In vitro synergy of azole antifungals and methotrexate against Candida albicans.

abstract：AIMS:The aim of the present study was to characterize TRPV4 channels in pregnant and nonpregnant mouse uterus and examine their functional role in spontaneous and agonist-induced contractions. MAIN METHODS:We used RT-PCR, Western blot and immunohistochemistry experiments to demonstrate the presence of TRPV4 mRNA and p...

journal_title：Life sciences

authors： Singh V,Ram M,Kandasamy K,Thangamalai R,Choudhary S,Dash JR,Kumar D,Parida S,Singh TU,Mishra SK

更新日期：2015-02-01 00:00:00

abstract：:The regions of muscarinic receptors that specify G-protein-coupling and ligand-binding have been defined in several recent studies. Overall, these studies have shown that amino acids within the third cytoplasmic loop of the receptors define their selectivity for different G-proteins, and that multiple, discontinuous e...

journal_title：Life sciences

authors： Brann MR,Klimkowski VJ,Ellis J

更新日期：1993-01-01 00:00:00

abstract：AIMS:Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) has been considered to be one of the most promising candidates in research on treatments for cancer, including renal cell carcinoma (RCC). However, many cells are resistant to TRAIL-induced apoptosis which limits the potential application of TRAIL in ...

journal_title：Life sciences

authors： Ou YC,Li JR,Kuan YH,Raung SL,Wang CC,Hung YY,Pan PH,Lu HC,Chen CJ

更新日期：2014-04-01 00:00:00

abstract：:To evaluate possible deleterious effects of commonly used herbicides on leukocytes, cytokine production was selected as a sensitive indicator. After in vitro exposure of human peripheral blood mononuclear cells from normal donors, the production of all 3 cytokines tested--interferon-gamma (a type 1 cytokine), interleu...

journal_title：Life sciences

authors： Hooghe RJ,Devos S,Hooghe-Peters EL

更新日期：2000-05-19 00:00:00

abstract：AIMS:Exposure to glucose and its metabolites in peritoneal dialysis fluid (PDF) results in structural alterations of the peritoneal membrane. Icodextrin-containing PDF eliminates glucose and reduces deterioration of peritoneal membrane function, but direct effects of icodextrin molecules on peritoneal mesothelial cells...

journal_title：Life sciences

authors： Matsumoto M,Tamura M,Miyamoto T,Furuno Y,Kabashima N,Serino R,Shibata T,Kanegae K,Takeuchi M,Abe H,Okazaki M,Otsuji Y

更新日期：2012-06-14 00:00:00

abstract：:We have reported that Sho-saiko-to (TJ-9) prevents liver fibrosis in vivo. To gain further insights into the effect of TJ-9, the matrix metalloproteinases (MMPs)/tissue inhibitors of metalloproteinases (TIMPs) balance was examined. Hepatic stellate cells (HSCs) were isolated from male Wistar rats and cultured with TJ-...

journal_title：Life sciences

authors： Sakaida I,Hironaka K,Kimura T,Terai S,Yamasaki T,Okita K

更新日期：2004-03-19 00:00:00

abstract：:The skin permeabilities of a series of eight salicylates and ten non-steroidal anti-inflammatory drugs were investigated in human subjects. The logarithms of % absorption through intact skin and of n-octanol/water partition coefficients (log P) of the test compounds were plotted against one another, and a parabolic re...

journal_title：Life sciences

authors： Yano T,Nakagawa A,Tsuji M,Noda K

更新日期：1986-09-22 00:00:00

abstract：:The two thalidomide (Thd) derivatives beta-EM12 and phthalimidophthalimide (Phtpht), which exhibit no obvious teratogenicity, were tested for their ability to induce changes in the pattern of lymphocyte subpopulations, and especially changes in integrin receptors, in marmosets (Callithrix jacchus). Previously, Thd and...

journal_title：Life sciences

authors： Nogueira AC,Neubert R,Felies A,Jacob-Müller U,Frankus E,Neubert D

更新日期：1996-01-01 00:00:00

abstract：:Grape seed extract (GSE) is a commonly available dietary supplement taken for the anti-oxidant activity that's attributed to its proanthocyanidin (oligomers of monomeric polyphenols) content. Similar polyphenol-enriched preparations from blueberries and soy have shown protection against ovariectomy-induced or age-rela...

journal_title：Life sciences

authors： Kim H,Deshane J,Barnes S,Meleth S

更新日期：2006-03-27 00:00:00

abstract：:Herba Epimedii is an important medicinal plant which has been used in various traditional Chinese formulations for thousands of years as well as in modern proprietary traditional Chinese medicine products. It has extensive clinical indications, especially for the treatment of sexual dysfunction and osteoporosis. There...

