Abstract:
:Clinical and preclinical studies have suggested that fluctuations in the peripheral and brain concentrations of progesterone and deoxycorticosterone and its metabolites 3alpha,5alpha-tetrahydroprogesterone and 3alpha,5alpha-tetrahydrodeoxycorticosterone, respectively, might play an important role in certain pathological conditions characterized by emotional or affective disturbances, including major depression, anxiety disorders, and schizophrenia. Moreover, it has been shown that administration of drugs having clinical relevance in the treatment of these pathologies influence the secretion of these steroids. It remains to be determined, however, whether such changes in the concentrations of neuroactive steroids are a cause of, a risk factor for, or a consequence of mental disorders. The observation that effective pharmacological treatment of some of these pathologies influences the concentrations of neuroactive steroids suggests that these endogenous compounds might themselves prove to be efficacious in the treatment of mental illness.
journal_name
Life Scijournal_title
Life sciencesauthors
Pisu MG,Serra Mdoi
10.1016/j.lfs.2003.12.002subject
Has Abstractpub_date
2004-05-14 00:00:00pages
3181-97issue
26eissn
0024-3205issn
1879-0631pii
S002432050400205Xjournal_volume
74pub_type
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