Abstract：
:Gestational exposure to nicotine has been shown to affect development of noradrenergic activity in both the central and peripheral nervous systems. In the current study, pregnant rats received nicotine infusions of 6 mg/kg/day throughout gestation, administered by osmotic minipump implants. After birth, offspring of the nicotine-infused dams exhibited marked increases in basal adenylate cyclase activity in membranes prepared from kidney and heart, as well as supersensitivity to stimulation by either a beta-adrenergic agonist, isoproterenol, or by forskolin. The altered responses were not accompanied by up-regulation of beta-adrenergic receptors: in fact, [125I]pindolol binding was significantly decreased in the nicotine group. These results indicate that fetal nicotine exposure affects enzymes involved in membrane receptor signal transduction, leading to altered responsiveness independently of changes at the receptor level.
journal_name
Life Scijournal_title
Life sciencesauthors
Slotkin TA,Navarro HA,McCook EC,Seidler FJdoi
10.1016/0024-3205(90)90185-tsubject
Has Abstractpub_date
1990-01-01 00:00:00pages
1561-7issue
17eissn
0024-3205issn
1879-0631pii
0024-3205(90)90185-Tjournal_volume
47pub_type
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