Abstract:
:Sleep is crucial to improve athlete performance and their circadian rhythm, but sleep patterns may be disturbed because athletes participate in several competitions. In addition, intensive training programs can cause muscle pain and psychological stress in athletes, resulting in a lack of sleep. Sleep also plays a critical role in the recovery of muscle injury induced by exercise. The current study evaluated the effect of sleep deprivation on the recovery of muscle injury induced by high-intensity exercise in a mouse model. In this study, 28 mice were randomly assigned to four groups (N = 7): control (Control), exercise (EX), sleep deprivation (SD), and sleep deprivation with exercise (EX+SD). The mice from the EX and EX+SD groups were subjected to high-intensity swimming. The results showed that 72-h sleep deprivation increased food intake and reduced body weight. However, the manipulation of 8-week exercise and/or 72-h sleep deprivation did not have any effect in the elevated plus maze task and tail suspension test. Interestingly, the EX+SD group exhibited improved memory performance in the Morris water maze and impaired motor activity in the open field test. According to the TNF-α level and aspartate aminotransferase (AST), and creatine phosphokinase (CK) activities, only the EX+SD group exhibited muscle impairment. Overall, high-intensity exercise may cause muscle injury, and adequate sleep can recover muscle damage. However, sleep deprivation reduces protein synthesis, which decreases the ability to restore muscle damage and aggravates the harmful effect of high-intensity exercise.
journal_name
Life Scijournal_title
Life sciencesauthors
Yang DF,Shen YL,Wu C,Huang YS,Lee PY,Er NX,Huang WC,Tung YTdoi
10.1016/j.lfs.2019.116835subject
Has Abstractpub_date
2019-10-15 00:00:00pages
116835eissn
0024-3205issn
1879-0631pii
S0024-3205(19)30762-3journal_volume
235pub_type
杂志文章相关文献
LIFE SCIENCES文献大全abstract::The effects of capsaicin on cellular growth and intracellular calcium mobilization were examined in human cervical carcinoma derivation, HeLa cells. Capsaicin inhibited cellular growth and increased intracellular calcium level in HeLa cells. This capsaicin-induced intracellular calcium concentration rise was blocked b...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(99)00046-6
更新日期:1999-01-01 00:00:00
abstract::The effects of various vasorelaxant agents on aortas from control and genetically diabetic rats were examined. The concentration-response curves for the isoproterenol (ISO)-induced relaxation of both aortic strips with and without endothelium are shifted to the right in diabetic rats. The relaxation responses of diabe...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(92)90287-y
更新日期:1992-01-01 00:00:00
abstract::The ontogenetic development of [3H]-spiroperidol binding sites was measured in the optic tectum, cerebellum, forebrain base, and forebrain roof of 1-, 4-, and 16-day-old chicks. In the chick optic tectum and cerebellum both the density and the total number of [3H]-spiroperidol binding sites increased from 4- to 16-day...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(89)90331-7
更新日期:1989-01-01 00:00:00
abstract:AIMS:This study was performed to examine whether hypertension affects the sympathetic transmission to resistance vessels of pithed rats via inhibitory presynaptic cannabinoid CB1 receptors and whether endocannabinoids are involved in this response. MATERIALS AND METHODS:We compared uninephrectomised rats rendered hype...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2015.03.022
更新日期:2015-10-01 00:00:00
abstract::The aim of this study was to investigate the molecular mechanisms underlying the protective effects of hypoxia-inducible factor (HIF) signaling pathway activation in cardiomyocytes under anoxia-reoxygenation (A/R) injury. In this study, rat neonatal cardiomyocytes were pretreated with anti-Hif3A/Hif-3α siRNA or HIF-pr...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2018.04.021
更新日期:2018-06-01 00:00:00
abstract:AIMS:Epigenetic and genetic alterations are crucial events in the onset and progression of human cancers including colorectal cancer (CRC). This work aims to probe the relevance of lysine demethylase 5B (KDM5B) to the progression of CRC and the possible molecules involved. MATERIALS AND METHODS:KDM5B expression in CRC...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2020.118726
更新日期:2021-01-01 00:00:00
abstract::In order to assess the relative cytokine contribution to endotoxin stimulation of pituitary-adrenocortical hormone secretion, we measured plasma levels of interleukin-1beta (IL-1beta), tumor necrosis factor (TNF alpha), adrenocorticotropin (ACTH) and corticosterone following lipopolysaccharide (LPS) challenge in rats....
