当前位置： SCI文献检索 > LIFE SCIENCES期刊下所有文献 > Estradiol increases glucocorticoid binding and glucocorticoid induction of ornithine decarboxylase in the rat spinal cord.

Estradiol increases glucocorticoid binding and glucocorticoid induction of ornithine decarboxylase in the rat spinal cord.

Abstract：

:Previous results demonstrated that estradiol (E2) treatment of ovariectomized-adrenalectomized (OVX-ADX) rats increased glucocorticoid (GC) binding in brain regions. The experimental protocol was extended to the spinal cord, a GC target tissue in which ornithine decarboxylase (ODC) is markedly induced by GC treatment. First, we measured GC binding to type I and type II receptors in ventral horn, dorsal horn and lateral funiculus of OVX-ADX rats treated during 4 days with E2 or vehicle. In E2-treated rats, type II receptors increased solely in dorsal horn, whereas type I sites remained unchanged. Second, in a group of OVX-ADX rats receiving dexamethasone (DEX), pretreatment with E2 superinduced ODC in ventral horn and lateral funiculus, but not in dorsal horn. Third, we found that the dorsal horn was relatively enriched in E2 receptors compared to other areas. Therefore, E2 stimulation of GC binding to type II sites may be mediated through E2 receptors localized in the dorsal horn. We suggest that combined treatment with E2 and DEX employs a transsynaptic mechanism for ODC induction at the ventral horn and lateral funiculus, with hormonal interaction taking place at the dorsal horn level.

journal_name

Life Sci

journal_title

Life sciences

authors

Ferrini M,González S,De Nicola AF

doi

10.1016/0024-3205(93)90460-k

subject

Has Abstract

pub_date

1993-01-01 00:00:00

pages

677-85

issue

7

eissn

0024-3205

issn

1879-0631

pii

0024-3205(93)90460-K

journal_volume

52

pub_type

杂志文章

相关文献

LIFE SCIENCES文献大全
  • A systematical comparison of anti-angiogenesis and anti-cancer efficacy of ramucirumab, apatinib, regorafenib and cabozantinib in zebrafish model.

    abstract：AIMS:Gastric cancer (GC) is one of the most common malignant tumors in the world. Anti-angiogenic therapy is a useful strategy for the treatment of advanced GC. This study was aimed to systemically compare the anti-angiogenesis, anti-cancer efficacy, as well as the safety of four known anti-angiogenic drugs, namely ram...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2020.117402

    authors： Wu JQ,Fan RY,Zhang SR,Li CY,Shen LZ,Wei P,He ZH,He MF

    更新日期：2020-04-15 00:00:00

  • Effects of MFHAS1 on cognitive impairment and dendritic pathology in the hippocampus of septic rats.

    abstract：AIMS:To investigate the effects of malignant fibrous histiocytoma amplified sequence 1 (MFHAS1) on cognitive dysfunction, the expression of tumor necrosis factor-α (TNF-α), interleukin (IL)-1β and amyloid β peptide (Aβ) in the hippocampus, as well as dendritic pathology in the hippocampal CA1 region in sepsis-associate...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2019.116822

    authors： Zhong J,Guo C,Hou W,Shen N,Miao C

    更新日期：2019-10-15 00:00:00

  • Abolishment of TNBS-induced visceral hypersensitivity in mast cell deficient rats.

    abstract：:Mucosal mast cells are implicated in visceral hypersensitivity associated with irritable bowel syndrome (IBS). In this study, we investigated the role of mast cells in the development of visceral hypersensitivity by using mast cell deficient (Ws/Ws) rats and their control (W+/W+). In W+/W+ rats, an injection of 2,4,6-...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2007.11.027

    authors： Ohashi K,Sato Y,Kawai M,Kurebayashi Y

    更新日期：2008-02-13 00:00:00

  • The effects of verapamil and ethanol on body temperature and motor coordination.

