Characteristic of analgesia induced by noncatecholic phenylethylamines in mice.

abstract：AIMS:Microvascular endothelial cell dysfunction is a leading cause of radiation-induced heart disease (RIHD). BRCA1 plays an important role in DNA damage repair. The study aims to explore the effect of BRCA1 in endothelial cells involved in RIHD. MATERIALS AND METHODS:BRCA1 and p21 expression were detected in human um...

journal_title：Life sciences

authors： Zeng ZM,Du HY,Xiong L,Zeng XL,Zhang P,Cai J,Huang L,Liu AW

更新日期：2020-03-01 00:00:00

abstract：:Activation of the sympathetic system by phencyclidine (PCP) should result in catecholamine release from the adrenals. However, adrenalectomy does not reduce PCP-induced hypertension. In an attempt to rectify this inconsistency, the direct effects of PCP on the bovine adrenal medulla were examined. At (3 X 10(-6) M), P...

journal_title：Life sciences

authors： Malavé A,Borowitz JL,Yim GK

更新日期：1983-08-08 00:00:00

abstract：:Male, adult mice of the Binghamton heterogeneous stock received one of two doses of ethanol (1.0 g/kg or 2.0 g/kg in saline) alone or in combination with the calcium (Ca2+) slow channel blocker, verapamil (5.45 mg/kg in 25% v/v ethanol in saline). Hypothermic responses and motor incoordination were assessed in terms o...

journal_title：Life sciences

authors： Johnston JE,Draski LJ,Molina JC,Burright RG,Reynoso G,Calendrillo BA,Isaacson RL

更新日期：1986-12-01 00:00:00

abstract：AIMS:Tianeptine is an atypical antidepressant drug that has a different mechanism of action than other antidepressants. Olanzapine is an atypical antipsychotic drug used for the treatment of schizophrenia. The present study was undertaken to investigate effects of chronic administration of tianeptine or olanzapine on u...

journal_title：Life sciences

authors： Mutlu O,Gumuslu E,Ulak G,Celikyurt IK,Kokturk S,Kır HM,Akar F,Erden F

更新日期：2012-12-17 00:00:00

abstract：:10(-4) M ouabain increases aldosterone production at 3.6 and 5.4 mM potassium concentrations, whereas at high potassium concentration (7 mM) even lower concentration of ouabain (10(-8) M) decreases it. As ouabain has been shown to be produced by the adrenal cortex, a local paracrine regulation of aldosterone productio...

journal_title：Life sciences

authors： Szalay KS

更新日期：1993-01-01 00:00:00

abstract：AIMS:Periodic acceleration (pGz) is a method that applies repetitive sinusoidal head-to-foot motion to the horizontally positioned body. pGz adds pulses to the circulation as a function of frequency, thereby increasing shear stress to the endothelium. Pulsatile shear stress increases release of cardioprotective endothe...

journal_title：Life sciences

authors： Adams JA,Wu H,Bassuk JA,Arias J,Uryash A,Jorapur V,Lamas GA,Kurlansky P

更新日期：2010-05-08 00:00:00

abstract：:The aim of this study was to investigate the effects of cyclosporin (CyA) treatment on biliary glutathione efflux in rats of different ages (1, 2, 4, and 24 months). CyA treatment reduced the liver content of total glutathione in 1-, 2- and 24 month old rats (-30%, -43% and -30%, respectively). By contrast, oxidized g...

journal_title：Life sciences

authors： Palomero J,Galán AI,Muñoz ME,Tuñón MJ,González-Gallego J,Jiménez R

更新日期：2003-11-14 00:00:00

abstract：AIMS:We recently reported that acute exposure to nicotine vasodilates the renal vasculature of male rats via facilitation of endothelial nitric oxide synthase (eNOS). In this study, we investigated whether this effect of nicotine is sexually dimorphic and the role of estrogen in modulating the nicotine effect. MAIN ME...

journal_title：Life sciences

authors： el-Mas MM,el-Gowilly SM,Gohar EY,Ghazal AR,Abdel-Rahman AA

更新日期：2011-01-17 00:00:00

abstract：:Beriberi is a disease caused by thiamine deficiency (TD), which may lead to heart problems, including heart failure. Despite the fact that thiamine prevalence is reduced in the industrialized world, it remains a health hazard especially due to chronic alcohol consumption. Diagnosing the presence of TD based on both el...

journal_title：Life sciences

authors： Roman-Campos D,Cruz JS

更新日期：2014-03-07 00:00:00

abstract：:As soon as a pathogen invades through the physical barriers of its corresponding host, host mounts a series of protective immune response to get rid of the invading pathogen. Host's pattern recognition receptors (PRR), localized at the cellular surface, cytoplasm and also in the nucleus; recognises pathogen associated...

