Abstract:
:The aggregation of melanin-granules within fish pigment cells (melanophores) can be elicited either by electrical stimulation of intrinsic nerves or by the addition of adrenergic agonists. The pigment aggregation seems to be mediated by alpha-2-adrenoceptors. In this investigation we have used various agonists and antagonists (noradrenaline, (+)- and (-)-adrenaline, isoprenaline, yohimbine and prazosin) to further characterize the pigment-aggregating receptor of Labrus ossifagus. All the results obtained support the notion of alpha-2-adrenoceptor-mediated pigment aggregation. The pertussis toxin, islet-activating protein (IAP), is known to inhibit the alpha-2-adrenoceptor-mediated signal transduction in mammals. We have used IAP to investigated whether fish melanophore alpha-2-adrenoceptors are also inhibited by this toxin. We found that IAP inactivated the alpha-2-adrenoceptor-mediated pigment aggregation in a dose-dependent manner. The inhibitory IAP-effect had a remarkably short onset-time in the melanophores (maximal effect was obtained within 10 min of incubation). Interestingly, binding of an agonist (noradrenaline) to the receptors prevented IAP from exerting its inhibitory action, whereas binding of an antagonist (yohimbine) gave no protection against the IAP-inactivation. In conclusion, the pigment-aggregating receptors of melanophores of L. ossifagus are very similar to the mammalian alpha-2-adrenoceptors. It is possible to inactivate the melanophore receptor system with IAP and this inactivation has a remarkably short onset-time. Stimulation of the alpha-2-adrenoceptors prevents IAP from inactivating the receptor system.
journal_name
Life Scijournal_title
Life sciencesauthors
Karlsson JO,Grundström N,Wikberg JE,Friedman R,Andersson RGdoi
10.1016/0024-3205(85)90595-8subject
Has Abstractpub_date
1985-09-16 00:00:00pages
1043-9issue
11eissn
0024-3205issn
1879-0631pii
0024-3205(85)90595-8journal_volume
37pub_type
杂志文章相关文献
LIFE SCIENCES文献大全abstract::Although the aging effect of dopamine D2 receptor in the striatum is well-documented, the effect of age on the extrastriatal dopamine D2 receptor has not been fully examined. Since the density of extrastriatal dopamine D2 receptor is very low, suitable ligands are limited. In this study, we used [11C]FLB 457 to quanti...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(01)01205-x
更新日期:2001-07-20 00:00:00
abstract::Castanospermine is a potent inhibitor of rat intestinal glycohydrolases in vitro and prevents the hyperglycemic response to an oral sucrose challenge in vivo. Among the glycohydrolases tested, castanospermine was most effective against sucrase with an IC50 of 1.1 x 10(-7) M. In vivo, a significant effect was seen at d...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(87)90546-7
更新日期:1987-11-16 00:00:00
abstract::The challenge of discovering new, urgently needed anti-TB drugs from natural sources requires a truly interdisciplinary research. Cutting-edge mycobacteriology and innovative natural products chemistry tools have to be developed and employed in tandem, in order to meet these demands. The present review provides cross-...
journal_title:Life sciences
pub_type: 杂志文章,评审
doi:10.1016/j.lfs.2005.09.004
更新日期:2005-12-22 00:00:00
abstract::There are many studies of the mechanisms of antidepressants; however, most of these studies were conducted on the hippocampus or frontal cortex. In the present study, we hypothesized that the nucleus accumbens and caudate/putamen might be major targets for antidepressant effects. Thus, we focused on G(olf) protein, a ...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2006.01.033
更新日期:2006-06-27 00:00:00
abstract::Intestinal mucosal capsaicin-sensitive afferent nerves mediate, in part, the mesenteric hyperemia after intraduodenal acidification. The hyperemia plays a role in protecting the duodenal mucosa against acid damage. We tested the hypothesis that bradykinin contributes to this protective hyperemia. A specific antagonist...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(01)01455-2
更新日期:2002-01-04 00:00:00
abstract:OBJECTIVE:To explore the correlation of the viscus fat area (VFA) with the Framingham 10-year general cardiovascular disease risk in patients with type 2 diabetes mellitus (T2DM). METHODS:A total of 202 patients with T2DM were divided into two groups based on VFA (a VFA ≥ 100 cm2 group and a VFA < 100 cm2 group), or f...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2019.01.036
更新日期:2019-03-01 00:00:00
abstract::Female mice of the inbred strains C57BL/6J, BALB/cJ and DBA/2J were used to determine the possible existence of a genetically-based differential susceptibility to the effects of treatment with an extract of Ginkgo biloba (EGb 761). Timm's silver-sulphide staining method was used to visualize and determine changes in t...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(94)00915-5
