Abstract：
:Plasma and urinary levels of MHPG were determined in six normal volunteers. Samples were obtained at 3-hour intervals for plasma and at 12-hour intervals for urine. Acrophase, amplitude and period were determined for plasma MHPG levels. A sinusoidal pattern was obtained for diurnal plasma MHPG with a peak at 15:00 hrs. +/- 46 min. Urinary MHPG, corrected for creatinine levels, correlated with both 9 AM plasma MHPG and with baseline plasma MHPG. Furthermore, the relationship between plasma and urinary MHPG was linear when the rhythm of urinary levels was assumed to lag 6.2 hours behind the plasma rhythm. It was concluded that free MHPG is evenly distributed in the total body space and that conjugated MHPG is largely restricted to the blood.
journal_name
Life Scijournal_title
Life sciencesauthors
DeMet EM,Halaris AE,Gwirtsman HE,Reno RMdoi
10.1016/0024-3205(85)90302-9subject
Has Abstractpub_date
1985-11-04 00:00:00pages
1731-41issue
18eissn
0024-3205issn
1879-0631pii
0024-3205(85)90302-9journal_volume
37pub_type
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