Liver injury in septic mice were suppressed by a camptothecin-bile acid conjugate via inhibiting NF-κB signaling pathway.

abstract：:A fostering/crossfostering analysis of the effects of maternal ethanol exposure on jejunal and ileal folate absorption was performed. Male and female rats were randomized into two groups. In the first group, ethanol-treated rats received ad libitum 5, 10 and 15% ethanol in the drinking fluid during three successive we...

journal_title：Life sciences

authors： Murillo-Fuentes ML,Murillo ML,Carreras O

更新日期：2003-09-12 00:00:00

abstract：AIMS:With the purpose of exploring combinatorial options that could enhance the bactericide efficacy of linezolid against Gram-negative bacteria, we assessed the extent of combination of nano-silver and linezolid. MAIN METHODS:In this study, we selected Escherichia coli MTCC 443 as a model to study the combinatorial e...

journal_title：Life sciences

authors： Anuj SA,Gajera HP,Hirpara DG,Golakiya BA

更新日期：2019-08-01 00:00:00

abstract：:The present study was designed to investigate the effects of chronic administration of the alcoholic extract of Terminalia arjuna (TAAE) bark on isoproterenol induced myocardial injury. The TAAE was administered orally to Wistar albino rats (150-200 g) in three different doses, by gastric gavage [3.4 mg/kg: (T1), 6.75...

journal_title：Life sciences

authors： Karthikeyan K,Bai BR,Gauthaman K,Sathish KS,Devaraj SN

更新日期：2003-10-10 00:00:00

abstract：:Time-course studies revealed the increased susceptibility of the gastric mucosa to noxious injury in portal hypertension correlates with the level of elevated portal venous pressure and hyperglucagonemia. Whether acute elevation of portal venous pressure by exogenous glucagon aggravates such injury is not known. We te...

journal_title：Life sciences

authors： Tsui CP,Sung JJ,Leung FW

更新日期：2003-07-18 00:00:00

abstract：OBJECTIVE:To explore the correlation of the viscus fat area (VFA) with the Framingham 10-year general cardiovascular disease risk in patients with type 2 diabetes mellitus (T2DM). METHODS:A total of 202 patients with T2DM were divided into two groups based on VFA (a VFA ≥ 100 cm2 group and a VFA < 100 cm2 group), or f...

journal_title：Life sciences

authors： Xu L,Song P,Xu J,Zhang H,Yu C,Guan Q,Zhao M,Zhang X

更新日期：2019-03-01 00:00:00

abstract：:There is a significant need to evaluate the therapeutic potential of natural products and other compounds purported to be hepatoprotective. Acetaminophen-induced liver injury, especially in mice, is an attractive and widely used model for this purpose because it is both clinically relevant and experimentally convenien...

journal_title：Life sciences

authors： Jaeschke H,McGill MR,Williams CD,Ramachandran A

更新日期：2011-04-25 00:00:00

abstract：:The drug transporter, multidrug resistance-associated protein 2 (ABCC2/Mrp2), is known to play important roles in excretion of various drugs. In the present study, we investigated whether Mrp2 is involved in the transport of micafungin, a newly developed antifungal agent. When Sprague-Dawley rats received an intraveno...

journal_title：Life sciences

authors： Abe F,Ueyama J,Kimata A,Kato M,Hayashi T,Nadai M,Saito H,Takeyama N,Noguchi H,Hasegawa T

更新日期：2008-08-15 00:00:00

abstract：:In order to investigate possible neurobiologic mechanisms underlying carbon dioxide-induced anxiety, the effects of oral alprazolam 0.75 mg and intravenous clonidine 2 mcg/kg on CO2-induced increases in ratings of subjective anxiety, pulse rate, and ventilation were measured in healthy human subjects. Pretreatment wit...

journal_title：Life sciences

authors： Woods SW,Krystal JH,Heninger GR,Charney DS

更新日期：1989-01-01 00:00:00

abstract：:The effects of methyl vitamin B12 (5-6 mg/kg, p.o.) on the entrainment of circadian running wheel activity rhythm to a new lighting schedule were measured in rats. After the light-dark (LD) cycle was abruptly reversed, rats given vitamin B12 took less time to entrain their circadian locomotor activity rhythm to the ne...

journal_title：Life sciences

authors： Tsujimaru S,Ida Y,Satoh H,Egami H,Shirao I,Mukasa H,Nakazawa Y

更新日期：1992-01-01 00:00:00

abstract：:Antinociceptive effect of nifedipine (15 mg/kg i.p.) and verapamil (10 mg/kg s.c.) was examined in rats chronically exposed to nicotine (6 mg/kg/day via Alzet osmotic pump for 28 days) and after nicotine withdrawal. Sham operated rats served as control for testing DMSO (dimethylsulfoxide, a solvent for nifedipine), ni...

