Abstract：
:Experiments were undertaken to examine the characteristics of the adrenergic receptor-coupled cAMP system in rat brain slices. It was found that the potentiation of isoproterenol-stimulated cAMP accumulation by 6-fluoronorepinephrine, an alpha-adrenergic agonist, is largely dependent upon the degree of beta-receptor occupancy, with prazosin-sensitive alpha-adrenergic receptors contributing less to this interaction. Chronic administration of a variety of antidepressants decreased the potentiating interaction between 6-fluoronorepinephrine and isoproterenol even under conditions where there were no obvious effects on the alpha- or beta- adrenergic components themselves. Chronic administration of imipramine had no effect on the interaction between 6-fluoronorepinephrine and adenosine, suggesting that the drug selectively modifies the coupling between the alpha- and beta-adrenergic systems. The results suggest that antidepressants influence the coupling between 6-fluoronorepinephrine and isoproterenol receptors independent of any effect on the individual recognition sites.
journal_name
Life Scijournal_title
Life sciencesauthors
Pilc A,Enna SJdoi
10.1016/0024-3205(85)90129-8subject
Has Abstractpub_date
1985-09-30 00:00:00pages
1183-94issue
13eissn
0024-3205issn
1879-0631pii
0024-3205(85)90129-8journal_volume
37pub_type
杂志文章相关文献
LIFE SCIENCES文献大全abstract：:A highly purified rat urinary bladder smooth muscle cell culture was obtained by a modified enzymic isolation method, and the presence of functional muscarinic as well as beta-adrenergic receptors were subsequently determined. At 7-10 days of culture, cells became elongated and spindle-shaped showing a typical "hills ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(01)01488-6
更新日期：2002-01-25 00:00:00
abstract：:Bromopride (BRO) and domperidone (DOMP) are dopamine D2 blocking agents used in gastroenterology clinics because of their anti emetic effect as well as their central and peripheral actions of increasing gastrointestinal motor activity. The rationale for these experiments was to compare BRO- and DOMP-effects on plasma,...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(94)00429-v
更新日期：1995-01-01 00:00:00
abstract：AIMS:Cytokines interfere with signaling pathways and mediators of vascular contraction. Endothelin-1 (ET-1) plays a major role on vascular dysfunction in conditions characterized by increased circulating levels of adipokines. In the present study we tested the hypothesis that the adipokine chemerin increases vascular c...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2012.04.013
更新日期：2012-10-15 00:00:00
abstract：:Novel magnetic resonance imaging sequences have and still continue to play an increasing role in neuroimaging and neuroscience. Among these techniques, diffusion-weighted imaging (DWI) has revolutionized the diagnosis and management of diseases such as stroke, neoplastic disease and inflammation. However, the effects ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2005.06.032
更新日期：2006-02-09 00:00:00
abstract：:In rat prefrontal cortical slices, the excitatory amino acids N-methyl-D-aspartate (NMDA), ibotenate, L-aspartate, quisqualate, kainate and L-glutamate inhibit carbachol-induced phosphoinositide hydrolysis as measured by the accumulation of [3H]inositol-1-phosphate ([3H]IP1). NMDA dose-dependently inhibited the carbac...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(89)90213-0
更新日期：1989-01-01 00:00:00
abstract：:DL-alpha-difluoromethylornithine (DFMO), 4-deoxypyridoxine (4-DOP), and methylglyoxal bis (guanylhydrazone) (MGBG) were tested as inhibitors of acute skin graft rejection. Proximal full thickness tail skins were exchanged between C57BL/6 and Balb/C mice. Distal autografts were placed to monitor healing. Inhibitors wer...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(91)90349-g
更新日期：1991-01-01 00:00:00
abstract：:Using in vivo microdialysis and flow-injection, we evaluated the production of nitric oxide (NO) in the striatum and substantia nigra of freely moving rats in response to challenge doses of L-dihydroxyphenylalanine (L-DOPA) by measuring the NO metabolite levels of nitrate and nitrite. The dopamine and 3,4-dihydroxyphe...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(98)00275-6
更新日期：1998-01-01 00:00:00
abstract：:Central administration of the selective mu opioid agonist, dermorphin, produces a concurrent diuretic and antinatriuretic response in conscious rats. To determine whether central mu opioids differentially affect the renal excretion of water and sodium, we examined changes in renal function produced by intracerebrovent...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(95)00065-e