journal_title：Life sciences

authors： Li C,Li Q,Mei Q,Lu T

更新日期：2015-04-01 00:00:00

abstract：:[3H]A-69024 has been prepared as a radioligand for studying the dopamine D1 receptor. [3H]A-69024 binds to rat striatal membranes with a KD = 14.3 +/- 3.2 nM (mean +/- SEM; n = 3) and Bmax = 63.5 +/- 12.8 fmol/mg wet tissue (1.8 +/- 0.3 pmol/mg protein). This ligand binds to only one site with a Hill coefficient close...

journal_title：Life sciences

authors： Kassiou M,Scheffel UA,Musachio JL,Stathis M,Dannals RF

更新日期：1995-01-01 00:00:00

abstract：:Formation of etretinate, ethyl ester of acitretin, can be confirmed in vitro and in vivo using acitretin as the substrate. Etretinate was identified by LC/MS. The in vitro incubation was performed using rat and human liver 12,000 g supernatant, and the in vivo experiment was conducted in rats after oral dosing of acit...

journal_title：Life sciences

authors： Chou RC,Wyss R,Huselton CA,Wiegand UW

更新日期：1991-01-01 00:00:00

abstract：:The purpose of this study was to explore the feasibility of utilizing the granatanol: N-methyl [9-azabicyclo (3.3.1) nonane] 3-alpha-ol as the terminal group in a series of new bisquaternary azabicycyclic diester-type neuromuscular blocking agents. Fifty two bisquaternary ammonium derivatives of several dicarboxylic a...

journal_title：Life sciences

authors： Gyermek L,Lee C,Cho YM,Nguyen N

更新日期：2006-07-04 00:00:00

abstract：:The present investigation examined the interaction between fluoxetine enantiomers and LSD in rats trained with LSD as a discriminative stimulus. The dose response relationships for LSD alone and in combination with either (+)- or (-)-fluoxetine were determined. In both instances, the LSD dose response relationship was...

journal_title：Life sciences

authors： Fiorella D,Helsley S,Rabin RA,Winter JC

更新日期：1996-01-01 00:00:00

abstract：AIM:To compare embryonic developmental competence and clinical outcomes of oocytes matured in vivo (IVF oocytes) and those matured in vitro (IVM oocytes) from the same IVM/IVF cycles, and to analyze the clinical efficiency of a melatonin-supplemented in vitro maturation system combined with a modified IVM/IVF protocol....

journal_title：Life sciences

authors： Li X,Mu Y,Elshewy N,Ding D,Zou H,Chen B,Chen C,Wei Z,Cao Y,Zhou P,Zhang Z

更新日期：2021-01-01 00:00:00

abstract：:Oxidative stress has been implicated to play an important role in the pathogenesis of diabetic neuropathy, which is the most common complication of diabetes mellitus affecting more than 50% of diabetic patients. In the present study, we have investigated the effect of U83836E [(-)-2-((4-(2,6-Di-1-pyrrolidinyl-4-pyrimi...

journal_title：Life sciences

authors： Sayyed SG,Kumar A,Sharma SS

更新日期：2006-07-17 00:00:00

abstract：:NSAIDs can elevate blood pressure through mechanisms such as renal vasoconstriction and sodium retention. These effects are particularly evident in hypertensive individuals. Nitric oxide-releasing NSAID derivatives have been shown to have greatly reduced toxicity in the gastrointestinal tract and kidney. We therefore ...

journal_title：Life sciences

authors： Muscará MN,McKnight W,Del Soldato P,Wallace JL

更新日期：1998-01-01 00:00:00

abstract：AIMS:Schisandra is a good choice in Traditional Chinese Medicine for the therapy of cardiovascular diseases, but whether it contains a or some specific component (s) responsible these effects are still unclear. In the present study, we explored whether Schisantherin A (SCA) causes vasorelaxation in isolated rat thoraci...

journal_title：Life sciences

authors： Yang S,Xu Z,Lin C,Li H,Sun J,Chen J,Wang C

更新日期：2020-03-15 00:00:00

abstract：:Based on the finding of decreased mitochondrial complex I activity in the substantia nigra of patients with Parkinson's disease, we propose that the consequent reduction of ATP synthesis and increased generation of reactive oxygen species may be a possible cause of nigrostriatal cell death. Since sulfhydryl groups are...

journal_title：Life sciences

authors： Martínez M,Martínez N,Hernández AI,Ferrándiz ML

更新日期：1999-01-01 00:00:00

abstract：:Despite reductions in beta-adrenoreceptor (beta-AR)-mediated inotropic effects induced by sustained sympathetic activation in cardiac disease, whether these changes necessarily result in reductions in systolic function under resting conditions (baseline function) is not clear. Moreover, possible compensatory mechanism...

journal_title：Life sciences

authors： Osadchii O,Woodiwiss A,Alves N,Norton G

更新日期：2005-12-12 00:00:00

abstract：:In order to understand the mechanism of increasing body fat in perimenopausal and postmenopausal women, an ovariectomy-induced obesity model was used to study the role of leptin. In this investigation, a long-term study lasted for 13 weeks was conducted to monitoring the change of serum leptin level in rats after the ...

