A new aspect of the protective functions of the blood-brain barrier: activities of four drug-metabolizing enzymes in isolated rat brain microvessels.

abstract：:Clonidine, when administered for prolonged period showed no tolerance to its analgesic activity. Prior exposure to clonidine attenuated the tolerance development to morphine-induced analgesia and the supersensitivity to acetylcholine (ACh) in ileum during chronic morphine treatment. Further, acute administration of lo...

journal_title：Life sciences

authors： Ramaswamy S,Pillai NP,Gopalakrishnan V,Ghosh MN

更新日期：1983-09-19 00:00:00

abstract：:Effects of lithium (Li) deficiency and/or immobilization stress on the thymus weight and differential blood count of rats were studied. The thymus weight of the rats fed a low Li diet were lighter than those of rats fed a Li supplemented diet, whether the rats were exposed to stress or not. Of the rats not exposed to ...

journal_title：Life sciences

authors： Ono T,Iijima M,Shinoda S,Wada O

更新日期：1997-01-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to investigate the role of HLA-DR, HLA-G and CD99 during cervical carcinogenesis and to examine the prognostic significance of these protein expressions in invasive squamous cell carcinoma (SCC). METHODS:Using specific antibodies for HLA-DR, HLA-G and CD99, we examined protein expre...

journal_title：Life sciences

authors： Zhou JH,Ye F,Chen HZ,Zhou CY,Lu WG,Xie X

更新日期：2006-04-25 00:00:00

abstract：AIMS:Fructose administration induces hepatic oxidative stress, insulin resistance, inflammatory and metabolic changes. We tested their potential pathogenic relationship and whether these alterations can be prevented by R/S-α-lipoic acid. MAIN METHODS:Wistar rats received during 21days a commercial diet or the same die...

journal_title：Life sciences

authors： Castro MC,Massa ML,Arbeláez LG,Schinella G,Gagliardino JJ,Francini F

更新日期：2015-09-15 00:00:00

abstract：:Alzheimer's disease (AD) as a dementia and neurodegenerative disease, is mostly prevalent among people more than 65 years. AD is mostly manifested in the form of degraded mental function, such as losing memory and impaired cognitive function. Due to inefficiency of traditional pharmacological therapeutic approaches wi...

journal_title：Life sciences

authors： Chakari-Khiavi F,Dolati S,Chakari-Khiavi A,Abbaszadeh H,Aghebati-Maleki L,Pourlak T,Mehdizadeh A,Yousefi M

更新日期：2019-08-15 00:00:00

abstract：:High concentrations of cocaethylene (EC), the ethyl ester of benzoylecgonine, were measured in the blood of individuals who had concurrently used cocaine and ethanol. Since the powerful reinforcing effects of cocaine appear to be dependent on inhibition of dopamine reuptake in brain, we compared the effects of EC on t...

journal_title：Life sciences

authors： Jatlow P,Elsworth JD,Bradberry CW,Winger G,Taylor JR,Russell R,Roth RH

更新日期：1991-01-01 00:00:00

abstract：:While in vivo electrochemistry has been shown to be useful for discovering new neurophysiological phenomena, there is still considerable controversy about the identity of the compounds being measured and the concentration of those compounds in extracellular fluid in brain. We have found that carbon paste electrodes un...

journal_title：Life sciences

authors： Echizen H,Freed CR

更新日期：1986-07-07 00:00:00

abstract：:The effects of thioperamide, an H3 antagonist, and histamine H1 and H2 antagonists (s.c.) on morphine (s.c. or i.c.v.)- and U-50,488H (i.c.v.)-induced antinociception in male ddY mice were examined using the hot-plate (55 degrees C) test. Thioperamide significantly inhibited morphine-induced antinociception, but not U...

journal_title：Life sciences

authors： Suzuki T,Takamori K,Takahashi Y,Narita M,Misawa M,Onodera K

更新日期：1994-01-01 00:00:00

abstract：:Preliminary data suggest that amygdalar corticotropin-releasing factor (CRF) is regulated by nicotinic agonists. We sought to confirm and extend these observations by determining the effects of various concentrations of nicotine on CRF messenger RNA expression in the AR-5 immortalized amygdalar cell line. Nicotine pro...

journal_title：Life sciences

authors： Kasckow JW,Regmi A,Sheriff S,Mulchahey J,Geracioti TD Jr

更新日期：1999-01-01 00:00:00

abstract：:Neuron specific enolase (NSE), an isoenzyme of the glycolytic enzyme enolase, has been established by immunocytochemical means as a marker of morphological and functional maturation in central neurons and appears late in development. However, little is known about the presence of NSE in developing peripheral neurons a...

