The anti-inflammatory effects of quinolinic acid in the rat.

Abstract:

:Quinolinic acid (QUIN) levels are elevated in patients and animals suffering from chronic infectious diseases. In the present study, male Sprague-Dawley rats were used to test the anti-inflammatory effects of QUIN using the carrageenan (CGN)-induced paw edema assay and the CGN sponge assay. Results of these studies indicate that QUIN (30, 100 or 300 mg/kg i.p.) caused a reduction of carrageenan-induced inflammation by as much as 80% at the highest dose. Moreover, QUIN reduced exudate volume and inhibited leukocyte migration in the sponge granuloma assay. In another experiment, the anti-inflammatory activity of QUIN was eliminated in adrenalectomized rats. QUIN did not reduce edema caused by arachidonic acid, bradykinin or compound 48/80. Neither morphine nor naloxone altered the anti-inflammatory activity of QUIN. These results may suggest that QUIN exerts its anti-inflammatory activity through a direct action on neutrophils or vascular permeability.

journal_name

Life Sci

journal_title

Life sciences

authors

Heyliger SO,Mazzio EA,Soliman KF

doi

10.1016/s0024-3205(99)00049-1

subject

Has Abstract

pub_date

1999-01-01 00:00:00

pages

1177-87

issue

14

eissn

0024-3205

issn

1879-0631

pii

S0024320599000491

journal_volume

64

pub_type

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