In vivo and in vitro effect of naloxone on prolactin response to TRH in rat.

abstract：:Met-enkephalin, administered microiontophoretically, produced a greater increase in firing in cells in area CA 3-4 in the hippocampus of both young and aged Fisher 344 rats than it did in the CA 1 area. Furthermore, the effect of met-enkephalin on neuronal firing rates was not as great in old rats as it was in young r...

journal_title：Life sciences

authors： Haigler HJ,Cahill LF,Crager MR,Charles E

更新日期：1987-01-12 00:00:00

abstract：OBJECTIVE:Stem cell transplantation is a promising tool to treat burn injuries. However, the inflammatory microenvironment in damaged skin limits the efficiency of stem cell-based therapy via poorly understood mechanisms. The aim of our study is to explore the contribution and mechanism of Sirtuin-1 (Sirt1) in TNFα-med...

journal_title：Life sciences

authors： Liu J,Xu Y,Wu Q,Ding Q,Fan W

更新日期：2018-11-01 00:00:00

abstract：:Cholinergic neurons in the laterodorsal (LDT) and the pedunculopontine (PPT) tegmental nuclei act to promote REM sleep (REMS). The predominantly glutamatergic neurons of the REMS-induction region of the medial pontine reticular formation are in turn activated by cholinergic cells, which results in the occurrence of to...

journal_title：Life sciences

authors： Monti JM,Monti D

更新日期：2000-04-14 00:00:00

abstract：:Histamine is a biogenic amine that plays an essential role in controlling many physiological functions, both in the central nervous system (CNS) and the peripheral nervous system (PNS). Most of these physiological effects are mediated through interactions with four histamine receptor subtypes, all of which are members...

journal_title：Life sciences

authors： Micallef S,Stark H,Sasse A

更新日期：2013-10-10 00:00:00

abstract：AIMS:The present study evaluated the carvacrol (CARV) effect on hyperalgesia and nociception induced by sarcoma 180 (S180) in mice. MAIN METHODS:Carvacrol treatment (12.5-50mg/kgs.c.) once daily for 15days was started 24h after injection of the sarcoma cells in the hind paw (s.c.). Mice were evaluated for mechanical s...

journal_title：Life sciences

authors： Guimarães AG,Scotti L,Scotti MT,Mendonça Júnior FJ,Melo NS,Alves RS,De Lucca Júnior W,Bezerra DP,Gelain DP,Quintans Júnior LJ

更新日期：2014-10-22 00:00:00

abstract：:Interleukin-1 (IL-1) is a monokine which has been demonstrated to produce a variety of seemingly diverse metabolic events including fever, neutrophilia, anorexia, altered mineral metabolism, muscle catabolism, and fibroblast proliferation. Because many of the clinical features of alcoholic hepatitis are metabolic abno...

journal_title：Life sciences

authors： McClain CJ,Cohen DA,Dinarello CA,Cannon JG,Shedlofsky SI,Kaplan AM

更新日期：1986-10-20 00:00:00

abstract：:Obesity is caused by energy imbalance and accompanied by adipocyte hypertrophy and hyperplasia. Therefore, both enhancement of adipocyte energy expenditure and inhibition of adipogenesis are viable ways to combat obesity. Using the Ucp1-2A-luciferase reporter animal model previously reported by us as a screening platf...

journal_title：Life sciences

authors： Zhao S,Chu Y,Zhang Y,Zhou Y,Jiang Z,Wang Z,Mao L,Li K,Sun W,Li P,Jia S,Wang C,Xu A,Loomes K,Tang S,Wu D,Hui X,Nie T

更新日期：2019-04-01 00:00:00

abstract：AIMS:The molecular pathogenesis of COVID-19 is similar to other coronavirus (CoV) infections viz. severe acute respiratory syndrome (SARS) in human. Due to scarcity of the suitable treatment strategy, the present study was undertaken to explore host protein(s) targeted by potent repurposed drug(s) in COVID-19. MATERIA...

journal_title：Life sciences

authors： Hazra S,Chaudhuri AG,Tiwary BK,Chakrabarti N

更新日期：2020-09-15 00:00:00

abstract：:The regulation of the production of platelet-derived growth factor (PDGF) and the influence of high glucose concentration, eicosapentaenoic acid (EPA) were studied in cultured human umbilical vein endothelial cells (HUE). The PDGF production of HUE increased markedly depending on glucose concentration. However, EPA (3...

journal_title：Life sciences

authors： Mizutani M,Okuda Y,Suzuki S,Sawada T,Soma M,Yamashita K

更新日期：1995-01-01 00:00:00

abstract：AIMS:Epigenetic and genetic alterations are crucial events in the onset and progression of human cancers including colorectal cancer (CRC). This work aims to probe the relevance of lysine demethylase 5B (KDM5B) to the progression of CRC and the possible molecules involved. MATERIALS AND METHODS:KDM5B expression in CRC...

