Abstract：
:The aim of the present study was to observe the effect of repeated subcutaneous (sc) injections of low doses of ketamine for the treatment of acute inflammatory pain in a complete Freund's adjuvant-induced monoarthritic pain model in rats. The results show: (1) sc injection of ketamine at a dose of 2 mg x kg(-1) or 10 mg x kg(-1) produced significant analgesia (P<0.01) in arthritic rats starting from the 2nd week and 3rd week, respectively. (2) Repeated administration of ketamine produced a significant reduction of the circumference of the arthritic ankle (P<0.05 and P<0.01 with different doses). (3) The body weight of the rats was not affected by continuous administration of ketamine for 4 weeks. No abnormal locomotor behavior was observed (It was concerned but not systemically evaluated in this study). The results suggest that repeated sc injection of ketamine for 4 weeks significantly reduce inflammatory pain in monoarthritis without notable aversive side effects.
journal_name
Life Scijournal_title
Life sciencesauthors
Wang Y,Huang C,Cao Y,Han JSdoi
10.1016/s0024-3205(00)00625-1subject
Has Abstractpub_date
2000-06-08 00:00:00pages
261-7issue
3eissn
0024-3205issn
1879-0631pii
S0024320500006251journal_volume
67pub_type
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