Involvement of the tuberomammillary nucleus of the hypothalamus in the modulation of nociception and joint edema in a model of monoarthritis.

abstract：:The effects of free fatty acids in the blood on osmotic fragility and water content of erythrocytes when combined with hyperthermia were investigated. The isotonic buffer, containing the fatty acid, was added to the erythrocyte suspension to a final concentration of 200 microM/L. The samples were kept for one hour in ...

journal_title：Life sciences

authors： Kogawa H,Yabushita N,Nakajima T,Kageyama K

更新日期：1998-01-01 00:00:00

abstract：:Recent evidence suggests that the Type 1 opiate receptor (in rat striatal patches) is a mobile receptor which is able to adopt a mu, delta, or kappa opiate receptor ligand selectivity pattern under appropriate conditions. In this paper, we have investigated such a possibility for Type 2 opiate receptors which are visu...

journal_title：Life sciences

authors： Olgiati V,Quirion R,Bowen WD,Pert CB

更新日期：1982-10-18 00:00:00

abstract：AIM:Myocardial infarction (MI), an important cause of morbidity and mortality, can be followed by left ventricular dysfunction and cardiomyocyte loss. Cardiac repair mechanisms may subsequently improve left ventricular function. Exercise training has been suggested to have cardioprotective effects against MI damage, bu...

journal_title：Life sciences

authors： Naderi N,Hemmatinafar M,Gaeini AA,Bahramian A,Ghardashi-Afousi A,Kordi MR,Darbandi-Azar A,Karimzade F,Mohebbi H,Barati M

更新日期：2019-03-15 00:00:00

abstract：:Rats were made sensitive to the effects of the opioid antagonist naltrexone by treating them once weekly with cumulative doses of the drug (1, 3, 10, 30 and 100 mg/kg). Sensitization was monitored by measuring salivation following naltrexone administration. During the first week of treatment, no salivation was noted f...

journal_title：Life sciences

authors： Schindler CW,Marley RJ,Goldberg SR

更新日期：1992-01-01 00:00:00

abstract：:The endogenous cannabinoid anandamide (AEA) exerts the majority of its effects at CB1 and CB2 receptors and is degraded by fatty acid amide hydrolase (FAAH). FAAH KO mice and animals treated with FAAH inhibitors are impaired in their ability to hydrolyze AEA and other non-cannabinoid lipid signaling molecules, such as...

journal_title：Life sciences

authors： Muldoon PP,Lichtman AH,Parsons LH,Damaj MI

更新日期：2013-03-19 00:00:00

abstract：:Recent head-twitch response (HTR) studies in mice have indicated that withdrawal from chronic cocaine exposure produces deficits in CNS conversion of L-tryptophan to 5-HT. In the present study, the ability of 5-HT releaser, d-fenfluramine, was utilized to induce the HTR in mice following abstinence from chronic cocain...

journal_title：Life sciences

authors： Darmani NA

更新日期：1997-01-01 00:00:00

abstract：:PD 128907 [4a R, 10 b R-(+)-trans-3, 4, 4a, 10 b - tetrahydro - 4- n -propyl2 H,5H-[1]benzop-yrano[4,3-b]1,4-oxazin-9-ol.], a selective dopamine (DA) D3 receptor agonist ligand exhibits about a 1000-fold selectivity for human D3 receptors (Ki, 1 nM) versus human D2 receptors (Ki, 1183 nM) and a 10000-fold selectivity ...

journal_title：Life sciences

authors： Akunne HC,Towers P,Ellis GJ,Dijkstra D,Wikström H,Heffner TG,Wise LD,Pugsley TA

更新日期：1995-01-01 00:00:00

abstract：:In order to understand the mechanism of increasing body fat in perimenopausal and postmenopausal women, an ovariectomy-induced obesity model was used to study the role of leptin. In this investigation, a long-term study lasted for 13 weeks was conducted to monitoring the change of serum leptin level in rats after the ...

journal_title：Life sciences

authors： Chu SC,Chou YC,Liu JY,Chen CH,Shyu JC,Chou FP

更新日期：1999-01-01 00:00:00

abstract：AIMS:We previously reported that cysteinyl leukotriene receptor 2 (CysLT(2)) mediates ischemic astrocyte injury, and leukotriene D(4)-activated CysLT(2) receptor up-regulates the water channel aquaporin 4 (AQP4). Here we investigated the mechanism underlying CysLT(2) receptor-mediated ischemic astrocyte injury induced ...

journal_title：Life sciences

authors： Qi LL,Fang SH,Shi WZ,Huang XQ,Zhang XY,Lu YB,Zhang WP,Wei EQ

更新日期：2011-01-03 00:00:00

abstract：:The pathogenesis of abdominal aortic aneurysm remains unclear. The aim of the present study was to establish whether isoleucyl-tRNA synthetase (Iars) regulates the differentiation and apoptosis of vascular smooth muscle cells (VSMCs) during the development of abdominal aortic aneurysm (AAA). In addition, the contribut...

