[11C]S21007, a putative partial agonist for 5-HT3 receptors PET studies. Rat and primate in vivo biological evaluation.

abstract：:We investigated the mechanism mediating cholinergic control of cell-to-cell adhesion of human epidermal keratinocytes (KC) by non-neuronal acetylcholine produced by KC themselves. We first measured cholinergic effects on the expression of desmoglein (Dsg) 1 and 3 in KC using the semi-quantitative immunofluorescence an...

journal_title：Life sciences

authors： Nguyen VT,Arredondo J,Chernyavsky AI,Kitajima Y,Grando SA

更新日期：2003-03-28 00:00:00

abstract：:Despite reductions in beta-adrenoreceptor (beta-AR)-mediated inotropic effects induced by sustained sympathetic activation in cardiac disease, whether these changes necessarily result in reductions in systolic function under resting conditions (baseline function) is not clear. Moreover, possible compensatory mechanism...

journal_title：Life sciences

authors： Osadchii O,Woodiwiss A,Alves N,Norton G

更新日期：2005-12-12 00:00:00

abstract：:L-Histidine, histamine ivc, and amodiaquine (inhibitor of histamine catabolism) enhanced catalepsy induced by morphine, codeine and fentanyl. Haloperidol catalepsy was increased only by ivc histamine. H1 (but not H2) receptor antagonists have shown anticataleptic effect in the action of analgesics and haloperidol. ...

journal_title：Life sciences

authors： Malec D,Langwiński R

更新日期：1983-01-01 00:00:00

abstract：:The role of p44/42 mitogen-activated protein kinase (MAPK) in the expression of intercellular adhesion molecule-1 (ICAM-1) in NCI-H292 cells, a human bronchial epithelial cell line, was analyzed. Treatment with the protein kinase C (PKC) activator 12-O-tetradecanoylphorbol 13-acetate (TPA) (16.2 nM) or interferon-gamm...

journal_title：Life sciences

authors： Shibuya Y,Hirasawa N,Sakai T,Togashi Y,Muramatsu R,Ishii K,Yamashita M,Takayanagi M,Ohuchi K

更新日期：2004-06-11 00:00:00

abstract：:The effect of various fractions of black tea [(Camellia Sinensis) (L) O. Kuntze (Theaceae)] on the function of mammalian skeletomotor apparatus was studied. The theaflavin fraction (Tfs) produced a concentration- dependent facilitation of indirect twitch responses of the rat phrenic nerve diaphragm preparation and the...

journal_title：Life sciences

authors： Basu S,Chaudhuri T,Chauhan SP,Das Gupta AK,Chaudhury L,Vedasiromoni JR

更新日期：2005-05-13 00:00:00

abstract：:The interaction of cell surface hormone receptors with heterotrimeric G proteins is crucial for hormonal actions. The domains of the receptor, which interact with and activate G protein, have been extensively studied. However, precise molecular mechanisms underlying regulation of the receptor-induced G protein activat...

journal_title：Life sciences

authors： Sugimoto Y,Nakato T,Kita A,Hatae N,Tabata H,Tanaka S,Ichikawa A

更新日期：2003-12-05 00:00:00

abstract：:The association between various parameters of acute and chronic smoking status and plasma levels of three proteins, C9, C1-inhibitor (C1-INH) and alpha 1-protease inhibitor (alpha 1-PI) were determined for 49 male cigarette smokers and 49 age-matched nonsmokers (mean age = 32.2 years). The mean number of cigarettes sm...

journal_title：Life sciences

authors： Bridges RB,Rehm SR,Wyatt RJ

更新日期：1985-03-11 00:00:00

abstract：:In order to better understand the mechanisms underlying the reduction in GH secretion in diabetic rats, we have characterized and measured SRIH receptors in the hypothalamus and anterior pituitary gland 5 and 9 days after induction of diabetes in the rat. Experimental diabetes was induced by an intraperitoneal injecti...

journal_title：Life sciences

authors： Pesce G,Guillaume V,Dutour A,Dadoun F,Joanny P,Steinberg J,Oliver C

更新日期：1994-01-01 00:00:00

abstract：:This work was designed to study neurogenic, atropine resistant contractions of the cat urinary bladder. Urinary bladder contractions were induced by pelvic nerve stimulation (PNS) and the administration of acetylcholine (Ach) and purine compounds. The results show that atropine (2 mg/kg) depresses the maintained porti...

journal_title：Life sciences

authors： Theobald RJ Jr

更新日期：1983-05-23 00:00:00

abstract：AIM:Nuclear factor-kappa B inhibitor alpha (IκBα) polymorphisms were found to be associated with inflammatory diseases. However, the association between IκBα polymorphisms with gastric cancer is still unknown. We aim to investigate the association between IκBα polymorphisms and gastric cancer risk in a large population...