更新日期：1995-01-01 00:00:00
abstract：AIM:Over-expression of histone deacetylase 8 (HDAC8) has been demonstrated in breast cancer. But the underlying molecular mechanism of HDAC8 on the progression of breast cancer remains unknown. MicroRNAs (miRs) are proposed as important molecules in cancer progression by targeting specific oncogenes or tumor-suppressor...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2019.116945
更新日期：2019-11-15 00:00:00
abstract：:Two recently isolated peptides, endomorphin-1 (Tyr-Pro-Trp-Phe-NH2) and endomorphin-2 (Tyr-Pro-Phe-Phe-NH2), are highly selective micro-opioid receptor agonists with analgesic actions in the tail-flick test. To further assess the analgesic properties of these peptides, the effects of endomorphin-1, endomorphin-2, and ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(00)00689-5
更新日期：2000-07-14 00:00:00
abstract：AIMS:Parathyroid hormone-related protein (PTHrP) is a peptide growth factor produced in a wide range of tissues from brain and parathyroid, to kidney and uterus. The purpose of this study was to determine whether the adrenal cortical hormones, hydrocortisone (cortisol), modulate PTHrP expression and glucocorticoid rece...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2011.08.001
更新日期：2011-10-24 00:00:00
abstract：:The feasibility of using human cells isolated from peritoneal dialysis effluent as a model for studying lipoprotein and cholesterol metabolism was investigated. Human peritoneal cells degraded low density lipoproteins (LDL) and acetylated LDL (acetyl-LDL) by saturable, high affinity receptor-mediated processes. Positi...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(96)00138-5
更新日期：1996-01-01 00:00:00
abstract：:The effects of erythropoietin (EPO) on cytosolic free calcium concentration ([Ca2+]i) in platelets of 20 essential hypertensive patients (HT) and of 25 normotensive subjects (NT) were investigated using the fura2 technique. In resting platelets [Ca2+]i were not significantly higher in HT compared to NT (74.3 +/- 7.8 n...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(92)90010-m
更新日期：1992-01-01 00:00:00
abstract：AIMS:The antihypertensive mechanism (s) of the epigallocatechin-3-gallate (EGCG), a major effective component in green tea, might associate with microRNAs (miRNAs). Here, we aimed to investigate which microRNA in aorta of spontaneously hypertensive rats (SHRs) were modulated by administration of EGCG and its mechanism....
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2018.04.041
更新日期：2018-06-15 00:00:00
abstract：:Neem seed preparations contain not only azadirachtin as the active insect antifeedant or growth regulator but also a variety of their limonoids, some of which are cytotoxic to N1E-115 neuroblastoma (mouse), 143B.TK- osteosarcoma (human) and Sf9 (insect) cultured cell lines. The most potent of these limonoids is nimbol...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(96)00061-6
更新日期：1996-01-01 00:00:00
abstract：:During the myocardial protection induced by ischemic preconditioning a reduction in myocardial metabolism occurs due to activation of the A1 adenosine receptors. This study investigates whether preconditioning changes both resting coronary flow and the magnitude of coronary reactive hyperemia and whether A1 adenosine ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(99)00034-x
更新日期：1999-01-01 00:00:00
abstract：:We investigated the effects of VA-045, an apovincaminic acid derivative, on isolated blood vessels. VA-045 (10(-7)-10(-5) M) and vinpocetine (10(-7)-10(-5) M) inhibited the 64 mM KCl-induced and 10(-6)M norepinephrine (NE)-induced contraction of rat aortic strips. VA-045 (10(-7)-10(-4) M) and vinpocetine (10(-7)-10(-4...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(93)90115-j
更新日期：1993-01-01 00:00:00
abstract：:This study, conducted on isolated guinea pig ileum, was designed to establish the mechanism of presynaptic alpha 2-adrenoreceptor blockade by the tetramine disulfides, benextramine and pyrextramine. At 1 microM these drugs irreversibly blocked norepinephrine (NE)-induced inhibition of the twitch response to electrical...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(86)90407-8
更新日期：1986-05-05 00:00:00
abstract：:Inflammation, inflammatory mediators, cyclooxygenase (COX)-2, and inducible nitric oxide (iNOS) are all influenced by age-related oxidative status. To investigate the effect of dietary fish oil (FO) and calorie restriction (CR) on oxidative stress-related inflammatory status with age, (NZB/NZW) F1 (B/W) mice were fed ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2005.10.034
