Vasopressin neuropeptides and acquisition of heroin and cocaine self-administration in rats.

Abstract:

:The effect of the vasopressin neuropeptide des-glycinamide (Arg8)-vasopressin (DGAVP) on reducing the acquisition of intravenous heroin self-administration in rats was analyzed. When rats reduced in body weight were allowed to self-administer heroin for 1 h per day in the presence of a fixed time, non contingent food delivery schedule, it appeared that heroin intake was related in an orderly way to the unit dose of heroin delivered. DGAVP decreased heroin intake during days 4 and 5 of acquisition, especially when a high dose of heroin was delivered. DGAVP decreased heroin intake more effectively when rats were tested without the food delivery schedule and for 6 h instead of 1 h sessions per day. Structure activity relationship studies revealed that the peptide (pGlu4, Cyt6)AVP-(4-8) was the shortest active sequence mimicking the effect of DGAVP and that this peptide was somewhat more potent than DGAVP in this respect. The peptide (pGlu4,Cyt6)AVP-(4-9) increased the heroin intake of the rats. DGAVP and (pGlu4,Cyt6)-AVP-(4-8) also decreased cocaine intake of body weight reduced rats given the opportunity to self-administer cocaine intravenously in daily 6 h sessions. It is concluded that vasopressin neuropeptides may decrease the reinforcing efficacy of heroin and cocaine during acquisition of drug self-administration rather than interact with nutritional and environmental factors influencing drug taking behavior.

journal_name

Life Sci

journal_title

Life sciences

authors

van Ree JM,Burbach-Bloemarts EM,Wallace M

doi

10.1016/0024-3205(88)90565-6

subject

Has Abstract

pub_date

1988-01-01 00:00:00

pages

1091-9

issue

10

eissn

0024-3205

issn

1879-0631

pii

0024-3205(88)90565-6

journal_volume

42

pub_type

杂志文章
  • Potentiation of LSD-induced stimulus control by fluoxetine in the rat.

    abstract::The present investigation examined the interaction between fluoxetine enantiomers and LSD in rats trained with LSD as a discriminative stimulus. The dose response relationships for LSD alone and in combination with either (+)- or (-)-fluoxetine were determined. In both instances, the LSD dose response relationship was...

    journal_title:Life sciences

    pub_type: 杂志文章

    doi:10.1016/0024-3205(96)00490-0

    authors: Fiorella D,Helsley S,Rabin RA,Winter JC

    更新日期:1996-01-01 00:00:00

  • Epigallocatechin-3-gallate protects against 1,3-dichloro-2-propanol-induced lipid accumulation in C57BL/6J mice.

    abstract:AIMS:Chloropropanol is a contaminant produced during food processing, and 1,3-dichloro-2-propanol (1,3-DCP) is one of the most-studied and most common chloropropanol-related food contaminants. Epigallocatechin-3-gallate (EGCG) is the most abundant ester catechin in tea polyphenols. We studied the potential therapeutic ...

    journal_title:Life sciences

    pub_type: 杂志文章

    doi:10.1016/j.lfs.2018.08.007

    authors: Lu J,Fang B,Huang Y,Tao S,Sun B,Guan S,Jin Y

    更新日期:2018-09-15 00:00:00

  • Arachidonic acid is involved in the regulation of hCG induced steroidogenesis in rat Leydig cells.

    abstract::Phospholipase C (PLC), an enzyme involved in the hydrolysis of membrane phospholipid- phosphatidylinositol-bisphosphate to inositol triphosphate and diacylglycerol, and Phorbol 12, myristate 13, acetate (PMA), a tumor promoting agent, could significantly stimulate testosterone (T) secretion from Leydig cells. Arachido...

    journal_title:Life sciences

    pub_type: 杂志文章

    doi:10.1016/0024-3205(87)90223-2

    authors: Didolkar AK,Sundaram K

    更新日期:1987-07-27 00:00:00

  • The signal peptide of pro-opiomelancortin: validation of a specific radioimmunoassay.

    abstract::The N-terminus portion of the POMC leader sequence (signal peptide) was synthesized, and an antiserum was raised against it. A radioimmunoassay was developed which is effective at a dilution of 1:500,000, and sensitive at less than 1 fmole/tube. Since leader sequences often exhibit structural homologies, and since syn...

