Abstract：
:Based on our earlier animal study, we became interested to investigate if thromboxane A2 (TXA2) is involved in angiotensin converting enzyme (ACE) induced cough in man. To 11 patients with hypertension, who had developed cough induced by ACE inhibitors, a TXA2 synthetase inhibitor, ozagrel was given for 1 to 2 months together with the ACE inhibitors. One patient developed headache induced by ozagrel and was eliminated from the study after 3 weeks. In other 10 patients, no obvious drug attributable abnormality was observed in subjective and objective symptoms or laboratory tests. In ten patients, cough scores were taken just before and after the administration of a combination of an ACE inhibitor with ozagrel. Median values of cough scores after the combination was significantly (p=0.012) lower than before the combination. Ozagrel reduced cough scores in 5 patients, completely suppressed cough in 3 patients and in 2 of 10 patients, ozagrel did not affect cough scores. Our observations suggest that TXA2 may somehow, mediate coughing induced by the ACE inhibitors. Further, patients on ACE inhibitors who develop cough may benefit from TXA2 synthetase inhibitors.
journal_name
Life Scijournal_title
Life sciencesauthors
Umemura K,Nakashima M,Saruta Tdoi
10.1016/s0024-3205(97)00124-0subject
Has Abstractpub_date
1997-01-01 00:00:00pages
1583-8issue
18eissn
0024-3205issn
1879-0631pii
S0024320597001240journal_volume
60pub_type
杂志文章相关文献
LIFE SCIENCES文献大全abstract：:Initial acute behavioral studies in mice indicated that phencyclidine (PCP) produced marked motor impairment as measured by the inverted screen technique with an ED50 value of 4.1 muMole/kg (i.v.). Phenylcyclohexene (PC) was considerably less active with an ED50 value of 325 muMole/kg (i.v.). PCP was also shown to be ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(82)90708-1
更新日期：1982-08-23 00:00:00
abstract：:Cyclic octapeptide analogues of somatostatin (SS) like SMS 201-995 [H-(D) Phe-Cys-Phe-(D) Trp-Lys-Thr-Cys-Thr(ol)] or its Tyr3-derivative 204-090, displaced [125I-Tyr11]-SS 100% from pancreatic membranes but only 62-75% from brain membranes; the remaining sites were displaced by SS. These data indicate that some mini-...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(85)90155-9
更新日期：1985-05-13 00:00:00
abstract：HEADING AIMS:MicroRNA-27b (miR-27b) has been shown to play a role in the progression of many different forms of cancer, but its specific relevance in the context of non-small cell lung cancer (NSCLC) remains uncertain. As such, this study sought to explore the role of miR-27b in NSCLC and the mechanisms whereby it func...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2019.117238
更新日期：2020-08-01 00:00:00
abstract：:Involvement of a central histaminergic mechanism in the stimulating effect of beta-endorphin (beta-End) on the pituitary-adrenocortical activity, measured indirectly through corticosterone secretion, was investigated in conscious rats. The rise in serum corticosterone levels, induced by beta-End injected intraventricu...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(91)90458-n
更新日期：1991-01-01 00:00:00
abstract：:The effects of exposure to ionizing radiation on the nociceptive thresholds of CF-1 mice were examined. Significant increases in thermal response latencies, indicative of analgesia were observed after exposure to either high or low doses of radiation. However, the onset of analgesia occurred significantly more rapidly...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(84)90352-7
更新日期：1984-10-08 00:00:00
abstract：:The effect of chronic cigarette smoke exposure on the activity of rat trachea and lung ornithine decarboxylase (ODC) and s-adenosyl-methionine decarboxylase (AdoMet-DC) was determined. Male rats were exposed once daily for 10 min to mainstream (MS) or different sidestream (SS) dilutions of fresh Kentucky 2R1 cigarette...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(85)90567-3
更新日期：1985-12-09 00:00:00
abstract：:Sleep-disordered breathing is characterized by disruptions of normal breathing patterns during sleep. Obesity is closely related to hypoventilation or apnea and becomes a primary risk factor for sleep-disordered breathing. Leptin, a peptide secreted by adipose tissue, has been implicated in central control of breathin...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2020.117994
更新日期：2020-09-15 00:00:00
abstract：:The development of the specific uptake of dopamine in the rat striatum during the early postnatal period is compared with the ontogenetic changes of the specific binding of (3H)GBR 12783 to the site of uptake inhibition. During maturation, the increase in the specific binding of (3H)GBR 12783 parallels the increase in...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(89)90563-8