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(97)00780-7
更新日期:1997-01-01 00:00:00
abstract::The isolated cat superior cervical ganglion (SCG) was labeled in vitro with either 3H-norepinephrine (3H-NE) or 3H-choline and stimulated through its preganglionic trunk. The release of 3H-NE and 3H-acetylcholine (3H-ACh) elicited by the stimulation was measured under control conditions and in the presence of drugs. T...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(85)90371-6
更新日期:1985-04-29 00:00:00
abstract::The temporal relationship of changes in cAMP and cGMP to oocyte maturation was examined in proestrous hamsters (day 4). The first series of experiments showed, in normal cycling hamsters, an increase in cAMP and a decrease in cGMP at 1400 h shortly after the rise in LH with oocyte maturation beginning at 1800 h. When ...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(83)90726-9
更新日期:1983-10-24 00:00:00
abstract::We administered a series of alpha-blocking drugs to the nucleus reticularis lateralis (NRL) of the medulla oblongata, the main site for the hypotensive action of clonidine. These experiments were performed on pentobarbital anaesthetized cats. Drugs were injected through a needle which was stereotaxically inserted. Pra...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(87)90566-2
更新日期:1987-03-16 00:00:00
abstract::The effect of brief inhalation of carbon dioxide (CO2) was studied in a conflict situation (Vogel test) in the rat. This treatment, which inhibits gamma-aminobutyric acid (GABA)-mediated transmission in rat brain and induces anxiety and panic attacks in humans, elicited a proconflict effect. Exposure of rats for 1 min...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(95)00093-3
更新日期:1995-03-10 00:00:00
abstract:AIMS:Considering the implications that arose from several recent experimental studies using recombinant human erythropoietin in rodents, erythropoietin has been regarded as a pharmacological preconditioning agent. The purpose of the present study was to evaluate whether erythropoietin has a preconditioning effect again...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2008.12.025
更新日期:2009-03-13 00:00:00
abstract:AIMS:Dysfunction of the Hippo-Yes-Associated Protein (YAP) signaling pathway is known to be associated with hepatocellular carcinoma (HCC). Evodiamine (Evo), a plant-derived bioactive alkaloid, exerts inhibitory effects on cancer. However, the precise influence of Evo on HCC and its potential effects on Hippo-YAP signa...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2020.117424
更新日期:2020-06-15 00:00:00
abstract::Systemic administration of the selective D1 antagonist, SCH 23390, caused significant motor changes in healthy African green monkeys. The effects included the parkinsonian signs of motor freezing, incoordination, bradykinesia, poverty of movement, tremor and depressed blink rate. SCH 23390 administered to MPTP-treated...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(91)90299-q
更新日期:1991-01-01 00:00:00
abstract::Cyclic voltammetry data were obtained for most of the main classes of antiprotozoan agents, specifically, nitroheterocycles, quinones, metal complexes and derivatives, iminium-type ions, and azo compounds. The reductions were generally reversible in the range of -0.3 to -0.9 V. Catalytic production of oxidative pressu...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(87)90740-5
更新日期:1987-10-19 00:00:00
abstract::The effects of methylprednisolone (m-PSL) on IL-1beta-induced neutrophil-endothelial cell interactions, which are normally mediated by increased expression of both intercellular adhesion molecule-1 (ICAM-1) and E-selectin on endothelial cells, were examined using an in vitro flow system. Human neutrophilic polymorphon...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(97)00290-7
更新日期:1997-01-01 00:00:00
abstract::Aromatase transforms irreversibly androgens into estrogens and is present in the endoplasmic reticulum of various tissues including the mammalian testis. In rat all testicular cells except peritubular cells express aromatase. Indeed in adult rat germ cells (pachytene spermatocytes and round spermatids) we have demonst...
journal_title:Life sciences
pub_type: 杂志文章,评审
doi:10.1016/j.lfs.2011.06.004
更新日期:2011-10-10 00:00:00
abstract::This study analyzed the relationship between infection by human T-cell lymphotropic virus type 1 (HTLV-1) and changes in the pulmonary system. Cohort and case-control study models that analyzed a causal association between HTLV-1 and changes in the pulmonary system were considered. There were no restrictions on langua...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2020.117979
更新日期:2020-09-01 00:00:00
abstract::Premazepam (PRZ) in vitro competitively displaced 3H-diazepam (DIA), 3H-flunitrazepam (FLU) and 3H-RO 15-1788 from their binding sites on rat brain synaptosomes, with a potency intermediate to other benzodiazepines (BDZs), and Hill coefficients near 1 in different brain regions. Incubation at 37 degrees C reduced prem...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(84)90646-5
更新日期:1984-07-23 00:00:00
abstract::Calcium mobilization has been demonstrated to possess functional importance in myocardial excitation-contraction as well as cellular metabolism. So far, much progress has been made to explore the possibility of involvement of guanine nucleotide binding regulatory protein in the opening and closing of calcium channels ...
