The non-neuronal cholinergic system as novel drug target in the airways.

abstract：:We have recently demonstrated that the hypertensinogenic and natriuretic actions of ACTHI-39 can be found in a non-steroidogenic fragment of ACTH, ACTH4-10. These effects of ACTH or ACTH4-10 may be due to their ability to act as weak agonists of gamma MSH. gamma MSH is found in the 16K N-terminus of pro-opiocortin, an...

journal_title：Life sciences

authors： Klein MC,Hutchins PM,Lymangrover JR,Gruber KA

更新日期：1985-02-25 00:00:00

abstract：:Biphasic cutaneous reaction with peak response at 1 (early phase) and 24 to 48 hour (late phase) was elicited by epicutaneous challenge with antigen in actively and passively sensitized mice. Mice were actively immunized with dinitrophenylated (DNP) ascaris antigen and challenged with dinitrofluorobenzene (DNFB). Pass...

journal_title：Life sciences

authors： Sakurai T,Inagaki N,Nagai H

更新日期：1994-01-01 00:00:00

abstract：:The neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is rapidly metabolized to a 1-methyl-4-phenylpyridinium species (MPP+) in the squirrel monkey. After administration of toxic doses of MPTP, the concentration of MPP+ in the substantia nigra appears to increase during the first 72 hours, reaching the hi...

journal_title：Life sciences

authors： Irwin I,Langston JW

更新日期：1985-01-21 00:00:00

abstract：:The heterogeneity of muscarine receptors was examined in two brain regions (cerebral cortex and cerebellum) and in some parasympathetically innervated peripheral tissues (heart, salivary gland and intraorbital lacrimal gland), by in vitro binding techniques. As a tool, we used a new antimuscarinic compound, AF-DX 116 ...

journal_title：Life sciences

authors： Hammer R,Giraldo E,Schiavi GB,Monferini E,Ladinsky H

更新日期：1986-05-05 00:00:00

abstract：:Synthetic human pancreatic Growth Hormone-Releasing Factor (hpGRF) elevated the plasma concentration of growth hormone (GH) in young and adult domestic fowl. This in vivo effect of hpGRF appeared to be largely similar for both the 32 amino-acid (hpGRF 1-32) or 40 amino-acid (hpGRF 1-40) polypeptide, although the effec...

journal_title：Life sciences

authors： Scanes CG,Carsia RV,Lauterio TJ,Huybrechts L,Rivier J,Vale W

更新日期：1984-03-19 00:00:00

abstract：:Elevated total homocysteine concentrations and obesity are both associated with an increased risk of cardiovascular disease. However, previous studies of weight reduction on serum homocysteine concentrations have obtained inconsistent reports. We investigated the effect of folic acid supplementation on serum homocyste...

journal_title：Life sciences

authors： Sheu WH,Chin HM,Lee WJ,Wan CJ,Su HY,Lang HF

更新日期：2005-03-18 00:00:00

abstract：:Protein kinase C (PKC)-dependent phosphorylation of endogenous substrates was measured in electrically permeabilised rat islets of Langerhans. The PKC-activating phorbol ester, 4 beta-phorbol myristate acetate (PMA), caused a slow but prolonged increase in insulin secretion from permeabilised islets, which was accompa...

journal_title：Life sciences

authors： Jones PM,Persaud SJ,Howell SL

更新日期：1992-01-01 00:00:00

abstract：:A synthetic peptide corresponding to a sequence of 26 amino acids contained in endogenous rat atrial natriuretic factor (ANF), was infused into one renal artery of anesthetized dogs for a comprehensive in vivo evaluation of the renal and systemic effects of pure ANF. The results proved conclusively that ANF acted dire...

journal_title：Life sciences

authors： Seymour AA,Blaine EH,Mazack EK,Smith SG,Stabilito II,Haley AB,Napier MA,Whinnery MA,Nutt RF

更新日期：1985-01-07 00:00:00

abstract：:The uptake and acetylation of [3H]-choline, as well as the calcium-dependent release of a newly synthesized [3H]-ACh, was studied in a new rat atrial mince preparation. The hemicholinium-3-sensitive uptake and acetylation of [3H]-choline increased as [3H]-choline concentrations were elevated to 100 microM in atrial mi...

journal_title：Life sciences

authors： Meyer EM,Baker SP

更新日期：1986-10-13 00:00:00

abstract：:Six diterpenes (three clerodanes, two abietanes and one rosane) were tested for interactions with the cyclooxygenase and 5-lipoxygenase pathways of arachidonate metabolism and for effects of nitric oxide production. Two abietane diterpenes, aethiopinone and 11,12-dihydroxy-6-oxo-8,11,13-abietatriene and the rosane lag...

journal_title：Life sciences

authors： de las Heras B,Abad MJ,Silván AM,Pascual R,Bermejo P,Rodríguez B,Villar AM

更新日期：2001-12-07 00:00:00

abstract：:Immunotherapy with immune checkpoint inhibitors, such as anti-PD-1 drugs, is an area in increasing development for its efficacy and advantages in the treatment of advanced metastatic melanoma. In fact, immunotherapy has been the target of several and recent studies in different types of cancer, namely in melanoma, a g...

