Somatostatin antagonist analogue stimulates growth in rats.

abstract：:The gastric mucosa is frequently exposed to different exogenous and endogenous ulcerative agents. Alcoholism is one of the risk factors for the development of mucosal damage in the stomach. This study aimed to assess if a probiotic strain Lactobacillus rhamnosus GG (LGG) is capable of protecting the gastric mucosa fro...

journal_title：Life sciences

authors： Lam EKY,Tai EKK,Koo MWL,Wong HPS,Wu WKK,Yu L,So WHL,Woo PCY,Cho CH

更新日期：2007-05-16 00:00:00

abstract：:We conducted a study to determine whether angiotensin converting enzyme inhibitors (ACEIs) inhibit endothelin secretion from cultured human endothelial cells. Confluent umbilical vein endothelial cells were incubated in multi-well plates with culture medium containing either captopril (10(-6), 10(-5), 10(-4) M) or ena...

journal_title：Life sciences

authors： Yoshida H,Nakamura M

更新日期：1992-01-01 00:00:00

abstract：:The influence of stressful experiences on the development of vacuous chewing movements (VCM) was investigated in non-medicated rats. After an initial baseline period one group of rats was housed in a noisy environment while another group was housed in quiet surroundings. The development of VCM was recorded during a 16...

journal_title：Life sciences

authors： Glenthøj B,Hemmingsen R

更新日期：1991-01-01 00:00:00

abstract：:We have previously shown that transforming growth factor-beta1 (TGF-beta1) is involved in the fibroblast-induced organization and differentiation of transformed phenotypically crypt-like T84 intestinal epithelial cells into absorptive enterocyte-like cells, when cultured within a three-dimensional collagen gel. We hav...

journal_title：Life sciences

authors： Lindfors K,Halttunen T,Kainulainen H,Mäki M

更新日期：2001-08-10 00:00:00

abstract：AIMS:Intra-platelet 5-HT (IP 5-HT) and YAP exhibit an important role in hepatocellular carcinoma (HCC). The aim of the study was to investigate whether IP 5-HT and YAP could affect the progression and prognosis of HCC. METHODS:5-HT level and YAP expression were measured and were compared between HCC patients and contr...

journal_title：Life sciences

authors： Liu S,Zhai M,Xiao W,Zhou Q,Zhang D,Gong Y,Deng C,Liu C,Li L,He C

更新日期：2021-01-29 00:00:00

abstract：:A review of the rapidly accumulating data in the literature continues to support the notion that catecholamines regulate ovarian function, and extends the complexity of catecholaminergic effects on the ovary via interactions with pituitary and adrenal hormones. It is clear that catecholamines affect growth and differe...

journal_title：Life sciences

authors： Spicer LJ

更新日期：1986-11-10 00:00:00

abstract：:Reabsorption of 125I labeled unmodified and glycated albumin by the proximal tubule was studied using micropuncture technique in wistar rats of different ages. The data show a significant reabsorption of unmodified albumin while the glycated albumin was virtually excluded from reabsorption process. Among different exp...

journal_title：Life sciences

authors： Kowluru A,Kowluru RA,Solomon S,Martinez L

更新日期：1992-01-01 00:00:00

abstract：:Activation of GABA(B) receptors produces analgesia in acute and chronic pain models. Data indicate that a possible mechanism for this effect is a GABA(B) receptor-induced blockade of neurokinin-1 (NK-1) receptor gene expression in the spinal cord. While much more potent GABA(B) receptor agonists (CGP 44532) have been ...

journal_title：Life sciences

authors： Enna SJ,Harstad EB,McCarson KE

更新日期：1998-01-01 00:00:00

abstract：:To investigate the difference of metabolic pharmacokinetics between pure glycyrrhizin (GZ) and GZ in licorice decoction, six New Zealand White rabbits were orally given pure GZ and licorice decoction containing equivalent content of GZ in a randomized crossover design. HPLC methods were used for the quantitation of GZ...

journal_title：Life sciences

authors： Hou YC,Hsiu SL,Ching H,Lin YT,Tsai SY,Wen KC,Chao PD

更新日期：2005-01-21 00:00:00

abstract：:Previous experiments have shown that epinephrine-induced renin secretion in vivo apparently is initiated by activation of extrarenal adrenoceptors. However the location of these receptors has not been determined despite considerable search. The present experiments were designed to evaluate the hypothesis that epinephr...

journal_title：Life sciences

authors： Johnson MD

更新日期：1987-10-19 00:00:00

abstract：OBJECTIVE:To investigate the expression and time-dependent manner of bradykinin (BK) as well as its receptors (Bradykinin receptors 1 and 2, B1R and B2R) in spinal cord ischemia-reperfusion injury (SCII) in rat model. METHODS:Sprague-Dawley (SD) rats were subjected to 1 h of infra-renal abdominal aorta occlusion and r...

