Adrenergic control of lacrimal secretion in rabbits.

abstract：AIM:This study was undertaken to examine the effect of cyclooxygenase (COX) 2 inhibition on the development of muscular insulin resistance in high-fat-induced obese rats. MAIN METHODS:The rats were on a regular chow diet (C) or high-fat enriched diet (HFD) energy-restrictedly (HFr), or ad libitum (HFa) for 12weeks. Th...

journal_title：Life sciences

authors： Tian YF,Hsia TL,Hsieh CH,Huang DW,Chen CH,Hsieh PS

更新日期：2011-07-18 00:00:00

abstract：:The effects of a newly synthesized compound, 7-(3-[4-(2,3-dimethylphenyl)piperazinyl]propoxy)-2(1H)-quinolinone (OPC-4392), on tyrosine hydroxylation in situ and in vitro were studied using rat striatal slices and tyrosine hydroxylase (TH) purified from bovine adrenal medulla, respectively. OPC-4392 dose-dependently i...

journal_title：Life sciences

authors： Kiuchi K,Hirata Y,Minami M,Nagatsu T

更新日期：1988-01-01 00:00:00

abstract：:The effects of glucagon-(1-21)-peptide on pancreatic exocrine secretion and plasma glucose levels were studied and compared with those of native glucagon in anesthetized dogs. Intravenous bolus administration of 1 nmol or 10 nmol/kg of glucagon-(1-21)-peptide evoked a significant inhibition of secretin-stimulated panc...

journal_title：Life sciences

authors： Itoh H,Matsuyama T,Namba M,Watanabe N,Komatsu R,Kono N,Tarui S

更新日期：1989-01-01 00:00:00

abstract：:We previously showed that N1-phenyl-3,5-dinitro-N4,N4-di-n-butylsulfanilamide (denoted GB-II-150) possesses selective antimicrotubule activity against Leishmania donovani and Trypanosoma brucei in vitro [Bhattacharya, G., Herman, J., Delfin, D., Salem, M.M., Barszcz, T., Mollet, M., Riccio, G., Brun, R., Werbovetz, K....

journal_title：Life sciences

authors： Wu D,George TG,Hurh E,Werbovetz KA,Dalton JT

更新日期：2006-08-08 00:00:00

abstract：:Administration of a high dose of hydrocortisone hemisuccinate sodium (0.25 mumol/egg) to 15-day-old fertilized hen's eggs caused accumulation of biliverdin in the embryonic liver. The responses were 10 to 20-fold higher than controls within 48 hr as a result of stimulation of biliverdin synthesis in the liver and the ...

journal_title：Life sciences

authors： Nishigori H,Ishida O,Ogihara-Umeda I

更新日期：1993-01-01 00:00:00

abstract：:Preconditioning (PC) is a potential approach to myocardial protection. We hypothesize that brief ischemia or adenosine given prior to an extended period of warm ischemia may prevent myocardial stunning by altering myocardial metabolism. Using a global ischemia model, 19 dogs were subjected to no PC(control), two episo...

journal_title：Life sciences

authors： Phillips AB,Ko W

更新日期：2007-10-13 00:00:00

abstract：:According to recent epidemiological reports, almost 40% of American population use complimentary and alternative medicine (CAM) during their lifetime. Patients detected with HIV or cancer often consume herbal products especially St. John's wort (SJW) for antidepressants in combination with prescription medicines. Such...

journal_title：Life sciences

authors： Pal D,Mitra AK

更新日期：2006-03-27 00:00:00

abstract：:Although lipid peroxidation of biological samples may be assessed by different chemical and physical methods, those based on the measurement of malondialdehyde formed from the breakdown of endoperoxides during the last stages of the oxidation of a polyunsaturated fatty acid, appear as the most widely used. Among the v...

journal_title：Life sciences

authors： Valenzuela A

更新日期：1991-01-01 00:00:00

abstract：:Trichosanthin (TCS) is a type 1 ribosome-inactivating protein (RIP) effective against HIV-1 and HSV-1 replication. The mechanism of its antiviral activity is not clear. Many believe that it is related to ribosome inactivation. Some RIPs and viral infection affect the phosphorylation of MAPK and Bcl-2 and these protein...

journal_title：Life sciences

authors： Huang H,Chan H,Wang YY,Ouyang DY,Zheng YT,Tam SC

更新日期：2006-08-22 00:00:00

abstract：:For the first time the involvement of C-Reactive protein (CRP) in early (acute) and delayed ischemic (IPC) and pharmacological (chemical) preconditioning (CPC) in an in vivo model of rat myocardial infarction was presented. Acute IPC was produced by three 5 minute occlusion (ischemia) periods interspersed with 5 minut...