    abstract：:Male, adult mice of the Binghamton heterogeneous stock received one of two doses of ethanol (1.0 g/kg or 2.0 g/kg in saline) alone or in combination with the calcium (Ca2+) slow channel blocker, verapamil (5.45 mg/kg in 25% v/v ethanol in saline). Hypothermic responses and motor incoordination were assessed in terms o...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(86)90357-7

    authors： Johnston JE,Draski LJ,Molina JC,Burright RG,Reynoso G,Calendrillo BA,Isaacson RL

    更新日期：1986-12-01 00:00:00

  • Stimulation of uterine ornithine decarboxylase in organ culture by decreasing osmolality: possible relation to in vivo mechanisms.

    abstract：:Ornithine decarboxylase (ODC) activity increases during many growth responses. Some cells and tissues in culture also exhibit elevated enzyme activity with decreasing osmolality of the culture medium. We have found that this also occurs with uterine tissue from ovariectomized rats. Organ culture incubation under hypot...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(84)90551-4

    authors： Webster RA,Zaloudek CJ,Inman BC

    更新日期：1984-03-26 00:00:00

  • Existence of NO-triggered vagal afferent activation in the rat gastric mucosa.

    abstract：AIM:We previously reported the possible involvement of mucosal nitric oxide (NO)-triggered 5-HT release in luminal glutamate sensing by the gastric vagus nerve, and we proposed that the stomach, like the duodenum, could "taste" luminal nutrients. Nitric oxide synthase (NOS) is widely distributed in the gastric mucosa, ...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2009.10.009

    authors： Uneyama H,Niijima A,Kitamura A,Torii K

    更新日期：2009-12-16 00:00:00

  • Effect of monofluoromethyldopa (MFMD) on trace amine levels.

    abstract：:The concentrations of the trace amines, m-tyramine, p-tyramine, phenylethylamine and tryptamine, were measured in the striatum of the brain and in the kidney of adult rats treated with alpha-monofluoromethyldopa (MFMD), an inhibitor of aromatic amino acid decarboxylase. While MFMD decreased the levels of all four amin...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(87)90371-7

    authors： Dyck LE

    更新日期：1987-02-09 00:00:00

  • Impairment of renal compensatory hypertrophy by hypothyroidism in the rat.

    abstract：:Renal compensatory hypertrophy (RCH) occurs in hypothyroid rate, but it is impaired when compared to RCH found in euthyroid controls. It is due to cellular hypertrophy as the DNA content does not change and the Protein/DNA ratio increases in the compensating kidney. RCH is enhanced by thyroxine (T4) with a rise in the...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(82)90278-8

    authors： Stéphan F,Réville P,de Laharpe F,Köll-Back MH

    更新日期：1982-02-15 00:00:00

  • Elevated CSF dynorphin A [1-8] in Tourette's syndrome.

    abstract：:A recent neuropathological study has reported decreased levels of dynorphin A immunoreactivity in striato-pallidal fibers in the brain of a patient with severe Gilles de la Tourette's syndrome (TS). This observation, taken with the neuroanatomic distribution of dynorphin and its broad range of motor and behavioral eff...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(88)90575-9

    authors： Leckman JF,Riddle MA,Berrettini WH,Anderson GM,Hardin M,Chappell P,Bissette G,Nemeroff CB,Goodman WK,Cohen DJ

    更新日期：1988-01-01 00:00:00

  • Effects of different physical training protocols on ventricular oxidative stress parameters in infarction-induced rats.

    abstract：AIM:Physical exercise is important in the prevention and treatment of cardiovascular diseases. Nevertheless, controversy remains around type and intensity of effort required for significant biochemical protective changes. This study investigates two exercise protocols on ventricular oxidative parameters in rats post-in...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2012.01.018

    authors： Pinho CA,Tromm CB,Tavares AM,Silva LA,Silveira PC,Souza CT,Benetti M,Pinho RA

    更新日期：2012-04-09 00:00:00

  • Phencyclidine exposure alters in vitro cellular immune response parameters associated with host defense.

