Abstract：
:Neuroblastoma x glioma hybrid cells NG 108-15 were chronically treated with opioid agonists and tested for their development of "tolerance" as evaluated by the loss of inhibitory activity of opioids upon cAMP-accumulation. Desensitization was dose-dependent and non-competitive and highly selective, since the activity of other, non-opioid inhibitory compounds, such as noradrenaline and carbachol, was not altered. Moreover, naloxone-induced "withdrawal signs" (revealed in the lack of change in cAMP) were lacking in preparations completely desensitized ("tolerant") towards opiate effects. These results reject the assumption of a common biochemical mechanism underlying both opiate tolerance and dependence and rather support the significance of an uncoupling of receptors from subsequent effector systems upon chronic opiate action.
journal_name
Life Scijournal_title
Life sciencesauthors
Wüster M,Costa T,Gramsch Cdoi
10.1016/0024-3205(83)90512-xsubject
Has Abstractpub_date
1983-01-01 00:00:00pages
341-4eissn
0024-3205issn
1879-0631pii
0024-3205(83)90512-Xjournal_volume
33 Suppl 1pub_type
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