Abstract：
:The effects of aging on contractile response to angiotensin II and tachyphylaxis to it were investigated using aortic strips from rats aged 1.5, 4 and 22 months. Whether the endothelium was present or not, the contractile response to angiotensin II was greater and tachyphylaxis to it was less in 1.5-month-old rats than in 4- and 22-month-old rats. The differences between 4- and 22-month-old rats were not significant. Removal of the endothelium enhanced angiotensin II-induced maximal contraction and depressed the tachyphylaxis, these endothelial effects being greater in 4- rather than in 1.5-month-old rats. When the contractile force of angiotensin II was adjusted to a similar level for 1.5- and 4-month-old rats, the endothelial effect on the tachyphylaxis was greater in the 4-month-old rats, but no significant difference was noted in the endothelial effect on the contractile force. These results suggest that during growth, the contractile response of rat aorta to angiotensin II decreases while the endothelial effect on it increases.
journal_name
Life Scijournal_title
Life sciencesauthors
Wakabayashi I,Sakamoto K,Hatake K,Yoshimoto S,Kurahashi Mdoi
10.1016/0024-3205(90)90549-7subject
Has Abstractpub_date
1990-01-01 00:00:00pages
771-9issue
9eissn
0024-3205issn
1879-0631pii
0024-3205(90)90549-7journal_volume
47pub_type
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