Abstract：
:Clonidine, when administered for prolonged period showed no tolerance to its analgesic activity. Prior exposure to clonidine attenuated the tolerance development to morphine-induced analgesia and the supersensitivity to acetylcholine (ACh) in ileum during chronic morphine treatment. Further, acute administration of lower doses of clonidine (upto 1 mg) produced supersensitivity in ileum to Ach while the higher dose (10 mg) induced subsensitivity. In vas deferens, clonidine in all the concentrations tested induced dose and time dependent supersensitivity to norepinephrine (NE) similar to that produced by morphine. Chronic clonidine treatment failed to alter the ACh responses in ileum while it produced supersensitivity to NE in vas deferens. The results suggest that clonidine and morphine possess comparable properties and the antagonism of chronic morphine tolerance by clonidine may be the therapeutic basis for its clinical application in the treatment of opiate addicts.
journal_name
Life Scijournal_title
Life sciencesauthors
Ramaswamy S,Pillai NP,Gopalakrishnan V,Ghosh MNdoi
10.1016/0024-3205(83)90021-8subject
Has Abstractpub_date
1983-09-19 00:00:00pages
1167-72issue
12eissn
0024-3205issn
1879-0631pii
0024-3205(83)90021-8journal_volume
33pub_type
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