Abstract：
:The epicardial release of immunoreactive atrial natriuretic peptides (ir-ANPs) in inside-out perfused rabbit atria has been reported. In order to determine the presence of ir-ANPs in pericardial fluid and to evaluate their biochemical characteristics, we measured the concentration of ir-ANPs in pericardial fluid obtained from the patients with congenital heart diseases during open heart surgery. Serial dilution curves made with the extrats of pericardial fluid using Sep-Pak C18 cartridges were parallel with standard curve. The concentration of ir-ANPs in pericardial fluid was significantly lower than the corresponding plasma concentration. On gel permeation and reverse-phase high performance liquid chromatography, the ir-ANPs in pericardial fluid, plasma and atrial appendage showed both high and low molecular weights. The major peak of ir-ANPs in plasma was observed at the corresponding fraction to the alpha-human ANP and considerable amount of high molecular weight form of ir-ANPs was observed in pericardial fluid. However, the major peak of ir-ANPs in atrial appendage was observed at the corresponding fraction to the rat pro-ANP. The data suggest that ir-ANPs exist both high and low molecular weight forms in pericardial fluid.
journal_name
Life Scijournal_title
Life sciencesauthors
Kuh JH,Kim KS,Kim SH,Cho KW,Seul KH,Koh GYdoi
10.1016/0024-3205(90)90514-rsubject
Has Abstractpub_date
1990-01-01 00:00:00pages
1977-83issue
26eissn
0024-3205issn
1879-0631pii
0024-3205(90)90514-Rjournal_volume
46pub_type
杂志文章相关文献
LIFE SCIENCES文献大全abstract：:The effect of the vasopressin neuropeptide des-glycinamide (Arg8)-vasopressin (DGAVP) on reducing the acquisition of intravenous heroin self-administration in rats was analyzed. When rats reduced in body weight were allowed to self-administer heroin for 1 h per day in the presence of a fixed time, non contingent food ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(88)90565-6
更新日期：1988-01-01 00:00:00
abstract：:Different receptors mediating the release of endothelium-derived nitric oxide (EDNO) have been identified at endothelial level. In the present study we aimed to characterise, on rabbit aorta by means of pharmacological tools, the generation of EDNO by receptors located on endothelial cell membrane (M3, P2u, P2y) and b...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(97)01144-2
更新日期：1998-01-01 00:00:00
abstract：AIMS:Studies indicate that the pattern of shear stress determines the direction of endothelial progenitor cells (EPCs) differentiation. However, the mechanism remains largely unknown. Herein, we try to identify the role of oscillatory shear stress (OSS) in the transdifferentiation of EPCs into mesenchymal cells and the...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2020.117728
更新日期：2020-07-15 00:00:00
abstract：:The in vitro oxidative hemolysis of human red blood cells (RBCs) was used as a model to study the free radical-induced damage of biological membranes and the protective effect of flavonols and their glycosides (FOHs), i.e., myricetin (MY), quercetin (Q), morin (MO), kaempferol (K), rutin (R), quercetin galactopyranosi...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2005.10.009
更新日期：2006-04-18 00:00:00
abstract：:The present study was carried out in order to identify the changes in expression of multidrug resistance-associated protein (Mrp) 2 and P-glycoprotein (P-gp) in the intestine and remote organs after intestinal ischemia-reperfusion (I/R). Mrp2 expression in the jejunum and liver was decreased at 6 h after I/R. This dec...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2008.04.019
更新日期：2008-06-20 00:00:00
abstract：:Ethanol consumption was correlated with changes in acyl group profiles of phosphatidylcholine and triacylglycerols in serum of Sinclair(S-1) miniature boars. Serum triacylglycerols in the control pigs were high in linoleate (18:2) (48%) and low in stearate (18:0 (3%). Upon feeding with 10% (w/v) ethanol ad lib for two...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(84)90198-x
更新日期：1984-02-27 00:00:00
abstract：:Upregulation of vascular NAD(P)H oxidase has been considered an important source for elevated levels of reactive oxygen species that contribute to several cardiovascular disease states, including the vascular complications of diabetes mellitus. Previous studies have shown that treatment with antioxidants corrects impa...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(03)00508-3
更新日期：2003-08-22 00:00:00
abstract：:Vascular inflammation induced by the proinflammatory cytokine/NF-kappaB pathway is one of the key mechanisms in the development of atherosclerosis. Peroxisome proliferators-activated receptor-gamma (PPARgamma) plays an important role in the prevention of arterial inflammation and formation of atherogenesis. Herein we ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2006.08.030