journal_title：Life sciences

authors： Rai RC

更新日期：2020-01-01 00:00:00

abstract：:Female white-footed mice (Peromyscus leucopus) were injected twice daily with 5, 10, 50, 100 micrograms melatonin (MEL) or saline. Injections were given for 7 weeks at 2 and 12 hours after lights-on under a long day (LD 16:8) photoperiod. Afternoon administration of MEL induced gonadal regression, although a dose of 5...

journal_title：Life sciences

authors： Hall ES,Lynch GR

更新日期：1985-08-26 00:00:00

abstract：:Macrophages and osteoclasts derive from related cell lines. In osteopetrotic mutants the function of osteoclasts is greatly reduced compared to that in normal animals or children and macrophage function is variably affected depending upon the mutation. To further explore macrophage function in osteopetrosis we examine...

journal_title：Life sciences

authors： Popoff SN,Coderre JA,Marks SC Jr,Stock JL

更新日期：1989-01-01 00:00:00

abstract：:Human histiocytic lymphoma cells (U-937) undergo similar differentiation when incubated with the phorbol ester 12-0-tetradecanoyl phorbol-13-acetate (TPA) and 1,25-dihydroxycholecalciferol. In this action, TPA somehow implicates calcium-sensitive and phospholipid-dependent protein kinase (protein kinase C), which is r...

journal_title：Life sciences

authors： Mezzetti G,Bagnara GP,Monti MG,Pernecco Casolo L,Bonsi L,Brunelli MA

更新日期：1987-05-25 00:00:00

abstract：:Leptin-deficient Ob/Ob mice are hypometabolic and have reduced fat cell expression of beta-3 adrenoceptors (ARs). To determine whether leptin repletion restores beta-3 AR number, C57BL/6J Ob/Ob mice were given exogenous leptin (5 mg/kg I.P. daily) for 21 days. Leptin administration reduced body weight from 43.1+/-3.7 ...

journal_title：Life sciences

authors： Breslow MJ,An Y,Berkowitz DE

更新日期：1997-01-01 00:00:00

abstract：:Adrenals of young adult male mice kept on a LD 12:12 lighting regimen for three weeks prior to study and harvested at four different circadian stages were incubated for 2 hours with 0.4 IU synthetic ACTH in 2 ml Krebs-Ringer buffer (KR), or with 50, 150, and 450 microM of melatonin in KR containing 0.4 IU ACTH. The ad...

journal_title：Life sciences

authors： Haus E,Nicolau GY,Ghinea E,Dumitriu L,Petrescu E,Sackett-Lundeen L

更新日期：1996-01-01 00:00:00

abstract：:The plasma concentration of the dopamine (DA) metabolite, homovanillic acid (HVA), is used as an indicator of central nervous system dopaminergic activity. Using percutaneously inserted catheters we were able to obtain blood samples simultaneously from the right and left internal jugular veins. Veno-arterial HVA plasm...

journal_title：Life sciences

authors： Lambert GW,Eisenhofer G,Cox HS,Horne M,Kalff V,Kelly M,Jennings GL,Esler MD

更新日期：1991-01-01 00:00:00

abstract：:The purpose of this study was to investigate the involvement of calcium in K+ currents and its effects on amino acid accumulation and on the membrane potential regulated by tri-iodo-L-thyronine (T3) in Sertoli cells. Immature rat testes were pre-incubated for 30 min in Krebs-Ringer bicarbonate buffer and incubated for...

journal_title：Life sciences

authors： Volpato KC,Menegaz D,Leite LD,Barreto KP,de Vilhena Garcia E,Silva FR

更新日期：2004-01-23 00:00:00

abstract：AIMS:Fructose administration induces hepatic oxidative stress, insulin resistance, inflammatory and metabolic changes. We tested their potential pathogenic relationship and whether these alterations can be prevented by R/S-α-lipoic acid. MAIN METHODS:Wistar rats received during 21days a commercial diet or the same die...

journal_title：Life sciences

authors： Castro MC,Massa ML,Arbeláez LG,Schinella G,Gagliardino JJ,Francini F

更新日期：2015-09-15 00:00:00

abstract：:Ischemia-reperfusion of organs such as the kidney produces reactive oxygen and free radical species in tissues and leads to injury of intracellular molecules critical to cell homeostasis. Ischemia-reperfusion affects the NADPH-dependent monooxygenase system including P450 system, which is also a source of reactive oxy...

journal_title：Life sciences

authors： Tamura Y,Imaoka S,Gemba M,Funae Y

更新日期：1997-01-01 00:00:00

abstract：:Efficacy of chemotherapy may be maximized and its toxicity can be minimized if drugs would be administered at specified daily times. The present study was aimed to examine if the protection of amifostine against cisplatin toxicity is time dependent. Amifostine is an organic thiophosphate that protects selectively norm...