journal_title：Life sciences

authors： Ma Z,Dong Q,Lyu B,Wang J,Quan Y,Gong S

更新日期：2019-02-01 00:00:00

abstract：:The effects of the cannabinoid receptor agonist Win 55,212-2 and of the competitive cannabinoid receptor antagonist SR 141716A on the electrically-evoked peristalsis of isolated distal colon of mouse were studied. Intraluminal pressure, longitudinal displacement, ejected fluid volume and changes in morphology of exter...

journal_title：Life sciences

authors： Mancinelli R,Fabrizi A,Del Monaco S,Azzena GB,Vargiu R,Colombo GC,Gessa GL

更新日期：2001-05-25 00:00:00

abstract：:An increased level of melanin is characteristic of a large number of skin diseases, including acquired hyperpigmentation conditions such as melasma, post inflammatory melanoderma, and solar lentigo. Thus, there is an increasing need for the development of depigmenting agents. In order to evaluate the depigmenting capa...

journal_title：Life sciences

authors： Lee J,Jung K,Kim YS,Park D

更新日期：2007-06-27 00:00:00

abstract：:We compared the relative abilities of atropine sulfate and methylatropine, injected i.v. and into the cerebral ventricles (icv), to block pharmacological responses mediated through central and peripheral muscarinic receptors. The hypotensive response to i.v. injection of acetylcholine (peripheral muscarinic receptors)...

journal_title：Life sciences

authors： Brezenoff HE,Xiao YF,Vargas H

更新日期：1988-01-01 00:00:00

abstract：:The melanocortins are a family of bioactive peptides derived from proopiomelanocortin. Those peptides, included among hormones and comprising ACTH, alpha-MSH, beta-MSH and gamma-MSH, are best known mainly for their physiological effects, such as the control of skin pigmentation by alpha-MSH, and ACTH effects on pigmen...

journal_title：Life sciences

authors： Starowicz K,Przewłocka B

更新日期：2003-07-04 00:00:00

abstract：:Intracerebroventricularly (i.c.v.)-administered [D-Ala2]deltorphin II (20 micrograms) produced a marked locomotor hyperactivity in male ICR mice. The locomotor hyperactivity induced in response to i.c.v. [D-Ala2]deltorphin II (20 micrograms) was suppressed by pretreatment with naltriben (NTB, 10 micrograms) but not 7-...

journal_title：Life sciences

authors： Mizoguchi H,Narita M,Nagase H,Suzuki T,Quock RM,Tseng LF

更新日期：1996-01-01 00:00:00

abstract：AIMS:Centella asiatica has been used to treat kidney diseases in Chinese traditional medicine. Asiaticoside (an extraction of C. asiatica) exerts a variety of pharmacological effects including immunomodulatory and anti-inflammatory functions. However, the mechanism of asiaticoside in the treatment of renal diseases rem...

journal_title：Life sciences

authors： Wang Z,Liu J,Sun W

更新日期：2013-09-03 00:00:00

abstract：:The ontogenetic development of [3H]-spiroperidol binding sites was measured in the optic tectum, cerebellum, forebrain base, and forebrain roof of 1-, 4-, and 16-day-old chicks. In the chick optic tectum and cerebellum both the density and the total number of [3H]-spiroperidol binding sites increased from 4- to 16-day...

journal_title：Life sciences

authors： McDougall SA,Neisewander JL,Bardo MT,Zolman JF

更新日期：1989-01-01 00:00:00

abstract：AIMS:Chemerin has been recently identified as a vasoactive adipokine implicated in blood pressure regulation. In this context, we evaluated whether chemerin could influence pulmonary vasoreactive response. MATERIALS AND METHODS:Vascular reactivity to chemerin and to phenylephrine, serotonin and endothelin-1 after chem...

journal_title：Life sciences

authors： Hanthazi A,Jespers P,Vegh G,Degroot GN,Springael JY,Lybaert P,Dewachter L,Mc Entee K

更新日期：2019-08-15 00:00:00

abstract：:Two proteinous factors, designated here as ram p25 GDP dissociation inhibitor (I) and (II) (ram-GDI (I) and (II)), were detected in the cytosolic fraction of rat spleen, which inhibited the initial dissociation of GDP from ram p25 produced by E. coli by causing characteristic lag. They had very weak effects on the rat...

