Abstract：
:Heart rate (HR) and mean arterial blood pressure (BP) were recorded from conscious, chair-restrained squirrel monkeys surgically prepared with chronically indwelling arterial and venous catheters to determine the effects of acute intravenous injections of two opiate antagonists and an agonist. Naloxone (0.3--10.0 mg/kg) or naltrexone (0.3--10.0 mg/kg) had little effect on HR or BP during a 30-minute post-injection period. Morphine (3.0--5.6 mg/kg) produced biphasic effects comprising an initial decrease followed by an increase in HR, and an increase followed by a decrease in BP. Lower morphine doses had lesser effects during a 100-minute post-injection period. Pretreatment with 0.03 mg/kg naloxone attenuated the depressive effect of morphine on HR and BP, but increases in HR and BP due to morphine were enhanced. Pretreatment with 0.3 mg/kg naloxone prevented morphine-induced decreases in HR and BP, yet increases in HR and BP persisted. In previous behavioral studies, morphine in combination with naloxone similarly increased rates of responding in the squirrel monkey. Together, these data suggest an effect of naloxone that goes beyond mere pharmacological antagonism of the effects of morphine.
journal_name
Life Scijournal_title
Life sciencesauthors
Byrd LDdoi
10.1016/0024-3205(83)90085-1subject
Has Abstractpub_date
1983-01-24 00:00:00pages
391-8issue
4eissn
0024-3205issn
1879-0631pii
0024-3205(83)90085-1journal_volume
32pub_type
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