The renin angiotensin system and nociception in spontaneously hypertensive rats.

abstract：:Met-enkephalin, administered microiontophoretically, produced a greater increase in firing in cells in area CA 3-4 in the hippocampus of both young and aged Fisher 344 rats than it did in the CA 1 area. Furthermore, the effect of met-enkephalin on neuronal firing rates was not as great in old rats as it was in young r...

journal_title：Life sciences

authors： Haigler HJ,Cahill LF,Crager MR,Charles E

更新日期：1987-01-12 00:00:00

abstract：:Deficiencies in cellular cyclic AMP (cAMP) and nitric oxide (NO) production are thought to be involved in the pathogenesis of diabetic neuropathy. We used a human neuroblastoma cell line, SH-SY5Y, to investigate the effect of cilostazol, a specific cAMP phosphodiesterase inhibitor, on NO production and Na+, K+-ATPase ...

journal_title：Life sciences

authors： Inada H,Shindo H,Tawata M,Onaya T

更新日期：1999-01-01 00:00:00

abstract：:The effects of glucagon-(1-21)-peptide on pancreatic exocrine secretion and plasma glucose levels were studied and compared with those of native glucagon in anesthetized dogs. Intravenous bolus administration of 1 nmol or 10 nmol/kg of glucagon-(1-21)-peptide evoked a significant inhibition of secretin-stimulated panc...

journal_title：Life sciences

authors： Itoh H,Matsuyama T,Namba M,Watanabe N,Komatsu R,Kono N,Tarui S

更新日期：1989-01-01 00:00:00

abstract：:Morphogenesis, the generation of tissue form, is important not only in the embryogenesis of a new individual, but also because a change in morphogenesis may be involved in the establishment of differences between individuals during evolution. Morphogenetic movements are effected in part by coordinated changes in the s...

journal_title：Life sciences

authors： Stanisstreet M,Jumah H

更新日期：1983-10-10 00:00:00

abstract：:The ontogeny and regulation by isoproterenol of type II thyroxine 5'-deiodinase, N-acetyltransferase, and hydroxyindole-O-methyltransferase activities were studied in the rat Harderian gland. Both 5'-deiodinase and N-acetyltransferase activities exhibited maximal values at the first week of age. These activities gradu...

journal_title：Life sciences

authors： Osuna C,Rubio A,Goberna R,Guerrero JM

更新日期：1990-01-01 00:00:00

abstract：AIMS:The molecular pathogenesis of COVID-19 is similar to other coronavirus (CoV) infections viz. severe acute respiratory syndrome (SARS) in human. Due to scarcity of the suitable treatment strategy, the present study was undertaken to explore host protein(s) targeted by potent repurposed drug(s) in COVID-19. MATERIA...

journal_title：Life sciences

authors： Hazra S,Chaudhuri AG,Tiwary BK,Chakrabarti N

更新日期：2020-09-15 00:00:00

abstract：AIMS:Excessive production of nitric oxide (NO) and reactive oxygen species (ROS) in sepsis modulates different cell functions. Since the sepsis severity is associated with the degree of platelet activation, we decided to investigate the role of systemic generation of NO and ROS in modulating the platelet adhesion of li...

journal_title：Life sciences

authors： Casarin AL,Lopes-Pires ME,Morganti RP,Antunes E,Marcondes S

更新日期：2011-11-21 00:00:00

abstract：:Acetyltransferase was isolated by histone-Sepharose affinity chromatography from human cord blood red cells. The enzyme was detected only in very young red cells. The semipurified enzyme and [14C]acetyl-CoA were used to acetylate isolated Hb F tetramer and alpha and gamma subunits. The in vitro acetylated products wer...

journal_title：Life sciences

authors： Qiu CC,Kasten-Jolly J,Abraham EC

更新日期：1988-01-01 00:00:00

abstract：AIM:MicroRNAs (miRNAs) function as oncogenes or tumor suppressors in an extensive variety of human cancers, including prostate cancer (PCa). Herein, the aim of this study is to investigate the effect of miR-381 on autophagy and apoptosis of PCa cells through the reelin (RELN)-mediated the PI3K/AKT/mTOR signaling pathwa...

journal_title：Life sciences

authors： Liao W,Zhang Y

更新日期：2020-08-01 00:00:00

abstract：:We administered intravenous adenosine to 11 neonatal rabbits. Adenosine depressed respiration in 10 of 11 rabbits. For the group as a whole the adenosine-induced respiratory depression was highly significant (p less than 0.001). After aminophylline administration to the same animals the respiratory effect of intraveno...

journal_title：Life sciences

authors： Watt AH,Buss DC,Routledge PA

更新日期：1987-01-05 00:00:00

abstract：AIMS:Endurance exercise causes fatigue due to mitochondrial dysfunction and oxidative stress. In order to find an effective strategy to prevent fatigue or enhance recovery, the effects of a combination of mitochondrial targeting nutrients on physical activity, mitochondrial function and oxidative stress in exercised ra...