journal_title：Life sciences

authors： Sheppard MN,Marangos PJ,Bloom SR,Polak JM

更新日期：1984-01-16 00:00:00

abstract：AIMS:Rg1 is the most active component of traditional Chinese medicine ginseng, having anti-aging and anti-oxidative stress features in multiple organs. Cellular senescence of hepatocytes is involved in the progression of a wide spectrum of chronic liver diseases. In this study, we investigated the potential benefits an...

journal_title：Life sciences

authors： Qi R,Jiang R,Xiao H,Wang Z,He S,Wang L,Wang Y

更新日期：2020-08-01 00:00:00

abstract：:The regions of muscarinic receptors that specify G-protein-coupling and ligand-binding have been defined in several recent studies. Overall, these studies have shown that amino acids within the third cytoplasmic loop of the receptors define their selectivity for different G-proteins, and that multiple, discontinuous e...

journal_title：Life sciences

authors： Brann MR,Klimkowski VJ,Ellis J

更新日期：1993-01-01 00:00:00

abstract：:The hypothermia induced by apomorphine, a mixed dopamine (DA) agonist in male Swiss-Webster mice, was not blocked by the selective D-1 antagonist SCH 23390 but was completely blocked by the selective D-2 antagonists haloperidol, sulpiride and YM-09151-2. The selective D-1 agonist SKF 38393 did not elicit hypothermic r...

journal_title：Life sciences

authors： Menon MK,Gordon LI,Kodama CK,Fitten J

更新日期：1988-01-01 00:00:00

abstract：:Optically active hydroperoxides of phospholipids including phosphatidylcholine, phosphatidylethanolamine, phosphatidylglycerol, and phosphatidic acid were synthesized, and their cytotoxicity to cultured bovine pulmonary artery endothelial cells was examined. Phospholipid hydroperoxides were readily incorporated into c...

journal_title：Life sciences

authors： Kaneko T,Baba N,Matsuo M

更新日期：1994-01-01 00:00:00

abstract：:The intracellular ionic content of human erythrocytes may be altered by hyperglycaemia. Despite this, very little is known about the cellular mechanisms linking glucose and cellular magnesium homeostasis. We measured intracellular ionized magnesium in human lymphocytes, by means of a fluorimetric technique, total intr...

journal_title：Life sciences

authors： Delva P,Degan M,Pastori C,Faccini G,Lechi A

更新日期：2002-09-20 00:00:00

abstract：:Progesterone's (P) actions in the ventral medial hypothalamus (VMH) and the ventral tegmental area (VTA) are essential for sexual receptivity in hamsters. This study investigates the notion that P works in the VTA in the absence of intracellular P receptors (PRs) by 5 alpha-reduction to progestins, which would subsequ...

journal_title：Life sciences

authors： Frye CA,Leadbetter EA

更新日期：1994-01-01 00:00:00

abstract：:The substituted glucopyranose ring structure 2-hydroxypropyl-beta-cyclodextrin (CDEX) increases the solubility of molecules by inclusion of the agent in the lipophilic interior of the ring. This property is of particular use for the administration of molecules by the intracerebral (ICV) or intrathecal (IT) routes. In ...

journal_title：Life sciences

authors： Yaksh TL,Jang JD,Nishiuchi Y,Braun KP,Ro SG,Goodman M

更新日期：1991-01-01 00:00:00

abstract：:Since the late 1960's, radioenzymatic assays have gradually come to replace the less sensitive and less specific spectrofluorometric and bioassay procedures previously used to determine many of the neurotransmitters. These assays provide the means to measure picogram quantities of most of these substances, and have en...

journal_title：Life sciences

authors： Philips SR

更新日期：1987-08-17 00:00:00

abstract：:Thyrotropin-releasing hormone (TRH) produces a marked pressor effect, which may be mediated by central cholinergic neurons, which in turn enhance sympathetic nervous system activity. In this study, 22 subjects (10 patients with Alzheimer's disease and 12 elderly controls) were administered IV scopolamine or placebo pr...

journal_title：Life sciences

authors： Molchan SE,Hill JL,Minichiello M,Vitiello B,Sunderland T

更新日期：1994-01-01 00:00:00

abstract：:The present study examines the signal transduction mechanism that is involved in the growth of vascular smooth muscle cells exposed to 4-hydroxynonenal (HNE) in vitro. This aldehyde component of oxidized low-density lipoprotein has been identified in atherosclerotic lesion. Exposure to HNE caused ERK, JNK, and p38 MAP...

