Abstract：
:Superoxide dismutase (SOD) levels, thought to be the first cellular defence against free radicals, were studied in the nonobese diabetesprone (NOD-p) mouse, an animal model of type 1 diabetes in which about 100% of females and 20% of males become diabetic. Nonobese diabetes nonprone (NON-p) mice were used as controls. Animals were followed from 5th to 22nd week of life. Results show that SOD levels in female NOD-p mice are extremely low. In males, values are considerably higher than in females but still lower than values found in control mice. Moreover, SOD levels did not significantly change with age, degree of insulitis or level of diabetes. Islet beta cells in this strain, therefore, seem to be poorly protected against the negative effects of free radicals and this may predispose to diabetes. Furthermore, alterations of SOD may not be directly related to the development of the disease as the enzyme's activity is not further modified with age or the progression of diabetes.
journal_name
Life Scijournal_title
Life sciencesauthors
Papaccio G,Frascatore S,Pisanti FA,Latronico MV,Linn Tdoi
10.1016/0024-3205(95)00211-nsubject
Has Abstractpub_date
1995-01-01 00:00:00pages
2223-8issue
25eissn
0024-3205issn
1879-0631pii
002432059500211Njournal_volume
56pub_type
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