journal_title：Life sciences

authors： Li B,Wang Z,Chen R,Hong J,Wu Q,Hu J,Hu Z,Zhang M

更新日期：2019-05-01 00:00:00

abstract：:The ability of 2-chloroadenosine (2Cl Ado) to modulate lymphocyte function was examined in culture and in vivo. Mitogenic stimulation of B cell DNA synthesis was antagonized by 2Cl Ado while adenosine produced both stimulations and inhibitions. In culture, 2Cl Ado was found to suppress antibody production to sheep ery...

journal_title：Life sciences

authors： Samet MK

更新日期：1985-07-22 00:00:00

abstract：AIMS:To investigate the effects of aerobic exercise training on cardiomyocyte ultrastructure, oxidative stress, and activation of protein synthesis pathways in a model of cardiomyopathy induced by doxorubicin (Dox). MAIN METHODS:Male Sprague Dawley rats were randomly assigned to Control (saline, sedentary), Dox/sedent...

journal_title：Life sciences

authors： Sequeira CM,Martins MA,Alves R,Nascimento ALR,Botti GCRM,Rocha VN,Matsuura C

更新日期：2021-01-01 00:00:00

abstract：:Pancreatitis is an inflammatory disease of the pancreas characterized by acinar cell injury and is associated with the abnormal release of trypsin, which results in high mortality due to systemic inflammatory response syndrome (SIRS) and multiple organ dysfunction syndrome (MODS). The inflammatory response, impaired a...

journal_title：Life sciences

authors： Li Y,Li G,Suo L,Zhang J

更新日期：2021-01-01 00:00:00

abstract：:Ethanol consumption was correlated with changes in acyl group profiles of phosphatidylcholine and triacylglycerols in serum of Sinclair(S-1) miniature boars. Serum triacylglycerols in the control pigs were high in linoleate (18:2) (48%) and low in stearate (18:0 (3%). Upon feeding with 10% (w/v) ethanol ad lib for two...

journal_title：Life sciences

authors： Foudin L,Tumbleson ME,Sun AY,Geisler RW,Sun GY

更新日期：1984-02-27 00:00:00

abstract：:The role of endothelium-derived nitric oxide (NO) to cause smooth muscle phospholamban (PLB) phosphorylation was studied in the isolated perfused rat aorta precontracted with norepinephrine using a back-phosphorylation technique. NO-induced relaxation was associated with increased PLB-phosphorylation while norepinephr...

journal_title：Life sciences

authors： Karczewski P,Kelm M,Hartmann M,Schrader J

更新日期：1992-01-01 00:00:00

abstract：:Different ligands of both the "peripheral" and the "central" benzodiazepine receptors were tested for their ability to induce human monocyte chemotaxis. Only the ligands interacting with the "peripheral receptor" (diazepam and Ro 5-4864) were active, and their action was blocked by the specific antagonist PK 11-195, b...

journal_title：Life sciences

authors： Sacerdote P,Locatelli LD,Panerai AE

更新日期：1993-01-01 00:00:00

abstract：AIMS:The present study was to investigate the effect of hydrogen peroxide (H2O2) on bone marrow stem cells and their endothelial differentiation and the underlying mechanisms in vitro. MAIN METHODS:Rat bone marrow multipotent adult progenitor cells (MAPCs) were used as the source of bone marrow stem cells, and treated...

journal_title：Life sciences

authors： Xiao Y,Li X,Cui Y,Zhang J,Liu L,Xie X,Hao H,He G,Kander MC,Chen M,Liu Z,Verfaillie CM,Zhu H,Lei M,Liu Z

更新日期：2014-09-01 00:00:00

abstract：:Thymic and spleen cells were treated in vitro or in vivo with insulin. The in vitro treatments were done with 10(-6), 10(-9), 10(-12) and 10(-15) M concentrations for 30 min and after that histamine, serotonin, endorphin and triiodothyronine (T3) content of the cells were detected by using antibodies to the hormones a...

journal_title：Life sciences

authors： Csaba G,Kovács P,Pállinger E

更新日期：2006-02-02 00:00:00

abstract：:An acute injection of an intoxicating dose of alcohol to male rats 24 hours prior to breeding with drug-naive females produced no discernible effect on copulatory activity, as reflected in vaginal plugs, but resulted in markedly (> 50%) reduced pregnancy rates. Fetal outcome was also markedly affected in offspring sir...

journal_title：Life sciences

authors： Cicero TJ,Nock B,O'Connor LH,Sewing BN,Adams ML,Meyer ER

更新日期：1994-01-01 00:00:00

abstract：:Previous investigations showed that chronic metabolic acidosis (CMA) increased the paracellular permeability of ion and neutral hydrophilic molecules in the duodenum of rats and small intestinal-like cell lines. Since proteins of the claudin family have been known to regulate the paracellular transport in several epit...