    journal_title:Life sciences

    pub_type: 杂志文章

    doi:10.1016/0024-3205(82)90135-7

    authors: Akil H,Shiomi H,Thompson R,Lax S,Coy D,Watson S

    更新日期:1982-11-15 00:00:00

  • The effect of donor age on the sensitivity of osteoblasts to the proliferative effects of TGF(beta) and 1,25(OH(2)) vitamin D(3).

    abstract::The loss of osteoblast function in aging bone is one of the major causes of osteopenia, or loss of bone mass. In this study, this loss of function was investigated by examining the proliferative response of rat long bone periosteal osteoblasts to TGF(beta1) and 1,25-dihydroxy vitamin D(3) (1,25-D(3)) as a function of ...

    journal_title:Life sciences

    pub_type: 杂志文章

    doi:10.1016/s0024-3205(02)01548-5

    authors: Shiels MJ,Mastro AM,Gay CV

    更新日期:2002-05-10 00:00:00

  • Effect of intracerebral hydroxytyrosol and its nitroderivatives on striatal dopamine metabolism: A study by in vivo microdialysis.

    abstract:AIMS:The natural phenolic oil compound hydroxytyrosol (HTy) is widely studied because of its antioxidant and neuroprotective properties. Nitroderivatives of HTy have been studied in order to evaluate their putative effects on catechol-O-methyltransferase (COMT) activity. MAIN METHODS:To study its effect on dopamine me...

    journal_title:Life sciences

    pub_type: 杂志文章

    doi:10.1016/j.lfs.2015.04.026

    authors: Gallardo E,Madrona A,Palma-Valdés R,Espartero JL,Santiago M

    更新日期:2015-08-01 00:00:00

  • Analysis of the interactions of Nrf-2, PMF-1, and CSN-7 with the 5'-flanking sequence of the mouse 4E-BP1 gene.

    abstract::Nuclear factor erythroid 2-related factor 2 (Nrf-2) binds to a specific polyamine responsive element (PRE) in the promoter region of the spermidine-spermine acetyltransferase (SSAT) gene, a key component of the polyamine catabolic pathway. Regulation of SSAT gene transcription requires the additional interaction of Nr...

    journal_title:Life sciences

    pub_type: 杂志文章

    doi:10.1016/j.lfs.2006.03.042

    authors: Stephenson AH,Seidel ER

    更新日期:2006-08-22 00:00:00

  • Cardioprotective effect of the alcoholic extract of Terminalia arjuna bark in an in vivo model of myocardial ischemic reperfusion injury.

    abstract::The present study was designed to investigate the effects of chronic administration of the alcoholic extract of Terminalia arjuna (TAAE) bark on isoproterenol induced myocardial injury. The TAAE was administered orally to Wistar albino rats (150-200 g) in three different doses, by gastric gavage [3.4 mg/kg: (T1), 6.75...

    journal_title:Life sciences

    pub_type: 杂志文章

    doi:10.1016/s0024-3205(03)00671-4

    authors: Karthikeyan K,Bai BR,Gauthaman K,Sathish KS,Devaraj SN

    更新日期:2003-10-10 00:00:00

  • Intrarenal conversion of big endothelin-1 to endothelin-1 in the rat.

    abstract::Intravenous (i.v.) or intrarenal arterial (i.r.a.) injection of big endothelin-1 (big ET-1) (1.6 nmol/kg) in anesthetized rats produced a significant increase in mean arterial pressure (MAP), a decrease in renal blood flow (RBF) and an increase in renal vascular resistance (RVR). Although the pressor responses to big ...

    journal_title:Life sciences

    pub_type: 杂志文章

    doi:10.1016/0024-3205(94)90067-1

    authors: Fujita K,Matsumura Y,Kita S,Hisaki K,Takaoka M,Morimoto S

    更新日期:1994-01-01 00:00:00

  • Demethylation of ribosomal RNA by hepatocyte microsomal preparations.

    abstract::Previous work has shown that hypomethylation of rRNA is an important control for protein synthesis in rat hepatocytes, and that the net hypomethylation appears to arise from cytoplasmic events. Here we show that demethylation of rRNA is catalyzed by microsomal preparations. The rRNA demethylation is dependent upon NAD...

    journal_title:Life sciences

    pub_type: 杂志文章

    doi:10.1016/0024-3205(91)90283-h

    authors: Choe WT,Hatem CL,Clawson GA

    更新日期:1991-01-01 00:00:00

  • Characterization of quinone reductase, glutathione and glutathione S-transferase in human myeloid cell lines: induction by 1,2-dithiole-3-thione and effects on hydroquinone-induced cytotoxicity.

