Abstract：
:The present study investigates the effect of a pituitary hormone (LH) and a thymic factor (Thymosin Fraction 5 = TF5) on in vitro and in vivo spleen cell proliferative response of 2, 6 and 8-month-old Balb/c mice. In vitro experiments showed that the addition of LH at various concentrations (0.5, 5, 50 or 500 ng/ml) to cultures increased significantly the proliferative response to some known mitogens (ConA, PHA, PWM). The LH stimulation was further enhanced by subsequent addition of TF5 to these cultures. However, the addition of LH to LPS cultures resulted in a blockage of the cell growth which persisted after the addition of TF5. In vivo experiments showed that injection of LH (5 or 50 ng/ml) to 2, 6 and 8-month-old Balb/c mice had a significant increase on blast transformation of lymphoid cells following their incubation with ConA, PHA and PWM, and a significant decrease when they were incubated with LPS. The physiological significance of these findings which point out an intimate connection between immune and endocrine functions is discussed.
journal_name
Life Scijournal_title
Life sciencesauthors
Rouabhia M,Ghanmi Z,Chakir J,Othmane O,Deschaux Pdoi
10.1016/0024-3205(90)90031-lsubject
Has Abstractpub_date
1990-01-01 00:00:00pages
257-64issue
4eissn
0024-3205issn
1879-0631pii
0024-3205(90)90031-Ljournal_volume
46pub_type
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