Abstract：
:The purpose of this study was to evaluate the induction of oxidative stress in heart and erythrocytes from rats with abdominal aorta coarctation (Coa) compared with sham-operated normotensive controls (Sham). The group of Coa animals developed myocardial hypertrophy, showing heart homogenates markedly increased levels of reduced glutathione (48%), lipid peroxidation (148%) and activation of superoxide dismutase and glutathione peroxidase (189% and 37%, respectively), compared with controls. Other oxidative stress indicators were also altered in erythrocytes from Coa rats: increased protein carbonyl content (141%) and total glutathione level (349%) were determined. Inactivation of the antioxidant enzymes catalase (27%), superoxide dismutase (58%) and glutathione peroxidase (25%) was observed in erythrocytes from the Coa group. Taken jointly our results provide strong evidence for the production of oxidative stress in heart and erythrocytes from aortic coarcted rats.
journal_name
Life Scijournal_title
Life sciencesauthors
Polizio AH,Gorzalczany S,Taira C,Peña Cdoi
10.1016/j.lfs.2006.02.004subject
Has Abstractpub_date
2006-07-04 00:00:00pages
596-600issue
6eissn
0024-3205issn
1879-0631pii
S0024-3205(06)00121-4journal_volume
79pub_type
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