当前位置： SCI文献检索 > LIFE SCIENCES期刊下所有文献 > Viscus fat area contributes to the Framingham 10-year general cardiovascular disease risk in patients with type 2 diabetes mellitus.

Viscus fat area contributes to the Framingham 10-year general cardiovascular disease risk in patients with type 2 diabetes mellitus.

Abstract：

OBJECTIVE:To explore the correlation of the viscus fat area (VFA) with the Framingham 10-year general cardiovascular disease risk in patients with type 2 diabetes mellitus (T2DM). METHODS:A total of 202 patients with T2DM were divided into two groups based on VFA (a VFA ≥ 100 cm2 group and a VFA < 100 cm2 group), or four groups based on sex and age (a middle-aged male group, an elderly male group, a middle-aged female group, and an elderly female group). The correlation between the Framingham 10-year general cardiovascular disease risk and body fat indexes was analyzed. RESULTS:Patients in the VFA ≥ 100 cm2 group had higher body fat indexes and Framingham Risk Scores (FRSs) and lower levels of high density lipoprotein-cholesterol (HDL-C) when compared to the VFA < 100 cm2 group (P < 0.05). Female patients had higher body fat mass (BFM) and body fat percentage (BFP) levels and a lower VFA when compared to male patients. The VFA was significantly higher in the elderly than in the middle-aged patients. The waist hip fat ratio (WHFR) was significantly higher in elderly females than in elderly males (P < 0.05). Elderly females had the highest FRS of all patients. Multiple stepwise regression analysis revealed the VFA as a contributor to the Framingham 10-year general cardiovascular disease risk after statistical correction for other multiple factors affecting cardiovascular disease risk. CONCLUSION:The VFA is an independent factor that contributes to the Framingham 10-year general cardiovascular disease risk in patients with T2DM.

journal_name

Life Sci

journal_title

Life sciences

authors

Xu L,Song P,Xu J,Zhang H,Yu C,Guan Q,Zhao M,Zhang X

doi

10.1016/j.lfs.2019.01.036

subject

Has Abstract

pub_date

2019-03-01 00:00:00

pages

69-75

eissn

0024-3205

issn

1879-0631

pii

S0024-3205(19)30050-5

journal_volume

220

pub_type

杂志文章

相关文献

LIFE SCIENCES文献大全
  • Enzymatic activity and distribution of phospholipase A2 in human cartilage.

    abstract：:Extracellular phospholipase A2 (PLA2) with proinflammatory activity has recently been discovered in synovial fluids in inflammatory arthritides. In the search for the sources of synovial fluid PLA2, human synovium and articular cartilage were found to contain large quantities of the enzyme. In rheumatoid arthritis (RA...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(91)90381-k

    authors： Pruzanski W,Bogoch E,Stefanski E,Wloch M,Vadas P

    更新日期：1991-01-01 00:00:00

  • Effect of luteotrophic hormone (LH) and thymosin on mitogen-induced blast transformation of Balb/c mouse lymphoid cells.

    abstract：:The present study investigates the effect of a pituitary hormone (LH) and a thymic factor (Thymosin Fraction 5 = TF5) on in vitro and in vivo spleen cell proliferative response of 2, 6 and 8-month-old Balb/c mice. In vitro experiments showed that the addition of LH at various concentrations (0.5, 5, 50 or 500 ng/ml) t...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(90)90031-l

    authors： Rouabhia M,Ghanmi Z,Chakir J,Othmane O,Deschaux P

    更新日期：1990-01-01 00:00:00

  • Rapamycin and MCC950 modified gut microbiota in experimental autoimmune encephalomyelitis mouse by brain gut axis.

    abstract：AIMS:Multiple sclerosis (MS) whose pathogenesis is still unclear is a chronic progressive disease in the central nervous system. Gut microbiota can directly or indirectly affect the immune system through the brain gut axis to engage in the occurrence and development of the disease. MATERIALS AND METHODS:C57BL/6 mice w...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2020.117747

    authors： Xu L,Zhang C,He D,Jiang N,Bai Y,Xin Y

    更新日期：2020-07-15 00:00:00

  • Influence of an alternative reinforcer on human cocaine self-administration.

