Abstract：
:Synaptic mechanisms were studied ex vivo in the aged rat hippocampus, using a slice preparation and intracellular electrophysiological recordings of the CA1 pyramidal neurons. A dramatic depression of the slow cholinergic excitatory postsynaptic potential (EPSP) and of the slow, GABAB-mediated inhibitory postsynaptic potential (IPSP) were observed. These age-related changes were consistently found in three different strains of rats. The mechanisms involve 1) changes in the properties of the postsynaptic muscarinic receptors, and possibly in acetylcholine release (for the postsynaptic muscarinic receptors, and possbily in acetylcholine release (for the cholinergic EPSP), and 2) alterations in the presynaptic GABAergic interneurons, as shown by a loss in calbindin immunoreactivity (for the GABAergic IPSP). The immunoreactivity for three calcium binding proteins (calbindin, parvalbumin and calretinin) was studied in the aged rat brain. Immunoreactivity for calbindin was dramatically reduced in the pyramidal neurons of the CA1 field and in a subpopulation of interneurons in the hippocampus. Immunoreactivity for parvalbumin was reduced in the medial septal area, and in the cingulate cortex, whereas no change was observed for calretinin. These age-related alterations could 1) modify the functions of the hippocampal networks, and possibly contribute to the age-related cognitive deficits, and 2) compromise intraneuronal calcium buffering, and thus make neurons more vulnerable to toxic insults.
journal_name
Life Scijournal_title
Life sciencesauthors
Krzywkowski P,Potier B,Billard JM,Dutar P,Lamour Ydoi
10.1016/0024-3205(96)00321-9subject
Has Abstractpub_date
1996-01-01 00:00:00pages
421-8issue
5-6eissn
0024-3205issn
1879-0631pii
0024-3205(96)00321-9journal_volume
59pub_type
杂志文章相关文献
LIFE SCIENCES文献大全abstract：:The mechanism of the generation and the quantitative analysis of singlet oxygen (1O2) formed by the exposure of a hematoporphyrin derivative (HpD) to light was re-evaluated by electron spin resonance (ESR) combined with 2,2,6,6,-tetramethyl-4-piperidine (TMPD). The change from TMPD to 2,2,6,6,-tetramethyl-4-piperidine...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(97)00835-7
更新日期：1997-01-01 00:00:00
abstract：:Peptides derived from tryptic hydrolysate of jumbo squid (Dosidicus gigas) skin gelatin were assessed for their antioxidant properties in different in vitro assay systems. The hydrolysate itself exhibited a strong lipid peroxidation inhibition and it was much higher than that of natural antioxidant, alpha-tocopherol. ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2005.03.016
更新日期：2005-09-09 00:00:00
abstract：:The activity in cerebrospinal fluid (CSF) of dynorphin-converting enzyme (DCE) has been studied after voluntary exercise in the spontaneously hypertensive (SH) rat. The exercise consisted of spontaneous running in wheels for 4-5 weeks and the average running distance during the last two weeks was 4.0 km/24h. CSF sampl...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(93)90274-7
更新日期：1993-01-01 00:00:00
abstract：AIMS:We elucidated the therapeutic potential of human umbilical vein endothelial cells (HUVECs) for ameliorating progressive heart failure in a myocardial infarction (MI) rat model. MAIN METHODS:MI was induced by ligation of left anterior descending artery, and HUVEC was transplanted 1week after MI. Cardiac function w...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2014.02.009
更新日期：2014-04-17 00:00:00
abstract：:Methotrexate was found to stimulate asparagine synthetase activity in vivo by approximately six-fold in rat liver. The maximum effect of methotrexate on hepatic asparagine synthetase activity was observed sixteen hours after intraperitoneal injection of the drug. Cycloheximide, like methotrexate, is a protein synthesi...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(82)90524-0
更新日期：1982-03-22 00:00:00
abstract：AIMS:Fenofibrate is a peroxisome proliferator-associated receptor alpha agonist (PPARα) used clinically for the management of dyslipidemia and is a myocardial fatty acid oxidation stimulator. It has also been shown to have cardiac anti-hypertrophic properties but the effects of fenofibrate on the development of eccentr...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2012.10.022
更新日期：2013-01-17 00:00:00
abstract：:A single intravenous injection of alloxan in mice induced hyperglycemia in a dose dependent fashion. This diabetogenic action of alloxan was prevented by a single intraperitoneal injection of the alpha 2-adrenergic agonists, i.e. oxymetazoline, clonidine or epinephrine 40 min prior to the injection of alloxan. The alp...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(83)90301-6
更新日期：1983-02-14 00:00:00
abstract：OBJECTIVE:To investigate the expression and time-dependent manner of bradykinin (BK) as well as its receptors (Bradykinin receptors 1 and 2, B1R and B2R) in spinal cord ischemia-reperfusion injury (SCII) in rat model. METHODS:Sprague-Dawley (SD) rats were subjected to 1 h of infra-renal abdominal aorta occlusion and r...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2018.12.034
更新日期：2019-02-01 00:00:00
abstract：:Thermodynamic analysis of pharmacologic data potentially offers an insight into the molecular events underlying drug-receptor interactions not obtainable by other techniques. Embodied in thermodynamics are the laws governing the interconvertibility of heat and work and, hence, it is a particularly apt framework for th...
