Abstract:
:Six diterpenes (three clerodanes, two abietanes and one rosane) were tested for interactions with the cyclooxygenase and 5-lipoxygenase pathways of arachidonate metabolism and for effects of nitric oxide production. Two abietane diterpenes, aethiopinone and 11,12-dihydroxy-6-oxo-8,11,13-abietatriene and the rosane lagascatriol showed a remarkable effect on COX-1 pathway of PGE2 release in calcium ionophore A23187-stimulated peritoneal macrophages. Only the two latter diterpenes showed inhibition on COX-2 pathway of PGE2 release in E. coli LPS-stimulated peritoneal macrophages. In addition, all compounds assayed were inhibitors of LTC4 release with IC50 < or = 10 microM. Clerodane diterpenes were inactive in COX assay. None of the diterpenes assayed, except 11,12-dihydroxy-6-oxo-8,11,13-abietatriene, affected NO production. The results obtained suggest that the cellular mechanisms of action of some of these substances may involve inhibition of cyclooxygenase/lipoxygenase pathways and nitric oxide production.
journal_name
Life Scijournal_title
Life sciencesauthors
de las Heras B,Abad MJ,Silván AM,Pascual R,Bermejo P,Rodríguez B,Villar AMdoi
10.1016/s0024-3205(01)01402-3subject
Has Abstractpub_date
2001-12-07 00:00:00pages
269-78issue
3eissn
0024-3205issn
1879-0631pii
S0024320501014023journal_volume
70pub_type
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