Abstract：
AIM:Vitamin C and vitamin E supplementations and their beneficial effects on type 2 diabetes mellitus (T2DM) have been subjected to countless controversial data. Hence, our aim is to investigate the hepatic molecular mechanisms of any diabetic predisposing risk of the chronic administration of different doses of vitamin E or vitamin C in rats. MAIN METHODS:The rats were supplemented with different doses of vitamin C or vitamin E for eight months. KEY FINDINGS:Vitamin C and vitamin E increased fasting blood glucose, insulin, and homeostasis model assessment index for insulin resistance (HOMA). Vitamin C disrupted glucose tolerance by attenuating upstream hepatic insulin action through impairing the phosphorylation and activation of insulin receptor and its subsequent substrates; however, vitamin E showed its effect downstream insulin receptor in the insulin signaling pathway, reducing hepatic glucose transporter-2 (GLUT2) and phosphorylated protein kinase (p-Akt). Moreover, both vitamins showed their antioxidant capabilities [nuclear factor-erythroid-2-related factor 2 (Nrf2), total and reduced glutathione] and their negative effect on Wnt pathway [phosphorylated glycogen synthase kinase-3β (p-GSK-3β)], by altering the previously mentioned parameters, inevitably leading to severe reduction of reactive oxygen species (ROS) below the physiological levels. SIGNIFICANCE:In conclusion, a detrimental effect of chronic antioxidant vitamins supplementation was detected; leading to insulin resistance and impaired glucose tolerance obviously through different mechanisms. Overall, these findings indicate that the conventional view that vitamins promote health benefits and delay chronic illnesses and aging should be modified or applied with caution.
journal_name
Life Scijournal_title
Life sciencesauthors
Ali MA,Eid RMHM,Hanafi MYdoi
10.1016/j.lfs.2017.12.039subject
Has Abstractpub_date
2018-02-01 00:00:00pages
196-204eissn
0024-3205issn
1879-0631pii
S0024-3205(17)30689-6journal_volume
194pub_type
杂志文章相关文献
LIFE SCIENCES文献大全abstract：:C57BL6/J (B6) mice lacking Se-dependent GSH peroxidase 1 and 2 (GPx1/2-DKO) develop mild to moderate ileocolitis around weaning. These DKO mice have a disease resembling human very-early-onset inflammatory bowel disease (VEOIBD), which is associated with mutations in NADPH oxidase genes. Drugs including dexamethasone ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2019.116884
更新日期：2019-12-15 00:00:00
abstract：:Cardiovascular risk factors associated with hypertension include alterations in arterial compliance and an increased tendency to thrombosis. In this study we examined the relationship between arterial compliance and endothelial derived components of the hemostatic system: von Willebrand factor (vWF) and tissue plasmin...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(93)90192-6
更新日期：1993-01-01 00:00:00
abstract：:The hypothermia induced by apomorphine, a mixed dopamine (DA) agonist in male Swiss-Webster mice, was not blocked by the selective D-1 antagonist SCH 23390 but was completely blocked by the selective D-2 antagonists haloperidol, sulpiride and YM-09151-2. The selective D-1 agonist SKF 38393 did not elicit hypothermic r...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(88)90515-2
更新日期：1988-01-01 00:00:00
abstract：:The ontogeny of endothelin (ET) system in rats was studied in preterm (18 days of gestation), term (21 days of gestation) and 1 week post term rats. Brains were dissected out and (1) processed for the estimation of endogenous ET-1 by RIA and (2) membranes were prepared for radioreceptor binding. Receptor characteristi...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(92)90300-e
更新日期：1992-01-01 00:00:00
abstract：:Voltage clamp recordings of GH3/B6 pituitary cells reveal the presence of non linear steady state membrane properties at the level of the resting potential (about -41 mV). Clamping the cells to potentials more depolarized than -60 mV is associated with a potential dependent increase in membrane conductance and membran...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(82)90475-1
更新日期：1982-05-31 00:00:00
abstract：:Species-related specific differences in the pharmacological profile of vasopressin V1a receptors have been reported. Thus, the aim of the present study was to identify a vascular preparation of human origin expressing V1a receptors. Vasopressin was found to contract human gastric artery strips without endothelium with...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(96)00635-2
更新日期：1997-01-01 00:00:00
abstract：:The effect of brief inhalation of carbon dioxide (CO2) was studied in a conflict situation (Vogel test) in the rat. This treatment, which inhibits gamma-aminobutyric acid (GABA)-mediated transmission in rat brain and induces anxiety and panic attacks in humans, elicited a proconflict effect. Exposure of rats for 1 min...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(95)00093-3