    abstract：:Phencyclidine hydrochloride (PCP) was tested for its ability to alter a variety of immune effector and regulatory functions in vitro. B6C3F1 murine splenic lymphocytes or elicited peritoneal macrophages were cultured in vitro with medium only or medium containing 10(-10)-10(-4) M PCP. Macrophages cultured with or with...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(93)90584-p

    authors： Thomas PT,House RV,Bhargava HN

    更新日期：1993-01-01 00:00:00

  • Evidence that a mitogen-inducible prolactin-immunoreactive protein in rat spleen lymphocytes is aldolase A.

    abstract：:This study characterizes several proteins in rat spleen lymphocyte lysates and conditioned medium that are recognized by antiserum to purified rat pituitary prolactin (PRL). One of these proteins, rat prolactin-immunoreactive protein (rPIP-43), has a relative molecular mass (Mr) of 43,000 and is strongly induced by mi...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/s0024-3205(97)00232-4

    authors： Masten SA,Shiverick KT

    更新日期：1997-01-01 00:00:00

  • Behavioral pharmacology of designer cathinones: a review of the preclinical literature.

    abstract：:"Bath salts" is one street name for a family of synthetic cathinones that display pharmacological effects resembling cocaine and commonly abused amphetamines. Despite extensive legislation aimed at the criminalization of bath salts, several designer cathinones are gaining a foothold in the illicit drug scene; for exam...

    journal_title：Life sciences

    pub_type： 杂志文章,评审

    doi：10.1016/j.lfs.2013.10.033

    authors： Gregg RA,Rawls SM

    更新日期：2014-02-27 00:00:00

  • The vascular endothelin system in obesity and type 2 diabetes: pathophysiology and therapeutic implications.

    abstract：:Obesity, the metabolic syndrome (MetS), and type 2 diabetes (T2DM) are associated with heightened cardiovascular risk. Given the vasoconstrictor and proatherogenic properties of endothelin (ET)-1, increased ET-1 activity has been postulated to participate in the derangement of adiposity-related vascular homeostasis. T...

    journal_title：Life sciences

    pub_type： 杂志文章,评审

    doi：10.1016/j.lfs.2014.02.028

    authors： Campia U,Tesauro M,Di Daniele N,Cardillo C

    更新日期：2014-11-24 00:00:00

  • Neurosteroids and neuroactive drugs in mental disorders.

    abstract：:Clinical and preclinical studies have suggested that fluctuations in the peripheral and brain concentrations of progesterone and deoxycorticosterone and its metabolites 3alpha,5alpha-tetrahydroprogesterone and 3alpha,5alpha-tetrahydrodeoxycorticosterone, respectively, might play an important role in certain pathologic...

    journal_title：Life sciences

    pub_type： 杂志文章,评审

    doi：10.1016/j.lfs.2003.12.002

    authors： Pisu MG,Serra M

    更新日期：2004-05-14 00:00:00

  • Effects of bicyclol on dimethylnitrosamine-induced liver fibrosis in mice and its mechanism of action.

    abstract：:The aim was to investigate the suppressive effect of bicyclol on hepatic fibrosis induced by dimethylnitrosamine (DMN) in mice and the mechanism of its action. Hepatic fibrosis was established by intraperitoneal injection of 8 mg kg(-1) day(-1) on three consecutive days of each week for 4 or 5 weeks. In the prophylact...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2006.02.025

    authors： Hu QW,Liu GT

    更新日期：2006-07-04 00:00:00

  • NH2-terminal big gastrin immunoreactivity in human urine.

    abstract：:The concentrations and molecular forms of urinary and plasma gastrin from normal subjects were studied by radioimmunoassays using two region-specific antisera. Urinary concentration of NH2-terminal big gastrin (G-34) immunoreactivity was several hundred times as great as that of COOH-terminal gastrin immunoreactivity....