journal_title：Life sciences

authors： Kakishita H,Hattori Y

更新日期：2001-06-29 00:00:00

abstract：:Plants are potentially important for novel therapeutic drug leads, but the slowness of conventional methods for investigation of plants limits enthusiasm in the pharmaceutical industry. To overcome some of the drawbacks, we have applied high throughput pharmacological screening (HTPS) to crude plant extracts. Using a ...

journal_title：Life sciences

authors： Littleton J,Rogers T,Falcone D

更新日期：2005-12-22 00:00:00

abstract：:Time-course studies revealed the increased susceptibility of the gastric mucosa to noxious injury in portal hypertension correlates with the level of elevated portal venous pressure and hyperglucagonemia. Whether acute elevation of portal venous pressure by exogenous glucagon aggravates such injury is not known. We te...

journal_title：Life sciences

authors： Tsui CP,Sung JJ,Leung FW

更新日期：2003-07-18 00:00:00

abstract：:Withania somnifera (ashwagandha, Indian ginseng) is an immunostimulant herbal medicine used to improve overall health and prevent diseases, particularly in the elderly. However, the mechanisms underlying its immunostimulant effect is poorly understood. To elucidate the mechanism of Withania somnifera, we investigated ...

journal_title：Life sciences

authors： Iuvone T,Esposito G,Capasso F,Izzo AA

更新日期：2003-02-21 00:00:00

abstract：AIMS:Cytokines interfere with signaling pathways and mediators of vascular contraction. Endothelin-1 (ET-1) plays a major role on vascular dysfunction in conditions characterized by increased circulating levels of adipokines. In the present study we tested the hypothesis that the adipokine chemerin increases vascular c...

journal_title：Life sciences

authors： Lobato NS,Neves KB,Filgueira FP,Fortes ZB,Carvalho MH,Webb RC,Oliveira AM,Tostes RC

更新日期：2012-10-15 00:00:00

abstract：UNLABELLED:Isolation of meiotic arrested oocytes from mammalian ovaries involves a resumption of the meiosis. Studying the effect of FSH on this process it was found that doses up to of 0.1 IU/ml did not maintain the meiotic arrest in hamster oocytes in pre-antral follicles during static incubation conditions. However,...

journal_title：Life sciences

authors： Goverde HJ,van de Venne WP

更新日期：1994-01-01 00:00:00

abstract：:In rats with a unilateral 6-OHDA lesion of the substantia nigra exposure to footshock or immobilization stress produced a long-lasting enhancement in the rotational behavior evoked by a subsequent injection of amphetamine. However, the effect was dependent on the environmental context in which stress was applied. It i...

journal_title：Life sciences

authors： Robinson TE,Angus AL,Becker JB

更新日期：1985-09-16 00:00:00

abstract：:The interaction of cell surface hormone receptors with heterotrimeric G proteins is crucial for hormonal actions. The domains of the receptor, which interact with and activate G protein, have been extensively studied. However, precise molecular mechanisms underlying regulation of the receptor-induced G protein activat...

journal_title：Life sciences

authors： Sugimoto Y,Nakato T,Kita A,Hatae N,Tabata H,Tanaka S,Ichikawa A

更新日期：2003-12-05 00:00:00

abstract：:Previously we have reported a decreased GABAB receptor expression in brain of spontaneously hepertensive rats (SHR). Moreover, decreased receptor numbers were accompanied by depressed stimulation of cAMP formation. We have now quantified Gi alpha protein by immunoblotting in cerebral membranes from 11-week-old normote...

journal_title：Life sciences

authors： Ichida T,Takeda K,Sasaki S,Nakagawa M,Kuriyama K

更新日期：1996-01-01 00:00:00

abstract：:Previous results demonstrated that estradiol (E2) treatment of ovariectomized-adrenalectomized (OVX-ADX) rats increased glucocorticoid (GC) binding in brain regions. The experimental protocol was extended to the spinal cord, a GC target tissue in which ornithine decarboxylase (ODC) is markedly induced by GC treatment....

journal_title：Life sciences

authors： Ferrini M,González S,De Nicola AF

更新日期：1993-01-01 00:00:00

abstract：:Hyperglycemia and/or hypoinsulinemia have been found to inhibit L-ascorbic acid cellular transport. The resultant decrease in intracellular ascorbic acid may de-inhibit aryl sulfatase B and increase degradation of sulfated glycosaminoglycans (sGAG). This could lead to a degeneration of the extracellular matrix and res...

journal_title：Life sciences

authors： Fay MJ,Bush MJ,Verlangieri AJ

更新日期：1990-01-01 00:00:00