journal_title：Life sciences

authors： Zbuzek VK,Cohen B,Wu W

更新日期：1997-01-01 00:00:00

abstract：:We studied the incorporation of 14C-formate into uric acid and allantoin in different organs (liver, lung, kidney, spleen), isolated hepatocytes, perfused liver and urine of the rat. Allantoin had a higher specific radioactivity than uric acid after 14C-formate load in the liver in vivo. This was found to be a strictl...

journal_title：Life sciences

authors： Pizzichini M,Pandolfi ML,Arezzini L,Terzuoli L,Fe L,Bontemps F,Van den Berghe G,Marinello E

更新日期：1996-01-01 00:00:00

abstract：:Ancylostoma ceylanicum, the human hookworm parasite, exhibited significant secretion of cholinesterase when maintained in vitro in RPMI-1640 medium. Secretion of the enzyme was linear up-to 4 hours of incubation. About 40 percent of the total cholinesterase activity was localized in the soluble fraction, while remaini...

journal_title：Life sciences

authors： Tekwani BL

更新日期：1992-01-01 00:00:00

abstract：:This paper describes the use of complex liposomes as real membrane models to evaluate the potential benefits of several antioxidants in relation to lipid peroxidation. The xanthine oxidase/Fe(3+)-ADP-EDTA and the Fe(2+)/H2O2 systems have been used to generate hydroxyl radicals and the water soluble azo-compound 2,2'-a...

journal_title：Life sciences

authors： Gutiérrez ME,García AF,Africa de Madariaga M,Sagrista ML,Casadó FJ,Mora M

更新日期：2003-04-11 00:00:00

abstract：:Biliary excretion is the main route of disposal of bilirubin and impaired excretion results in jaundice, a well recognisable symptom of liver disease. Conjugation of bilirubin in the liver is essential for its clearance. The glucuronidation of bilirubin is catalysed by the microsomal UDP-glucuronosyltransferase UGT1A1...

journal_title：Life sciences

authors： Bustamante N,Cantarino MH,Arahuetes RM,Cubero FJ,Ortiz A

更新日期：2006-03-06 00:00:00

abstract：AIMS:Nanoparticles (NPs)-based drugs have been recently introduced to improve the efficacy of current therapeutic strategies for the treatment of cancer; however, the molecular mechanisms by which a NP interacts with cellular systems still need to be delineated. Here, we utilize the autophagic potential of TiO2 NPs for...

journal_title：Life sciences

authors： Azimee S,Rahmati M,Fahimi H,Moosavi MA

更新日期：2020-05-01 00:00:00

abstract：:Nitric oxide (NO) is a key mediator in many physiological processes and one of the major receptors through which NO exerts its effects is soluble guanylyl cyclase. Guanylyl cyclase converts GTP to cyclic GMP as part of the cascade that results in physiological processes such as smooth muscle relaxation, neurotransmiss...

journal_title：Life sciences

authors： Miller LN,Nakane M,Hsieh GC,Chang R,Kolasa T,Moreland RB,Brioni JD

更新日期：2003-01-17 00:00:00

abstract：AIMS:Evidence has indicated U50,488H, a selective κ-opioid receptor (κ-OR) agonist, administered before ischemia attenuates apoptosis and infarction during ischemia and reperfusion (I/R). However, it remains unclear whether U50,488H postconditioning reduces apoptosis during I/R. This study was designed, therefore, to t...

journal_title：Life sciences

authors： Tong G,Sun Z,Wei X,Gu C,Kaye AD,Wang Y,Li J,Zhang Q,Guo H,Yu S,Yi D,Pei J

更新日期：2011-01-03 00:00:00

abstract：:Striatal D-2 dopamine (DA) antagonist and agonist binding sites were measured during the rat estrous cycle and compared to ovariectomized (OVX) rats. Dopaminergic D-2 antagonist binding sites were constant during the estrous cycle while agonist binding sites show a rapid and significant decrease of the ratio of high t...

journal_title：Life sciences

authors： Di Paolo T,Falardeau P,Morissette M

更新日期：1988-01-01 00:00:00

abstract：AIM:To investigate the cytotoxic effect of Peruvoside and mechanism of action in human cancers. MAIN METHODS:Cell viability was measured by MTT assay and the cell cycle arrest was identified by FACS. Real-time qPCR and western blotting studies were performed to identify important gene and protein expressions in the di...

journal_title：Life sciences

authors： Reddy D,Kumavath R,Tan TZ,Ampasala DR,Kumar AP

更新日期：2020-01-15 00:00:00

abstract：:A heterogeneous particulate fraction of mouse brain homogenates binds NRDC 157 (3-phenoxybenzyl [1R, cis]-3-(2,2-dibromovinyl)-2,2-dimethylcyclopropanecarboxylate), a potent pyrethroid insecticide, stereospecifically and with high affinity. Stereospecific binding is a minor component of total binding (2.8%); the remai...

