Abstract:
:We find a significantly lower level of specific [3H]nicotine binding in the fetal rat forebrain of 20 day gestational age as compared to adult rat tissue, and a progressive increase in the [3H]nicotine binding in the early neonatal forebrain, reaching adult level at 14-28 days of age. The maximal binding sites (Bmax) for the brain [3H]-nicotine binding at the ages of 3, 14 and 28 days were 36%, 74% and 98% respectively of the adult value. Neosurugatoxin (NSTX) was a potent inhibitor of [3H]nicotine binding in the neonatal forebrain (IC50 = 205, 81 and 103 nM at the 3, 14 and 28 days of age) as well as in the adult tissue (IC50 = 79 nM). Both the choline acetyltransferase (ChAT) activity and high affinity uptake of [14C]choline were not detectable or extremely low in the 1 week neonatal forebrain, and then increased progressively with age to reach the adult level at about 6 weeks of age. These data indicate that central nicotinic receptors may mature prior to the development of presynaptic cholinergic elements.
journal_name
Life Scijournal_title
Life sciencesauthors
Yamada S,Kagawa Y,Isogai M,Takayanagi N,Hayashi Edoi
10.1016/0024-3205(86)90057-3subject
Has Abstractpub_date
1986-02-17 00:00:00pages
637-44issue
7eissn
0024-3205issn
1879-0631pii
0024-3205(86)90057-3journal_volume
38pub_type
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