Abstract:
:The application of acetic acid to the hind leg of a frog will induce a spinally mediated wiping reflex only if the acetic acid concentration is above a certain threshold. By using this reflex as the basis of a test for nociception, we show that morphine sulfate is a potent analgesic in the frog when injected into the lumbar area of the spinal cord. Significant analgesia is induced within 5 min after injection of as little as 0.0316 microgram of morphine sulfate. Low doses of morphine sulfate (0.0316 or 0.1 microgram) induce analgesia which dissipates within 1 h while for higher doses (0.316, 1.0 or 3.16 micrograms) the analgesia persists for at least 3 h. The analgesic effect of 0.316 micrograms of morphine sulfate is completely blocked by naloxone HCl at either 0.158 or 0.316 micrograms. Animals receiving naloxone alone (0.316 micrograms) appear to be slightly hyperalgesic compared to saline injected controls but this effect is not significant.
journal_name
Life Scijournal_title
Life sciencesauthors
Stevens CW,Pezalla PDdoi
10.1016/0024-3205(83)90333-8subject
Has Abstractpub_date
1983-11-21 00:00:00pages
2097-103issue
21eissn
0024-3205issn
1879-0631pii
0024-3205(83)90333-8journal_volume
33pub_type
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