journal_title：Life sciences

authors： Sun L,Shen W,Liu Z,Guan S,Liu J,Ding S

更新日期：2010-01-02 00:00:00

abstract：:Amyloid beta protein (Abeta) alters signal transduction systems, including increases in the cytosolic free calcium ([Ca2+]i) response which have pathophysiological significance in Alzheimer's disease (AD). The purposes of this study were to elucidate the mechanism involved in Abeta's effect on the Ca2+ signal and to e...

journal_title：Life sciences

authors： Huang HM,Ou HC,Hsieh SJ,Chiang LY

更新日期：2000-01-01 00:00:00

abstract：:Cocaine cues elicit craving and physiological responses. The cerebral circuits involved in these are poorly understood. The purpose of this study was to assess the relation between regional brain activation and cocaine cue elicited responses. Thirteen right-handed cocaine abusers were scanned with positron emission to...

journal_title：Life sciences

authors： Wang GJ,Volkow ND,Fowler JS,Cervany P,Hitzemann RJ,Pappas NR,Wong CT,Felder C

更新日期：1999-01-01 00:00:00

abstract：:Pitavastatin is a 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor that is used for suppressing cholesterol biosynthesis. Previously, we have reported that pitavastatin induces the activation of endothelial nitric oxide synthase (eNOS) and increases nitric oxide (NO) production in vascular endothelial cells (...

journal_title：Life sciences

authors： Wang J,Tokoro T,Matsui K,Higa S,Kitajima I

更新日期：2005-03-25 00:00:00

abstract：:The association of [3H] [D-Ala2, D-Leu5] enkephalin ([3H]DADLE]) with mouse neuroblastoma cells (N4TG1) was investigated. Under identical conditions the time course, dose response curve and temperature dependence for ligand uptake were similar to those for ligand-induced receptor loss (down regulation). Uptake of [3H]...

journal_title：Life sciences

authors： Blanchard SG,Chang KJ,Cuatrecasas P

更新日期：1982-09-20 00:00:00

abstract：:The effects of aging on contractile response to angiotensin II and tachyphylaxis to it were investigated using aortic strips from rats aged 1.5, 4 and 22 months. Whether the endothelium was present or not, the contractile response to angiotensin II was greater and tachyphylaxis to it was less in 1.5-month-old rats tha...

journal_title：Life sciences

authors： Wakabayashi I,Sakamoto K,Hatake K,Yoshimoto S,Kurahashi M

更新日期：1990-01-01 00:00:00

abstract：:To examine the physiological significance of plasma ghrelin in generating pulsatile growth hormone (GH) secretion in rats, plasma GH and ghrelin levels were determined in freely moving male rats. Plasma GH was pulsatilely secreted as reported previously. Plasma ghrelin levels were measured by both N-RIA recognizing th...

journal_title：Life sciences

authors： Okimura Y,Ukai K,Hosoda H,Murata M,Iguchi G,Iida K,Kaji H,Kojima M,Kangawa K,Chihara K

更新日期：2003-04-18 00:00:00

abstract：:Experiments were undertaken to examine the characteristics of the adrenergic receptor-coupled cAMP system in rat brain slices. It was found that the potentiation of isoproterenol-stimulated cAMP accumulation by 6-fluoronorepinephrine, an alpha-adrenergic agonist, is largely dependent upon the degree of beta-receptor o...

journal_title：Life sciences

authors： Pilc A,Enna SJ

更新日期：1985-09-30 00:00:00

abstract：BACKGROUND/AIMS:Previous studies have demonstrated that Galactooligosaccharides (GOS), known as "bifidus factor", has anti-inflammatory effects. Colitis, a kind of colonic inflammatory damage could be induced by different chemicals. The pathogenesis and mechanism of colitis remains unclear, and may be related to intest...

journal_title：Life sciences

authors： Chu H,Tao X,Sun Z,Hao W,Wei X

更新日期：2020-02-01 00:00:00

abstract：:The present study was to test whether the recently described endogenous ligand for the cannabinoid receptor; arachidonyl-ethanolamide (anandamide, ANA), may produce similar effects on pregnancy as the main psychoactive component of marihuana: delta9-tetrahydrocannabinol (THC) in rats. ANA, THC (0.02 mg/kg i.p./day, re...

journal_title：Life sciences

authors： Wenger T,Fragkakis G,Giannikou P,Probonas K,Yiannikakis N

更新日期：1997-01-01 00:00:00

abstract：AIMS:High level of saturated fatty acids leads to mitochondrial dysfunction and inflammation in the development of insulin resistance in skeletal muscle. We recently found that puerarin improved impaired insulin signaling in skeletal muscle in diabetic animals and in myotubes in vitro. However, whether puerarin can act...