journal_title：Life sciences

authors： Charoenphandhu N,Wongdee K,Tudpor K,Pandaranandaka J,Krishnamra N

更新日期：2007-04-17 00:00:00

abstract：:The effects of exposure to ionizing radiation on the nociceptive thresholds of CF-1 mice were examined. Significant increases in thermal response latencies, indicative of analgesia were observed after exposure to either high or low doses of radiation. However, the onset of analgesia occurred significantly more rapidly...

journal_title：Life sciences

authors： Teskey GC,Kavaliers M

更新日期：1984-10-08 00:00:00

abstract：:Previous behavioral studies on triazolam (TZ), which are small in number, could only speculate about tolerance to the anxiolytic effect of TZ, as the experiments did not cover sufficient time (of 4 to 7 days) for tolerance to develop. Therefore longer time for chronic TZ administration is used. We investigated the eff...

journal_title：Life sciences

authors： Aburawi SM,Elhwuegi AS,Ahmed SS,Saad SF,Attia AS

更新日期：2003-10-31 00:00:00

abstract：:We investigated lithium-induced changes in norepinephrine (NE) catabolism. NE and its major metabolites 3-methoxy-4-hydroxyphenylglycol (MHPG) and 3,4-dihydroxyphenyl glycol (DHPG), ions such as lithium (Li(+)), magnesium (Mg(2+)), and potassium (K(+)) were measured in rat plasma and cerebral cortex using an HPLC meth...

journal_title：Life sciences

authors： Sastre E,Nicolay A,Bruguerolle B,Portugal H

更新日期：2005-07-01 00:00:00

abstract：:The temporal relationship of changes in cAMP and cGMP to oocyte maturation was examined in proestrous hamsters (day 4). The first series of experiments showed, in normal cycling hamsters, an increase in cAMP and a decrease in cGMP at 1400 h shortly after the rise in LH with oocyte maturation beginning at 1800 h. When ...

journal_title：Life sciences

authors： Hubbard CJ

更新日期：1983-10-24 00:00:00

abstract：:N-acyl dehydroalanines have been shown to react with and scavenge oxygen derived free radicals. One of those compounds, the AD-5 (N-(paramethoxyphenylacetyl) dehydroalanine) has been examined for its ability to decrease the amount of reactive oxygen species which appeared when liver microsomes (isolated from rats pret...

journal_title：Life sciences

authors： Buc-Calderon P,Roberfroid M

更新日期：1990-01-01 00:00:00

abstract：:A novel beta-carboline with benzodiazepine-like properties has recently been synthesized. We compared the effect of the i.v. administration of this drug, ZK 93423, with diazepam on the activity of nigral pars reticulata neurons which are known to be very sensitive to the inhibitory effect produced by GABA-mimetics and...

journal_title：Life sciences

authors： Mereu G,Corda MG,Carcangiu P,Giorgi O,Biggio G

更新日期：1987-04-06 00:00:00

abstract：AIMS:This study aims to evaluate the relationship between the amount of physical activity and different traditional and novel cardiometabolic risk factors, as well as atheroprotective agents, in male children and adolescents. MAIN METHODS:Cross-sectional study. A total of 337 male children and adolescents aged 7-14 ye...

journal_title：Life sciences

authors： Verona J,Gilligan LE,Giménez C,Verona MF,Lombardo SM,Baenz A,Divita V,González CD,Gómez Rosso L,Brites F

更新日期：2013-07-30 00:00:00

abstract：:Hyperglycemia and/or hypoinsulinemia have been found to inhibit L-ascorbic acid cellular transport. The resultant decrease in intracellular ascorbic acid may de-inhibit aryl sulfatase B and increase degradation of sulfated glycosaminoglycans (sGAG). This could lead to a degeneration of the extracellular matrix and res...

journal_title：Life sciences

authors： Fay MJ,Bush MJ,Verlangieri AJ

更新日期：1990-01-01 00:00:00

abstract：AIMS:Alterations in the expression of antioxidant enzymes are associated with changes in cancer cell sensitivity to chemotherapeutic drugs (menadione and β-lapachone). Mechanisms of acquisition of resistance to pro-oxidant drugs were investigated using a model of oxidative stress-resistant MCF-7 breast cancer cells (Re...

journal_title：Life sciences

authors： Glorieux C,Sandoval JM,Dejeans N,Ameye G,Poirel HA,Verrax J,Calderon PB

更新日期：2016-01-15 00:00:00

abstract：:BMP-3b is a novel BMP-3-related protein and its biological functions are unknown. In order to investigate the biological actions of BMP-3b, we constructed a BMP-3b-expressing recombinant adenoviral vector (AxCAKBMP-3b). We show that over expression of BMP-3b stimulated the induction of differentiation and the osteoind...

journal_title：Life sciences

authors： Kaihara S,Bessho K,Okubo Y,Sonobe J,Komatsu Y,Miura M,Miyatake S,Nakao K,Iizuka T

更新日期：2003-02-28 00:00:00