Abstract：
:The mechanism of spontaneous coronary contractions was investigated in the rabbit. Arteries with intact endothelium did not spontaneously contract. However, spontaneous coronary contractions were generated after the removal of the endothelium. NG-nitro-L-arginine methyl ester and methylene blue, the inhibitors of the formation and the action of nitric oxide, respectively, induced contractions in endothelium-intact arteries. Spontaneously produced contractions in endothelium-denuded arteries were reversibly inhibited by a Ca(2+)-free solution and by nifedipine, but not by inhibitors of neurotransmitters or prostanoids. These findings may indicate that spontaneous coronary contractions in the rabbit may be attributed to Ca2+ influx via the voltage-sensitive Ca2+ channel. The basal release of endothelium-derived nitric oxide may, in part, antagonize this Ca2+ influx.
journal_name
Life Scijournal_title
Life sciencesauthors
Omote M,Mizusawa Hdoi
10.1016/0024-3205(94)00492-7subject
Has Abstractpub_date
1994-01-01 00:00:00pages
PL157-61issue
8eissn
0024-3205issn
1879-0631pii
0024-3205(94)00492-7journal_volume
55pub_type
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