    abstract::In this study, we have characterized quinone reductase (QR), glutathione (GSH), glutathione S-transferase (GST) and their induction by a chemoprotector, 1,2-dithiole-3-thione (D3T), in the human myeloid cell lines ML-1 and HL-60. In addition, we also examined the toxicity of hydroquinone (HQ), a benzene metabolite, to...

    journal_title:Life sciences

    pub_type: 杂志文章

    doi:10.1016/0024-3205(94)00626-1

    authors: Li Y,Lafuente A,Trush MA

    更新日期:1994-01-01 00:00:00

  • Dextrorphan: an antagonist for phencyclidine receptors.

    abstract::Radio-binding assay, bioassay and HPLC detection were used to observe the antagonistic effects of dextrorphan on PCP's actions. Dextrorphan displayed high affinity to PCP receptor in the rabbit mesenteric blood vessels. It had weak PCP-like bioactivity, but could antagonize PCP's action dose-dependently in vitro study...

    journal_title:Life sciences

    pub_type: 杂志文章

    doi:10.1016/0024-3205(87)90502-9

    authors: Sun FY,Zhu H,Zhang LM,Xu XR,Zhang AZ

    更新日期:1987-06-15 00:00:00

  • Metabolic alteration in neural tissue of rat embryos exposed to beta-hydroxybutyrate during organogenesis.

    abstract::Hyperketonemia has been identified as an important factor in diabetic pregnancy affecting growth and development of the offspring. In order to assess the immediate metabolic alterations in embryos caused by excess ketone bodies, we studied rat embryonic neural tissue exposed to a high concentration of beta-hydroxybuty...

    journal_title:Life sciences

    pub_type: 杂志文章

    doi:10.1016/s0024-3205(97)01110-7

    authors: Yang X,Borg LA,Eriksson UJ

    更新日期:1998-01-01 00:00:00

  • Oleic acid protects against cadmium induced cardiac and hepatic tissue injury in male Wistar rats: A mechanistic study.

    abstract:AIMS:The aim of the present study was to evaluate the possible antioxidant role of oleic acid (OA) against Cd-induced injuries in the heart and liver tissues of male Wistar rats. MAIN METHODS:Rats were treated with either vehicle (control), or OA (10 mg/kg b.w., fed orally), or Cd (0.44 mg/kg b.w., s.c.), or both (OA ...

    journal_title:Life sciences

    pub_type: 杂志文章

    doi:10.1016/j.lfs.2020.117324

    authors: Bhattacharjee B,Pal PK,Chattopadhyay A,Bandyopadhyay D

    更新日期:2020-03-01 00:00:00

  • Cardiovascular protective properties of oxytocin against COVID-19.

    abstract::SARS-CoV-2 infection or COVID-19 has become a worldwide pandemic; however, effective treatment for COVID-19 remains to be established. Along with acute respiratory distress syndrome (ARDS), new and old cardiovascular injuries are important causes of significant morbidity and mortality in COVID-19. Exploring new approa...

    journal_title:Life sciences

    pub_type: 杂志文章,评审

    doi:10.1016/j.lfs.2021.119130

    authors: Wang SC,Wang YF

    更新日期:2021-01-26 00:00:00

  • The behavioral response induced by intravesical instillation of capsaicin rats is mediated by pudendal urethral sensory fibers.

    abstract::The behavioral response induced by the intravesical instillation of capsaicin has been investigated in catheter-implanted, freely moving, conscious male and female rats. Intravesical instillation of capsaicin (25 nmol/rat in 0.5 ml) evoked an intense licking directed toward the lower abdominal and perineal skin which ...

    journal_title:Life sciences

    pub_type: 杂志文章

    doi:10.1016/0024-3205(94)90054-x

    authors: Lecci A,Giuliani S,Lazzeri M,Benaim G,Turini D,Maggi CA

    更新日期:1994-01-01 00:00:00

  • Modulation of macrophage superoxide release by purine metabolism.

    abstract::Metabolic flux through the purine salvage pathway appears to modulate superoxide secretion by elicited macrophages. Exogenous adenosine, the first substrate of this pathway, stimulates superoxide secretion, and Allopurinol, a specific inhibitor of xanthine oxidase, inhibits superoxide secretion. The effects of these a...

    journal_title:Life sciences

    pub_type: 杂志文章

    doi:10.1016/0024-3205(83)90811-1

    authors: Tritsch GL,Niswander PW

    更新日期:1983-03-21 00:00:00

  • Protective effect of cepharanthin on cisplatin-induced renal toxicity through metallothionein expression.