    abstract：:Identifying factors that modulate cocaine self-administration is fundamental to the development of effective strategies to treat and prevent cocaine abuse. In the present study, the influence of an alternative reinforcer on the probability of cocaine use was examined in four adult humans under controlled laboratory co...

    journal_title：Life sciences

    pub_type： 临床试验,杂志文章

    doi：10.1016/0024-3205(94)00878-7

    authors： Higgins ST,Bickel WK,Hughes JR

    更新日期：1994-01-01 00:00:00

  • Expression of isoforms of NADPH oxidase components in rat pancreatic islets.

    abstract：:Increased oxidative stress plays a role in the pathogenesis of beta-cell dysfunction and death. We studied isoforms of NADPH oxidase components in islets of Langerhans isolated from rat pancreas and tumoral rat beta-cell line RINm5F cells by RT-PCR and sequencing of its products. RT-PCR revealed that isolated islets c...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2006.08.031

    authors： Uchizono Y,Takeya R,Iwase M,Sasaki N,Oku M,Imoto H,Iida M,Sumimoto H

    更新日期：2006-12-14 00:00:00

  • Receptor-like stereospecific binding of a pyrethroid insecticide to mouse brain membranes.

    abstract：:A heterogeneous particulate fraction of mouse brain homogenates binds NRDC 157 (3-phenoxybenzyl [1R, cis]-3-(2,2-dibromovinyl)-2,2-dimethylcyclopropanecarboxylate), a potent pyrethroid insecticide, stereospecifically and with high affinity. Stereospecific binding is a minor component of total binding (2.8%); the remai...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(83)90385-5

    authors： Soderlund DM,Ghiasuddin SM,Helmuth DW

    更新日期：1983-07-18 00:00:00

  • Role of autophagy in the pathogenesis of rheumatoid arthritis: Latest evidence and therapeutic approaches.

    abstract：:Autophagy is considered as an important intracellular mechanism that degrades cytoplasmic components to furnish additional energy. It has cytoprotective effects through the degradation of intracellular pathogens, damaged organelles, and protein aggregates. On the other hand, there are reports of an association between...

    journal_title：Life sciences

    pub_type： 杂志文章,评审

    doi：10.1016/j.lfs.2020.117734

    authors： Karami J,Masoumi M,Khorramdelazad H,Bashiri H,Darvishi P,Sereshki HA,Shekarabi M,Sahebkar A

    更新日期：2020-08-01 00:00:00

  • Glutamine as a gamma-glutamyl donor for gamma-glutamyl transpeptidase: gamma-glutamyl peptide formation.

    abstract：:This study demonstrates the formation of gamma-glutamyl peptides from glutamine and plasma amino acids, as catalyzed by gamma-glutamyl transpeptidase. It also establishes the effect of various amino acids in modulating the rate of glutamine utilization as well as the hydrolytic or transfer product formed. The mechanis...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(83)90682-3

    authors： Dass PD

    更新日期：1983-10-31 00:00:00

  • Roles of chymase in stenosis occurring after polytetrafluoroethylene graft implantations.

    abstract：:Chymase is an important enzyme for the generation of angiotensin (Ang) II and in the activation of transforming growth factor (TGF)-beta1. Therefore, chymase may be involved in the hemodialysis access dysfunction, which is caused by intimal hyperplasia that occurs after polytetrafluoroethylene (PTFE) graft implantatio...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2007.09.004

    authors： Jin D,Ueda H,Takai S,Muramatsu M,Furubayashi K,Ibaraki T,Kishi K,Katsuoka Y,Miyazaki M

    更新日期：2007-09-29 00:00:00

  • MAPK (ERK2) kinase--a key target for NSAIDs-induced inhibition of gastric cancer cell proliferation and growth.