journal_title:Life sciences
pub_type: 杂志文章,评审
doi:10.1016/0024-3205(91)90264-c
更新日期:1991-01-01 00:00:00
abstract::We recently suggested that peroxisome proliferators (PP)-induced hepatocyte DNA synthesis may be mediated by a specific peroxisome proliferator activated receptor (PPAR). Heterodimers of the PPAR with the retinoid nuclear receptor, RXR, activate transcription after binding to DR1 response elements of the target genes....
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(96)00039-2
更新日期:1996-01-01 00:00:00
abstract::The important immunological activities of Thymosin alpha 1 (T alpha 1), a peptide derived from the thymus, led to its use in combination therapies in cancer patients. Prothymosin alpha (ProT alpha) is a highly acidic polypeptide, first isolated as the putative precursor of T alpha 1. However ProT alpha is now known to...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(96)00157-9
更新日期:1996-01-01 00:00:00
abstract:AIMS:Serotonergic neurons and amino acid neurons are involved in the central nervous control of lower urinary tract function. We investigated the role of the serotonergic system in the central regulation of micturition, as well as the relationship between serotonergic neurons and amino acid neurons in the lumbosacral c...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2009.08.013
更新日期:2009-10-07 00:00:00
abstract::Galectin-10 (gal-10, also known as Charcot-Leyden crystal protein) is a member of the galectin family of beta-galactoside binding proteins that is expressed uniquely in eosinophilic and basophilic leukocytes. To gain a better understanding of galectin gene expression, we present an analysis of the transcriptional regu...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(01)01104-3
更新日期:2001-06-01 00:00:00
abstract::The pupillary effects of intravenous buprenorphine were studied in eight nondependent male subjects who reported previous opiate use. Buprenorphine (0.3, 0.6, and 1.2 mg) decreased pupil size, the amplitude of the light reflex, and the velocities of constriction and dilation. Significant pupillary effects occurred wit...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(91)90026-8
更新日期:1991-01-01 00:00:00
abstract:AIMS:Previous study demonstrated that Ginsenoside Rd. (GS-Rd) could improve cognitive and memory function in animal model of Alzheimer's disease. This study was aimed to investigate whether GS-Rd could improve non-amyloidogenic pathway by activating estrogen receptor (ER). MAIN METHODS:10mg/kg GS-Rd in ovariectomy (OV...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2016.11.002
更新日期:2017-01-01 00:00:00
abstract::A novel bioactive lipid, cyclic phosphatidic acid (cPA), was identified in lipids bound to human serum albumin. A cPA fraction was extracted and purified from human serum albumin by use of a combination of preparative TLC and HPLC. Electrospray ionization mass spectrometry of the purified fraction showed molecular ion...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(99)00483-x
更新日期:1999-01-01 00:00:00
abstract::Clinical and preclinical studies have suggested that fluctuations in the peripheral and brain concentrations of progesterone and deoxycorticosterone and its metabolites 3alpha,5alpha-tetrahydroprogesterone and 3alpha,5alpha-tetrahydrodeoxycorticosterone, respectively, might play an important role in certain pathologic...
journal_title:Life sciences
pub_type: 杂志文章,评审
doi:10.1016/j.lfs.2003.12.002
更新日期:2004-05-14 00:00:00
abstract::Plasma and urinary levels of MHPG were determined in six normal volunteers. Samples were obtained at 3-hour intervals for plasma and at 12-hour intervals for urine. Acrophase, amplitude and period were determined for plasma MHPG levels. A sinusoidal pattern was obtained for diurnal plasma MHPG with a peak at 15:00 hrs...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(85)90302-9
更新日期:1985-11-04 00:00:00
abstract::Although several reports imply that anticoagulants and preservatives contain zinc, the quantity of zinc in heparin, if any, has not been documented. Zinc concentration was determined by flame atomic absorption spectroscopy in varying dilutions of multiple commercially obtained samples of purified sodium heparin N = 15...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(83)90348-x
更新日期:1983-12-26 00:00:00