CD123 and its potential clinical application in leukemias.

abstract：:To investigate the difference of metabolic pharmacokinetics between pure glycyrrhizin (GZ) and GZ in licorice decoction, six New Zealand White rabbits were orally given pure GZ and licorice decoction containing equivalent content of GZ in a randomized crossover design. HPLC methods were used for the quantitation of GZ...

journal_title：Life sciences

authors： Hou YC,Hsiu SL,Ching H,Lin YT,Tsai SY,Wen KC,Chao PD

更新日期：2005-01-21 00:00:00

abstract：:Histidine decarboxylase (HDC) activity and histamine content were measured in endoscopic gastric biopsy specimens of 19 control subjects with normogastrinemia and 6 patients with hypergastrinemia. In controls, the HDC activity was 3 fold higher in fundic mucosa (120 +/- 13 fmol/min/mg protein, mean +/- S.E.) than in a...

journal_title：Life sciences

authors： Miyazaki Y,Imamura I,Shinomura Y,Wada H,Tarui S

更新日期：1991-01-01 00:00:00

abstract：AIMS:The aim of the present study was to investigate the protective effects of AGK2 as a selective SIRT2 inhibitor on thioacetamide (TAA)-induced acute liver failure (ALF) in mice and its potential mechanism. MAIN METHODS:All male C57BL/6 mice were separated into control, TAA, AGK2 + TAA, and AGK2 groups. The histolog...

journal_title：Life sciences

authors： Jiao FZ,Wang Y,Zhang WB,Zhang HY,Chen Q,Shi CX,Wang LW,Gong ZJ

更新日期：2019-08-01 00:00:00

abstract：:Rats treated chronically with the anticancer agent adriamycin (1.5 mg/kg/week X 14 weeks) exhibited cardiac and renal lesions typical of anthracycline toxicity, and had serum hyperlipidemia characterized by 4 to 10 fold elevations in all lipoprotein classes. Heparin-releasable lipoprotein lipase activity measured in p...

journal_title：Life sciences

authors： Thayer WS

更新日期：1985-02-18 00:00:00

abstract：:The muscarinic pharmacology of C1-methyl-substituted chiral compounds related to McN-A-343 and of (R)- and (S)-dimethindene has been studied. Among the McN-A-343 analogues, the (S)-enantiomers were more potent and had higher affinity than the (R)-isomers. The quaternary compound (S)-BN 228 was found to be the most pot...

journal_title：Life sciences

authors： Lambrecht G,Gross J,Hacksell U,Hermanni U,Hildebrandt C,Hou X,Moser U,Nilsson BM,Pfaff O,Waelbroeck M

更新日期：1995-01-01 00:00:00

abstract：:We have recently demonstrated that the hypertensinogenic and natriuretic actions of ACTHI-39 can be found in a non-steroidogenic fragment of ACTH, ACTH4-10. These effects of ACTH or ACTH4-10 may be due to their ability to act as weak agonists of gamma MSH. gamma MSH is found in the 16K N-terminus of pro-opiocortin, an...

journal_title：Life sciences

authors： Klein MC,Hutchins PM,Lymangrover JR,Gruber KA

更新日期：1985-02-25 00:00:00

abstract：:To examine the therapeutic effect of 4-(o-benzylphenoxy)-N-methylbutylamine hydrochloride (bifemelane) on neuronal ischemia-reperfusion injury, we evaluated the neurological score in gerbils subjected to unilateral common carotid occlusion. Using the neurological score method, we selected animals which showed stroke s...

journal_title：Life sciences

authors： Hata R,Matsumoto M,Kitagawa K,Tagaya M,Matsuyama T,Sugita M,Kamada T

更新日期：1995-01-01 00:00:00

abstract：:To clarify the mechanism by which Delta9-tetrahydrocannabinol, a major psychoactive component of marijuana, impairs spatial memory in the 8-arm radial maze in rats via the cholinergic system, we used two acetylcholinesterase inhibitors, physostigmine and tetrahydroaminoacridine. Moreover, we examined the effect of Del...

journal_title：Life sciences

authors： Mishima K,Egashira N,Matsumoto Y,Iwasaki K,Fujiwara M

更新日期：2002-12-20 00:00:00

abstract：AIMS:Multiple sclerosis (MS) whose pathogenesis is still unclear is a chronic progressive disease in the central nervous system. Gut microbiota can directly or indirectly affect the immune system through the brain gut axis to engage in the occurrence and development of the disease. MATERIALS AND METHODS:C57BL/6 mice w...

journal_title：Life sciences

authors： Xu L,Zhang C,He D,Jiang N,Bai Y,Xin Y

更新日期：2020-07-15 00:00:00

abstract：:Beriberi is a disease caused by thiamine deficiency (TD), which may lead to heart problems, including heart failure. Despite the fact that thiamine prevalence is reduced in the industrialized world, it remains a health hazard especially due to chronic alcohol consumption. Diagnosing the presence of TD based on both el...

