Abstract：
:Two recently isolated peptides, endomorphin-1 (Tyr-Pro-Trp-Phe-NH2) and endomorphin-2 (Tyr-Pro-Phe-Phe-NH2), are highly selective micro-opioid receptor agonists with analgesic actions in the tail-flick test. To further assess the analgesic properties of these peptides, the effects of endomorphin-1, endomorphin-2, and morphine were examined in the formalin test. Male Swiss Webster mice were injected i.c.v. with endomorphin-1, endomorphin-2, or morphine (0, 1, 3, 10 microg) 5 min before injection of 20 microl of 5% formalin s.c. into the plantar surface of one hind-paw. The mice were observed for 60 min after formalin injection. Endomorphin-1 and endomorphin-2 produced dose-dependent analgesia that was shorter in duration than for morphine. Increased locomotion was observed after morphine, but not after endomorphin-1 or endomorphin-2. These findings extend previous results and suggest that endomorphins may have therapeutic potential for the treatment of acute pain.
journal_name
Life Scijournal_title
Life sciencesauthors
Soignier RD,Vaccarino AL,Brennan AM,Kastin AJ,Zadina JEdoi
10.1016/s0024-3205(00)00689-5subject
Has Abstractpub_date
2000-07-14 00:00:00pages
907-12issue
8eissn
0024-3205issn
1879-0631pii
S0024320500006895journal_volume
67pub_type
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