更新日期：2006-04-18 00:00:00
abstract：AIMS:To investigate the effects of aerobic exercise training on cardiomyocyte ultrastructure, oxidative stress, and activation of protein synthesis pathways in a model of cardiomyopathy induced by doxorubicin (Dox). MAIN METHODS:Male Sprague Dawley rats were randomly assigned to Control (saline, sedentary), Dox/sedent...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2020.118698
更新日期：2021-01-01 00:00:00
abstract：:The effects of ethanol on the production of oxygen-derived free radicals by neutrophils are controversial. Osmolarity-mediated alteration of cell volume appears to be an important mechanism for regulating neutrophil activity. We investigated in neutrophils from healthy volunteers the effect of isotonic/hypertonic etha...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(98)00396-8
更新日期：1998-01-01 00:00:00
abstract：:Net water, Na+, Cl- and HCO3- fluxes were measured in in vivo rabbit ileal loops, while mucus secretion was assessed by measuring the glycoprotein or total sialic acid secreted into the lumen, or by measuring the luminal fluid viscosity. Inoculating loops with cholera enterotoxin (CT) produced a sustained secretion of...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(83)90220-5
更新日期：1983-02-21 00:00:00
abstract：:Interleukin-18 (IL-18) is a novel proinflammatory cytokine that was recently found in synovial fluids and synovial tissues from patients with rheumatoid arthritis (RA). To investigate the role of IL-18 in rheumatoid synovitis, the levels of IL-18 and serum amyloid A (SAA) were measured in synovial fluids from 24 patie...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2003.08.025
更新日期：2004-02-13 00:00:00
abstract：:Effects of sub-acute cocaine treatment on 3H-naloxone binding to 6 brain regions were examined in spontaneously hypertensive (SHR) and Wistar-Kyoto (WKY) rats. Cocaine hydrochloride (3 mg/kg, i.v.) was given by bolus injection daily for five days. Rats were decapitated 24 hr following the final injection and crude mem...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(88)90421-3
更新日期：1988-01-01 00:00:00
abstract：:YM-09151-2(cis-N-(1-benzyl-2-methylpyrrolidin-3-yl) -5-chloro-2-methoxy-4-methylaminobenzamide) is a new benzamide which has been reported to be an antagonist of dopamine (DA) at D1-type DA receptors. In the present study, we have examined the extent of the interaction of YM-09151-2 with D2-type DA receptors in the an...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(83)90933-5
更新日期：1983-02-28 00:00:00
abstract：:gamma-Aminobutyric acid (GABA) receptor-mediated 36chloride (36Cl-) uptake was measured in synaptoneurosomes from rat brain. GABA and GABA agonists stimulated 36Cl- uptake in a concentration-dependent manner with the following order of potency: Muscimol greater than GABA greater than piperidine-4-sulfonic acid (P4S)gr...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(87)90207-4
更新日期：1987-09-07 00:00:00
abstract：:The binding characteristics of the sigma-1 selective benzomorphan [3H]-(+)-pentazocine were determined in human cerebellar membranes. Saturation binding analysis revealed two affinity sites with a KDH of 1.4 +/- 0.7 nM and a KDL of 33.6 +/- 11.9 nM. Kinetic studies performed at 25 degrees C demonstrated reversible bin...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(94)00322-x
更新日期：1994-01-01 00:00:00
abstract：:This paper describes a new formulation for triggered delivery of insulin which consisted of magnetic particles dispersed in alginate spheres. When magnetic field was applied to that system, the release rate of insulin was about 50 times higher than in the absence of magnetic field. The influence of oscillating magneti...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(88)90009-4
更新日期：1988-01-01 00:00:00
abstract：:Activation of polyamine metabolism may be important to initiation of pancreatic cell growth. We are reporting that such activation did occur during pancreatic growth initiation by caerulein, a cholecystokinin analog. Maximal increases in total putrescine (319%), spermidine (63%) and spermine (50%) were observed 12, 96...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(84)90456-9
更新日期：1984-12-10 00:00:00
abstract：:In our previous studies, exposure of mice to millimeter waves (MW) increased the duration of anesthesia caused by either ketamine or chloral hydrate, and this effect was blocked by naloxone. To further characterize the biological effects of MW, we have chosen a new animal model of experimental itch. Male Swiss albino ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(98)00436-6
更新日期：1998-01-01 00:00:00
