Abstract：
:Endothelin-1 (ET-1) has been proposed as one of the possible mediators of the vasoconstriction seen following ischemia and reperfusion. We investigated the effect of ischemia and reperfusion on the contractile response of canine renal and iliac arteries to the dihydropyridine-type calcium channel agonist (+/-)Bay K 8644, following subthreshold doses of ET-1. No significant difference in the maximum tension was observed between the ischemic and nonischemic arteries in response to Bay K 8644 in the absence of ET-1. The addition of subthreshold dose of ET-1 (10(-10) M) resulted in a significant increase in sensitivity to Bay K 8644 in both the ischemic-reperfused and non-ischemic-reperfused arteries, with a 38 fold increase in iliac arteries and about 8 fold increase in the renal arteries. However, the ET-1 potentiated response was enhanced in the ischemic-reperfused in comparison to the non-ischemic-reperfused vessels in the iliac artery. These data suggest that the potentiating mechanism of ET-1 is not only intact, but enhanced in ischemic-reperfused vessels. Since the enhanced release of ET-1 in vivo is preceded by ischemia and reperfusion, the vasospastic phenomenon observed following these events could well be mediated by ET-1.
journal_name
Life Scijournal_title
Life sciencesauthors
Edwards JD,McGregor PE,Dovgan PS,Agrawal DKdoi
10.1016/0024-3205(95)00267-asubject
Has Abstractpub_date
1995-01-01 00:00:00pages
225-34issue
3eissn
0024-3205issn
1879-0631pii
002432059500267Ajournal_volume
57pub_type
杂志文章相关文献
LIFE SCIENCES文献大全abstract：:Adrenocortical activity varies on a circannual basis with increased secretion in the winter and decreased secretion in the summer. One consequence of this variation is a circannual pattern in immune function. Adrenal corticosteroids, especially glucocorticoids, depress cellular immune function and seem to be more effe...
journal_title：Life sciences
pub_type： 杂志文章,评审
doi：10.1016/0024-3205(83)90767-1
更新日期：1983-05-16 00:00:00
abstract：:Three neurodegenerative diseases, Huntington's disease (HD), Kennedy's disease (hereditary spinobulbar muscular atrophy, SBMA), and type 1 spinocerebellar ataxia (SCA-1) have been found to share a common genetic defect: an unstable region of repeated CAG trinucleotides which are thought to be translated into a polyglu...
journal_title：Life sciences
pub_type： 杂志文章,评审
doi：10.1016/0024-3205(94)90012-4
更新日期：1994-01-01 00:00:00
abstract：:Recent studies suggest lipopolysaccharide (LPS) mediated cell death as underlying mechanism of hyporesponsiveness and dysfunction of macrophages in the late phase of septic shock. In the present study LPS (0.001 - 30 microg/ml) caused a concentration-dependent toxicity in the macrophage cell line (J774.1A) within 24 h...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(98)00031-9
更新日期：1998-01-01 00:00:00
abstract：:This study investigated the protective effects of acteoside, a phenylethanoid glycoside, on the carbon tetrachloride-induced hepatotoxicity as well as the possible mechanisms involved in this protection in mice. Pretreatment with acteoside prior to the administration of carbon tetrachloride significantly prevented the...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2003.07.020
更新日期：2004-01-09 00:00:00
abstract：:This work was designed to study neurogenic, atropine resistant contractions of the cat urinary bladder. Urinary bladder contractions were induced by pelvic nerve stimulation (PNS) and the administration of acetylcholine (Ach) and purine compounds. The results show that atropine (2 mg/kg) depresses the maintained porti...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(83)90374-0
更新日期：1983-05-23 00:00:00
abstract：:Sleep-disordered breathing is characterized by disruptions of normal breathing patterns during sleep. Obesity is closely related to hypoventilation or apnea and becomes a primary risk factor for sleep-disordered breathing. Leptin, a peptide secreted by adipose tissue, has been implicated in central control of breathin...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2020.117994
更新日期：2020-09-15 00:00:00
abstract：AIMS:Gastrointestinal cancers are a kind of deadly malignancy afflicting close to a million peoples worldwide. 5-Fluorouracil (5-Fu) is a main chemotherapeutic agent for cancer treatment. However, prolonged exposure of 5-Fu to cancer cells may cause chemoresistance and decrease the therapeutic potential of 5-Fu. MAIN ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2018.03.054
更新日期：2018-05-15 00:00:00
abstract：:Cultured adult skin fibroblasts were studied for binding and functional evidence of muscarinic receptors in order to assess their utility as a model of cholinergic function in affective illness. Saturable, specific, high affinity binding could be demonstrated in intact cells from some cell lines with [3H]-NMS, but not...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(86)90473-x