journal_title：Life sciences

authors： Yan G,Li S,Yue M,Li C,Kang Z

更新日期：2021-01-01 00:00:00

abstract：:Electrically evoked release of dopamine from the caudate nucleus is reduced by the dopamine receptor agonists, apomorphine and bromocriptine, and facilitated by neuroleptic drugs, which act as dopamine autoreceptor antagonists. The potencies of chlorpromazine, fluphenazine, levomepromazine and their hydroxy-metabolite...

journal_title：Life sciences

authors： Nowak JZ,Arbilla S,Dahl SG,Langer SZ

更新日期：1990-01-01 00:00:00

abstract：:The additive effects of combined valsartan and spironolactone on plasma and cardiac aldosterone escape were evaluated in spontaneously hypertensive rats (SHRs). Twenty-four SHRs were treated with valsartan (30 mg/kg body weight per day), spironolactone (20 mg/kg body weight per day) and a combination of both for 4 mon...

journal_title：Life sciences

authors： Liang YH,Wang JM,Zhou Y,Jiang XJ,Jiang H,Huang CX

更新日期：2004-08-27 00:00:00

abstract：:Fibrotic lung diseases qualify among the most dreaded irreversible interstitial pulmonary complications with progressive yet largely unpredictable clinical course. Idiopathic pulmonary fibrosis (IPF) is the most challenging prototype characterized by unknown and complex molecular etiology, severe dearth of non-invasiv...

journal_title：Life sciences

authors： Mazumder S,Barman M,Bandyopadhyay U,Bindu S

更新日期：2020-10-01 00:00:00

abstract：:Involvement of cyclic AMP-dependent protein kinase in the desensitization of GABAB receptor expressed in Xenopus oocytes was studied. GABA produced an outward current in the presence of bicuculline, under voltage-clamp conditions. Baclofen mimicked the effect of GABA, thereby indicating that the response to GABA in th...

journal_title：Life sciences

authors： Yoshimura M,Yoshida S,Taniyama K

更新日期：1995-11-17 00:00:00

abstract：:Ovine fetal renal responses to ANF decrease during the last third of gestation, although circulating fetal plasma atrial natriuretic factor (ANF) levels are higher than in the maternal circulation, and do not change with gestation. This study examined whether previously reported maturational changes in fetal renal res...

journal_title：Life sciences

authors： Dodd A,Kullama LK,Ervin MG,Leake RD,Ross MG

更新日期：1994-01-01 00:00:00

abstract：AIMS:Despite impressive survival benefits from new agents to treat metastasized prostate cancer (PCa), progressive drug resistance hinders long-term response and restricts the efficacy of subsequent therapy. Due to reported antitumor activity of amygdalin and growing popularity for complementary and alternative medicin...

journal_title：Life sciences

authors： Makarević J,Tsaur I,Juengel E,Borgmann H,Nelson K,Thomas C,Bartsch G,Haferkamp A,Blaheta RA

更新日期：2016-02-15 00:00:00

abstract：AIMS:This study was aimed to investigate the effect of Lycium barbarum polysaccharides (LBP) on renal function and inflammatory reaction in rabbits with diabetic nephropathy. MAIN METHODS:Diabetes was induced by injecting alloxan (ALX). Japanese male white rabbits were randomly assigned into 5 groups: normal control g...

journal_title：Life sciences

authors： Zhao Q,Li J,Yan J,Liu S,Guo Y,Chen D,Luo Q

更新日期：2016-07-15 00:00:00

abstract：AIMS:To assess the relationship between endothelial dysfunction, endothelin 1 (ET-1) plasma levels and subclinical inflammation in primary open angle glaucoma (POAG) patients. MAIN METHODS:We enrolled 40 POAG patients with progressive visual field damage, although well controlled intraocular pressure (IOP) and compare...

journal_title：Life sciences

authors： Cellini M,Strobbe E,Gizzi C,Balducci N,Toschi PG,Campos EC

更新日期：2012-10-15 00:00:00

abstract：:Human UDP-glucuronosyltransferases (UGTs) 1A6 and 1A9 were expressed using Semliki Forest virus (SFV) vectors. Infection of chinese hamster lung fibroblast V79 cells with recombinant SFV-UGT viruses resulted in efficient protein expression as detected by metabolic labeling, Western blot analyses and immunofluorescence...

journal_title：Life sciences

authors： Forsman T,Lautala P,Lundström K,Monastyrskaia K,Ouzzine M,Burchell B,Taskinen J,Ulmanen I

更新日期：2000-10-06 00:00:00

abstract：:The phenomenon has raised the concerns about the safety of an extended manned mission into deep space due to the high potential for exposure to high-LET radiation during space missions. Heavy ions such as (56)Fe are main radiation sources in deep space, which could pose a significant hazard to space flight crews durin...

