Neurosteroids and neuroactive drugs in mental disorders.

Abstract:

:Clinical and preclinical studies have suggested that fluctuations in the peripheral and brain concentrations of progesterone and deoxycorticosterone and its metabolites 3alpha,5alpha-tetrahydroprogesterone and 3alpha,5alpha-tetrahydrodeoxycorticosterone, respectively, might play an important role in certain pathological conditions characterized by emotional or affective disturbances, including major depression, anxiety disorders, and schizophrenia. Moreover, it has been shown that administration of drugs having clinical relevance in the treatment of these pathologies influence the secretion of these steroids. It remains to be determined, however, whether such changes in the concentrations of neuroactive steroids are a cause of, a risk factor for, or a consequence of mental disorders. The observation that effective pharmacological treatment of some of these pathologies influences the concentrations of neuroactive steroids suggests that these endogenous compounds might themselves prove to be efficacious in the treatment of mental illness.

journal_name

Life Sci

journal_title

Life sciences

authors

Pisu MG,Serra M

doi

10.1016/j.lfs.2003.12.002

subject

Has Abstract

pub_date

2004-05-14 00:00:00

pages

3181-97

issue

26

eissn

0024-3205

issn

1879-0631

pii

S002432050400205X

journal_volume

74

pub_type

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