Endurance exercise causes mitochondrial and oxidative stress in rat liver: effects of a combination of mitochondrial targeting nutrients.

abstract：:Advanced chronic kidney disease is associated with high rates of cardiovascular disease. Considering the crucial role of capillaries in renal function, our study aimed to evaluate microparticles related to vascular physiology examining the link between stages of chronic kidney disease with circulating endothelial (EMP...

journal_title：Life sciences

authors： Fonseca F,Ballerini AP,Izar MC,Kato J,Ferreira CE,Fonzar W,do Amaral J,Rezende P,Machado-Santelli G,França C

更新日期：2020-11-01 00:00:00

abstract：:Superoxide dismutase (SOD), neuron specific enolase (NSE) and lactic dehydrogenase (LDH) were measured in the serum and cerebrospinal fluid (CSF) of ischemic cerebrovascular patients, other neurological patients and in age-matched healthy controls (serum only). The levels of SOD in the CSF or serum of the ischemic pat...

journal_title：Life sciences

authors： Gruener N,Gross B,Gozlan O,Barak M

更新日期：1994-01-01 00:00:00

abstract：:There is now some evidence that i) the availability of plasma tryptophan, the precursor of serotonin, is significantly lower in pregnant women at the end of term and the first few days after delivery than in nonpregnant women; and ii) both pregnancy and the early puerperium are accompanied by activation of the inflamm...

journal_title：Life sciences

authors： Maes M,Verkerk R,Bonaccorso S,Ombelet W,Bosmans E,Scharpé S

更新日期：2002-09-06 00:00:00

abstract：AIM:Despite recent advances in therapeutic strategies, cancer is still a leading cause of mortality worldwide. Mitochondrial dysfunction is implicated in cancer initiation and metastasis, and even in chemo- and radio-resistance. However, the precise role of mitochondria in cancer is crosstalk and controversial. This st...

journal_title：Life sciences

authors： Kheirandish-Rostami M,Roudkenar MH,Jahanian-Najafabadi A,Tomita K,Kuwahara Y,Sato T,Roushandeh AM

更新日期：2020-03-01 00:00:00

abstract：:The effects of central administration of two serotonin receptor agonists, 8-OH-DPAT and mCPP, on tuberoinfundibular dopaminergic (TIDA) neuron activity and serum prolactin (PRL) levels in ovariectomized, estrogen-treated rats were determined. 8-OH-DPAT dose-dependently (0.1-10 microgram/rat, icv) stimulated serum PRL ...

journal_title：Life sciences

authors： Pan JT,Yang IC

更新日期：1996-01-01 00:00:00

abstract：:The present study is undertaken to investigate whether the phospholipase A(2) (PLA(2)) influences mRNA nucleocytoplasmic transport evaluated by nucleoside triphosphatase (NTPase) activity and mRNA export in isolated hepatic nuclear envelope. Isolated hepatic nuclei from rat liver were exposed to PLA(2) (10(-5) approxi...

journal_title：Life sciences

authors： Li JX,Li ZQ,Pang YZ,Tang CS

更新日期：2003-07-11 00:00:00

abstract：:Ancylostoma ceylanicum, the human hookworm parasite, exhibited significant secretion of cholinesterase when maintained in vitro in RPMI-1640 medium. Secretion of the enzyme was linear up-to 4 hours of incubation. About 40 percent of the total cholinesterase activity was localized in the soluble fraction, while remaini...

journal_title：Life sciences

authors： Tekwani BL

更新日期：1992-01-01 00:00:00

abstract：:The binding characteristics of the sigma-1 selective benzomorphan [3H]-(+)-pentazocine were determined in human cerebellar membranes. Saturation binding analysis revealed two affinity sites with a KDH of 1.4 +/- 0.7 nM and a KDL of 33.6 +/- 11.9 nM. Kinetic studies performed at 25 degrees C demonstrated reversible bin...

journal_title：Life sciences

authors： Zabetian CP,Staley JK,Flynn DD,Mash DC

更新日期：1994-01-01 00:00:00

abstract：AIMS:Multiple sclerosis (MS) is one of the commonest neurologic disorders globally. LncRNA OIP5-AS1 has been found to be implicated in the etiology of MS. This study was to explore the roles and molecular mechanisms of OIP5-AS1 in the development of MS. MATERIALS AND METHODS:RT-qPCR assay was used to measure expressio...

journal_title：Life sciences

authors： Liu R,Li Y,Zhou H,Wang H,Liu D,Wang H,Wang Z

更新日期：2021-01-27 00:00:00

abstract：:The effects of a newly synthesized compound, 7-(3-[4-(2,3-dimethylphenyl)piperazinyl]propoxy)-2(1H)-quinolinone (OPC-4392), on tyrosine hydroxylation in situ and in vitro were studied using rat striatal slices and tyrosine hydroxylase (TH) purified from bovine adrenal medulla, respectively. OPC-4392 dose-dependently i...