journal_title：Life sciences
pub_type： 杂志文章,评审
doi：10.1016/0024-3205(89)90182-3
更新日期：1989-01-01 00:00:00
abstract：:We studied the effect of interleukin-1 alpha (IL-1) on corticotropin-releasing hormone (CRH) secretion by explanted rat hypothalami in vitro. We also assessed possible mediation of arachidonic acid metabolites on IL-1-stimulated CRH secretion, by preincubating hypothalami with the cyclooxygenase inhibitor indomethacin...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(90)90190-3
更新日期：1990-01-01 00:00:00
abstract：:Platelets from normal and malignant hyperthermia (MH)-susceptible pigs were evaluated for differences in 45calcium uptake in the absence or presence of caffeine (2-16 mM), halothane (0.05-0.5%), or halothane and caffeine together. There were no statistically significant differences in basal or halothane-inhibited calc...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(91)90184-d
更新日期：1991-01-01 00:00:00
abstract：:Previous research in this laboratory has shown that chronic treatment of adult male rats with an anabolic-androgenic steroid (AAS) produced anxiolytic behavior and increased the functional response of cortical gamma-aminobutyric acid(A) (GABA(A)) receptors. The experiments reported here were aimed at further character...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(95)02326-7
更新日期：1996-01-01 00:00:00
abstract：:In this study, we evaluated whether butein can inhibit the effects of tumor necrosis factor alpha (TNF-alpha), an inflammatory mediator, in intestinal epithelial HT-29 cells. Butein significantly inhibited TNF-alpha-induced interleukin 8 (IL-8) secretion and mRNA expression. Moreover, butein suppressed the expression ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2007.09.024
更新日期：2007-11-10 00:00:00
abstract：:The effects of the novel anticonvulsant felbamate, which binds to the 5-7 dichlorokynurenic binding sites, were tested towards the CA1 epileptiform activity induced in rat hippocampal slices by kainic acid. The effects of the kynurenic acid derivatives 7-chlorokynurenic acid and 5-7 dichlorokynurenic acid and of the N...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(96)00251-2
更新日期：1996-05-24 00:00:00
abstract：:Traditionally, Ehrlich's tumor is used in experimental oncology to investigate the therapeutic capacity of different synthetic chemotherapeutic agents or to evaluate the antitumoral activity of different substances of natural origin. However, the understanding of immune mechanisms during Ehrlich carcinogenesis is stil...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2020.118578
更新日期：2021-01-01 00:00:00
abstract：:Effects of emodin (EMD) treatment on mitochondrial ATP generation capacity and antioxidant components as well as susceptibility to ischemia-reperfusion (I-R) injury were examined in male and female rat hearts. Isolated-perfused hearts prepared from female rats were less susceptible to I-R injury than those of male rat...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2005.03.027
更新日期：2005-10-14 00:00:00
abstract：AIMS:This study's purpose was to evaluate the effect of ultrasound in air at a frequency of 0.04MHz and an intensity of 50mW/cm2 on neural differentiation of hBM-MSCs in vitro and on neurogenesis in an ischemic stroke model. MATERIALS AND METHODS:hBM-MSCs were exposed to 0.04MHz ultrasound and then compared with no ex...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2016.08.029
更新日期：2016-11-15 00:00:00
abstract：:Tumor angiogenesis and lymphangiogenesis are key features of tumor progression and metastasis. The role of tumor cells-derived factors in the promotion of associated angiogenesis and lymphangiogenesis is much studied and, no doubt, very important for the understanding of cancer progression. This review aims to present...