journal_title：Life sciences

authors： Wang S,Zhang M,Zeng Z,Tian L,Wu K,Chu J,Fan D,Hu P,Sung JJ,Yu J

更新日期：2011-04-25 00:00:00

abstract：:The effects of different kinds of acute stress on collagen-induced whole blood platelet aggregation and fibrinolysis in relation to blood serotonergic measures were studied. In rats water-immersion restraint stress resulted in a shortening of euglobulin clot lysis time (ECLT), an increase in tissue plasminogen activat...

journal_title：Life sciences

authors： Malyszko J,Urano T,Takada Y,Takada A

更新日期：1994-01-01 00:00:00

abstract：:Ethanol consumption was correlated with changes in acyl group profiles of phosphatidylcholine and triacylglycerols in serum of Sinclair(S-1) miniature boars. Serum triacylglycerols in the control pigs were high in linoleate (18:2) (48%) and low in stearate (18:0 (3%). Upon feeding with 10% (w/v) ethanol ad lib for two...

journal_title：Life sciences

authors： Foudin L,Tumbleson ME,Sun AY,Geisler RW,Sun GY

更新日期：1984-02-27 00:00:00

abstract：AIMS:The beneficial effects of cannabinoid type 2 receptor (CB2R) activation have been verified in various tissue repair processes. Our recent study revealed CB2R activation promotes myogenesis partly through Nrf2 signaling in a mouse skeletal muscle ischemia-reperfusion (IR) injury model. Other relevant mechanisms nee...

journal_title：Life sciences

authors： Jiang P,Wang L,Zhang M,Zhang M,Wang C,Zhao R,Guan D

更新日期：2020-09-01 00:00:00

abstract：AIMS:slc26a proteins are responsible for a large number of functions either in normal physiology or in human disease. We have previously reported that proximal tubular epithelial (PTE) cells immortalized from spontaneously hypertensive rats (SHRs) were endowed with increased Cl(-)/HCO3(-) exchanger activity and slc26a6...

journal_title：Life sciences

authors： Simão S,Gomes P,Pinho MJ,Soares-da-Silva P

更新日期：2013-10-06 00:00:00

abstract：:Resveratrol is an antioxidant present in grapes and their related products. We investigated whether dietary resveratrol could inhibit the proliferation and metastasis of tumors and hyperlipidemia in Donryu rats subcutaneously implanted with an ascites hepatoma cell line of AH109A. By feeding 10 or 50 ppm resveratrol i...

journal_title：Life sciences

authors： Miura D,Miura Y,Yagasaki K

更新日期：2003-08-01 00:00:00

abstract：:The Wnt/β-catenin or Wnt canonical pathway controls multiple biological processes throughout development and adult life. Growing evidences have suggested that deregulation of the Wnt canonical pathway could be involved in the pathogenesis of neurodegenerative diseases. The Wnt canonical signaling is a pathway tightly ...

journal_title：Life sciences

authors： Libro R,Bramanti P,Mazzon E

更新日期：2016-08-01 00:00:00

abstract：:Cardiovascular effects of the essential oil of Croton zehntneri (EOCZ) were investigated in conscious rats. In these preparations, intravenous (i.v.) injections of EOCZ (1-20 mg kg(-1)) and its main constituents anethole and estragole (both at 1-10 mg kg(-1)) elicited brief and dose-dependent hypotension and bradycard...

journal_title：Life sciences

authors： de Siqueira RJ,Magalhães PJ,Leal-Cardoso JH,Duarte GP,Lahlou S

更新日期：2006-04-11 00:00:00

abstract：AIMS:Gastric cancer (GC) is one of the most common malignant tumors in the world. Anti-angiogenic therapy is a useful strategy for the treatment of advanced GC. This study was aimed to systemically compare the anti-angiogenesis, anti-cancer efficacy, as well as the safety of four known anti-angiogenic drugs, namely ram...

journal_title：Life sciences

authors： Wu JQ,Fan RY,Zhang SR,Li CY,Shen LZ,Wei P,He ZH,He MF

更新日期：2020-04-15 00:00:00

abstract：:A review of the rapidly accumulating data in the literature continues to support the notion that catecholamines regulate ovarian function, and extends the complexity of catecholaminergic effects on the ovary via interactions with pituitary and adrenal hormones. It is clear that catecholamines affect growth and differe...

journal_title：Life sciences

authors： Spicer LJ

更新日期：1986-11-10 00:00:00

abstract：:C57BL6/J (B6) mice lacking Se-dependent GSH peroxidase 1 and 2 (GPx1/2-DKO) develop mild to moderate ileocolitis around weaning. These DKO mice have a disease resembling human very-early-onset inflammatory bowel disease (VEOIBD), which is associated with mutations in NADPH oxidase genes. Drugs including dexamethasone ...