更新日期：1986-04-14 00:00:00
abstract：:A simple, selective reverse-phase HPLC-fluorometric method is described for the determination of serotonin (5HT) in cisternal CSF of the rat. The mean (+/- SE) value of CSF 5HT observed in control adult rats was 457 +/- 83 pg/ml (N = 16). In an attempt to validate the measure as an index of extracellular, or functiona...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(87)90061-0
更新日期：1987-06-08 00:00:00
abstract：AIMS:Fenofibrate (FF) is commonly used clinically as a lipid-lowering drug, but whether it participates in endoplasmic reticulum (ER) stress and decreases inflammation in skeletal muscle is still unknown. The aim of this study is to determine whether FF treatment reduces insulin resistance (IR) by alleviating ER stress...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2016.06.008
更新日期：2016-07-15 00:00:00
abstract：:The sodium-ion coupled transporters for 5-hydroxytryptamine (5HT), noradrenaline and dopamine function to reduce extracellular levels of biogenic amines. Over the past fifteen years selective inhibitors of these transport systems have been developed including fluoxetine, citalopram, paroxetine, litoxetine (for 5HT), n...
journal_title：Life sciences
pub_type： 杂志文章,评审
doi：10.1016/0024-3205(92)90236-i
更新日期：1992-01-01 00:00:00
abstract：:Castanospermine is a potent inhibitor of rat intestinal glycohydrolases in vitro and prevents the hyperglycemic response to an oral sucrose challenge in vivo. Among the glycohydrolases tested, castanospermine was most effective against sucrase with an IC50 of 1.1 x 10(-7) M. In vivo, a significant effect was seen at d...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(87)90546-7
更新日期：1987-11-16 00:00:00
abstract：:The effects of erythropoietin (EPO) on cytosolic free calcium concentration ([Ca2+]i) in platelets of 20 essential hypertensive patients (HT) and of 25 normotensive subjects (NT) were investigated using the fura2 technique. In resting platelets [Ca2+]i were not significantly higher in HT compared to NT (74.3 +/- 7.8 n...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(92)90010-m
更新日期：1992-01-01 00:00:00
abstract：:Efonidipine is a dihydropyridine Ca2+ antagonist with inhibitory effects on both L-type and T-type Ca2+ channels and potent bradycardiac activity especially in patients with high heart rate. In the present study, we examined the frequency dependence of efonidipine action on the T-type Ca2+ channel in isolated guinea-p...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(00)00932-2
更新日期：2000-12-08 00:00:00
abstract：UNLABELLED:Acute exercise is a stress stimulus that may cause cell damage through the activation of the toll-like receptor (TLR)4 pathway, resulting in the translocation of nuclear factor kappa B (NF-κB) into the cell nucleus and the upregulation of inflammatory genes. Nonsteroidal anti-inflammatory drugs, such as dicl...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2016.02.006
更新日期：2016-03-01 00:00:00
abstract：:The additive effects of combined valsartan and spironolactone on plasma and cardiac aldosterone escape were evaluated in spontaneously hypertensive rats (SHRs). Twenty-four SHRs were treated with valsartan (30 mg/kg body weight per day), spironolactone (20 mg/kg body weight per day) and a combination of both for 4 mon...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2004.04.012
更新日期：2004-08-27 00:00:00
abstract：:The effect of the diterpene forskolin on vascular permeability alone and in combination with bradykinin, prostaglandin E1, adenosine or histamine has been investigated in rats. Vascular permeability in rat skin was measured using [125I]-labelled bovine serum albumin ([125I]BSA) as a tracer. In addition, the effect of ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(83)90712-9
更新日期：1983-07-04 00:00:00
abstract：:First isolated some 10 years ago as the endogenous ligand for the "orphan opioid receptor" (ORL-1, now designated NOP), nociceptin/orphanin FQ (N/OFQ) has proved to be a potent inhibitory neuropeptide found across the neuraxis. Because of the homologies between opioids and N/OFQ, functional studies of this peptide hav...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2005.06.001
更新日期：2005-11-04 00:00:00
abstract：:Injection of carbon tetrachloride (CCl4) intraperitoneally into model animals induces acute liver injury mediated by reactive oxygen species (ROS) as normal metabolites in hepatocytes. In this study, the molecular process in this type of liver injury was analyzed from the aspect of liver function and regulatory factor...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2004.02.030