更新日期:1995-01-01 00:00:00
abstract::Recent head-twitch response (HTR) studies in mice have indicated that withdrawal from chronic cocaine exposure produces deficits in CNS conversion of L-tryptophan to 5-HT. In the present study, the ability of 5-HT releaser, d-fenfluramine, was utilized to induce the HTR in mice following abstinence from chronic cocain...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(97)01012-6
更新日期:1997-01-01 00:00:00
abstract::An acute injection of an intoxicating dose of alcohol to male rats 24 hours prior to breeding with drug-naive females produced no discernible effect on copulatory activity, as reflected in vaginal plugs, but resulted in markedly (> 50%) reduced pregnancy rates. Fetal outcome was also markedly affected in offspring sir...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(94)90109-0
更新日期:1994-01-01 00:00:00
abstract::The adverse effects of prenatal nicotine and alcohol exposure on human reproductive outcomes are a major scientific and public health concern. In the United States, substantial percentage of women (20-25%) of childbearing age currently smoke cigarettes and consume alcohol, and only a small percentage of these individu...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2017.12.010
更新日期:2018-02-01 00:00:00
abstract:AIMS:Keratinocytes are the predominant cells in the epidermis, exerting their primary role of physical barrier through sophisticated differentiation process. In addition, keratinocytes contribute to the activation of innate immunity, providing the surveillant role against external pathogens. It has been known that chro...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2016.05.023
更新日期:2016-06-15 00:00:00
abstract:AIMS:Transient ischemia of osteoporotic bones during elective orthopedic surgery or fracture repair carries risks for serious complications, and estrogen loss or replacement has a potential to influence ischemia-reperfusion-induced inflammatory activation. To clarify this, we investigated the periosteal inflammatory ch...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2010.11.004
更新日期:2011-01-17 00:00:00
abstract::P120-catenin (P120) was known to function in adhesion between cells and signal transduction in many types of cells. In this study, we investigated the expression and role of P120 in pulmonary fibrosis and transforming growth factor beta (TGF-β) mediated lung fibroblast-to-myofibroblast differentiation (fibroblast diff...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2019.05.052
更新日期:2019-08-01 00:00:00
abstract:AIM:Acute lung injury (ALI) is characterized by alveolar macrophage overactivation and uncontrolled pulmonary inflammation. Mitochondrial damage-associated molecular patterns (MTDs), one type of damage-associated molecular patterns (DAMPs) released from ruptured mitochondrial, can induce inflammation which participates...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2020.118833
更新日期:2021-01-15 00:00:00
abstract::Vascular disease is one of the complicating features of diabetes mellitus. Magnesium deficiency has recently been proposed as a novel factor implicated in the pathogenesis of diabetes complications. Several studies have indicated that hypertension in diabetic patients is an independent altered reaction of blood vessel...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2004.07.027
更新日期:2005-02-11 00:00:00
abstract::11β-hydroxysteroid dehydrogenase 1 (11β-HSD1) inhibitors have been shown to treat type 2 diabetes (T2D). Since gossypol is an 11β-HSD1 inhibitor, the objective of the present study was to treat T2D and T2D-related liver fibrosis in rat model using low-dose gossypol. T2D was induced by feeding with high fat diet plus i...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2016.02.044
更新日期:2016-03-15 00:00:00
abstract::The role of dopamine (DA) input on the activity of glutamate neurons was investigated on rat striatal and cortical tissue using the measurement of sodium-dependent high affinity glutamate uptake (HAGU) as an index. Incubation of the tissue in the presence of DA, apomorphine or bromocriptine produced marked inhibition ...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(82)90658-0
更新日期:1982-04-05 00:00:00
abstract::A natural product betulinic acid (BA) has gained a huge significance in the recent years for its strong cytotoxicity. Surprisingly, in spite of being an interesting cancer protecting agent on a variety of tumor cells, the normal cells and tissues are rarely affected by BA. Betulinic acid and analogues (BAs) generally ...