journal_title：Life sciences

authors： Nagata K,Suzuki T,Okano Y,Nozawa Y

更新日期：1992-01-01 00:00:00

abstract：:Hypoxia-induced neuronal damage and glutamate release were investigated in a N(2)- or in xenon-atmosphere for embryonic rat cortical neurons; cellular damage and glutamate over-release were observed in N(2)-treated cells whereas xenon protected the cells from the hypoxic insult. The protective effect of xenon was stro...

journal_title：Life sciences

authors： Petzelt C,Blom P,Schmehl W,Müller J,Kox WJ

更新日期：2003-03-14 00:00:00

abstract：:Striatal D-2 dopamine (DA) antagonist and agonist binding sites were measured during the rat estrous cycle and compared to ovariectomized (OVX) rats. Dopaminergic D-2 antagonist binding sites were constant during the estrous cycle while agonist binding sites show a rapid and significant decrease of the ratio of high t...

journal_title：Life sciences

authors： Di Paolo T,Falardeau P,Morissette M

更新日期：1988-01-01 00:00:00

abstract：:We report that both Na+ and Ca2+ currents are involved in the action potentials and in the hormone release from rat somatotrophs in primary culture. Single somatotrophs were identified by reverse hemolytic plaque assay (RHPA) and transmembrane voltage and currents were recorded using the whole-cell mode of the patch-c...

journal_title：Life sciences

authors： Chen C,Zhang J,Vincent JD,Israel JM

更新日期：1990-01-01 00:00:00

abstract：:Since many patients complain about halitosis without there being any clinical evidence of its cause, psychological symptoms have been pointed out as halitosis-inducing factors. The aim of this study was to evaluate the influence of anxiety on the production of volatile sulfur compounds (VSC). Seventeen undergraduate m...

journal_title：Life sciences

authors： Calil CM,Marcondes FK

更新日期：2006-07-10 00:00:00

abstract：:The purpose of this study was to evaluate the induction of oxidative stress in heart and erythrocytes from rats with abdominal aorta coarctation (Coa) compared with sham-operated normotensive controls (Sham). The group of Coa animals developed myocardial hypertrophy, showing heart homogenates markedly increased levels...

journal_title：Life sciences

authors： Polizio AH,Gorzalczany S,Taira C,Peña C

更新日期：2006-07-04 00:00:00

abstract：:Although effects of a metastasis suppressor gene, KiSS-1, have been postulated to be mediated by its receptor, hOT7T175, the mechanism of such effects remains unknown. This study was designed to evaluate the mechanism of how KiSS-1 works and to assess effects of a synthesized truncated KiSS-1 protein on the invasive a...

journal_title：Life sciences

authors： Yoshioka K,Ohno Y,Horiguchi Y,Ozu C,Namiki K,Tachibana M

更新日期：2008-08-29 00:00:00

abstract：:The beta adrenoceptor antagonist radioligand [3H] dihydroalprenolol (DHA) has been used to characterise beta adrenoceptors in membranes prepared from rat renal glomeruli. Association of the ligand was rapid and had reached equilibrium within 10 mins at 37 degrees C. Dissociation occurred in two distinct phases, a rapi...

journal_title：Life sciences

authors： McPherson GA,Summers RJ

更新日期：1983-07-04 00:00:00

abstract：:Lymphocyte apoptosis occurs in response to stressors such as thermal injury, trauma, sepsis, and surgery. This study evaluated the effect of a single bout of physical exercise stress on the induction of apoptosis in murine thymocytes and splenic lymphocytes. Female C57BL/6 mice, treadmill exercised at a submaximal int...

journal_title：Life sciences

authors： Hoffman-Goetz L,Zajchowski S,Aldred A

更新日期：1999-01-01 00:00:00

abstract：AIM:Ischemia/reperfusion (I/R) injury is the major cause of neurological deficit following stroke. Our previous study showed neuroprotective effects of hispidulin against cerebral ischemia reperfusion injury (IRI). In this study, we further examined the involvement of pyroptosis in this neuroprotective function. MATER...

journal_title：Life sciences

authors： An P,Xie J,Qiu S,Liu Y,Wang J,Xiu X,Li L,Tang M

更新日期：2019-09-01 00:00:00

abstract：:SR 142801 is the first potent and selective non-peptide antagonist of the tachykinin NK3 receptor. It inhibited [MePhe7]NKB binding to its receptor from various species, including humans. SR 142801 was a competitive antagonist of [MePhe7]NKB-mediated contractions of guinea-pig ileum and inhibited the acetylcholine rel...

journal_title：Life sciences

authors： Emonds-Alt X,Bichon D,Ducoux JP,Heaulme M,Miloux B,Poncelet M,Proietto V,Van Broeck D,Vilain P,Neliat G

更新日期：1995-01-01 00:00:00