Abstract:
:Liver sections removed from phenobarbital induced rats 24 to 48 hours after a 2 hour exposure to 1.0% halothane with 10% oxygen and subjected to immunocytochemical treatment showed evidence of centrilobular damage as well as evidence of the production of a protein which has immunoreactivity with anti HSP 72 antibodies. The cells showing evidence of immunoreactivity were within the area of the centrilobular lesion. The level of immunoreactive protein varied directly with the intensity of the lesion. Liver sections from animals treated with phenobarbital alone, phenobarbital plus 10% oxygen, or phenobarbital plus 20% oxygen and 1.0% halothane all were without lesions as well as the immunoreactive protein.
journal_name
Life Scijournal_title
Life sciencesauthors
Van Dyke RA,Mostafapour S,Marsh HM,Li Y,Chopp Mdoi
10.1016/0024-3205(92)90394-5subject
Has Abstractpub_date
1992-01-01 00:00:00pages
PL41-5issue
7eissn
0024-3205issn
1879-0631pii
0024-3205(92)90394-5journal_volume
50pub_type
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