journal_title：Life sciences

authors： Soderlund DM,Ghiasuddin SM,Helmuth DW

更新日期：1983-07-18 00:00:00

abstract：:The regions of muscarinic receptors that specify G-protein-coupling and ligand-binding have been defined in several recent studies. Overall, these studies have shown that amino acids within the third cytoplasmic loop of the receptors define their selectivity for different G-proteins, and that multiple, discontinuous e...

journal_title：Life sciences

authors： Brann MR,Klimkowski VJ,Ellis J

更新日期：1993-01-01 00:00:00

abstract：:It is well known that the immune function can be compromised by stress. To investigate immune function in mice stressed by experimental restraint or unavoidable and opioid dependent stress, we evaluated the changes in total body weight and in organ weights (liver, spleen and thymus) of these animals, as well as the ph...

journal_title：Life sciences

authors： Teshima H,Sogawa H,Kihara H,Kubo C,Mori K,Nakagawa T

更新日期：1990-01-01 00:00:00

abstract：:Immunotherapy with immune checkpoint inhibitors, such as anti-PD-1 drugs, is an area in increasing development for its efficacy and advantages in the treatment of advanced metastatic melanoma. In fact, immunotherapy has been the target of several and recent studies in different types of cancer, namely in melanoma, a g...

journal_title：Life sciences

authors： Moreira RS,Bicker J,Musicco F,Persichetti A,Pereira AMPT

更新日期：2020-01-01 00:00:00

abstract：:Classical studies have demonstrated that the visual centers in primates consist of cortical areas V1, V2 and V4 and their branches. However, nothing is known about how these visual areas change in postnatal development. In the present studies, therefore, pigs aged 2, 4, and 6 months old, were stimulated visually with ...

journal_title：Life sciences

authors： Fang M,Li J,Rudd JA,Wai SM,Yew JC,Yew DT

更新日期：2006-02-09 00:00:00

abstract：:This study in conscious normotensive rats was performed to assess the effect of the vasoconstrictor peptide, neuropeptide Y (NPY), on blood pressure responsiveness to exogenous norepinephrine in endotoxaemia. NPY and endotoxin were infused at doses which had no effect on blood pressure, whether given alone or in combi...

journal_title：Life sciences

authors： Evéquoz D,Waeber B,Corder R,Nussberger J,Gaillard R,Brunner HR

更新日期：1987-12-07 00:00:00

abstract：:The localization of vasoactive intestinal polypeptide (VIP) in the male genitourinary tract was investigated in the rabbit and man by means of radioimmunoassay and immunohistochemistry. In addition, the in vitro effect of VIP upon penile smooth muscle from man, the Vervet monkey, and the rabbit was investigated. Signi...

journal_title：Life sciences

authors： Willis EA,Ottesen B,Wagner G,Sundler F,Fahrenkrug J

更新日期：1983-07-25 00:00:00

abstract：:11β-hydroxysteroid dehydrogenase 1 (11β-HSD1) inhibitors have been shown to treat type 2 diabetes (T2D). Since gossypol is an 11β-HSD1 inhibitor, the objective of the present study was to treat T2D and T2D-related liver fibrosis in rat model using low-dose gossypol. T2D was induced by feeding with high fat diet plus i...

journal_title：Life sciences

authors： Chen G,Wang R,Chen H,Wu L,Ge RS,Wang Y

更新日期：2016-03-15 00:00:00

abstract：:We reported recently that ventromedial hypothalamic (VMH) lesions increased the synthesis of DNA in the gastrointestinal tract of rats by the firing of vagus nerve activity, mainly via cholinergic receptor mechanisms. In the present study, we examined whether the mitotic response is due to proliferation of a cell popu...

journal_title：Life sciences

authors： Kiba T,Tanaka K,Hoshino M,Numata K,Okano K,Inoue S

更新日期：1995-01-01 00:00:00

abstract：:Mycobacterium tuberculosis is the most successful pathogen with multiple mechanisms to subvert host immune response, resulting in insidious disease. There are few studies on whether the bacteria undergo antigenic variation in response to host immune pressure. Studies on T cell epitopes of M. tuberculosis can help us f...

journal_title：Life sciences

authors： Jiang Y,Liu H,Dou X,Zhao X,Li M,Li G,Bai Y,Zhang W,Lian L,Yu Q,Zhang J,Wan K

更新日期：2018-09-15 00:00:00

abstract：:Clinical studies of cholinergic pharmacotherapy, together with the putative role of the muscarinic receptor system in the neurophysiology of human behavior, support a possible muscarinic cholinergic involvement in schizophrenia. The present study has measured the density of [3H]AF-DX 384 labelled receptors (muscarinic...

journal_title：Life sciences

authors： Crook JM,Dean B,Pavey G,Copolov D

更新日期：1999-01-01 00:00:00