Cytotoxicity and genotoxicity of gold nanorods assisted photothermal therapy against Ehrlich carcinoma in-vivo.

abstract：:Cordyceps sinensis (C. sinensis) is one of the well known fungi used in traditional Chinese medicine for treatment asthma and bronchial and lung inflammation. In this study, effects of C. sinensis methanolic extracts on bronchoalveolar lavage fluids (BALF) cells proliferation, inflammatory cytokines production, and ge...

journal_title：Life sciences

authors： Kuo YC,Tsai WJ,Wang JY,Chang SC,Lin CY,Shiao MS

更新日期：2001-01-19 00:00:00

abstract：AIM:This study aimed to evaluate the effects of Wortmannin, an inhibitor of phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt), on aortic hyporeactivity to Phenylephrine (Phe) and nitric oxide bioavailability associated with pregnancy in hypertensive rats. MAIN METHODS:The intact aortic rings of pregnant and ...

journal_title：Life sciences

authors： Zancheta D,Troiano JA,Potje SR,Cavalari P,Sumida DH,Antoniali C

更新日期：2015-02-01 00:00:00

abstract：:The present study was designed to investigate the effects of chronic administration of the alcoholic extract of Terminalia arjuna (TAAE) bark on isoproterenol induced myocardial injury. The TAAE was administered orally to Wistar albino rats (150-200 g) in three different doses, by gastric gavage [3.4 mg/kg: (T1), 6.75...

journal_title：Life sciences

authors： Karthikeyan K,Bai BR,Gauthaman K,Sathish KS,Devaraj SN

更新日期：2003-10-10 00:00:00

abstract：AIMS:Chloropropanol is a contaminant produced during food processing, and 1,3-dichloro-2-propanol (1,3-DCP) is one of the most-studied and most common chloropropanol-related food contaminants. Epigallocatechin-3-gallate (EGCG) is the most abundant ester catechin in tea polyphenols. We studied the potential therapeutic ...

journal_title：Life sciences

authors： Lu J,Fang B,Huang Y,Tao S,Sun B,Guan S,Jin Y

更新日期：2018-09-15 00:00:00

abstract：AIMS:This study was designed to investigate the molecular mechanisms underlying the anti-inflammatory and anti-fibrosis effects of Berberine hydrochloride (BBR) following canalicular laceration (CL) surgical repair. MAIN METHODS:We used a rabbit CL model in this study. BBR and the control medicine were administered du...

journal_title：Life sciences

authors： Bai F,Tao H,Wang P,Wang L,Zhou X,Wang F,Liu C,Huang Y

更新日期：2020-11-15 00:00:00

abstract：:This study was undertaken to examine the receptor selectivity of Met-enkephalin-Arg6-Phe7 (MERF) employing radioreceptor binding assays in human cerebral cortex membranes, and to elucidate the responsible receptors that mediate the regulatory action of MERF on high (20 mM) K+-stimulated release of [3H]norepinephrine (...

journal_title：Life sciences

authors： Kim KW,Woo RS,Kim CJ,Cheong YP,Kim JK,Kwun J,Cho KP

更新日期：2000-05-26 00:00:00

abstract：:Macrophages and osteoclasts derive from related cell lines. In osteopetrotic mutants the function of osteoclasts is greatly reduced compared to that in normal animals or children and macrophage function is variably affected depending upon the mutation. To further explore macrophage function in osteopetrosis we examine...

journal_title：Life sciences

authors： Popoff SN,Coderre JA,Marks SC Jr,Stock JL

更新日期：1989-01-01 00:00:00

abstract：:Diazepam binding inhibitor (DBI) is a 9-kD polypeptide that was first isolated in 1983 from rat brain by monitoring its ability to displace diazepam from the benzodiazepine (BZD) recognition site located on the extracellular domain of the type A receptor for gamma-aminobutyric acid (GABAA receptor) and from the mitoch...

journal_title：Life sciences

authors： Costa E,Guidotti A

更新日期：1991-01-01 00:00:00

abstract：:The binding of the D2-like agonists, (+)-7-hydroxy-N,N-di-n-[3H]propyl-2-aminotetralin (7-OH-DPAT) and [3H]pramipexole (2-amino-4,5,6-tetrahydro-6-propylaminobenzthiazole; MIRAPEX) were determined in membranes from adult male Sprague-Dawley and Fischer-344 rats. Saturation analysis, which optimized binding to D3 recep...

journal_title：Life sciences

authors： Wallace DR,Owens J,Booze RM

更新日期：1998-01-01 00:00:00

abstract：:Abbott-81282 (A-81282) has been identified among a series of related compounds as being a highly potent and selective antagonist of angiotensin receptors. At AT1 receptors of the rabbit aorta, A-81282 exhibited a pA2 of 9.64 (+/- 0.33) vs. angiotensin-II, and demonstrated characteristics consistent with competitive an...

journal_title：Life sciences

authors： Hancock AA,Buckner SA,Lee JY,Brune M,Morse PA,Oheim K,Warner RB,Winn M,Zydowsky TM,De B