更新日期：1995-03-10 00:00:00
abstract：:An attenuation of adrenergic activity during the inhibition of endogenous angiotensin II formation was evaluated by determining plasma norepinephrine concentration after a single oral administration of captopril compared to that after nifedipine in essential hypertension. Captopril produced a fall in mean arterial pre...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(91)90415-8
更新日期：1991-01-01 00:00:00
abstract：:Ethanol-induced emesis were investigated using Suncus murinus and the emetogenic mechanisms of ethanol were compared with those of cisplatin. Intraperitoneal injection of ethanol caused dose-dependent emesis with ED50 value of 22.3% (v/v) when injection volume was adjusted to 4 ml/kg. Intraperitoneal and subcutaneous ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(96)00625-x
更新日期：1997-01-01 00:00:00
abstract：:Inhibitors of neuronal norepinephrine (NE) uptake are useful for the treatment of a variety of diseases including depression and urinary incontinence. In the present study, we synthesized and evaluated a novel analog of the potent and selective NE uptake inhibitor, nisoxetine. Thionisoxetine more potently inhibited th...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(95)00166-4
更新日期：1995-01-01 00:00:00
abstract：:Two groups of individuals, 26 normotensive normolipemic and 37 normotensive hyperlipemic, all without family history of hypertension have been selected in attempt to demonstrate whether Li-Na countertransport of erythrocytes is influenced by plasma and membrane lipid composition. The maximal rate of Li-Na countertrans...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(87)90637-0
更新日期：1987-08-31 00:00:00
abstract：:Autophagy is a metabolic process that maintains the homeostasis of the intracellular environment by degrading damaged proteins and organelles in lysosomes. Recently, independent studies have indicated that some hepatitis viruses develop abilities to hijack autophagy for their replication, such as hepatitis B (HBV) and...
journal_title：Life sciences
pub_type： 杂志文章,评审
doi：10.1016/j.lfs.2019.117206
更新日期：2020-02-01 00:00:00
abstract：AIMS:Osteoclasts, the unique bone-resorbing polykaryons, are responsible for many bone-destructive diseases, such as osteoporosis and rheumatoid arthritis. Hence, the regulation of osteoclast formation is considered a potential therapeutic approach for these diseases. In this study, we investigated the effect of a nove...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2012.09.009
更新日期：2012-11-02 00:00:00
abstract：:We analyzed PGE2 production in primary-cultured human hepatic macrophages (HHM phi) and peripheral monocytes (MO) from patients with and without liver cirrhosis, and correlated PGE2 production with the patients' liver function. Serum choline esterase (ChE) levels were used as an indicator of liver function. PGE2 produ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(93)90751-n
更新日期：1993-01-01 00:00:00
abstract：:Chronic cocaine abuse has been associated with cerebrovascular pathology. This is likely to reflect its vasoactive effects; cocaine produces vasoconstriction and reduces cerebral blood flow. We propose that cerebrovascular pathology in chronic cocaine abusers would result in abnormal BOLD [blood oxygenation level depe...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(03)00548-4
更新日期：2003-08-29 00:00:00
abstract：AIMS:Lipid soluble vitamin E plays a role in several physiological mechanisms, however, the mechanism of this action is controversial. We investigated how tocopherol (α-tocopherol acid succinate) influences the effects of cyclooxygenase inhibitors (COXi) in the smooth muscles. MAIN METHODS:The contractility of the sam...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2017.11.048
更新日期：2018-01-01 00:00:00
abstract：:Using an isolated, perfused rat lung model, we examined the hypoxic pulmonary vasoconstriction (HPV). We studied the alterations in HPV induced by the selective DA1 receptor agonist, fenoldopam, the selective DA1 antagonist, SCH 23390, as well as a combination of these agents. Fenoldopam significantly attenuated HPV. ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(92)90630-8
更新日期：1992-01-01 00:00:00
abstract：:There is a growing literature indicating that opioid abuse by human addicts and opioid administration to animals have profound effects on the immune system. In the present study, implantation of morphine pellets in mice was associated with reduced phenotypic expression of the cell surface antigens specific to T-lympho...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(92)90607-q
更新日期：1992-01-01 00:00:00
