Abstract:
:Classical studies have demonstrated that the visual centers in primates consist of cortical areas V1, V2 and V4 and their branches. However, nothing is known about how these visual areas change in postnatal development. In the present studies, therefore, pigs aged 2, 4, and 6 months old, were stimulated visually with a colored checker board and the active sites in the cortex, cerebellum and brainstem recorded using functional magnetic resonance imaging (fMRI). In pigs aged 2 months old, visual stimulation induced an increase in activation of sites in the V2 and V4 cortical areas, as well as in the areas of the inferior aspect of the parietal and middle aspect of the temporal cortices, but not in the medial and caudal occipital cortex (V1 area). At 4 months old, the V1 area was also activated, and by 6 months old, an inferior sector in the prefrontal cortex was also activated. As the pigs aged, functional active sites were further demonstrated in the cerebellum and the brainstem, which probably had to do with action memory, and the control of the ocular muscles, respectively. It is concluded that the visual pathway of the pig mainly involves cortical areas that mature at 6 months of age.
journal_name
Life Scijournal_title
Life sciencesauthors
Fang M,Li J,Rudd JA,Wai SM,Yew JC,Yew DTdoi
10.1016/j.lfs.2005.06.030subject
Has Abstractpub_date
2006-02-09 00:00:00pages
1197-201issue
11eissn
0024-3205issn
1879-0631pii
S0024-3205(05)00857-Xjournal_volume
78pub_type
杂志文章相关文献
LIFE SCIENCES文献大全abstract::Alpha-inhibin-92 (alpha-IB-92) has been characterized from human seminal plasma and found to be active in suppressing FSH release in vitro and in vivo. In order to determine if smaller fragments of this 92 amino acid peptide would still be active to suppress FSH release, we have evaluated 5 of these fragments for thei...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(94)90100-7
更新日期:1994-01-01 00:00:00
abstract::Trimidox (3,4,5-trihydroxybenzohydroxamidoxime), a recently synthesized inhibitor of ribonucleotide reductase (RR), was shown to exert anti-proliferative activities in HL-60 and K562 human leukemia cell lines and to prolong the life span of mice inoculated with L1210 mouse leukemia cells. Here we test whether trimidox...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(00)00901-2
更新日期:2000-11-17 00:00:00
abstract::To investigate the properties of the gamma-aminobutyric acid (GABA) synthesizing enzyme, glutamate decarboxylase (GAD), in the brain and the pancreatic islets of the rat, GABA concentration in the brain and the pancreatic islets was measured after administration of 3-mercaptopropionic acid (3-MP) at 25 mg/kg intraperi...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(94)00445-5
更新日期:1994-01-01 00:00:00
abstract:AIMS:Intestinal alkaline phosphatase (IAP) is an intestinal brush border enzyme that is shown to function as a gut mucosal defense factor, but its defensive mechanism remains unclear. The aims of this study were to evaluate the effect of IAP on intestinal epithelial cells and macrophages, and on chronic colitis in inte...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2014.02.003
更新日期:2014-04-01 00:00:00
abstract::Addition of synthesized atriopeptin II (AP-2), a 23 amino acid peptide of rat atria, to rat thoracic aorta smooth muscle cells results in the stimulation of cyclic GMP production by the cells. The EC50 for the effect is 81 nM and a 7 fold increase occurs at 10 microM AP-2. Cyclic GMP levels increased within 15 seconds...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(85)90425-4
更新日期:1985-08-19 00:00:00
abstract::Silica (SiO2) nanoparticles (NPs) were synthesized by laser ablation method and were characterized by TEM and DLS techniques. Afterwards, their inhibition activity against carbonic anhydrase (CA) isoforms (CA I and CA II) was explored by experimental and theoretical analysis. Also, the protective effect of SiO2 NPs ag...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2021.119032
更新日期:2021-01-12 00:00:00
abstract::Using an isolated, perfused rat lung model, we examined the hypoxic pulmonary vasoconstriction (HPV). We studied the alterations in HPV induced by the selective DA1 receptor agonist, fenoldopam, the selective DA1 antagonist, SCH 23390, as well as a combination of these agents. Fenoldopam significantly attenuated HPV. ...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(92)90630-8
更新日期:1992-01-01 00:00:00
abstract::Lymphocyte apoptosis occurs in response to stressors such as thermal injury, trauma, sepsis, and surgery. This study evaluated the effect of a single bout of physical exercise stress on the induction of apoptosis in murine thymocytes and splenic lymphocytes. Female C57BL/6 mice, treadmill exercised at a submaximal int...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(98)00551-7
更新日期:1999-01-01 00:00:00
abstract::Two-dimensional and line-scan analyses of the early phase Ca2+ transients in rat cardiomyocytes were performed with a rapid-scanning laser confocal microscope and fluo-3 to elucidate the mechanism of activation of Ca2+ release from the sarcoplasmic reticulum in atrial myocytes which lack a well developed T-tubular net...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(01)01436-9