    abstract：UNLABELLED:Limited clinical and experimental studies indicate that nonsteroidal anti-inflammatory drugs (NSAIDs) may inhibit gastric cancer growth. However, the mechanisms involved are not completely understood and cannot be explained by COX-2 inhibition alone. MAPK signaling pathway is essential for cell proliferation...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/s0024-3205(01)01411-4

    authors： Husain SS,Szabo IL,Pai R,Soreghan B,Jones MK,Tarnawski AS

    更新日期：2001-11-09 00:00:00

  • Metformin therapy confers cardioprotection against the remodeling of gap junction in tachycardia-induced atrial fibrillation dog model.

    abstract：OBJECTIVE:Metformin, introduced in 1957, is widely used as an anti-diabetic drug and has considerable benefits in cardiovascular disease reportedly, dependent or independent on its glucose-lowering effects. Aim of this study was to investigate the effect of metformin on gap junction and the inducibility of AF. METHODS...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2020.117759

    authors： Li J,Li B,Bai F,Ma Y,Liu N,Liu Y,Wang Y,Liu Q

    更新日期：2020-08-01 00:00:00

  • Norharman-induced changes of extracellular concentrations of dopamine in the nucleus accumbens of rats.

    abstract：:In vivo microdialysis was used to investigate the effects of acute injections of norharman on extraneuronal concentrations of dopamine (DA) in the nucleus accumbens of rats. Administration of norharman (2.44 and 43.97 mumol/kg, i.p.) elicited an increase of the DA efflux by 70% and 160% respectively which returned to ...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(95)98578-4

    authors： Baum SS,Hill R,Rommelspacher H

    更新日期：1995-01-01 00:00:00

  • Influence of adrenal cortex on testicular activity in the toad during the breeding season.

    abstract：:The aim of the present study was to determine the role of adrenals in gonadal activity in the male toad during the breeding season. Exogenous administration of corticosterone or metapyrone for 6 days inhibited adrenal delta5-3beta(delta 5-3 beta) hydroxysteroid (delta5-3beta-HSD) and testicular 17beta (17 beta) hydrox...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/s0024-3205(00)00433-1

    authors： Biswas NM,Chaudhuri GR,Sarkar M,Sengupta R

    更新日期：2000-02-18 00:00:00

  • Surgical and pharmacological reductions in sympathetic nerve activity increase the neuropeptide Y-immunoreactivity content of the rat iris but not the vas deferens.

    abstract：:Decentralization of the superior cervical ganglion (S.C.G.) of the rat elevated the neuropeptide-Y immunoreactivity (NPY-ir) content of the ganglion on day 1 (+43%) but not on day 3 post-surgery. The content of NPY-ir in the iris was increased by decentralization (+40%) 3 days post-surgery, and treatment with clonidin...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(88)90333-5

    authors： Maccarrone C,Jarrott B

    更新日期：1988-01-01 00:00:00

  • Muscarinic receptor binding in the mouse heart: the selective modulatory effect of fluoride ion on agonist binding.

    abstract：:The effect of fluoride ion on the binding of the specific muscarinic agonist ligand [3H]cis methyldioxolane ([3H]CD) to the mouse cardiac muscarinic receptor was investigated. Utilizing equilibrium ligand binding experiments, sodium fluoride (10mM) was shown to decrease [3H]CD binding, measured at a concentration of 2...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(82)90602-6

    authors： Barritt D,Yamamura HI,Roeske WR

    更新日期：1982-03-08 00:00:00

  • Zebrafish let-7b acts downstream of hypoxia-inducible factor-1α to assist in hypoxia-mediated cell proliferation and cell cycle regulation.

    abstract：AIMS:Hypoxia-inducible factor-1α (HIF-1α) is a transcriptional regulator of cellular responses to hypoxic stress. MicroRNAs (miRNAs) play an essential role in hypoxia-mediated cellular responses. Previous studies have identified some let-7 family members as hypoxia-regulated miRNAs (HRMs). In the present study, we aime...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2017.01.005

    authors： Huang CX,Chen N,Wu XJ,He Y,Huang CH,Liu H,Wang WM,Wang HL

    更新日期：2017-02-15 00:00:00

  • Regulation of G protein-coupled receptor endocytosis and trafficking by Rab GTPases.