journal_title：Life sciences

authors： Chu SC,Chou YC,Liu JY,Chen CH,Shyu JC,Chou FP

更新日期：1999-01-01 00:00:00

abstract：:Ethanol consumption was correlated with changes in acyl group profiles of phosphatidylcholine and triacylglycerols in serum of Sinclair(S-1) miniature boars. Serum triacylglycerols in the control pigs were high in linoleate (18:2) (48%) and low in stearate (18:0 (3%). Upon feeding with 10% (w/v) ethanol ad lib for two...

journal_title：Life sciences

authors： Foudin L,Tumbleson ME,Sun AY,Geisler RW,Sun GY

更新日期：1984-02-27 00:00:00

abstract：:Obesity, the metabolic syndrome (MetS), and type 2 diabetes (T2DM) are associated with heightened cardiovascular risk. Given the vasoconstrictor and proatherogenic properties of endothelin (ET)-1, increased ET-1 activity has been postulated to participate in the derangement of adiposity-related vascular homeostasis. T...

journal_title：Life sciences

authors： Campia U,Tesauro M,Di Daniele N,Cardillo C

更新日期：2014-11-24 00:00:00

abstract：AIMS:Right ventricular failure (RVF) varies significantly from the more common left ventricular failure (LVF). This study was undertaken to determine potential molecular pathways that are important in human right ventricular (RV) function and may mediate RVF. MATERIALS AND METHODS:We analyzed mRNA of human non-failing...

journal_title：Life sciences

authors： Williams JL,Cavus O,Loccoh EC,Adelman S,Daugherty JC,Smith SA,Canan B,Janssen PML,Koenig S,Kline CF,Mohler PJ,Bradley EA

更新日期：2018-03-01 00:00:00

abstract：:Significant elevation in plasma corticosterone of rats achieved by intraperitoneal (i.p.) administration of corticosterone (2.4 mg/kg) was associated with a rapid (2.5 min) and significant increase in hypothalamic histamine (HA) levels which persisted for 60 min. Midbrain and cortical HA concentrations were not affect...

journal_title：Life sciences

authors： Mazurkiewicz-Kwilecki IM

更新日期：1983-03-07 00:00:00

abstract：:Ro 15-1788 (10 mg/kg, ip) and CGS 8216 (10 mg/kg, ip) significantly reversed the inhibitory effect of diazepam (5 mg/kg, ip) on electrically induced head-turning in rats. Neither antagonist alone, at the dose level which blocked diazepam, had any intrinsic activity in this model. The specificity of the interaction bet...

journal_title：Life sciences

authors： Goldstein JM,Sutton EB,Malick JB

更新日期：1986-02-03 00:00:00

abstract：:Using in vivo microdialysis and flow-injection, we evaluated the production of nitric oxide (NO) in the striatum and substantia nigra of freely moving rats in response to challenge doses of L-dihydroxyphenylalanine (L-DOPA) by measuring the NO metabolite levels of nitrate and nitrite. The dopamine and 3,4-dihydroxyphe...

journal_title：Life sciences

authors： Kashihara K,Sakai K,Marui K,Shohmori T

更新日期：1998-01-01 00:00:00

abstract：:Cysteinyl-leukotrienes, i.e. leukotriene (LT) C4, D4 and E4, are inflammatory mediators and potent airway- and vasoconstrictors. Two different cysteinyl-leukotriene receptors, CysLT1 and CysLT2, have been cloned and functionally characterised using potent CysLT1 receptor antagonists and the dual CysLT1/CysLT2 receptor...

journal_title：Life sciences

authors： Bäck M

更新日期：2002-06-28 00:00:00

abstract：AIMS:Parathyroid hormone-related protein (PTHrP) is a peptide growth factor produced in a wide range of tissues from brain and parathyroid, to kidney and uterus. The purpose of this study was to determine whether the adrenal cortical hormones, hydrocortisone (cortisol), modulate PTHrP expression and glucocorticoid rece...

journal_title：Life sciences

authors： Yoo YM,Baek MG,Jung EM,Yang H,Choi KC,Yu FH,Jeung EB

更新日期：2011-10-24 00:00:00

abstract：:The effects of glucagon-(1-21)-peptide on pancreatic exocrine secretion and plasma glucose levels were studied and compared with those of native glucagon in anesthetized dogs. Intravenous bolus administration of 1 nmol or 10 nmol/kg of glucagon-(1-21)-peptide evoked a significant inhibition of secretin-stimulated panc...

journal_title：Life sciences

authors： Itoh H,Matsuyama T,Namba M,Watanabe N,Komatsu R,Kono N,Tarui S

更新日期：1989-01-01 00:00:00