更新日期：1993-01-01 00:00:00

abstract：AIMS:The aim of the present study was to investigate the protective effects of AGK2 as a selective SIRT2 inhibitor on thioacetamide (TAA)-induced acute liver failure (ALF) in mice and its potential mechanism. MAIN METHODS:All male C57BL/6 mice were separated into control, TAA, AGK2 + TAA, and AGK2 groups. The histolog...

journal_title：Life sciences

authors： Jiao FZ,Wang Y,Zhang WB,Zhang HY,Chen Q,Shi CX,Wang LW,Gong ZJ

更新日期：2019-08-01 00:00:00

abstract：:Obesity is caused by energy imbalance and accompanied by adipocyte hypertrophy and hyperplasia. Therefore, both enhancement of adipocyte energy expenditure and inhibition of adipogenesis are viable ways to combat obesity. Using the Ucp1-2A-luciferase reporter animal model previously reported by us as a screening platf...

journal_title：Life sciences

authors： Zhao S,Chu Y,Zhang Y,Zhou Y,Jiang Z,Wang Z,Mao L,Li K,Sun W,Li P,Jia S,Wang C,Xu A,Loomes K,Tang S,Wu D,Hui X,Nie T

更新日期：2019-04-01 00:00:00

abstract：:Reoxygenation of the ischemic tissue promotes the generation of various reactive oxygen metabolites (ROM) which are known to have deleterious effects on various cellular functions. This study was designed to determine the possible protective effect of mesna (2-Mercaptoethane Sulfonate) on renal ischemia/reperfusion (I...

journal_title：Life sciences

authors： Kabasakal L,Sehirli AO,Cetinel S,Cikler E,Gedik N,Sener G

更新日期：2004-09-24 00:00:00

abstract：:The pressor effect of hemoglobin-based blood substitutes is due partly to their capacity to scavenge nitric oxide (NO), a potent vasodilator. NO also appears to modulate the release of norepinephrine (NE) from sympathetic nerve endings in some blood vessels. Thus studies were designed to determine if contraction occur...

journal_title：Life sciences

authors： Hunter LW,Tyce GM,Rorie DK

更新日期：1996-01-01 00:00:00

abstract：:The bradykinin-induced sensitization of cutaneous nociceptors to heat was previously shown to be abolished by cyclooxygenase blockade suggesting that endogenous prostaglandins exerted a heat-sensitizing action. The present study aimed at investigating the effects of exogenous prostaglandin E(2) (PGE(2)) and I(2) (PGI(...

journal_title：Life sciences

authors： Derow A,Izydorczyk I,Kuhn A,Reeh PW,Petho G

更新日期：2007-12-14 00:00:00

abstract：AIMS:Endoplasmic reticulum stress (ERS) as an emerging factor is involved in insulin resistance (IR), which is the pathological basis of diabetes mellitus. Accumulation of asymmetric dimethylarginine (ADMA), an endogenous inhibitor of nitric oxide synthase is associated with IR, but the underlying mechanisms have not b...

journal_title：Life sciences

authors： Qiu N,Wei XM,Zhang ZJ,He YL,Zhou XK,Xiong Y

更新日期：2020-11-01 00:00:00

abstract：AIMS:Ovarian cancer (OC) is the most lethal gynecologic malignant tumors all over the world. HOX antisense intergenic RNA myeloid 1 (HOTAIRM1) has been reported as an important regulator in multiple tumors. However, the functions of HOTAIRM1 in OC and its possible molecular mechanisms remain unclear. MAIN METHODS:qRT-...

journal_title：Life sciences

authors： Chao H,Zhang M,Hou H,Zhang Z,Li N

更新日期：2020-02-15 00:00:00

abstract：HEADING AIMS:Abdominal aortic aneurysm (AAA) is featured by the growth impediment and apoptosis surge of VSMCs (vascular smooth muscle cells). MicroRNAs (miRNAs) are suggested to affect cellular behaviors including cell growth and apoptosis. This study concentrated on unraveling the emerging role of miR-28-5p in abdomi...

journal_title：Life sciences

authors： Yue J,Zhu T,Yang J,Si Y,Xu X,Fang Y,Fu W

更新日期：2020-07-15 00:00:00

abstract：:In fish liver catecholamines bind to beta-adrenoceptors (AR) and increase glucose release via cAMP augmentation. Alpha1-AR have recently been shown to mediate IP3 and Ca2+ elevation in catfish and eel hepatocytes, although their coupling to a physiological response has remained doubtful. We have perifused isolated cat...

journal_title：Life sciences

authors： Fabbri E,Buzzi M,Biondi C,Capuzzo A

更新日期：1999-01-01 00:00:00

abstract：AIMS:Changes in cardiac autonomic nervous function have been evaluated by studying the related indexes of heart rate variability (HRV) in patients with focal epilepsy (FE) in the interictal period. MAIN METHODS:A total of 30 FE patients who were treated in our department from July 2015 to May 2017, were included into ...