    abstract:AIMS:Cisplatin (CDDP) is a potent anticancer agent, but severe renal toxicity can limit its use. We investigated the protective effect of cepharanthin (CE), a biscoclaurin alkaloid, on the renal toxicity of CDDP. MAIN METHODS:Mice were given CDDP along with CE. Effects of CE on CDDP toxicity were investigated by assay...

    journal_title:Life sciences

    pub_type: 杂志文章

    doi:10.1016/j.lfs.2013.01.031

    authors: Sogawa N,Hirai K,Sogawa C,Ohyama K,Miyazaki I,Tsukamoto G,Asanuma M,Sasaki A,Kitayama S

    更新日期:2013-04-09 00:00:00

  • Effects of isatin on atrial natriuretic peptide-mediated accumulation of cGMP and guanylyl cyclase activity of PC12 cells.

    abstract::We have previously demonstrated that isatin (indole-2,3 dione), an endogenous compound widely distributed in mammalian tissues and body fluids, effectively inhibits atrial natriuretic peptide (ANP) receptor binding and ANP-stimulated guanylyl cyclase activity of rat membrane preparations. In the present study the effe...

    journal_title:Life sciences

    pub_type: 杂志文章

    doi:10.1016/s0024-3205(01)01270-x

    authors: Medvede AE,Abakumova OYu,Podobed OV,Tsvetkova TA,Sandler M,Glover V

    更新日期:2001-08-31 00:00:00

  • Thalidomide derivatives and the immune system. 6. Effects of two derivatives with no obvious teratogenic potency on the pattern of integrins and other surface receptors on blood cells of marmosets.

    abstract::The two thalidomide (Thd) derivatives beta-EM12 and phthalimidophthalimide (Phtpht), which exhibit no obvious teratogenicity, were tested for their ability to induce changes in the pattern of lymphocyte subpopulations, and especially changes in integrin receptors, in marmosets (Callithrix jacchus). Previously, Thd and...

    journal_title:Life sciences

    pub_type: 杂志文章

    doi:10.1016/0024-3205(95)02293-7

    authors: Nogueira AC,Neubert R,Felies A,Jacob-Müller U,Frankus E,Neubert D

    更新日期:1996-01-01 00:00:00

  • The effects of an interferon inducer, polyriboinosinic polyribocytidylic acid on cytochrome P-450 dependent hepatic progesterone metabolism.

    abstract::A time course study on the effects of an interferon inducing agent, polyriboinosinic polyribocytidylic acid (poly rIrC) on the hepatic cytochrome P-450 dependent progesterone metabolism was performed. Administration of a single dose of poly rIrC (10 mg/kg i.p.) to adult male Wistar rats caused a time dependent effect ...

    journal_title:Life sciences

    pub_type: 杂志文章

    doi:10.1016/0024-3205(93)90029-3

    authors: Wong JY,Lee EJ,Moochhala SM

    更新日期:1993-01-01 00:00:00

  • Nitric oxide signaling participates in norepinephrine-induced activity of neuronal intracellular survival pathways.

    abstract::Much evidence has gathered that nitric oxide (NO) signaling, via cGMP-dependent mechanisms, may activate pro-survival pathways in hippocampal neurons and inhibit apoptosis. Past research has revealed that the enhancement of monoaminergic neurotransmission via exercise or treatment with antidepressant medications leads...

    journal_title:Life sciences

    pub_type: 杂志文章

    doi:10.1016/j.lfs.2007.09.003

    authors: Chen MJ,Russo-Neustadt AA

    更新日期:2007-09-29 00:00:00

  • A simplified procedure for the purification of large quantities of fetal bovine serum acetylcholinesterase.

    abstract::A simple procedure has been developed for the large scale purification of fetal bovine serum acetylcholinesterase (AChE) (EC 3.1.1.7). The procedure involves two steps: batch adsorption of the AChE from 250 L of serum onto a procainamide affinity Sepharose 4B gel; and analytical procainamide affinity chromatography of...

    journal_title:Life sciences

    pub_type: 杂志文章

    doi:10.1016/0024-3205(86)90530-8

    authors: De la Hoz D,Doctor BP,Ralston JS,Rush RS,Wolfe AD

    更新日期:1986-07-21 00:00:00

  • Chemical characterization of the persistent fraction of hydroxyethyl starch in rat serum and spleen.