journal_title：Life sciences

authors： Asna N,Lewy H,Ashkenazi IE,Deutsch V,Peretz H,Inbar M,Ron IG

更新日期：2005-03-04 00:00:00

abstract：:Alpha(1)-adrenergic receptors are one of the three subfamilies of G protein coupled receptors activated by epinephrine and norepinephrine to control important functions in many target organs. Three human subtypes (alpha(1A), alpha(1B), alpha(1D)) are derived from separate genes and are highly homologous in their trans...

journal_title：Life sciences

authors： Hague C,Chen Z,Uberti M,Minneman KP

更新日期：2003-12-12 00:00:00

abstract：:In rat prefrontal cortical slices, the excitatory amino acids N-methyl-D-aspartate (NMDA), ibotenate, L-aspartate, quisqualate, kainate and L-glutamate inhibit carbachol-induced phosphoinositide hydrolysis as measured by the accumulation of [3H]inositol-1-phosphate ([3H]IP1). NMDA dose-dependently inhibited the carbac...

journal_title：Life sciences

authors： Noble EP,Sincini E,Bergmann D,ten Bruggencate G

更新日期：1989-01-01 00:00:00

abstract：:The role of K+ channels in the relaxations induced by bradykinin, lemakalim, an activator of ATP-sensitive K+ channels and sodium nitroprusside (SNP), a nitric oxide (NO) donor was examined in the isolated mouse trachea precontracted by methacholine (1 microM). 4-aminopyridine (4-AP, 0.1-2 mM), an inhibitor of 4-AP se...

journal_title：Life sciences

authors： Li L,Vaali K,Paakkari I,Vapaatalo H

更新日期：1997-01-01 00:00:00

abstract：:Insulin resistance (IR) impairs endothelium-mediated vasodilation in cerebral arteries as well as K+ channel function in vascular smooth muscle. Peripheral arteries also show an impaired endothelium-dependent vasodilation in IR and concomitantly show an enhanced contractile response to endothelin-1 (ET-1). However, th...

journal_title：Life sciences

authors： Simandle SA,Erdös B,Snipes JA,Miller AW,Busija DW

更新日期：2005-09-16 00:00:00

abstract：BACKGROUND:The prevalence and mortality of the outbreak of the COVID-19 pandemic show marked geographic variation. The presence of several subtypes of the coronavirus and the genetic differences in the populations could condition that variation. Thus, the objective of this study was to propose variants in genes that en...

journal_title：Life sciences

authors： Vargas-Alarcón G,Posadas-Sánchez R,Ramírez-Bello J

更新日期：2020-11-01 00:00:00

abstract：:Two proteinous factors, designated here as ram p25 GDP dissociation inhibitor (I) and (II) (ram-GDI (I) and (II)), were detected in the cytosolic fraction of rat spleen, which inhibited the initial dissociation of GDP from ram p25 produced by E. coli by causing characteristic lag. They had very weak effects on the rat...

journal_title：Life sciences

authors： Nagata K,Suzuki T,Okano Y,Nozawa Y

更新日期：1992-01-01 00:00:00

abstract：:Thymol induced superoxide production (O2-) by blood leukocytes was examined in various primates including man. Leukocytes of chimpanzee and hamadryas baboon cells showed only 35% of the maximal O2- production rate obtained in human cells, and those of the Japanese monkey and orang-utan failed to respond. In contrast, ...

journal_title：Life sciences

authors： Suzuki Y,Nakamura S,Sugiyama K,Furuta H

更新日期：1987-09-28 00:00:00

abstract：:The experiments were designed to study whether the inhibitors of the uptake of serotonin (5-HT) potentiated the prejunctional effects of 5-HT on peripheral sympathetic nerves. The effect of two selective 5-HT uptake inhibitors, citalopram and fluoxetine, were studied on the presynaptic actions of 5-HT in the cat isola...

journal_title：Life sciences

authors： Adler-Graschinsky E,Butta NV,Elgoyhen AB

更新日期：1986-07-07 00:00:00

abstract：:Neuron specific enolase (NSE), an isoenzyme of the glycolytic enzyme enolase, has been established by immunocytochemical means as a marker of morphological and functional maturation in central neurons and appears late in development. However, little is known about the presence of NSE in developing peripheral neurons a...

journal_title：Life sciences

authors： Sheppard MN,Marangos PJ,Bloom SR,Polak JM

更新日期：1984-01-16 00:00:00

abstract：:Although renin-angiotensin system (RAS) imbalance is manifested in cardiomyopathies with different etiologies, the impact of RAS effectors on Chagas cardiomyopathy and skeletal myositis is poorly understood. Given that diminazene aceturate (DMZ) shares trypanocidal, angiotensin-converting enzyme 2 (ACE2) and angiotens...

journal_title：Life sciences

authors： Souza-Silva TG,Vilas-Boas DF,Gonçalves-Santos E,Mazzeti AL,Caldas IS,Gonçalves RV,Diniz LF,Novaes RD

更新日期：2020-09-15 00:00:00