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Current status of artemisinin and its derivatives as antimalarial drugs.

Abstract：

:Artemisinin is a promising and a potent antimalarial drug, which meets the dual challenge posed by drug-resistant parasites and rapid progression of malarial illness. This review article focuses on the progress achieved during the last years in the production of artemisinin from Artemisia annua. The structure, biosynthesis and analysis of artemisinin and its mode of action are described. The review also focuses on clinical studies, toxicity studies, pharmacokinetics and activity of artemisinin related compounds. The production strategies including organic synthesis, extraction from plants, in vitro cultures and alternative strategies for enhancing the yields are also discussed.

journal_name

Life Sci

journal_title

Life sciences

authors

Dhingra V,Vishweshwar Rao K,Lakshmi Narasu M

doi

10.1016/s0024-3205(99)00356-2

subject

Has Abstract

pub_date

2000-01-01 00:00:00

pages

279-300

issue

4

eissn

0024-3205

issn

1879-0631

pii

S0024320599003562

journal_volume

66

pub_type

杂志文章,评审

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