    abstract：:G protein-coupled receptors (GPCRs) are integral membrane proteins that, in response to activation by extracellular stimuli, regulate intracellular second messenger levels via their coupling to heterotrimeric G proteins. GPCR activation also initiates a series of molecular events that leads to G protein-coupled recept...

    journal_title：Life sciences

    pub_type： 杂志文章,评审

    doi：10.1016/j.lfs.2003.09.009

    authors： Seachrist JL,Ferguson SS

    更新日期：2003-12-05 00:00:00

  • Effects of sub-chronic aluminum chloride exposure on rat ovaries.

    abstract：AIMS:This experiment investigated the effects of sub-chronic aluminum chloride (AlCl3) exposure on rat ovaries. MAIN METHODS:Eighty female Wistar (5weeks old) rats, weighed 110-120g, were randomly divided into four treatment groups: control group (CG), low-dose group (LG, 64mg/kg BW AlCl3), mid-dose group (MG, 128mg/k...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2014.01.081

    authors： Fu Y,Jia FB,Wang J,Song M,Liu SM,Li YF,Liu SZ,Bu QW

    更新日期：2014-03-28 00:00:00

  • Theoretical study of the reactivity properties of two forms of stobadine.

    abstract：:The cardio- and neuroprotective effect of the pyridoindole stobadine (S) is conditioned mainly by its good radical scavenging properties. It has been showed by EPR experiment, that the ultimate product of the reaction of stobadine with hydroxyl radical is the nitroxyl radical. However, for the unsaturated dehydrostoba...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/s0024-3205(99)00440-3

    authors： Májeková M,Májek P,Mach P

    更新日期：1999-01-01 00:00:00

  • Identification of HDM2 as a regulator of VEGF expression in cancer cells.

    abstract：:Overexpression of vascular endothelial growth factor (VEGF) and the extent of neoangiogenesis are closely correlated with tumor development and cancer metastases. To assess whether VEGF mediated angiogenesis is regulated by HDM2, we treated the GI-101A and HL-60 cells with HDM2 gene specific antisense phosphorothioate...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2008.04.004

    authors： Narasimhan M,Rose R,Ramakrishnan R,Zell JA,Rathinavelu A

    更新日期：2008-06-20 00:00:00

  • Myocardial hypothermia induced after reperfusion does not prevent adverse left ventricular remodeling nor improve cardiac function.

    abstract：AIMS:The purpose of the study was to determine whether late therapeutic hypothermia (LTH), administered after reperfusion, could prevent adverse left ventricular (LV) remodeling and improve cardiac function in the rat myocardial ischemia/reperfusion model. MAIN METHODS:Rats were randomized to normothermia (n = 10) or ...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2019.04.026

    authors： Shi J,Dai W,Carreno J,Hale SL,Kloner RA,Kay GL

    更新日期：2019-07-15 00:00:00

  • Cerebrospinal fluid dynorphin-converting enzyme activity is increased by voluntary exercise in the spontaneously hypertensive rat.

    abstract：:The activity in cerebrospinal fluid (CSF) of dynorphin-converting enzyme (DCE) has been studied after voluntary exercise in the spontaneously hypertensive (SH) rat. The exercise consisted of spontaneous running in wheels for 4-5 weeks and the average running distance during the last two weeks was 4.0 km/24h. CSF sampl...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(93)90274-7

    authors： Persson S,Jónsdóttir I,Thorén P,Post C,Nyberg F,Hoffmann P

    更新日期：1993-01-01 00:00:00

  • Brief debrisoquin administration to assess central dopaminergic function in children.

    abstract：:Central dopaminergic (DA) function in children was assessed by monitoring plasma-free homovanillic acid (pHVA) levels after brief (18 hour) administration with debrisoquin sulfate, a peripherally active antihypertensive agent that blocks peripheral, but not central, HVA production. Brief debrisoquin administration res...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(86)90239-0

    authors： Riddle MA,Shaywitz BA,Leckman JF,Anderson GM,Shaywitz SE,Hardin MT,Ort SI,Cohen DJ

    更新日期：1986-03-17 00:00:00

  • Anti-secretory activity of the novel H2-antagonist, HUK 978, in rat, guinea-pig and dog.