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(90)90112-5

    authors： Higashimoto Y,Himeno S,Shinomura Y,Kanayama S,Nagao K,Tarui S

    更新日期：1990-01-01 00:00:00

  • Uptake and biodistribution of dopamine in bone marrow, spleen and lymph nodes of normal and tumor bearing mice.

    abstract：:Significant labelled dopamine uptake was evident in bone marrow, spleen and lymph nodes of normal murine hosts in vivo. On the contrary animals bearing solid Ehrlich carcinoma, 3H-dopamine uptake was significantly reduced. The tumor tissue itself incorporated only insignificant amount of dopamine. Bone marrow cells, s...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(93)90645-j

    authors： Basu S,Dasgupta PS,Lahiri T,Chowdhury JR

    更新日期：1993-01-01 00:00:00

  • Myostatin propeptide gene delivery by gene gun ameliorates muscle atrophy in a rat model of botulinum toxin-induced nerve denervation.

    abstract：AIM:Muscle atrophy is a common symptom after nerve denervation. Myostatin propeptide, a precursor of myostatin, has been documented to improve muscle growth. However, the mechanism underlying the muscle atrophy attenuation effects of myostatin propeptide in muscles and the changes in gene expression are not well establ...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2015.12.056

    authors： Tsai SW,Tung YT,Chen HL,Yang SH,Liu CY,Lu M,Pai HJ,Lin CC,Chen CM

    更新日期：2016-02-01 00:00:00

  • Protective effects of Curcuma longa on ischemia-reperfusion induced myocardial injuries and their mechanisms.

    abstract：:The present study was undertaken to evaluate the cardioprotective potential of Curcuma longa (Turmeric) in the ischemia-reperfusion (I/R) model of myocardial infarction (MI). Wistar rats were divided into three groups and received saline orally (sham, control I/R group) and Curcuma longa 100 mg/kg (CL-100 treated grou...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2004.02.032

    authors： Mohanty I,Singh Arya D,Dinda A,Joshi S,Talwar KK,Gupta SK

    更新日期：2004-08-20 00:00:00

  • The involvement of secondary signaling molecules in cytochrome P-450 1A1-mediated inducible nitric oxide synthase expression in benzo(a)pyrene-treated rat polymorphonuclear leukocytes.

    abstract：:Benzo(a)pyrene induces cytochrome P-450 1A1 (CYP1A1) expression in rat polymorphonuclear leukocytes (PMNs) that upregulates expression of inducible nitric oxide synthase (iNOS). In the present study, the involvement of secondary signaling molecules in CYP1A1-mediated augmentation of iNOS expression in benzo(a)pyrene-t...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2007.09.032

    authors： Kumar A,Upadhyay G,Modi DR,Singh MP

    更新日期：2007-11-30 00:00:00

  • The Thirteenth International Conference on Endothelin (ET-13), Tokyo, 2013.

    abstract：:The Thirteenth International Conference on Endothelin (ET-13) was held from September 8-11, 2013 in Tokyo, Japan chaired by Noriaki Emoto, Kobe Pharmaceutical University, Japan, and Takashi Miyauchi, University of Tsukuba, Japan and held on the Tokyo Campus of Tsukuba University. The International Conferences on Endot...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2014.09.020

    authors： Emoto N,Yanagisawa M

    更新日期：2014-11-24 00:00:00

  • Age-related and diurnal changes in Met5-Enk-Arg6-Phe7 and Met5-enkephalin contents of pituitary and rat brain structures.

    abstract：:The beta-endorphin, met5-enkephalin-arg6-phe7 (MEAP) and met5-enkephalin (ME) changes related to age and diurnal rhythms were studied in various regions of rat brain and in the pituitary by specific radioimmunoassays. The contents of MEAP, met5-enkephalin and beta-endorphin were higher in the pituitary of old rats (18...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(84)90667-2

    authors： Tang F,Tang J,Chou J,Costa E

    更新日期：1984-08-27 00:00:00

  • Alteration of hepatic lipidperoxide levels during cataract formation caused by glucocorticoids in developing chick embryos.