journal_title：Life sciences

authors： Valtchanova-Matchouganska A,Gondwe M,Nadar A

更新日期：2004-07-09 00:00:00

abstract：:Since the late 1960's, radioenzymatic assays have gradually come to replace the less sensitive and less specific spectrofluorometric and bioassay procedures previously used to determine many of the neurotransmitters. These assays provide the means to measure picogram quantities of most of these substances, and have en...

journal_title：Life sciences

authors： Philips SR

更新日期：1987-08-17 00:00:00

abstract：:5-Bromo-2'-deoxyuridine (BrdU) has been recently found to enhance adrenal glucocorticoid secretion in rats. Since BrdU-labeling is today the most employed technique for assessing cell proliferation, we have investigated whether this side-effect of BrdU may influence mitotic activity (as evaluated by metaphase-arrested...

journal_title：Life sciences

authors： Malendowicz LK,Nussdorfer GG,Trejer M

更新日期：1997-01-01 00:00:00

abstract：:The infection epidemic event of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was formally declared a pandemic by World Health Organization on March 11th, 2020. Corona Virus Disease 2019 (COVID-19) is caused by SARS-CoV-2, a new type of coronavirus, which has high contagion and mainly causes respira...

journal_title：Life sciences

authors： Peng W,Wu H,Tan Y,Li M,Yang D,Li S

更新日期：2020-12-01 00:00:00

abstract：:In the present report, the putative effect of a single electrical stimulation (75, 150 or 300 microA) to the baso-lateral amygdala (BLA) nucleus was assessed in shock probe defensive burying behavior test (DB) and elevated plus maze (EPM). These models have been used for measuring anxiety levels and screening putative...

journal_title：Life sciences

authors： Saldívar-González JA,Posadas-Andrews A,Rodríguez R,Gómez C,Hernández-Manjarrez ME,Ortiz-León S,Martínez-Pineda A,Gómez-Laguna D,Salgado V,Manjarrez J,Alvarado R

更新日期：2003-01-03 00:00:00

abstract：:Catalase, glutathione peroxidase and superoxide dismutase enzymes were determined after administering dexamethasone. Catalase increased its activity over six times (0.388 U/mg DNA) the normal rate, while glutathione peroxidase caused 3 times an increase one hour after dexamethasone injection. Superoxide dismutase incr...

journal_title：Life sciences

authors： José HJ,Berenice SG,Cecilia VR

更新日期：1997-01-01 00:00:00

abstract：:The aim of the present work was to study whether physiological doses of melatonin (1nM) modified DNA synthesis in MCF-7 human breast cancer cells. Exponentially growing MCF-7 cells were incubated for 24 h with thymidine (2mM) for blocking mitosis and synchronizing the cell division cycle. Synchronization was assessed ...

journal_title：Life sciences

authors： Cos S,Fernández F,Sánchez-Barceló EJ

更新日期：1996-05-24 00:00:00

abstract：AIMS:The central melanocortin system regulates a variety of metabolic functions including lipid metabolism and hepatic lipogenic gene expression. The objective of the present study was to determine whether central melanocortin regulates hepatic lipogenic gene expression under insulin insufficient condition. MAIN METHO...

journal_title：Life sciences

authors： Leckstrom A,Lew PS,Poritsanos NJ,Mizuno TM

更新日期：2011-04-11 00:00:00

abstract：:Intracerebroventricularly (i.c.v.)-administered [D-Ala2]deltorphin II (20 micrograms) produced a marked locomotor hyperactivity in male ICR mice. The locomotor hyperactivity induced in response to i.c.v. [D-Ala2]deltorphin II (20 micrograms) was suppressed by pretreatment with naltriben (NTB, 10 micrograms) but not 7-...

journal_title：Life sciences

authors： Mizoguchi H,Narita M,Nagase H,Suzuki T,Quock RM,Tseng LF

更新日期：1996-01-01 00:00:00

abstract：:Nitric oxide (NO) surprisingly caused the opposite effect on histamine and serotonin edema. The local injection of acidified nitrite (0.3-30 micrograms/paw which correspond 10 micrograms-1 mg/kg) increased histamine edema of mice up to 45 +/- 4% and suppressed serotonin edema to 90 +/- 3%. Other NO-generators (nitropr...

journal_title：Life sciences

authors： Oyanagui Y,Sato S

更新日期：1993-01-01 00:00:00

abstract：:The additive effects of combined valsartan and spironolactone on plasma and cardiac aldosterone escape were evaluated in spontaneously hypertensive rats (SHRs). Twenty-four SHRs were treated with valsartan (30 mg/kg body weight per day), spironolactone (20 mg/kg body weight per day) and a combination of both for 4 mon...

journal_title：Life sciences

authors： Liang YH,Wang JM,Zhou Y,Jiang XJ,Jiang H,Huang CX

更新日期：2004-08-27 00:00:00

abstract：:Hemin (ferriprotoporphyrin IX-chloride) can mediate the covalent cross-linking and degradation of yeast glutathione reductase. This reaction requires both NADPH and oxygen suggesting the involvement of a reduced oxygen species in the cross-linking and degradation process. During the course of the reaction the enzymati...