更新日期：1989-01-01 00:00:00
abstract：:A phencyclidine (PCP) receptor binding site has been solubilized in an active ligand-binding state from rat cerebral cortical membranes with sodium deoxycholate. Optimal receptor solubilization occurs at a detergent/protein ratio of 0.5 (w/w); for 5 mg protein/ml solubilized with 0.25% sodium deoxycholate, about 60% o...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(89)90567-5
更新日期：1989-01-01 00:00:00
abstract：:The effect of resveratrol, a polyphenolic compound present in grapes and other plants, on proteinuria, hypoalbuminemia and hyperlipidemia was studied in rats with glomerulonephritis. The nephritis was induced by an intravenous injection of anti-rat kidney glomerular basement membrane rabbit antiserum. Nephritic rats w...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(01)01061-x
更新日期：2001-05-11 00:00:00
abstract：AIMS:Hypoxia makes cells death but it is not always true. Short term anoxia can boost remaining cells activities and promote tissue repair. This study is to explore the effects of hypoxic preconditioning (HP) on osteoblasts and analyze the involved lncRNA and mRNA. MAIN METHODS:Human osteoblast was used. Normoxic cont...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2018.07.014
更新日期：2018-09-01 00:00:00
abstract：AIMS:To investigate the roles of neutrophil alkaline phosphatase (NAP) in the migration, reactive oxygen species (ROS) generation and apoptosis of neutrophils. MAIN METHODS:NAP was overexpressed in neutrophil-like differentiated HL-60 cells via transfecting coding sequence of NAP by lentivirus. NAP overexpression in H...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2016.06.005
更新日期：2016-07-15 00:00:00
abstract：:Osteoarthritis (OA) is a complex joint disorder with a number of underlying physical, biochemical, biomechanical and genetic causes. Obesity is considered to be one of the major risk factors for the development and progression of OA. It actively contributes to the inflammatory status and to cartilage degradation in th...
journal_title：Life sciences
pub_type： 杂志文章,评审
doi：10.1016/j.lfs.2015.05.025
更新日期：2015-11-01 00:00:00
abstract：:The role of alpha 1-adrenoceptors in the mediation of autonomic functions, particularly in the control of the cardiovascular system, is widely known. It has been shown that alpha 1-adrenoceptors localized in human prostate mediate the contraction of prostatic smooth muscles which produces an increase in the intraureth...
journal_title：Life sciences
pub_type： 杂志文章,评审
doi：10.1016/0024-3205(94)90141-4
更新日期：1994-01-01 00:00:00
abstract：:In order to investigate possible neurobiologic mechanisms underlying carbon dioxide-induced anxiety, the effects of oral alprazolam 0.75 mg and intravenous clonidine 2 mcg/kg on CO2-induced increases in ratings of subjective anxiety, pulse rate, and ventilation were measured in healthy human subjects. Pretreatment wit...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(89)90255-5
更新日期：1989-01-01 00:00:00
abstract：AIMS:Investigate the involvement of the histaminergic projections from tuberomammillary nucleus (TMN) to the spinal cord in the modulation of nociception and peripheral edema in a model of monoarthritis. MAIN METHODS:Subacute monoarthritis was induced by an intraarticular injection of carrageenan followed by LPS 72 h ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2020.118521
更新日期：2020-12-01 00:00:00
abstract：:Sepsis is commonly associated with enhanced generation of reactive oxygen metabolites, which lead to multiple organ dysfunction. The aim of this study was to examine the role of melatonin, a potent antioxidant, in protecting the intestinal and bladder tissues against damage in a rat model of sepsis. Sepsis was induced...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2003.07.038
更新日期：2004-01-16 00:00:00
abstract：:Resveratrol, a polyphenolic phytoaxelin present in red wine, has been suggested to protect against atherosclerosis and cardiovascular disease because of its antioxidant effects. Intercellular adhesion molecule (ICAM-1), induced by cytokines, has been hypothesized to play a role in the early events during atheroscleros...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2005.04.052
更新日期：2005-12-12 00:00:00
abstract：:Diazepam binding inhibitor (DBI) is a 9-kD polypeptide that was first isolated in 1983 from rat brain by monitoring its ability to displace diazepam from the benzodiazepine (BZD) recognition site located on the extracellular domain of the type A receptor for gamma-aminobutyric acid (GABAA receptor) and from the mitoch...