    abstract：:The anti-secretory activity of the competitive H2-antagonist HUK 978 was determined in rat, guinea-pig and dog. In all systems examined, HUK 978 was more potent than cimetidine and ranitidine both intravenously and orally. In addition, the compound at approximately equipotent doses as these established H2-antagonists ...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(85)90300-5

    authors： Coombes JD,Norris DB,Rising TJ,Ross BC,Steward A

    更新日期：1985-11-04 00:00:00

  • Molecular mechanisms of curcumin and its analogs in colon cancer prevention and treatment.

    abstract：:Colorectal cancer remains to be the most prevalent malignancy in humans and 1.5 million men and women living in the United States are diagnosed with colorectal cancer, with a predicted 145,600 new cases to be diagnosed in 2019. Curcuminoids and its synthetic analogs are now of interest due to their bioactive attribute...

    journal_title：Life sciences

    pub_type： 杂志文章,评审

    doi：10.1016/j.lfs.2019.117032

    authors： Selvam C,Prabu SL,Jordan BC,Purushothaman Y,Umamaheswari A,Hosseini Zare MS,Thilagavathi R

    更新日期：2019-12-15 00:00:00

  • Dextran sulfate sodium enhances interleukin-1 beta release via activation of p38 MAPK and ERK1/2 pathways in murine peritoneal macrophages.

    abstract：:Interleukin (IL)-1 beta is a pro-inflammatory cytokine that has been shown to play a pivotal role in the onset of inflammatory bowel disease (IBD), however, the molecular mechanisms underlying the production of IL-1 beta in IBD are not fully understood. We investigated dextran sulfate sodium (DSS)-induced IL-1 beta pr...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2007.05.022

    authors： Kwon KH,Ohigashi H,Murakami A

    更新日期：2007-07-12 00:00:00

  • Immunocytochemical detection of the 72-kDa heat shock protein in halothane--induced hepatotoxicity in rats.

    abstract：:Liver sections removed from phenobarbital induced rats 24 to 48 hours after a 2 hour exposure to 1.0% halothane with 10% oxygen and subjected to immunocytochemical treatment showed evidence of centrilobular damage as well as evidence of the production of a protein which has immunoreactivity with anti HSP 72 antibodies...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(92)90394-5

    authors： Van Dyke RA,Mostafapour S,Marsh HM,Li Y,Chopp M

    更新日期：1992-01-01 00:00:00

  • STIM2 knockdown protects against ischemia/reperfusion injury through reducing mitochondrial calcium overload and preserving mitochondrial function.

    abstract：:Mitochondrial dysfunction caused by calcium overload is a vital factor for mediating cardiomyocyte death following ischemia/reperfusion (I/R) injury. The stromal interactive molecule 2 (STIM2) is a calcium sensor protein that regulates the store-operated calcium entry (SOCE). Whereas, whether STIM2 is associated with ...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2019.116560

    authors： Tu CC,Wan BY,Zeng Y

    更新日期：2020-04-15 00:00:00

  • Modulation of inducible nitric oxide synthase pathway by eugenol and telmisartan in carbon tetrachloride-induced liver injury in rats.

    abstract：AIMS:Inducible nitric oxide synthase (iNOS) pathway has been in the limelight since its discovery as a key mediator in the process of liver fibrogenesis. Therefore, the objective of the current study was to elucidate the in vivo molecular mechanism underlying the hepatic preventive relevance of eugenol (EUG) and telmis...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2018.11.031

    authors： Fathy M,Khalifa EMMA,Fawzy MA

    更新日期：2019-01-01 00:00:00

  • Endothelium-derived nitric oxide protection of spontaneous coronary contractions in the rabbit by countering Ca2+ influx via the voltage-sensitive Ca2+ channel.

    abstract：:The mechanism of spontaneous coronary contractions was investigated in the rabbit. Arteries with intact endothelium did not spontaneously contract. However, spontaneous coronary contractions were generated after the removal of the endothelium. NG-nitro-L-arginine methyl ester and methylene blue, the inhibitors of the ...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(94)00492-7

    authors： Omote M,Mizusawa H

    更新日期：1994-01-01 00:00:00