journal_title：Life sciences

authors： Roman-Campos D,Cruz JS

更新日期：2014-03-07 00:00:00

abstract：:Inositol hexaphosphate (InsP6 or IP6) is ubiquitous. At 10 microM to 1 mM concentrations, IP6 and its lower phosphorylated forms (IP(1-5)) as well as inositol (Ins) are contained in most mammalian cells, wherein they are important in regulating vital cellular functions such as signal transduction, cell proliferation a...

journal_title：Life sciences

authors： Shamsuddin AM,Vucenik I,Cole KE

更新日期：1997-01-01 00:00:00

abstract：:We demonstrate that injections of 1-methyl-4-phenyl-1,2,3,6-tetra-hydropyridine (MPTP), 1-methyl-4-phenyl-pyridinium ion (MPP+) and Paraquat (PQ+) produce in Rana Pipiens different behavioral, biochemical and skin pigmentation changes. MPTP causes in frogs the main symptoms of Parkinsonism (rigidity, akinesia and trem...

journal_title：Life sciences

authors： Barbeau A,Dallaire L,Buu NT,Poirier J,Rucinska E

更新日期：1985-10-21 00:00:00

abstract：AIM:The study is aimed at evaluating the chemosensitization and apoptotic effect of aglycone rich extracts of dietary phytoestrogens (derived from soybean and flaxseed) on estrogen receptor positive, MCF-7 and estrogen receptor negative, MDA-MB-231 cells. The extracts show potent activity on both the cell lines, hence,...

journal_title：Life sciences

authors： Dutta S,Kharkar PS,Sahu NU,Khanna A

更新日期：2017-09-15 00:00:00

abstract：:Somatostatin (SS) acts as a universal endocrine off-swich, and also inhibits the growth of neuroendocrine tumors through its specific receptors. Small cell lung cancer (SCLC) demonstrates some neuroendocrine characteristics and has been proposed as a candidate for treatment with SS and its analogues. In the present st...

journal_title：Life sciences

authors： Fujita T,Yamaji Y,Sato M,Murao K,Takahara J

更新日期：1994-01-01 00:00:00

abstract：:We investigated whether calcium channel antagonists would alter the induction of nitric oxide (NO) synthesis by bacterial lipopolysaccharide (LPS) alone or in combination with interferon-gamma (IFN gamma) in cultured J774 macrophages, rat vascular smooth muscle cells, rat renal mesangial cells, and rat cardiac myocyte...

journal_title：Life sciences

authors： Hattori Y,Kasai K,So S,Hattori S,Banba N,Shimoda S

更新日期：1995-01-01 00:00:00

abstract：:Nitric oxide (NO) may play an important regulatory role in airway function. We have, thus, investigated in vitro whether epithelium derived NO may modulate cholinergic neurotransmission, via release of NO in guinea pig trachea, by using L-arginine (L-ARG), a precursor of NO synthesis, and L-N(G)-nitro-arginine-methyl-...

journal_title：Life sciences

authors： Matera MG,D'agostino B,Cardone M,Calderaro V,Rossi F

更新日期：1995-02-17 00:00:00

abstract：:Chronic cocaine abuse has been associated with cerebrovascular pathology. This is likely to reflect its vasoactive effects; cocaine produces vasoconstriction and reduces cerebral blood flow. We propose that cerebrovascular pathology in chronic cocaine abusers would result in abnormal BOLD [blood oxygenation level depe...

journal_title：Life sciences

authors： Lee JH,Telang FW,Springer CS Jr,Volkow ND

更新日期：2003-08-29 00:00:00

abstract：:The intracellular ionic content of human erythrocytes may be altered by hyperglycaemia. Despite this, very little is known about the cellular mechanisms linking glucose and cellular magnesium homeostasis. We measured intracellular ionized magnesium in human lymphocytes, by means of a fluorimetric technique, total intr...

journal_title：Life sciences

authors： Delva P,Degan M,Pastori C,Faccini G,Lechi A

更新日期：2002-09-20 00:00:00

abstract：:Diazepam binding inhibitor (DBI) is a 9-kD polypeptide that was first isolated in 1983 from rat brain by monitoring its ability to displace diazepam from the benzodiazepine (BZD) recognition site located on the extracellular domain of the type A receptor for gamma-aminobutyric acid (GABAA receptor) and from the mitoch...

journal_title：Life sciences

authors： Costa E,Guidotti A

更新日期：1991-01-01 00:00:00

abstract：:Since hypertension may compromise the ability to withstand hypernatremic dehydration, we investigated the impact of two experimental models of hypertension and pharmacologic normalization of blood pressure on the tolerance to chronic hypernatremic dehydration. In DOCA-salt hypertensive animals and the spontaneously-hy...