journal_title：Life sciences

authors： Aft RL,Mueller GC

更新日期：1985-06-03 00:00:00

abstract：AIM:The aim of this study was to investigate the effect of protolichesterinic acid, a lichen secondary metabolite, on anti-proliferative activity of doxorubicin in three human cancer cell lines, HeLa, SH-SY5Y and K562 cells. MAIN METHODS:The data obtained from MTT assays, performed on cells treated with protolichester...

journal_title：Life sciences

authors： Brisdelli F,Perilli M,Sellitri D,Bellio P,Bozzi A,Amicosante G,Nicoletti M,Piovano M,Celenza G

更新日期：2016-08-01 00:00:00

abstract：:The effects of the mixed class I and II mGLUR agonist (+) 1S,3R-trans-amino-cyclopentane-1,3-dicarboxylic acid (ACPD) and antagonists (+) alpha-methyl-4-carboxyphenylglycine (MCPG) and L-2-amino-3-phosphonopropionic acid (L-AP3) on the basal neuronal excitability and on the expression of in vitro epileptiform activity...

journal_title：Life sciences

authors： Tebano MT,Marinelli S,Sagratella S

更新日期：1997-01-01 00:00:00

abstract：AIMS:Naphtho[1,2-b]furan-4,5-dione (NFD), prepared from 2-hydroxy-1,4-naphthoquinone and chloroacetaldehyde in an efficient one-pot reaction, exhibits an anti-carcinogenic effect. This study was performed to elucidate whether EGFR and PI3K signaling pathways are involved in NFD-induced apoptosis of human lung adenocarc...

journal_title：Life sciences

authors： Su JC,Lin KL,Chien CM,Tseng CH,Chen YL,Chang LS,Lin SR

更新日期：2010-01-30 00:00:00

abstract：AIMS:Cyclooxygenase-2 (COX-2)-controlled production of prostaglandin E(2) (PGE(2)) has been implicated in cell growth and metastasis in many cancers. Recent studies have found that COX-2 is co-expressed with survivin in many cancers. Survivin is a member of the inhibitor-of-apoptosis protein family. Some COX-2 inhibito...

journal_title：Life sciences

authors： Bai XM,Jiang H,Ding JX,Peng T,Ma J,Wang YH,Zhang L,Zhang H,Leng J

更新日期：2010-01-30 00:00:00

abstract：:5-hydroxytryptamine (5-HT) caused concentration-dependent relaxation of isolated rings from porcine vena cava contracted with alpha-methyl 5-HT or prostaglandin F2 alpha. Relaxation was not blocked by propranolol (1 micron), atropine (1 micron), indomethacin (3 microns), mepyramine (1 micron), cimetidine (1 micron), o...

journal_title：Life sciences

authors： Trevethick MA,Feniuk W,Humphrey PP

更新日期：1984-07-30 00:00:00

abstract：:We have examined the role of membrane hyperpolarization in mediating vascular hyporeactivity induced by bacterial lipopolysaccharide (LPS) in endothelial-denuded strips of rat thoracic aorta ex vivo. The injection of rats with LPS caused a significant fall of blood pressure and a severe vascular hyporeactivity to nore...

journal_title：Life sciences

authors： Chen SJ,Wu CC,Yang SN,Lin CI,Yen MH

更新日期：2000-12-29 00:00:00

abstract：:There is evidence that senescence affects neurotransmission at different levels. In particular, this review summarizes the studies on age-dependent modifications in protein phosphorylation, which represents the final pathway in the action of transmitters and hormones at neuronal level. Cyclic AMP-dependent protein kin...

journal_title：Life sciences

authors： Magnoni MS,Govoni S,Battaini F,Trabucchi M

更新日期：1991-01-01 00:00:00

abstract：:More than 140 thousands of women suffer from endometrial carcinoma in the worldwide, and over 40 thousand of the patients die before and after in surgery and chemoradiotherapy because of its metastasis. However, its molecular mechanism is much less known compared to other cancers. In this study, we demonstrated that l...

journal_title：Life sciences

authors： Zhang C,Shao S,Zhang Y,Wang L,Liu J,Fang F,Li P,Wang B

更新日期：2020-02-15 00:00:00

abstract：AIMS:Baicalein is a widely used Chinese herbal medicine extracted from Labiatae plants Scutellaria baicalensis Georgi's dry root, which has multiple pharmacological activities. However, the precise mechanism of baicalein against myocardial remodeling remains poorly understood. The aim of our study was to investigate th...

journal_title：Life sciences

authors： Zhao F,Fu L,Yang W,Dong Y,Yang J,Sun S,Hou Y

更新日期：2016-01-15 00:00:00