journal_title：Life sciences

authors： Kiuchi K,Hirata Y,Minami M,Nagatsu T

更新日期：1988-01-01 00:00:00

abstract：:We examined the direct effect of magnesium ion on aldosterone production by adrenal cells using collagenase-dispersed zona-glomerulosa cells in rats. The effects of magnesium on aldosterone production stimulated by angiotensin II or ACTH were also investigated. Both magnesium sulphate (MgSO4) and magnesium chloride (M...

journal_title：Life sciences

authors： Atarashi K,Matsuoka H,Takagi M,Sugimoto T

更新日期：1989-01-01 00:00:00

abstract：:Rats implanted subcutaneously with an empty osmotic pump connected by a polyethylene catheter to a jugular vein for 5 to 10 days evinced a decreased splenocyte responsiveness to blastogenic stimulation in vitro to bacterial lipopolysaccharide, a known B cell stimulator, as well as to the plant mitogens pokeweed mitoge...

journal_title：Life sciences

authors： Pross S,Newton C,Widen R,Klein TW,Friedman H,Spitzer JA

更新日期：1992-01-01 00:00:00

abstract：AIMS:This study sought to determine the impact of in vitro exposure to the herbicide atrazine (ATR) or its major mammalian metabolite diaminochlorotriazine (DACT) on dopaminergic cell differentiation. MAIN METHODS:N27 dopaminergic cells were exposed for 24 or 48 h to ATR or DACT (12-300 μM) and their effects on cell v...

journal_title：Life sciences

authors： Lin Z,Dodd CA,Filipov NM

更新日期：2013-01-17 00:00:00

abstract：:The phenomenon has raised the concerns about the safety of an extended manned mission into deep space due to the high potential for exposure to high-LET radiation during space missions. Heavy ions such as (56)Fe are main radiation sources in deep space, which could pose a significant hazard to space flight crews durin...

journal_title：Life sciences

authors： Zhao Q,Mao A,Yan J,Si J,Zhou R,Gan L,Liu Y,Zhang H

更新日期：2016-07-15 00:00:00

abstract：:Phospholipase C (PLC), an enzyme involved in the hydrolysis of membrane phospholipid- phosphatidylinositol-bisphosphate to inositol triphosphate and diacylglycerol, and Phorbol 12, myristate 13, acetate (PMA), a tumor promoting agent, could significantly stimulate testosterone (T) secretion from Leydig cells. Arachido...

journal_title：Life sciences

authors： Didolkar AK,Sundaram K

更新日期：1987-07-27 00:00:00

abstract：:Herba Epimedii is an important medicinal plant which has been used in various traditional Chinese formulations for thousands of years as well as in modern proprietary traditional Chinese medicine products. It has extensive clinical indications, especially for the treatment of sexual dysfunction and osteoporosis. There...

journal_title：Life sciences

authors： Li C,Li Q,Mei Q,Lu T

更新日期：2015-04-01 00:00:00

abstract：AIMS:Ganoderma lucidum, a traditional Chinese medicine, is well known as a modulator of functions of the immune system as well as an anti-tumour agent. However, its active compounds and their molecular mechanisms of action are not well established. GLIS, a proteoglycan isolated from the fruiting body of G. lucidum, sti...

journal_title：Life sciences

authors： Zhang J,Tang Q,Zhou C,Jia W,Da Silva L,Nguyen LD,Reutter W,Fan H

更新日期：2010-11-20 00:00:00

abstract：:In adult male Wistar rats submitted to a standardized noise stress, intravenous TRH induced a prolactin (PRL) secretory response. Prior IV naloxone administration not only lowered plasma PRL levels in those stressed rats but abolished also the stimulatory action of TRH. This effect was further studied by superfusion e...

journal_title：Life sciences

authors： Velkeniers B,Buydens P,Baldys A,De Boel S,Finné E,Golstein J,Vanhaelst L

更新日期：1987-06-22 00:00:00

abstract：:Hypoxic preconditioning (HPC) has been well demonstrated to have potent protective effects in many cell types; however, the mechanisms responsible for this phenomenon are not fully understood. Recently, glucose-regulated protein 78 (GRP78), an inducible molecular chaperon, was indicated to be associated with ischemic ...

journal_title：Life sciences

authors： Pan YX,Ren AJ,Zheng J,Rong WF,Chen H,Yan XH,Wu C,Yuan WJ,Lin L

更新日期：2007-09-08 00:00:00

abstract：:The gastric mucosa is frequently exposed to different exogenous and endogenous ulcerative agents. Alcoholism is one of the risk factors for the development of mucosal damage in the stomach. This study aimed to assess if a probiotic strain Lactobacillus rhamnosus GG (LGG) is capable of protecting the gastric mucosa fro...