journal_title：Life sciences

authors： Trachtman H,del Pizzo R,Sturman J

更新日期：1990-01-01 00:00:00

abstract：:Opiate antagonists have been shown to reliably attenuate drinking behavior. Recent research points to a central site of action for this antidipsogenic effect. To pursue this issue of site specificity, naloxone, a specific opiate antagonist, was delivered into a number of discrete subcortical areas in 23 hour water-dep...

journal_title：Life sciences

authors： Czech DA,Stein EA,Blake MJ

更新日期：1983-08-22 00:00:00

abstract：:The hypocholesterolemic effect of taurine was examined in mice fed a high-cholesterol diet containing 1% cholesterol and 0.25% sodium cholate. Male C57BL/6 mice were divided into 3 groups: control group (HC), 1% taurine-supplemented group (HCT+), and taurine-deficient group (HCT-) produced by supplying 0.5% guanidinoe...

journal_title：Life sciences

authors： Chen W,Matuda K,Nishimura N,Yokogoshi H

更新日期：2004-02-27 00:00:00

abstract：AIMS:Chemerin has been recently identified as a vasoactive adipokine implicated in blood pressure regulation. In this context, we evaluated whether chemerin could influence pulmonary vasoreactive response. MATERIALS AND METHODS:Vascular reactivity to chemerin and to phenylephrine, serotonin and endothelin-1 after chem...

journal_title：Life sciences

authors： Hanthazi A,Jespers P,Vegh G,Degroot GN,Springael JY,Lybaert P,Dewachter L,Mc Entee K

更新日期：2019-08-15 00:00:00

abstract：:Quercetin, a plant flavonoid, blocks signal transduction pathways by inhibiting 1-phosphatidylinositol 4-kinase (EC 2.7.1.67, PI kinase) and 1-phosphatidylinositol 4-phosphate 5-kinase (EC 2.7.1.68, PIP kinase), resulting in a reduction of inositol 1,4,5-trisphosphate (IP3) concentration which decreases the release of...

journal_title：Life sciences

authors： Yeh YA,Herenyiova M,Weber G

更新日期：1995-01-01 00:00:00

abstract：:To evaluate the relative contributions of the ovarian inhibin and estradiol-17 beta (E) on the regulation of FSH secretion, inhibin and E in ovarian venous plasma (OVP) and FSH and LH in peripheral plasma were simultaneously measured using superovulating rats with special reference to follicular maturation. By the tra...

journal_title：Life sciences

authors： Tsukamoto I,Taya K,Watanabe G,Sasamoto S

更新日期：1986-07-14 00:00:00

abstract：:An improved two-dimensional HPTLC procedure was developed for separating phospholipids including individual phosphoinositides, phosphatidic acids and plasmalogens. This procedure was used to examine the time course for uptake of label by phospholipids in brain subcellular membranes after intracerebral injection of [ga...

journal_title：Life sciences

authors： Sun GY,Lin TN

更新日期：1989-01-01 00:00:00

abstract：:The effects of elevated glucose and aldose reductase inhibitor (ARI:ONO-2235) on nitric oxide (NO) production in cultured human umbilical endothelial cells (HUVEC) were evaluated. Aldose reductase and nitric oxide synthase(NOS) share NADPH as an obligate cofactor, therefore it is suggested that the enhanced of glucose...

journal_title：Life sciences

authors： Okuda Y,Kawashima K,Suzuki S,Asakura Y,Asano M,Tsurumaru K,Dai H,Tachi Y,Bannai C,Saitoh M,Yamashita K

更新日期：1997-01-01 00:00:00

abstract：:Stability and distribution of orally administered epidermal growth factor (EGF) were examined in newborn and 5-day-old pigs. Forty-five minutes after oral administration of iodine-125 labeled EGF, 60 and 50% of the radioactivity administered were recovered from the internal organs in newborn and 5-day-old pigs, respec...

journal_title：Life sciences

authors： Shen WH,Xu RJ

更新日期：1998-01-01 00:00:00

abstract：:The skin permeabilities of a series of eight salicylates and ten non-steroidal anti-inflammatory drugs were investigated in human subjects. The logarithms of % absorption through intact skin and of n-octanol/water partition coefficients (log P) of the test compounds were plotted against one another, and a parabolic re...

journal_title：Life sciences

authors： Yano T,Nakagawa A,Tsuji M,Noda K

更新日期：1986-09-22 00:00:00

abstract：:The microscopic localization of angiotensin II receptors in the rat brainstem has been accomplished utilizing in vitro receptor autoradiographic techniques. These receptors are highly localized to discrete nuclear regions of the brainstem. Significant densities of autoradiographic grains, indicating the presence of sp...

journal_title：Life sciences

authors： Gehlert DR,Speth RC,Healy DP,Wamsley JK

更新日期：1984-04-16 00:00:00