journal_title：Life sciences
pub_type： 杂志文章,评审
doi：10.1016/j.lfs.2012.10.008
更新日期：2013-02-07 00:00:00
abstract：:The novel guanidines N-(3,4-dimethoxy-2-chlorobenzylideneamino)-guanidine (ME 10092) and N-(3,4-dimethoxy-2-chlorobenzylideneamino)-N1-hydroxyguanidine (PR5) were recently reported to exhibit promising cardioprotective activities in myocardial ischaemia and reperfusion in rats. The current study investigated for the f...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2004.03.030
更新日期：2004-09-10 00:00:00
abstract：:Chlordimeform (CDM) and demethylchloridimeform (DCDM) mimic the action of octopamine in elevating adenylate cyclase activity in intact nerve cords of the American cockroach, Periplaneta americana. At a concentration of 1 x 10(-5)M, DCDM (13.5x increase within 20 minutes) is a more potent effector of the response than ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(83)90644-6
更新日期：1983-06-27 00:00:00
abstract：:Female white-footed mice (Peromyscus leucopus) were injected twice daily with 5, 10, 50, 100 micrograms melatonin (MEL) or saline. Injections were given for 7 weeks at 2 and 12 hours after lights-on under a long day (LD 16:8) photoperiod. Afternoon administration of MEL induced gonadal regression, although a dose of 5...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(85)90549-1
更新日期：1985-08-26 00:00:00
abstract：:The effects of subcutaneous (sc) administration of estradiol (50 micrograms/100 microliters/day x 10 day) or testosterone (15 mg/100 microliters twice a week x 2 weeks) on ANF release were examined in isolated perfused rat atria. The concentration of ANF in the perfusate was measured by radioimmunoassay, under basal c...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(93)90245-x
更新日期：1993-01-01 00:00:00
abstract：:Autism spectrum disorder (ASD) is a neurodevelopmental condition characterized by symptoms that include social communication impairments, interaction deficits, and repetitive and stereotyped behaviors. Recent studies have suggested that imbalanced cytokine levels are associated with impaired behavioral outcomes in ind...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2019.116930
更新日期：2019-11-15 00:00:00
abstract：:The effect of metoclopramide (10 mg, iv.) or physiological saline on the exercise-induced (standardized bicycle ergometry) increase in blood pressure and heart rate of patients with essential hypertension was investigated in a double blind, randomized, self controlled study. Metoclopramide had no effect on the exercis...
journal_title：Life sciences
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/0024-3205(87)90378-x
更新日期：1987-04-13 00:00:00
abstract：:Alpha-lipoic acid (ALA), a potent biological antioxidant, improves insulin action of skeletal muscle glucose transport and metabolism in both human and animal models of insulin resistance. In order to obtain further insight into the potential intracellular mechanisms for the action of ALA on insulin-stimulated glucose...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(97)00562-6
更新日期：1997-01-01 00:00:00
abstract：:Two proteolytic activities that convert big ET to ET at neutral pH were identified in solubilized membranes prepared from rat lung. The endothelin-converting activities were partially purified by using A80227 ((2S,3R,4S)-2-([N-acetylcyclohexylalanyl-isoleucyl]amino)-1-(2-nap hthyl)-3,4-dihydroxy-6-methylheptane) coupl...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(94)90033-7
更新日期：1994-01-01 00:00:00
abstract：AIMS:The study aimed to investigate the protective effect of chronic intermittent hypobaric hypoxia (CIHH) on endothelium function and relaxation of mesenteric artery in metabolism syndrome (MS) rats. MAIN METHODS:Male adult Sprague-Dawley rats were randomly divided into control (CON), CIHH (treated with 28-days hypob...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2018.05.008
更新日期：2018-07-15 00:00:00
abstract：:We have previously shown that matrix metalloproteinases (MMPs) play a role in osteoclastic bone resorption by facilitating migration of osteoclastic cells toward bone surface through matrices. Of MMPs identified so far, MMP-9 is likely the most important proteinase for the action, since osteoclasts express this enzyme...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2006.05.024
更新日期：2006-09-20 00:00:00
abstract：:The multiple functions of the blood-brain barrier (BBB) consist mostly in membrane properties controlling the bidirectional exchange of molecules between the general circulation and the central nervous system. As lipophilic molecules are able to easily penetrate the membrane of brain microvessels endothelial cells, an...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(88)90351-7
更新日期：1988-01-01 00:00:00
abstract：:We reported recently that ventromedial hypothalamic (VMH) lesions increased the synthesis of DNA in the gastrointestinal tract of rats by the firing of vagus nerve activity, mainly via cholinergic receptor mechanisms. In the present study, we examined whether the mitotic response is due to proliferation of a cell popu...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(95)02014-a
更新日期：1995-01-01 00:00:00