journal_title：Life sciences

authors： Lam EKY,Tai EKK,Koo MWL,Wong HPS,Wu WKK,Yu L,So WHL,Woo PCY,Cho CH

更新日期：2007-05-16 00:00:00

abstract：AIMS:To explore the carcinostatic effects of platinum nanocolloid (Pt-nc) combined with gamma rays on human esophageal squamous cell carcinoma (ESCC). MAIN METHODS:ESCC-derived KYSE-70 cells were treated with various concentrations of Pt-nc and/or gamma irradiation, and subsequently cultured in phenol red free DMEM wi...

journal_title：Life sciences

authors： Li Q,Tanaka Y,Saitoh Y,Tanaka H,Miwa N

更新日期：2015-04-15 00:00:00

abstract：:This study examined the protective role of metallothionein (MT) against pulmonary damage caused by acute exposure to metallic mercury (Hg0) vapor using MT-null and wild-type mice. Both strains of mice were exposed to Hg0 at 6.6 to 7.5 mg/m3 for 4 hr each day for 3 consecutive days. This dosing protocol was lethal to o...

journal_title：Life sciences

authors： Yoshida M,Satoh M,Shimada A,Yasutake A,Sumi Y,Tohyama C

更新日期：1999-01-01 00:00:00

abstract：:Chlordimeform (CDM) and demethylchloridimeform (DCDM) mimic the action of octopamine in elevating adenylate cyclase activity in intact nerve cords of the American cockroach, Periplaneta americana. At a concentration of 1 x 10(-5)M, DCDM (13.5x increase within 20 minutes) is a more potent effector of the response than ...

journal_title：Life sciences

authors： Gole JW,Orr GL,Downer RG

更新日期：1983-06-27 00:00:00

abstract：AIMS:The purpose of this study was to investigate mechanisms of chronic alcohol-induced cardiac remodeling and dysfunction. We also sought to determine the role of cardiac fibroblasts, which play a dynamic role in cardiac remodeling, in mediating these effects. MAIN METHODS:Adult male Wistar rats were exposed to ethan...

journal_title：Life sciences

authors： Mouton AJ,El Hajj EC,Ninh VK,Siggins RW,Gardner JD

更新日期：2020-03-15 00:00:00

abstract：:Opiate addiction could involve a change in the binding of endogenous antiopiates. A candidate for such a role is Tyr-MIF-1 (Tyr-Pro-Leu-Gly-NH2), a brain peptide that can antagonize exogenous and endogenous opiates and bind to opiate receptors. Its primary action, however, may be through its own binding site in brain,...

journal_title：Life sciences

authors： Zadina JE,Kastin AJ,Ge LJ,Gulden H,Bungart KJ

更新日期：1989-01-01 00:00:00

abstract：:The effects of ethanol on the production of oxygen-derived free radicals by neutrophils are controversial. Osmolarity-mediated alteration of cell volume appears to be an important mechanism for regulating neutrophil activity. We investigated in neutrophils from healthy volunteers the effect of isotonic/hypertonic etha...

journal_title：Life sciences

authors： Sato K,Sato N,Mori M

更新日期：1998-01-01 00:00:00

abstract：:The centrally mediated pharmacological effects of thyrotropin releasing hormone (TRH), their mechanistic basis and therapeutic implications, along with the possible physiological significance of extrahypothalamic TRH, have been the subject of numerous investigations for over a decade. Despite this effort a holistic pe...

journal_title：Life sciences

authors： Yarbrough GG

更新日期：1983-07-11 00:00:00

abstract：:The effects of muscarinic and alpha-adrenergic receptor stimulation on phosphoinositide turnover in rat atria have been compared. Despite the similar densities of muscarinic receptors in rat left and right atria, 0.1 mM carbachol increased [32P]phosphate incorporation into phosphatidylinositol (PI) by 35% (p less than...

journal_title：Life sciences

authors： Sekar MC,Roufogalis BD

更新日期：1984-10-01 00:00:00

abstract：AIMS:Hepatocyte growth factor (HGF) modulates intestinal epithelial cell proliferation and migration. We previously reported that systemic administration of recombinant human HGF (rh-HGF) ameliorated experimental colitis. However, an increase in serum HGF concentrations may induce undesired systemic effects, limiting t...

journal_title：Life sciences

authors： Setoyama H,Ido A,Numata M,Moriuchi A,Yamaji N,Tamai T,Funakawa K,Fujita H,Sakiyama T,Uto H,Oketani M,Tsubouchi H

更新日期：2011-08-15 00:00:00

abstract：AIMS:Nicotine is known to promote body weight loss and to disturb glucose homeostasis and lipoprotein metabolism. Electronic cigarettes, as a substitute to nicotine, are becoming increasingly popular, although there is no evidence regarding their safety. Considering the dearth of information about e-cigarette toxicity,...

journal_title：Life sciences

authors： El Golli N,Dkhili H,Dallagi Y,Rahali D,Lasram M,Bini-Dhouib I,Lebret M,Rosa JP,El Fazaa S,Allal-El Asmi M

更新日期：2016-02-01 00:00:00