更新日期:2001-12-28 00:00:00
abstract:AIMS:We investigated the pathophysiological changes in mice lacking α2-antiplasmin (α2-AP) and plasminogen activator inhibitor type-1 (PAI-1) genes, and elucidated the involvement of these inhibitors for fibrinolysis in immune response. MAIN METHODS:The pathophysiological changes induced by a lack of both α2-AP and PA...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2013.05.023
更新日期:2013-07-30 00:00:00
abstract:BACKGROUND:Polychlorinated biphenyls (PCBs) are persistent organic pollutants that bioaccumulate in adipose tissue, disturbing its metabolism and the balance of adipokines, related to obesity. The altering secretion pattern of adipokines from the adipose tissue and the increasing mechanical load in weight-bearing joint...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2016.06.010
更新日期:2016-07-15 00:00:00
abstract:AIMS:The aims of the present study were to investigate the effect of crebanine on memory and cognition impairment in mice and to elucidate the underlying molecular mechanisms. MAIN METHODS:The memory-enhancing effects of crebanine were assessed with a water maze test using scopolamine-induced amnesic mice. The molecul...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2012.06.017
更新日期:2012-08-21 00:00:00
abstract:AIMS:TsTX-I scorpion toxin, also known as γ-toxin, is a β-toxin which binds to site 4 of the sodium channel, shifting its activation potential. There are few studies about its pharmacological action in the central nervous system. The objective of this work was to determine the electroencephalographic, behavioral and hi...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2010.09.007
更新日期:2010-10-09 00:00:00
abstract:AIMS:Anaphylactic shock sometimes accompanies pulmonary vaso- and broncho-constriction. We previously reported the hemodynamic features of mouse anaphylaxis (Life Sci. 2014; 116: 98-105). However, the effects of anaphylactic chemical mediators on the hemodynamics of in vivo mice are not well known. Furthermore, it is u...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2016.01.034
更新日期:2016-02-15 00:00:00
abstract::This study analyses possible changes during surgical and chemical castration in the expression and pharmacological characteristics of alpha1-adrenoceptor in adult rat seminal vesicle. Ribonuclease protection assays indicated that alpha1a--was the predominant mRNA, while alpha1b-and alpha1d-adrenoceptor transcripts wer...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2004.03.011
更新日期:2004-08-06 00:00:00
abstract::We provide direct evidence that verapamil inhibits active digoxin secretion in renal tubular cells (LLC-PK1), and that verapamil increases cellular accumulation of digoxin. These findings suggest that verapamil inhibits the digoxin active secretory transport at the apical membranes, supporting the theory that P-glycop...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(93)90667-r
更新日期:1993-01-01 00:00:00
abstract::Pulmonary surfactant release from lamellar bodies in alveolar type II cells in response to exogenous and circulating catecholamines is well documented but sympathetic influences from direct nerve stimulation are not as extensively studied. In order to study sympathetic nerve influence on release, ultrastructure of typ...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(94)00662-8
更新日期:1994-01-01 00:00:00
abstract::The study was designed to investigate the role of molybdenum iron-sulfur flavin hydroxylases in the pathogenesis of liver injuries induced by structurally and mechanistically diverse hepatotoxicants. While carbon tetrachloride (CCl4), thioacetamide (TAA) and chloroform (CHCl3) inflict liver damage by producing free ra...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2008.01.011
更新日期:2008-03-26 00:00:00
abstract::The effects of taurine on hepatic cholesterol metabolism were investigated in hamsters fed a high-fat diet or normal chow. Two weeks-treatment of taurine at 1% in drinking water prevented high-fat diet-induced increase in cholesterol levels of serum and liver. The decrease in serum cholesterol by taurine was due to de...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(02)01507-2
更新日期:2002-04-05 00:00:00
abstract::Alpha2-adrenoceptor (alpha2-AR)-regulated binding of the labelled GTP analog, guanosine 5'-O-(3-[35S]thiotriphosphate) ([35S]GTPgammaS), to guanine-nucleotide-binding proteins (G proteins) was studied in human platelet membranes. Under optimal conditions, the potent alpha2-AR agonist, 5-bromo-6-(2-imidazolin-2-ylamino...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(99)00074-0
更新日期:1999-01-01 00:00:00
abstract::Brown adipose tissue (BAT) has multiple functions in the human body, including the production of heat and increasing energy consumption. However, BAT is also related to many kinds of diseases, such as obesity and metabolic disorders. The progression of such diseases occurs at the cellular level, and thus, imaging tech...