更新日期：2006-12-14 00:00:00
abstract：:Hepatotoxicity is a common side effect encountered with tamoxifen (TAM) administration. Due to the great value of TAM in breast cancer treatment, hepato-protection is seriously recommended. AIMS:The present study investigated the hepato-protective effect of celecoxib (CX) against TAM-induced hepatotoxicity in rats. ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2019.116573
更新日期：2019-08-15 00:00:00
abstract：AIMS:Few studies have compared the interaction of single and repeated administration of amitriptyline (amit) with the nitrergic system and glutamatergic system in the experimental model of neuropathic pain. We aimed to evaluate the antinociceptive effect of single and repeated administration of amit and to assess wheth...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2019.116752
更新日期：2019-09-15 00:00:00
abstract：:Activation of the sympathetic system by phencyclidine (PCP) should result in catecholamine release from the adrenals. However, adrenalectomy does not reduce PCP-induced hypertension. In an attempt to rectify this inconsistency, the direct effects of PCP on the bovine adrenal medulla were examined. At (3 X 10(-6) M), P...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(83)90124-8
更新日期：1983-08-08 00:00:00
abstract：:This study investigated the effects of captopril, hydralazine and losartan on the locomotor activity, tailflick and hot plate latencies in spontaneously hypertensive rats (SHR) and their genetic controls the Wistar-Kyoto rat (WKY). The increased hot plate latencies normally exhibited by the spontaneously hypertensive ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(95)00043-6
更新日期：1995-02-17 00:00:00
abstract：:The aim of this study was to assess the anxiolytic effect of berberine (abbrev. BER) using two experimental anxiety models in the mouse. In the black and white test of anxiety, berberine (100, 500 mg/kg) produced an increase in the first time entry, time spent in the white section, and total changes between two compar...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2004.04.032
更新日期：2004-10-01 00:00:00
abstract：:High salt intake is involved in the genesis of hypertension and vascular changes in salt-sensitive patients. Although many mechanisms have been proposed, the underlying mechanisms of these alterations in healthy rats are not completely elucidated. The aim of this study was to investigate if male Wistar rats fed a high...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2005.09.028
更新日期：2006-04-04 00:00:00
abstract：:We developed an experimental model to study the effect of daily cocaine administration on the mucosal immune system during murine acquired immune deficiency syndrome (MAIDS). Mice were infected with LP-BM5 murine leukemia virus, a retrovirus which causes immunosuppression with development of functional murine AIDS. Mi...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(94)00874-4
更新日期：1994-01-01 00:00:00
abstract：:We have previously shown that matrix metalloproteinases (MMPs) play a role in osteoclastic bone resorption by facilitating migration of osteoclastic cells toward bone surface through matrices. Of MMPs identified so far, MMP-9 is likely the most important proteinase for the action, since osteoclasts express this enzyme...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2006.05.024
更新日期：2006-09-20 00:00:00
abstract：AIMS:Our overall objective was to investigate the effect of the adenosine derivative 2',3',5'-tri-O-acetyl-N6-(3-hydroxylaniline) adenosine (WS010117) on AMP-activated protein kinase (AMPK) activation and lipid metabolism and to also assess the underlying mechanisms involved in these processes. MAIN METHODS:HepG2 cell...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2011.09.001
更新日期：2012-01-02 00:00:00
abstract：:Autophagy is considered as an important intracellular mechanism that degrades cytoplasmic components to furnish additional energy. It has cytoprotective effects through the degradation of intracellular pathogens, damaged organelles, and protein aggregates. On the other hand, there are reports of an association between...
journal_title：Life sciences
pub_type： 杂志文章,评审
doi：10.1016/j.lfs.2020.117734
更新日期：2020-08-01 00:00:00
abstract：:Alcohol-induced oxidative stress is linked to the metabolism of ethanol involving both microsomal and mitochondrial systems. Ethanol metabolism is directly involved in the production of reactive oxygen species (ROS) and reactive nitrogen species (RNS). These form an environment favourable to oxidative stress. Ethanol ...
