Abstract:
:The analgesic effects of bestatin and thiorphan, two enzymatic inhibitors protecting endogenous enkephalins from their degradation, and those of DAGO and deltakephalin, respectively mu and delta opioid peptides, are assessed on the electrical stimulation test of the mouse tail. The relative analgesic potency of DAGO and deltakephalin is in good agreement with their relative potency on mu pharmacological assays: inhibition of electrically-induced contractions of guinea-pig ileum, displacement of 3H DAGO on rat brain. Finally, the analgesic effects of DAGO, deltakephalin and bestatin + thiorphan, are antagonized by the mu antagonist naloxone with similar pA2, and they are not modified by the delta antagonist ICI 154, 129. We conclude that only mu and not delta receptors are involved in the analgesic effects of enkephalins.
journal_name
Life Scijournal_title
Life sciencesauthors
Chaillet P,Coulaud A,Fournié-Zaluski MC,Gacel G,Roques BP,Costentin Jdoi
10.1016/0024-3205(83)90595-7subject
Has Abstractpub_date
1983-01-01 00:00:00pages
685-8eissn
0024-3205issn
1879-0631pii
0024-3205(83)90595-7journal_volume
33 Suppl 1pub_type
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