journal_title：Life sciences

authors： Chu FF,Esworthy RS,Shen B,Gao Q,Doroshow JH

更新日期：2019-12-15 00:00:00

abstract：:Promoter methylation is an important mechanism of regulating E-cadherin expression. Methylation-specific PCR (MSP) assay was done to evaluate the promoter methylation status of E-cadherin gene in primary tumor samples from 23 cases of Chinese women with invasive ductal breast cancers. Western blotting assay was employ...

journal_title：Life sciences

authors： Hu XC,Loo WT,Chow LW

更新日期：2002-08-09 00:00:00

abstract：:Heterotrimeric G-protein signalling systems are primarily activated via cell surface receptors possessing the seven membrane span motif. Several observations suggest the existence of other modes of input to such signalling systems either downstream of effectors or at the level of G-proteins themselves. Using a functio...

journal_title：Life sciences

authors： Cismowski MJ,Takesono A,Bernard ML,Duzic E,Lanier SM

更新日期：2001-04-06 00:00:00

abstract：:Growth-related oncogene protein-alpha (GRO-alpha) is a member of the C-X-C chemokine family with a wide variety of biological activities. We studied the production of GRO-alpha by human umbilical vein endothelial cells (HUVEC) in response to the stimulation with soluble form of interleukin-6 receptor alpha (sIL-6R). s...

journal_title：Life sciences

authors： Matsumiya T,Imaizumi T,Itaya H,Shibata T,Yoshida H,Sakaki H,Kimura H,Satoh K

更新日期：2002-05-17 00:00:00

abstract：:Several neuronal cell lines were screened for endogenous expression of neuronal nitric oxide synthase (nNOS) protein using Western blot analysis. Detectable levels of the nNOS protein were evident in the SK-N-SH, SH-SY5Y, and N1E-115 neuroblastoma cell lines, as well as the NG108-15 neuroblastoma x glioma hybrid. Only...

journal_title：Life sciences

authors： Grant MK,Cuadra AE,El-Fakahany EE

更新日期：2002-07-05 00:00:00

abstract：AIMS:Normal human cells in culture progressively lose their capacity for replication, ending in an irreversible arrested state known as replicative senescence. Senescence has been functionally associated to the process of organismal ageing and is also considered a major tumor-suppressing mechanism. Although a great dea...

journal_title：Life sciences

authors： Maeda M,Scaglia N,Igal RA

更新日期：2009-01-16 00:00:00

abstract：:The use of more than one drug to achieve a desired effect has been a common practice in pharmacologic testing and in clinical practice. For example, combinations of analgesics are frequently prescribed with a view to enhancing pain relief and reducing adverse effects. It is also well established that administration of...

journal_title：Life sciences

authors： Tallarida RJ,Porreca F,Cowan A

更新日期：1989-01-01 00:00:00

abstract：:The epicardial release of immunoreactive atrial natriuretic peptides (ir-ANPs) in inside-out perfused rabbit atria has been reported. In order to determine the presence of ir-ANPs in pericardial fluid and to evaluate their biochemical characteristics, we measured the concentration of ir-ANPs in pericardial fluid obtai...

journal_title：Life sciences

authors： Kuh JH,Kim KS,Kim SH,Cho KW,Seul KH,Koh GY

更新日期：1990-01-01 00:00:00

abstract：:The scientific interest in irisin, a myokine discovered in 2012, has grown exponentially in recent years. Irisin, which is mainly produced in skeletal muscle, influences the browning process of adipose tissue and lipid and energy metabolism. Recent discoveries highlight that the potential of this hormone may have been...

journal_title：Life sciences

authors： Flori L,Testai L,Calderone V

更新日期：2021-02-15 00:00:00

abstract：:Oleuropein (Ole) is the main bioactive phenolic compound present in olive leaves, fruits and olive oil. This molecule has been shown to exert beneficial effects on several human pathological conditions. In particular, recent preclinical and observational studies have provided evidence that Ole exhibits chemo-preventiv...

journal_title：Life sciences

authors： Leto G,Flandina C,Crescimanno M,Giammanco M,Sepporta MV

更新日期：2021-01-01 00:00:00

abstract：:We studied the effect of thapsigargin on intracellular calcium levels ([Ca2+]i) measured by fura-2 fluorimetry in Madin Darby canine kidney (MDCK) cells. Thapsigargin elevated [Ca2+]i dose dependently with an EC50 of approximately 0.15 microM. The Ca2+ signal consisted of a slow rise, a gradual decay and a plateau. De...

journal_title：Life sciences

authors： Jan CR,Ho CM,Wu SN,Tseng CJ

更新日期：1999-01-01 00:00:00