journal_title:Life sciences
pub_type: 杂志文章,评审
doi:10.1016/j.lfs.2018.07.056
更新日期:2018-09-15 00:00:00
abstract::The effects of ethanol on the production of oxygen-derived free radicals by neutrophils are controversial. Osmolarity-mediated alteration of cell volume appears to be an important mechanism for regulating neutrophil activity. We investigated in neutrophils from healthy volunteers the effect of isotonic/hypertonic etha...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(98)00396-8
更新日期:1998-01-01 00:00:00
abstract::The effects of the mixed class I and II mGLUR agonist (+) 1S,3R-trans-amino-cyclopentane-1,3-dicarboxylic acid (ACPD) and antagonists (+) alpha-methyl-4-carboxyphenylglycine (MCPG) and L-2-amino-3-phosphonopropionic acid (L-AP3) on the basal neuronal excitability and on the expression of in vitro epileptiform activity...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(97)00941-7
更新日期:1997-01-01 00:00:00
abstract::Hyaluronic acid (HA), a major glycosaminoglycan component of the extracellular matrix, has regulatory influences on cells and cellular activities. To explore the effects of a high concentration (1 mg/mL) of high molecular weight HA (500-730 kD) on U937 macrophage growth dynamics, three factors that influence overall c...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2004.02.038
更新日期:2004-11-12 00:00:00
abstract::Phospholipid-sensitive Ca2+-dependent protein kinase and its endogenous substrate proteins were examined in acinar cells from rat pancreas. The enzyme was clearly demonstrable by DEAE-cellulose chromatography of acinar cell extract. At least four endogenous substrate proteins (Mr = 38K, 30K, 22K and 15K) for this Ca2+...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(83)90770-1
更新日期:1983-05-16 00:00:00
abstract::A series of cyclic conformationally restricted penicillamine containing somatostatin octapeptide analogues have been prepared by standard solid phase synthetic techniques and tested for their ability to inhibit specific [125I]CGP 23,996 (des-Ala1-,Gly2-[desamino-Cys3Tyr11]-dicarba3, 14-somatostatin), [3H]naloxone or [...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(86)90574-6
更新日期:1986-06-16 00:00:00
abstract::Although effects of a metastasis suppressor gene, KiSS-1, have been postulated to be mediated by its receptor, hOT7T175, the mechanism of such effects remains unknown. This study was designed to evaluate the mechanism of how KiSS-1 works and to assess effects of a synthesized truncated KiSS-1 protein on the invasive a...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2008.06.018
更新日期:2008-08-29 00:00:00
abstract::Sodium-dependent transport of D-glucose has been reported only in epithelial cells of small intestine and kidney, and well-differentiated tumors thereof. We observed a two-fold decrease (p < 0.05) in the intracellular distribution volume (Vic, defined as steady-state intracellular uptake divided by extracellular conce...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(96)00114-2
更新日期:1996-01-01 00:00:00
abstract::The relative distribution of muscarinic and nicotinic cholinergic receptors labeled with [3H]acetylcholine was determined using autoradiography. [3H]Acetylcholine binding to high affinity muscarinic receptors was similar to what has been described for an M-2 distribution: highest levels of binding occurred in the pont...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(86)90210-9
更新日期:1986-06-09 00:00:00
abstract::The effects of naloxone, an opiate "pure" receptor antagonist, on the release of prolactin and corticosterone in the rat were studied following the administration of the serotonin precursor 5-hydroxytryptophan or the serotonin receptor agonist (-) -m-chlorophenylpiperazine. Naloxone clearly antagonizes the release of ...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(83)90367-3
更新日期:1983-05-23 00:00:00
abstract:AIMS:Ovarian cancer (OC) is the most lethal gynecologic malignant tumors all over the world. HOX antisense intergenic RNA myeloid 1 (HOTAIRM1) has been reported as an important regulator in multiple tumors. However, the functions of HOTAIRM1 in OC and its possible molecular mechanisms remain unclear. MAIN METHODS:qRT-...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2020.117296
更新日期:2020-02-15 00:00:00
abstract::The neurological mutant whirler mouse, one of several strains of waltzing mice, may be suitable as an animal model for testing studies relative to hyperkinesis. As in hyperkinetic children, behaviorally the mice are extremely restless, nervous, excitable, irritable and aggressive but also show symptoms of rotation beh...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(85)90404-7
更新日期:1985-08-05 00:00:00
abstract::The ability of metformin (MF) to acutely relax phenylephrine (PE)-induced contraction in the isolated rat tail artery is reported to be accompanied by repolarization of the arterial smooth muscle cell (SMC) membranes. These membranes contain potassium (K) channels which if opened could mediate such repolarization and ...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(99)00522-6
更新日期:1999-10-29 00:00:00