journal_title：Life sciences

authors： Yu YL,Li NN,Shi MT,Lu HJ

更新日期：2018-09-15 00:00:00

abstract：:This study analyzed the relationship between infection by human T-cell lymphotropic virus type 1 (HTLV-1) and changes in the pulmonary system. Cohort and case-control study models that analyzed a causal association between HTLV-1 and changes in the pulmonary system were considered. There were no restrictions on langua...

journal_title：Life sciences

authors： Normando VMF PhD,Dias ÁRN Me,da Silva ALSE Lic,da Silva Pinto D PhD,de Souza Santos MC PhD,Rodrigues CL Lic,de Oliveira EM PhD,de Souza Filho LEC Me,de Brito Vieira W Esp,Andriolo RB PhD,Sousa RCM PhD,Falcão LFM PhD,Quaresma JAS

更新日期：2020-09-01 00:00:00

abstract：:Restraint stress is known to induce gastric ulcers in rats. Peripheral sympathetic activity and catecholamines are involved in the pathogenesis of these gastric ulcers. The aim of the present study was to evaluate the effects of restraint on mucosal and muscle catecholamine concentrations in the glandular stomach of r...

journal_title：Life sciences

authors： Gaudin C,Safar M,Cuche JL

更新日期：1990-01-01 00:00:00

abstract：UNLABELLED:Based on preclinical findings, cellular therapy has become a promising therapeutic approach for neonatal hypoxia-ischemia (HI). However, before translation into the clinical setting, new and effective routes of cell delivery must be determined. Intra-arterial (IA) delivery is an attractive route of cellular ...

journal_title：Life sciences

authors： Greggio S,de Paula S,Azevedo PN,Venturin GT,Dacosta JC

更新日期：2014-02-06 00:00:00

abstract：:The role of afferent sensory nerves in glucose tolerance and glucose stimulated insulin secretion was investigated in normal (N) or neonatal streptozotocin-induced diabetic (D) rats treated with capsaicin (NC and DC, respectively) during the neonatal period. In capsaicin treated animals, oral glucose tolerance was mar...

journal_title：Life sciences

authors： Guillot E,Coste A,Angel I

更新日期：1996-01-01 00:00:00

abstract：:We find a significantly lower level of specific [3H]nicotine binding in the fetal rat forebrain of 20 day gestational age as compared to adult rat tissue, and a progressive increase in the [3H]nicotine binding in the early neonatal forebrain, reaching adult level at 14-28 days of age. The maximal binding sites (Bmax) ...

journal_title：Life sciences

authors： Yamada S,Kagawa Y,Isogai M,Takayanagi N,Hayashi E

更新日期：1986-02-17 00:00:00

abstract：:The outbreak of COVID-19 in December 2019, has become an urgent and serious public health emergency. At present, there is no effective treatment or vaccine for COVID-19. Therefore, there is a crucial unmet need to develop a safe and effective treatment for COVID-19 patients. Mesenchymal stem cells (MSCs) are widely us...

journal_title：Life sciences

authors： Sadeghi S,Soudi S,Shafiee A,Hashemi SM

更新日期：2020-12-01 00:00:00

abstract：:Aminoalkylindoles (AAIs) are structurally dissimilar from the classical cannabinoids (CCs), however, both AAIs and CCs appear to bind at the same site on the cannabinoid receptor. To obtain better insights on the structural correlation between AAIs and CCs, we have studied the conformational properties of the potent c...

journal_title：Life sciences

authors： Xie XQ,Eissenstat M,Makriyannis A

更新日期：1995-01-01 00:00:00

abstract：AIMS:3-Nitropropionic acid (3-NPA) is a naturally occurring fungal toxin that leads to ATP-depletion by inhibiting mitochondrial succinate dehydrogenase and produces chemical anoxia. The present study was conducted to identify the involvement of inhibitory system in 3-NPA-induced depression of spinal reflexes. METHODS...

journal_title：Life sciences

authors： Gupta R,Deshpande SB

更新日期：2008-11-21 00:00:00

abstract：AIMS:The purpose of our investigative work has been to determine whether there can be therapeutic roles in the administration of sildenafil citrate, heparin and several neuropeptides on an animal model where gastric ulcers were induced with acetic acid, and to compare their efficacy. MATERIALS AND METHODS:The animals ...

journal_title：Life sciences

authors： Kalayci M,Kocdor MA,Kuloglu T,Sahin İ,Sarac M,Aksoy A,Yardim M,Dalkilic S,Gursu O,Aydin S,Akkoc RF,Ugras M,Artas G,Ozercan İH,Ugur K,Aydin S

更新日期：2017-10-01 00:00:00

abstract：:Protein binding determination in post heparin plasma samples is complicated by the continued post heparin lipase activity, in vitro, during the binding analysis. The decomposition of lipoproteins and accumulation of nonesterified fatty acids (NEFA) results in artifically elevated free fractions of many drugs. This art...

journal_title：Life sciences

authors： Pearce GA,Brown KF

更新日期：1983-10-10 00:00:00