journal_title：Life sciences

authors： Zhao Q,Mao A,Yan J,Si J,Zhou R,Gan L,Liu Y,Zhang H

更新日期：2016-07-15 00:00:00

abstract：AIMS:microRNA-96 (miR-96) is considered as a tumor suppressor in multiple malignancies. Some studies have indicated that EZRIN could be regulated by the miR-96 in several kinds of cancer cells. However, the function of miR-96 in human osteosarcoma has not been investigated intensively so far. In this study, we mainly e...

journal_title：Life sciences

authors： Yao Q,Pei Y,Zhang X,Xie B

更新日期：2018-06-15 00:00:00

abstract：:High performance liquid chromatography combined with either single quad or triple quad mass spectral detectors (LC/MS) was used to measure the brain distribution of receptor occupancy tracers targeting dopamine D2, serotonin 5-HT2A and neurokinin NK-1 receptors using the ligands raclopride, MDL-100907 and GR205171, re...

journal_title：Life sciences

authors： Chernet E,Martin LJ,Li D,Need AB,Barth VN,Rash KS,Phebus LA

更新日期：2005-12-12 00:00:00

abstract：:Recent immunohistochemical and radioimmunochemical observations have demonstrated a differential distribution of immunoreactive dynorphin (DYN) in rat brain. The presence of DYN immunoreactivity in a major intrinsic fiber pathway within the rat hippocampus (the mossy fiber system) has led us to evaluate the possible r...

journal_title：Life sciences

authors： Henriksen SJ,Chouvet G,Bloom FE

更新日期：1982-10-18 00:00:00

abstract：:Cumulative damage in cells from aged people could lead to a greater fragility against acute oxidative stress. The effects of acute oxidative stress on cell viability, cAMP and cGMP concentrations, and protein synthesis rates were studied in lymphocytes from 25 young and 26 elderly subjects. Lymphocytes were exposed to...

journal_title：Life sciences

authors： Lopez-Hellin J,Garcia-Arumi E,Schwartz S

更新日期：1998-01-01 00:00:00

abstract：:Epidemiological studies have shown that cigarette smoke, an oxidant agent, is a risk factor for the development of diabetic nephropathy (DN), in which pathogenesis transforming growth factor beta(1) (TGFbeta(1)) plays a key role. In our experimental model we exposed mesangial cell cultures to cigarette smoke concentra...

journal_title：Life sciences

authors： Mur C,Clària J,Rodela S,Lario S,Campistol JM,Titos E,Iñigo P,Cases A,Abián J,Esmatjes E

更新日期：2004-06-18 00:00:00

abstract：:The mechanism of spontaneous coronary contractions was investigated in the rabbit. Arteries with intact endothelium did not spontaneously contract. However, spontaneous coronary contractions were generated after the removal of the endothelium. NG-nitro-L-arginine methyl ester and methylene blue, the inhibitors of the ...

journal_title：Life sciences

authors： Omote M,Mizusawa H

更新日期：1994-01-01 00:00:00

abstract：:Peroxisome-proliferator activated receptor-gamma (PPARgamma) has been demonstrated to exert an inhibitory effect on cell growth in most cell types studied, but its role in colon cancer is still uncertain. The molecular mechanism between the activation of PPARgamma and its consequence is unknown. In the present report,...

journal_title：Life sciences

authors： Chen GG,Lee JF,Wang SH,Chan UP,Ip PC,Lau WY

更新日期：2002-04-19 00:00:00

abstract：:Six diterpenes (three clerodanes, two abietanes and one rosane) were tested for interactions with the cyclooxygenase and 5-lipoxygenase pathways of arachidonate metabolism and for effects of nitric oxide production. Two abietane diterpenes, aethiopinone and 11,12-dihydroxy-6-oxo-8,11,13-abietatriene and the rosane lag...

journal_title：Life sciences

authors： de las Heras B,Abad MJ,Silván AM,Pascual R,Bermejo P,Rodríguez B,Villar AM

更新日期：2001-12-07 00:00:00

abstract：:Polyamines (spermidine, spermine and putrescine) inhibited the adenylate cyclase activity in a concentration dependent manner in human erythrocyte plasma membranes. Spermidine (Spd) exhibited more inhibitory effect than spermine (Spm) and putrescine (Put). On the contrary, the addition of amino acids (arginine, glutam...

journal_title：Life sciences

authors： Khan NA,Quemener V,Moulinoux P

更新日期：1990-01-01 00:00:00

abstract：AIMS:This study aims to evaluate the relationship between the amount of physical activity and different traditional and novel cardiometabolic risk factors, as well as atheroprotective agents, in male children and adolescents. MAIN METHODS:Cross-sectional study. A total of 337 male children and adolescents aged 7-14 ye...

journal_title：Life sciences

authors： Verona J,Gilligan LE,Giménez C,Verona MF,Lombardo SM,Baenz A,Divita V,González CD,Gómez Rosso L,Brites F

更新日期：2013-07-30 00:00:00