fMRI mapping of cortical centers following visual stimulation in postnatal pigs of different ages.

Abstract:

:Classical studies have demonstrated that the visual centers in primates consist of cortical areas V1, V2 and V4 and their branches. However, nothing is known about how these visual areas change in postnatal development. In the present studies, therefore, pigs aged 2, 4, and 6 months old, were stimulated visually with a colored checker board and the active sites in the cortex, cerebellum and brainstem recorded using functional magnetic resonance imaging (fMRI). In pigs aged 2 months old, visual stimulation induced an increase in activation of sites in the V2 and V4 cortical areas, as well as in the areas of the inferior aspect of the parietal and middle aspect of the temporal cortices, but not in the medial and caudal occipital cortex (V1 area). At 4 months old, the V1 area was also activated, and by 6 months old, an inferior sector in the prefrontal cortex was also activated. As the pigs aged, functional active sites were further demonstrated in the cerebellum and the brainstem, which probably had to do with action memory, and the control of the ocular muscles, respectively. It is concluded that the visual pathway of the pig mainly involves cortical areas that mature at 6 months of age.

journal_name

Life Sci

journal_title

Life sciences

authors

Fang M,Li J,Rudd JA,Wai SM,Yew JC,Yew DT

doi

10.1016/j.lfs.2005.06.030

subject

Has Abstract

pub_date

2006-02-09 00:00:00

pages

1197-201

issue

11

eissn

0024-3205

issn

1879-0631

pii

S0024-3205(05)00857-X

journal_volume

78

pub_type

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