abstract：AIMS:The objective of this study was to establish a more accurate analytical model and method for grip strength test of mice and to investigate the beneficial effects of lifelong exercise training to prevent functional decline of muscle during aging. MAIN METHODS:Fifty randomly selected adult male BALB/c mice (24-56 w...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2020.117603
更新日期：2020-06-15 00:00:00
abstract：:Recent findings indicate that low concentrations of dopamine (DA) stimulate the secretion of prolactin (PRL) in vitro. In this study, we found that low concentrations of the highly-specific DA D2 receptor agonist, quinpirole hydrochloride (LY) stimulate PRL secretion in female rats, assessed by reverse hemolytic plaqu...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(93)90749-s
更新日期：1993-01-01 00:00:00
abstract：:Nitric oxide (NO) may play an important regulatory role in airway function. We have, thus, investigated in vitro whether epithelium derived NO may modulate cholinergic neurotransmission, via release of NO in guinea pig trachea, by using L-arginine (L-ARG), a precursor of NO synthesis, and L-N(G)-nitro-arginine-methyl-...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(95)00053-9
更新日期：1995-02-17 00:00:00
abstract：AIM:Epidermal growth factor receptor (EGFR) related reactive oxygen species (ROS) generation results in myocardial damage. We aimed to investigate the role of gefitinib (EGFR-tyrosine kinase inhibitor) in diabetic cardiomyopathy (DbCM). METHOD:DbCM was induced by injecting streptozotocin (55 mg/kg for 5 consecutive da...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2018.08.018
更新日期：2018-10-01 00:00:00
abstract：:This review is an attempt to establish a role for both glucocorticoid and thyroid hormones in the aging process as factors which mediate the regulation of transcription and translation of specific genetic domains. Furthermore, through a review of the current knowledge of the effect of long-term hypophysectomy on physi...
journal_title：Life sciences
pub_type： 杂志文章,评审
doi：10.1016/0024-3205(82)90762-7
更新日期：1982-08-16 00:00:00
abstract：:The association of [3H] [D-Ala2, D-Leu5] enkephalin ([3H]DADLE]) with mouse neuroblastoma cells (N4TG1) was investigated. Under identical conditions the time course, dose response curve and temperature dependence for ligand uptake were similar to those for ligand-induced receptor loss (down regulation). Uptake of [3H]...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(82)90369-1
更新日期：1982-09-20 00:00:00
abstract：:There are many studies of the mechanisms of antidepressants; however, most of these studies were conducted on the hippocampus or frontal cortex. In the present study, we hypothesized that the nucleus accumbens and caudate/putamen might be major targets for antidepressant effects. Thus, we focused on G(olf) protein, a ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2006.01.033
更新日期：2006-06-27 00:00:00
abstract：:The endocannabinoids are endogenous agonists of the cannabinoid receptors and some members of the transient receptor potential, vanilloid type (TRPV), family of cation channels. Endocannabinoids along with their target receptors comprise a signaling system that is not well characterized. There have been many advances ...
journal_title：Life sciences
pub_type： 杂志文章,评审
doi：10.1016/j.lfs.2005.05.010
更新日期：2005-08-19 00:00:00
abstract：:Adult rat offspring earlier exposed to maternally ingested caffeine during both gestation and lactation were observed in an open field following acute administration of diazepam or cyclohexyladenosine. While both drugs reduced measures of locomotion and emotional reactivity, caffeine-exposed rats showed evidence of gr...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(96)80009-9
更新日期：1996-01-01 00:00:00
abstract：:Unconjugated bilirubin (UCB), like trifluoperazine (TFP), dibucaine (DBC) and praziquantel (PZQ), induces erythrocyte morphological changes, lysis and lipid exfoliation. In the present study we determined whether TFP, DBC and PZQ toxicity to erythrocytes was potentiated or reverted by UCB. Human erythrocytes were eith...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(01)01171-7
更新日期：2001-07-13 00:00:00
abstract：:In recent years several synthetic peptides have been shown to be active in inducing GH secretion in different mammalian species. Among them GHRP-6, GHRP-1 and GHRP-2 have demonstrated high effectiveness and high selectivity in stimulating GH release. In the present paper we report studies on the GH-secreting propertie...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(94)00510-9
更新日期：1994-01-01 00:00:00
abstract：:Heart rate (HR) and mean arterial blood pressure (BP) were recorded from conscious, chair-restrained squirrel monkeys surgically prepared with chronically indwelling arterial and venous catheters to determine the effects of acute intravenous injections of two opiate antagonists and an agonist. Naloxone (0.3--10.0 mg/k...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(83)90085-1
更新日期：1983-01-24 00:00:00