journal_title：Life sciences

authors： Chen X,Yi L,Song S,Wang L,Liang Q,Wang Y,Wu Y,Gao Q

更新日期：2018-08-01 00:00:00

abstract：:The aim of this work was to evaluate the effect of the antioxidant stobadine on ischemia/reperfusion-induced injury of the isolated rat heart. Experiments were performed according to Langendorff. Ischemia was induced by stop-flow lasting 30 minutes and the duration of repefusion was 30 minutes. Reperfusion of the isch...

journal_title：Life sciences

authors： Knezl V,Sotníková R,Okruhlicová L,Navarová J

更新日期：1999-01-01 00:00:00

abstract：:The plasma concentration of the dopamine (DA) metabolite, homovanillic acid (HVA), is used as an indicator of central nervous system dopaminergic activity. Using percutaneously inserted catheters we were able to obtain blood samples simultaneously from the right and left internal jugular veins. Veno-arterial HVA plasm...

journal_title：Life sciences

authors： Lambert GW,Eisenhofer G,Cox HS,Horne M,Kalff V,Kelly M,Jennings GL,Esler MD

更新日期：1991-01-01 00:00:00

abstract：:The progeny of rats born and breastfed by mothers receiving dexamethasone (DEX) during pregnancy exhibits permanent reduction in body weight and adiposity but the precise mechanisms related to this programming are not fully understood. In order to clarify this issue, the present study investigated key aspects of lipop...

journal_title：Life sciences

authors： de Souza DN,Teixeira CJ,Veronesi VB,Murata GM,Santos-Silva JC,Hecht FB,Vicente JM,Bordin S,Anhê GF

更新日期：2021-01-15 00:00:00

abstract：:Nociceptin/orphanin FQ (=N/OFQ), the endogenous ligand of ORL1 receptor (=NOP), has been reported to induce, in rodents, after intracerebroventricular (i.c.v.) administration, anti-stress and anxiolytic effects. We have observed that the handling of mice followed by an i.c.v. injection of saline, induced a marked incr...

journal_title：Life sciences

authors： Le Cudennec C,Naudin B,Do Rego JC,Costentin J

更新日期：2002-11-29 00:00:00

abstract：:Early induction of VEGF was studied in liver, kidney and lung of spontaneously diabetic rats. Western blot analysis, northern hybridization were applied to show the expression of VEGF in different organs. Radiolabelled hypoxia responsive element (HRE) and cAMP responsive element (CRE) oligonucleotides were assayed by ...

journal_title：Life sciences

authors： Braun L,Kardon T,Reisz-Porszasz ZS,Banhegyi G,Mandl J

更新日期：2001-10-12 00:00:00

abstract：:To study the role of IL-5 in allergic airway hyperreactivity, the time course for the production of cytokines, the infiltration of inflammatory cells and the onset of airway hyperreactivity after three inhalations of antigens were studied in mice. The effect of the soluble alpha-chain of murine recombinant interleukin...

journal_title：Life sciences

authors： Yamaguchi S,Nagai H,Tanaka H,Tsujimoto M,Tsuruoka N

更新日期：1994-01-01 00:00:00

abstract：AIMS:Aging and drug-induced side effects may contribute to deteriorate mitochondrial bioenergetics in many tissues, including kidney and liver. One possibility is that the combination of both aging and drug toxicity accelerates the process of mitochondrial degradation, leading to progressive bioenergetic disruption. We...

journal_title：Life sciences

authors： Rocha-Rodrigues S,Santos-Alves E,Coxito PM,Marques-Aleixo I,Passos E,Guimarães JT,Martins MJ,Oliveira PJ,Magalhães J,Ascensão A

更新日期：2013-09-03 00:00:00

abstract：:Prolidase deficiency seems to be a rather rare metabolic disorder. However, many new cases can be detected because screening is easy to perform and enzymatic confirmation allows the differentiation from other iminodipeptidurias . Clinical symptoms are briefly reviewed, while biological considerations and prolidase pro...

journal_title：Life sciences

authors： Myara I,Charpentier C,Lemonnier A

更新日期：1984-05-21 00:00:00

abstract：:Advanced chronic kidney disease is associated with high rates of cardiovascular disease. Considering the crucial role of capillaries in renal function, our study aimed to evaluate microparticles related to vascular physiology examining the link between stages of chronic kidney disease with circulating endothelial (EMP...

journal_title：Life sciences

authors： Fonseca F,Ballerini AP,Izar MC,Kato J,Ferreira CE,Fonzar W,do Amaral J,Rezende P,Machado-Santelli G,França C

更新日期：2020-11-01 00:00:00