journal_title：Life sciences
pub_type： 杂志文章,评审
doi：10.1016/0024-3205(91)90440-m
更新日期：1991-01-01 00:00:00
abstract：:Thermodynamic analysis of pharmacologic data potentially offers an insight into the molecular events underlying drug-receptor interactions not obtainable by other techniques. Embodied in thermodynamics are the laws governing the interconvertibility of heat and work and, hence, it is a particularly apt framework for th...
journal_title：Life sciences
pub_type： 杂志文章,评审
doi：10.1016/0024-3205(89)90182-3
更新日期：1989-01-01 00:00:00
abstract：:Using hot plate method, analgesia induced by noncatecholic phenylethylamines, phenethylamine, phenylethanolamine and amphetamine, was inhibited by naloxone, reserpine, apomorphine and p-chlorophenylalanine, while potentiated by haloperidol. These results suggest that phenylethylamines induced analgesia involves centra...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(82)90347-2
更新日期：1982-09-20 00:00:00
abstract：:Ethanol consumption was correlated with changes in acyl group profiles of phosphatidylcholine and triacylglycerols in serum of Sinclair(S-1) miniature boars. Serum triacylglycerols in the control pigs were high in linoleate (18:2) (48%) and low in stearate (18:0 (3%). Upon feeding with 10% (w/v) ethanol ad lib for two...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(84)90198-x
更新日期：1984-02-27 00:00:00
abstract：:A 21 amino acid peptide containing the prepropendothelin sequence from amino acids 110 to 130 and two intrachain disulfide bonds was synthesized and tested for biological activity in the following endothelin assays: 1.) a competition binding assay using [125I]ET-1 and dog heart membranes, 2.) three RIA's using 125I-ET...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(90)90308-e
更新日期：1990-01-01 00:00:00
abstract：AIMS:Antitumour effects of pentapeptide (LH) derived from donkey serum albumin hydrolysates were tested against tumour cells both in vitro and in vivo. The mechanism of LH induced tumour cell apoptosis was investigated. MAIN METHODS:Human promyelocytic leukaemia cells (HL 60) were cultured to observe inhibition in vit...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2013.02.013
更新日期：2013-05-20 00:00:00
abstract：:A modification of beta-adrenoceptor binding has been observed in different human and animal tissues after glucocorticoid administration. In this study we observed that hydrocortisone increased human intact lymphocyte beta-adrenoceptors labelled with 3H-dyhydroalprenolol in vitro, in physiological and pharmacological c...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(84)90528-9
更新日期：1984-12-03 00:00:00
abstract：:Benzamide riboside (BR) is a novel anticancer agent exhibiting pronounced activity against several human tumor cell lines via the inhibition of inosine 5'-monophosphate dehydrogenase (IMPDH), thereby restricting the biosynthesis of guanylates. Although it has been demonstrated that BR inhibits IMPDH and induces apopto...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2003.11.026
更新日期：2004-05-28 00:00:00
abstract：:Maintenance of the cellular calcium homeostasis plays an important role for neuronal cell function and interneuronal cell to cell communication. Therefore, alterations of the neuronal Ca2+ homeostasis may play a crucial role for brain aging in general and for age-related deficits in cognitive functions particularly. N...
journal_title：Life sciences
pub_type： 杂志文章,评审
doi：10.1016/0024-3205(94)00381-5
更新日期：1994-01-01 00:00:00
abstract：:We investigated the effects of VA-045, an apovincaminic acid derivative, on isolated blood vessels. VA-045 (10(-7)-10(-5) M) and vinpocetine (10(-7)-10(-5) M) inhibited the 64 mM KCl-induced and 10(-6)M norepinephrine (NE)-induced contraction of rat aortic strips. VA-045 (10(-7)-10(-4) M) and vinpocetine (10(-7)-10(-4...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(93)90115-j
更新日期：1993-01-01 00:00:00
abstract：:The involvement of atriopeptin in hypertension was investigated in spontaneously hypertensive rats (SHR). It was found that intravenous injection of atriopeptin III (20-80 nmol/kg) markedly decreased the mean arterial pressure in anesthetized SHR in a dose dependent manner. The heart rate was not significantly affecte...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(86)90238-9
更新日期：1986-03-17 00:00:00
abstract：:To study the effects of volume overload and renal failure on plasma levels of immunoreactive atrial natriuretic hormone (IR-ANH), we measured levels of this hormone in normal subjects, in patients with advanced chronic renal failure (CRF) with and without clinically evident volume overload, and in patients with end-st...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(87)90732-6
更新日期：1987-09-28 00:00:00
