Abstract：
:Recent studies have demonstrated that the majority of muscarinic receptors in rabbit peripheral lung homogenates bind pirenzepine with high affinity (putative M1 subtype). In experiments of AF-DX 116 inhibiting [3H](-)quinuclidinyl benzilate or [3H]pirenzepine, we found similar inhibitory constants for AF-DX 116 binding in rat heart and rabbit peripheral lung that were 4-fold smaller (i.e. of higher affinity) than the inhibitory constant for rat cerebral cortex. This result demonstrates heterogeneity of the M1 muscarinic receptor subtype between peripheral lung and cerebral cortex.
journal_name
Life Scijournal_title
Life sciencesauthors
Bloom JW,Halonen M,Seaver NA,Yamamura HIdoi
10.1016/0024-3205(87)90226-8subject
Has Abstractpub_date
1987-07-27 00:00:00pages
491-6issue
4eissn
0024-3205issn
1879-0631pii
0024-3205(87)90226-8journal_volume
41pub_type
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