    abstract::Hydroxyethyl starch (HES) found in rat serum and spleen after single and daily administrations of 0.9 g/kg for 1 week was characterized by gas-liquid chromatography. There was very little difference in the degree of substitution (D.S.) and molar substitution (M.S.) of HES in serum samples obtained at 1 hour and 57 day...

    journal_title:Life sciences

    pub_type: 杂志文章

    doi:10.1016/0024-3205(83)90737-3

    authors: Sum CY,Lai CM,Yacobi A,Kalhorn TF

    更新日期:1983-11-14 00:00:00

  • Effects of cimetidine-like drugs on recombinant GABAA receptors.

    abstract::Even though conventional systemic doses of cimetidine and other histamine H(2) antagonists display minimal brain penetration, central nervous system (CNS) effects (including seizures and analgesia) have been reported after administration of these drugs in animals and man. To test the hypothesis that cimetidine-like dr...

    journal_title:Life sciences

    pub_type: 杂志文章

    doi:10.1016/j.lfs.2004.05.020

    authors: Cannon KE,Fleck MW,Hough LB

    更新日期:2004-10-08 00:00:00

  • Central mu opioids mediate differential control of urine flow rate and urinary sodium excretion in conscious rats.

    abstract::Central administration of the selective mu opioid agonist, dermorphin, produces a concurrent diuretic and antinatriuretic response in conscious rats. To determine whether central mu opioids differentially affect the renal excretion of water and sodium, we examined changes in renal function produced by intracerebrovent...

    journal_title:Life sciences

    pub_type: 杂志文章

    doi:10.1016/0024-3205(95)00065-e

    authors: Kapusta DR,Dzialowski EM

    更新日期:1995-01-01 00:00:00

  • Evidence for increased mitochondrial superoxide production in Down syndrome.

    abstract::Respiring mitochondria represent the major source of superoxide production in most cells, and superoxide anions function as direct precursors of hydrogen peroxide formation within mitochondria. We use a lucigenen-derived chemiluminescence (LDCL) assay to test the hypothesis that intramitochondrial superoxide productio...

    journal_title:Life sciences

    pub_type: 杂志文章

    doi:10.1016/s0024-3205(02)01538-2

    authors: Capone G,Kim P,Jovanovich S,Payne L,Freund L,Welch K,Miller E,Trush M

    更新日期:2002-05-03 00:00:00

  • Thioredoxin from Streptomyces aureofaciens controls coiling of plasmid DNA.

    abstract::A number of potential functions of thioredoxin have been proposed in literature, including a role for DNA replication. The aim of our study was to investigate the effects of thioredoxin from Streptomyces aureofaciens (Trx S.a.) on plasmid DNA. Trx S.a. was incubated with plasmid forms and the incubation product(s) cha...

    journal_title:Life sciences

    pub_type: 杂志文章

    doi:10.1016/s0024-3205(97)01133-8

    authors: Golubnitchaya-Labudova O,Horecka T,Kapalla M,Perecko D,Kutejova E,Lubec G

    更新日期:1998-01-01 00:00:00

  • Direct determination of homovanillic acid release from the human brain, an indicator of central dopaminergic activity.

    abstract::The plasma concentration of the dopamine (DA) metabolite, homovanillic acid (HVA), is used as an indicator of central nervous system dopaminergic activity. Using percutaneously inserted catheters we were able to obtain blood samples simultaneously from the right and left internal jugular veins. Veno-arterial HVA plasm...

    journal_title:Life sciences

    pub_type: 杂志文章

    doi:10.1016/0024-3205(91)90593-z

    authors: Lambert GW,Eisenhofer G,Cox HS,Horne M,Kalff V,Kelly M,Jennings GL,Esler MD

    更新日期:1991-01-01 00:00:00

  • Lipopolysaccharide stimulates the production of prostaglandin E2 and the receptor Ep4 in osteoblasts.

    abstract::Previous studies have indicated that one of the causes of alveolar bone destruction with periodontitis is lipopolysaccharide (LPS) from the cell wall of gram-negative bacteria in plaque, and that prostaglandin E(2) (PGE(2)) is one of the bone resorption factors that stimulate osteoclast formation through an intercellu...

    journal_title:Life sciences

    pub_type: 杂志文章

    doi:10.1016/j.lfs.2005.09.019

    authors: Shoji M,Tanabe N,Mitsui N,Tanaka H,Suzuki N,Takeichi O,Sugaya A,Maeno M

    更新日期:2006-03-20 00:00:00