Abstract：
:The effects of glucagon-(1-21)-peptide on pancreatic exocrine secretion and plasma glucose levels were studied and compared with those of native glucagon in anesthetized dogs. Intravenous bolus administration of 1 nmol or 10 nmol/kg of glucagon-(1-21)-peptide evoked a significant inhibition of secretin-stimulated pancreatic juice secretion and protein output in a dose-dependent manner, as equimolar doses of glucagon did. Native glucagon induced an immediate and transient increase in pancreatic juice volume, which was followed by a significant inhibition. However, glucagon-(1-21)-peptide showed only the inhibitory action. Glucagon-(1-21)-peptide had no effect on plasma glucose levels even when a dose of 10 nmol/kg was given. The results suggest that the N-terminal amino-acid residues of glucagon play an important role in the inhibition of pancreatic exocrine secretion.
journal_name
Life Scijournal_title
Life sciencesauthors
Itoh H,Matsuyama T,Namba M,Watanabe N,Komatsu R,Kono N,Tarui Sdoi
10.1016/0024-3205(89)90379-2subject
Has Abstractpub_date
1989-01-01 00:00:00pages
819-25issue
12eissn
0024-3205issn
1879-0631pii
0024-3205(89)90379-2journal_volume
44pub_type
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