    abstract：:The level of hepatic lipidperoxides in chick embryos was determined during cataract formation resulting from glucocorticoid treatment. When 15 day old chick embryos were administered 0.25 mumol of hydrocortisone acetate their hepatic lipidperoxide level, determined by thio-barbituric acid, increased after a lag time o...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(84)90664-7

    authors： Nishigori H,Lee JW,Iwamoto Y,Hayashi R,Maruyama K,Iwatsuru M

    更新日期：1984-08-27 00:00:00

  • Specific [3H]-N-methyl scopolamine binding without cholinergic function in cultured adult skin fibroblasts.

    abstract：:Cultured adult skin fibroblasts were studied for binding and functional evidence of muscarinic receptors in order to assess their utility as a model of cholinergic function in affective illness. Saturable, specific, high affinity binding could be demonstrated in intact cells from some cell lines with [3H]-NMS, but not...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(86)90473-x

    authors： Kelsoe JR Jr,Gillin JC,Janowsky DS,Brown JH,Risch SC,Lumkin B

    更新日期：1986-04-14 00:00:00

  • Statistical analysis of COVID-19 infection caused by environmental factors: Evidence from Pakistan.

    abstract：BACKGROUND:Coronavirus disease 2019 (COVID-19) has become a severe public health problem around the globe. Various epidemiological, statistical, and laboratory-based studies have shown that the role of temperature and other environmental factors has important influence in the transmission of coronaviruses. Scientific r...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2021.119093

    authors： Fawad M,Mubarik S,Malik SS,Ren J

    更新日期：2021-01-18 00:00:00

  • In vivo cellular responses to electrophoretically applied dynorphin in the rat hippocampus.

    abstract：:Recent immunohistochemical and radioimmunochemical observations have demonstrated a differential distribution of immunoreactive dynorphin (DYN) in rat brain. The presence of DYN immunoreactivity in a major intrinsic fiber pathway within the rat hippocampus (the mossy fiber system) has led us to evaluate the possible r...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(82)90210-7

    authors： Henriksen SJ,Chouvet G,Bloom FE

    更新日期：1982-10-18 00:00:00

  • Insulin therapy normalizes reduced myocardial β-adrenoceptors at both the onset and after sustained hyperglycemia in diabetic rats.

    abstract：AIMS:Reduced cardiac β-adrenoceptors (β-AR) and cardiovascular (CV) dysfunction occur in diabetes mellitus (DM) and can be normalized by insulin. It is unclear how the duration of untreated hyperglycemia prior to intervention impacts insulin's effects. This study assesses insulin's effect on reduced myocardial β-AR and...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2015.03.024

    authors： Haley JM,Thackeray JT,Kolajova M,Thorn SL,DaSilva JN

    更新日期：2015-07-01 00:00:00

  • Expression of human alpha-fetoprotein in yeast.

    abstract：:Human alpha-fetoprotein (AFP) was expressed in Saccharomyces cerevisiae, with a plasmid containing the cDNA sequence for human AFP fused with the rat AFP signal peptide. The recombinant AFP was purified from the yeast lysate by DEAE-cellulose and immunoaffinity chromatography. The amino acid composition and the molecu...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(90)90383-3

    authors： Yamamoto R,Sakamoto T,Nishi S,Sakai M,Morinaga T,Tamaoki T

    更新日期：1990-01-01 00:00:00

  • Selective G2/M arrest in a p53(Val135)-transformed cell line induced by lithium is mediated through an intricate network of MAPK and β-catenin signaling pathways.

    abstract：AIMS:Lithium is a common mood stabilizer to treat bipolar disorder. It has a narrow window of therapeutic action and its mechanism of action and possible side effects are still not fully understood. Lithium is a potent inhibitor of glycogen synthase kinase 3β (GSK-3β). Previous studies indicated that lithium can induce...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2012.07.027

    authors： Tsui MM,Tai WC,Wong WY,Hsiao WL

    更新日期：2012-09-24 00:00:00