sciences

authors： Pearce GA,Brown KF

更新日期：1983-10-10 00:00:00

abstract：:A growing number of studies reported that rosiglitazone (a PPARgamma agonist) could ameliorate the painful state and prevent stress-induced depression. However, whether rosiglitazone can prevent pain-induced depression is unclear. This study aimed to explore the antidepressant effects of rosiglitazone in L5 spinal ner...

journal_title：Life sciences

authors： Zong J,Liao X,Ren B,Wang Z

更新日期：2018-06-15 00:00:00