journal_title:Life sciences
pub_type: 杂志文章,评审
doi:10.1016/j.lfs.2020.117500
更新日期:2020-05-15 00:00:00
abstract::In fish liver catecholamines bind to beta-adrenoceptors (AR) and increase glucose release via cAMP augmentation. Alpha1-AR have recently been shown to mediate IP3 and Ca2+ elevation in catfish and eel hepatocytes, although their coupling to a physiological response has remained doubtful. We have perifused isolated cat...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(99)00216-7
更新日期:1999-01-01 00:00:00
abstract::The role of K+ channels in the relaxations induced by bradykinin, lemakalim, an activator of ATP-sensitive K+ channels and sodium nitroprusside (SNP), a nitric oxide (NO) donor was examined in the isolated mouse trachea precontracted by methacholine (1 microM). 4-aminopyridine (4-AP, 0.1-2 mM), an inhibitor of 4-AP se...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(97)00540-7
更新日期:1997-01-01 00:00:00
abstract::Physical exercise is known to increase oxygen consumption to compensate for enhanced ATP consumption and thus to induce oxidative stress in tissues. Our previous data indicate that training significantly increased the hydroxyl radical level in rat tissues after physical exercise, but reduced the basal level in aged ra...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(98)00468-8
更新日期:1998-01-01 00:00:00
abstract::In recent years, natural products have increasingly attracted more attention because of their potential anticancer activity and low intrinsic toxicity. Hispidulin is a natural flavonoid with a wide range of biological activities, including anti-inflammatory, antifungal, antiplatelet, anticonvulsant, anti-osteoporotic,...
journal_title:Life sciences
pub_type: 杂志文章,评审
doi:10.1016/j.lfs.2020.118395
更新日期:2020-10-15 00:00:00
abstract:AIM:A variety of evidence suggests that vitamin D can prevent the development of multiple sclerosis (MS). TGF-β pathway genes also play important roles in MS. Here, we aim to study whether vitamin D affects TGF-β pathway gene expression and Expanded Disability Status Scale (EDSS) scores in MS patients. MAIN METHODS:A ...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2015.05.017
更新日期:2015-08-01 00:00:00
abstract::The ontogenetic development of [3H]-spiroperidol binding sites was measured in the optic tectum, cerebellum, forebrain base, and forebrain roof of 1-, 4-, and 16-day-old chicks. In the chick optic tectum and cerebellum both the density and the total number of [3H]-spiroperidol binding sites increased from 4- to 16-day...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(89)90331-7
更新日期:1989-01-01 00:00:00
abstract:AIMS:This study aims to evaluate the relationship between the amount of physical activity and different traditional and novel cardiometabolic risk factors, as well as atheroprotective agents, in male children and adolescents. MAIN METHODS:Cross-sectional study. A total of 337 male children and adolescents aged 7-14 ye...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2013.05.021
更新日期:2013-07-30 00:00:00
abstract::Involvement of a central histaminergic mechanism in the stimulating effect of beta-endorphin (beta-End) on the pituitary-adrenocortical activity, measured indirectly through corticosterone secretion, was investigated in conscious rats. The rise in serum corticosterone levels, induced by beta-End injected intraventricu...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(91)90458-n
更新日期:1991-01-01 00:00:00
abstract::Vascular inflammation induced by the proinflammatory cytokine/NF-kappaB pathway is one of the key mechanisms in the development of atherosclerosis. Peroxisome proliferators-activated receptor-gamma (PPARgamma) plays an important role in the prevention of arterial inflammation and formation of atherogenesis. Herein we ...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2006.08.030
更新日期:2006-12-14 00:00:00