journal_title：Life sciences
pub_type： 杂志文章,评审
doi：10.1016/j.lfs.2007.05.005
更新日期：2007-06-27 00:00:00
abstract：:The study of opioid distribution in blood and cerebrospinal fluid (CSF) is required to understand pharmacokinetic-pharmacodynamic relationships following lumbar intrathecal (it) and intracerebroventicular (i.c.v.) administration, and to investigate the contributions of spinal or supraspinal sites of action. The sheep ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(96)00456-0
更新日期：1996-01-01 00:00:00
abstract：AIMS:To examine the role of trypsin in the immune response of macrophages and to determine whether protease-activated receptors (PARs) are involved in the effects of trypsin. MAIN METHODS:We used RAW264.7 cells and peritoneal macrophages isolated from C57BL/6 wild-type mice, PAR2 knockout mice, and ddY mice. Macrophag...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2012.06.030
更新日期：2012-08-21 00:00:00
abstract：:Many hormones are known to induce the activity of ornithine decarboxylase (ODC), the first and rate-limiting enzyme for polyamine biosynthesis, in their target tissues. Using ovariectomized rats, we have compared the effects of sex hormones on ODC activity in the uterus and the kidney which contain estrogen and androg...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(90)90219-h
更新日期：1990-01-01 00:00:00
abstract：:Diabetes mellitus is one of the major global health issues, which is closely related to metabolic dysfunction and the chronic inflammatory diseases. Multiple studies have demonstrated that serum bilirubin is negatively correlated with metabolic syndrome and associated inflammatory diseases, including atherosclerosis, ...
journal_title：Life sciences
pub_type： 杂志文章,评审
doi：10.1016/j.lfs.2020.118032
更新日期：2020-09-15 00:00:00
abstract：:To examine the direct effects of tributyltin acetate (TBTA) on osteoclasts and osteoblasts, teleost scale, which has both osteoclasts and osteoblasts and is similar to mammalian membrane bone, was used in the present study. The activities of tartrate-resistant acid phosphatase and alkaline-phosphatase, as respective i...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2005.10.004
更新日期：2006-04-18 00:00:00
abstract：:MicroRNAs plays important role in the development of myocardial infarction (MI). The aim of this study was to analyze whether miR-429 has effect on the process of autophagy in myocardial anoxia/reoxygenation (AR) or ischemia/reperfusion (IR) injury and explore the underlying mechanism. The results showed that miR-429 ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2019.116842
更新日期：2019-10-15 00:00:00
abstract：:Cd2+ (0.4 mg/kg) administration to growing rats (45 +/- 5 g) intraperitoneally, daily for 30 days was found to decrease the activity of superoxide dismutase (SOD) in all the brain regions, except hippocampus. The concentrations of lipid peroxides were significantly elevated in the cerebellum, cerebral cortex, corpus s...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(87)90518-2
更新日期：1987-11-09 00:00:00
abstract：:This study characterizes several proteins in rat spleen lymphocyte lysates and conditioned medium that are recognized by antiserum to purified rat pituitary prolactin (PRL). One of these proteins, rat prolactin-immunoreactive protein (rPIP-43), has a relative molecular mass (Mr) of 43,000 and is strongly induced by mi...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(97)00232-4
更新日期：1997-01-01 00:00:00
abstract：:Systemic administration of the amphetamine analogue, 3,4-methylenedioxymethamphetamine (MDMA) produced a dose-dependent increase in the extracellular concentration of dopamine (DA) in the striatum as measured by in vivo microdialysis in awake, freely-moving rats. The extracellular concentration of the DA metabolite, 3...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(90)90484-9
更新日期：1990-01-01 00:00:00
abstract：:Collagen is the most abundant protein in mammalian systems; it can be found in organs such as bones, the liver, kidney, heart, teeth, and skin. Collagen provides the necessary structural framework for tissues in which it is found. However, if there are any alterations in the delicate balance of collagen types in the e...
journal_title：Life sciences
pub_type： 杂志文章,评审
doi：10.1016/j.lfs.2019.04.042
更新日期：2019-07-01 00:00:00
abstract：:The effects of chronic treatment with piracetam (100 mg/Kg) plus choline (100 mg/Kg) on rabbits' hippocampal electrical activity and behavior have been studied. Animals were exposed to a neutral environment, in the absence of any external stimulus, and then to an object and a stuffed sparrow-hawk. Results show a drug ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(84)90189-9
更新日期：1984-09-10 00:00:00