更新日期：2004-08-13 00:00:00
abstract：:The metabolism and disposition of N-hydroxy-3,4-methylenedioxyamphetamine (N-OH MDA) was studied by utilizing rat liver slices as well as by intravenous pharmacokinetic studies in rats. In the liver slice experiments, N-OH MDA (16 micrograms/ml) was incubated with rat liver slices and the disappearance of N-OH MDA and...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(94)00726-8
更新日期：1994-01-01 00:00:00
abstract：:Opiate binding sites have been characterized on membranes from bovine adrenal medullas and six human pheochromocytomas. In human tumors, large variations in site distribution were observed. Kappa and benzomorphan sites represented the majority of the sites detected. The heterogeneity of the opiate sites on these tissu...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(83)90501-5
更新日期：1983-01-01 00:00:00
abstract：AIMS:Hyperhomocysteinemia (Hhcy) is an independent risk factor of atherosclerosis and promotes unstable plaque formation. Epigenetic mechanisms play an important role in the pathogenesis of atherosclerosis induced by Hhcy. However, the exact mechanism is still undefined. Lesional apoptotic cells and necrotic core forma...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2017.02.003
更新日期：2017-03-15 00:00:00
abstract：:The analgesic effects of bestatin and thiorphan, two enzymatic inhibitors protecting endogenous enkephalins from their degradation, and those of DAGO and deltakephalin, respectively mu and delta opioid peptides, are assessed on the electrical stimulation test of the mouse tail. The relative analgesic potency of DAGO a...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(83)90595-7
更新日期：1983-01-01 00:00:00
abstract：:To examine the physiological significance of plasma ghrelin in generating pulsatile growth hormone (GH) secretion in rats, plasma GH and ghrelin levels were determined in freely moving male rats. Plasma GH was pulsatilely secreted as reported previously. Plasma ghrelin levels were measured by both N-RIA recognizing th...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(03)00147-4
更新日期：2003-04-18 00:00:00
abstract：:A previously unreported anti-bacterial activity against Escherichia coli has been found in porcine and bovine sera, but not in human or chicken sera. The activity is not affected by heat inactivation of the complement system, and is bacteriostatic rather than bactericidal. Growth inhibition is reversible by addition o...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(95)00277-d
更新日期：1995-01-01 00:00:00
abstract：AIMS:Endothelial microparticles (EMPs) are extracellular vesicles secreted by endothelial cells. The purpose of this research is to explore that the clinical significance and roles in angiogenesis and endothelial dysfunction of circulating microparticles in Perthes disease. MAIN METHODS:We collected platelet-poor plas...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2020.118749
更新日期：2021-01-15 00:00:00
abstract：:Acyl glucuronides are reactive electrophilic metabolites of carboxylate drugs, capable of undergoing hydrolysis, rearrangement and covalent binding reactions with proteins in vivo. Such covalent drug-protein adducts may be prerequisites for certain idiosyncratic immune and toxic responses in susceptible individuals. T...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(00)00958-9
更新日期：2000-12-22 00:00:00
abstract：:Inducible nitric oxide synthase (iNOS) and cyclooxygenase (COX)-2 are expressed in vascular smooth muscle cells stimulated with interleukin-1beta (IL-1beta), resulting in the production of nitric oxide (NO) and prostaglandins (PGs) such as PGI2. The iNOS and COX-2 proteins and their mRNA expressions in cultured vascul...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(01)01464-3
更新日期：2002-01-11 00:00:00
abstract：:The roles of capsaicin-sensitive sensory nerves (CPSN), endogenous nitric oxide (NO), sulfhydryls (SHs), prostaglandins (PGs) in the gastroprotection by momordin Ic, an oleanolic acid oligoglycoside isolated from the fruit of Kochia scoparia (L.) SCHRAD., on ethanol-induced gastric mucosal lesions were investigated in...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(99)00241-6
更新日期：1999-01-01 00:00:00
abstract：AIMS:The aims of this study were to examine the role of endothelin-1 (ET-1), a pleiotropic peptide found at elevated levels in a number of malignancies and which has been shown to influence oral cancer cell behaviour via paracrine signalling pathways, on the phenotype of oral fibroblasts. MAIN METHODS:The effect of ET...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2012.04.001
更新日期：2012-10-15 00:00:00
