Abstract：
:Green tea and its major constituent epigallocatechin gallate (EGCG) have been extensively studied as a potential treatment for a variety of diseases, including cancer. Epidemiological data have suggested that EGCG may provide protective effects against hormone related cancers, namely breast or prostate cancer. Extensive in vitro investigations using both hormone responsive and non-responsive cell lines have shown that EGCG induces apoptosis and alters the expression of cell cycle regulatory proteins that are critical for cell survival and apoptosis. This review will highlight the important in vitro mechanistic actions elicited by EGCG in various breast and prostate cancer cell lines. Additionally, the actions of green tea/EGCG in in vivo models for these cancers as well as in clinical trials will be discussed.
journal_name
Life Scijournal_title
Life sciencesauthors
Stuart EC,Scandlyn MJ,Rosengren RJdoi
10.1016/j.lfs.2006.07.036subject
Has Abstractpub_date
2006-11-17 00:00:00pages
2329-36issue
25eissn
0024-3205issn
1879-0631pii
S0024-3205(06)00611-4journal_volume
79pub_type
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