journal_title：Life sciences

authors： Moreira RS,Bicker J,Musicco F,Persichetti A,Pereira AMPT

更新日期：2020-01-01 00:00:00

abstract：AIMS:Interleukin-1β (IL-1β) is a cytokine that is known to activate the stress axis and suppress the reproductive axis. Different brain areas are involved in the regulation of these two axes. However, they are both under the stimulatory control of the catecholamine, norepinephrine (NE). Here, we hypothesized that IL-1β...

journal_title：Life sciences

authors： Sirivelu MP,MohanKumar PS,MohanKumar SM

更新日期：2012-10-29 00:00:00

abstract：:In recent years, natural products have increasingly attracted more attention because of their potential anticancer activity and low intrinsic toxicity. Hispidulin is a natural flavonoid with a wide range of biological activities, including anti-inflammatory, antifungal, antiplatelet, anticonvulsant, anti-osteoporotic,...

journal_title：Life sciences

authors： Liu K,Zhao F,Yan J,Xia Z,Jiang D,Ma P

更新日期：2020-10-15 00:00:00

abstract：:The association of [3H] [D-Ala2, D-Leu5] enkephalin ([3H]DADLE]) with mouse neuroblastoma cells (N4TG1) was investigated. Under identical conditions the time course, dose response curve and temperature dependence for ligand uptake were similar to those for ligand-induced receptor loss (down regulation). Uptake of [3H]...

journal_title：Life sciences

authors： Blanchard SG,Chang KJ,Cuatrecasas P

更新日期：1982-09-20 00:00:00

abstract：:The activity in cerebrospinal fluid (CSF) of dynorphin-converting enzyme (DCE) has been studied after voluntary exercise in the spontaneously hypertensive (SH) rat. The exercise consisted of spontaneous running in wheels for 4-5 weeks and the average running distance during the last two weeks was 4.0 km/24h. CSF sampl...

journal_title：Life sciences

authors： Persson S,Jónsdóttir I,Thorén P,Post C,Nyberg F,Hoffmann P

更新日期：1993-01-01 00:00:00

abstract：AIMS:The aim of the present study was to evaluate the possible antioxidant role of oleic acid (OA) against Cd-induced injuries in the heart and liver tissues of male Wistar rats. MAIN METHODS:Rats were treated with either vehicle (control), or OA (10 mg/kg b.w., fed orally), or Cd (0.44 mg/kg b.w., s.c.), or both (OA ...

journal_title：Life sciences

authors： Bhattacharjee B,Pal PK,Chattopadhyay A,Bandyopadhyay D

更新日期：2020-03-01 00:00:00

abstract：:In a guinea-pig model of asthma, active immunization against substance P (SP) prevented the development of airways' hyperresponsiveness and reduced bronchospastic responses to SP (i.v.). The rat-mouse heterohybridoma NC1/34 secretes a specific, rat IgG1, anti-substance P antibody (alpha-SP Ab) which was isolated and p...

journal_title：Life sciences

authors： Jafarian A,Suresh MR,Kreutz FT,Biggs DF

更新日期：1995-01-01 00:00:00

abstract：:Ro41-0960 is a potent, fluorine containing COMT inhibitor which has be en reported to cross the blood brain barrier and to inhibit COMT in the brain. It is structurally similar to Ro40-7592 which is currently undergoing clinical trials in Parkinson's disease. Positron emission tomographic (PET) studies in baboon using...

journal_title：Life sciences

authors： Ding YS,Gatley SJ,Fowler JS,Chen R,Volkow ND,Logan J,Shea CE,Sugano Y,Koomen J

更新日期：1996-01-01 00:00:00

abstract：:In the present report we describe an NTPDase 1 (ATP diphosphohydrolase; ecto-apyrase; EC 3.6.1.5) in rat hippocampal slices. The effect of glutamate on the ATPase and ADPase activities in rat hippocampal slices of different ages was also studied since adenosine, the final product of an enzymatic chain that includes NT...

journal_title：Life sciences

authors： Bruno AN,Bonan CD,Wofchuk ST,Sarkis JJ,Battastini AM

更新日期：2002-05-31 00:00:00

abstract：AIM:Ethanol is one of the most widely used recreational drugs in the world. At high concentrations, it can induce carotid artery vasoconstriction. Hyperthermia potentiates its effects resulting in carotid artery vasoconstriction at any concentration. The aim of this study is to investigate the interaction between ethan...

journal_title：Life sciences

authors： Mustafa S,Ismael HN

更新日期：2017-11-01 00:00:00

abstract：:Previous investigations showed that chronic metabolic acidosis (CMA) increased the paracellular permeability of ion and neutral hydrophilic molecules in the duodenum of rats and small intestinal-like cell lines. Since proteins of the claudin family have been known to regulate the paracellular transport in several epit...

journal_title：Life sciences

authors： Charoenphandhu N,Wongdee K,Tudpor K,Pandaranandaka J,Krishnamra N

更新日期：2007-04-17 00:00:00

abstract：:C57BL6/J (B6) mice lacking Se-dependent GSH peroxidase 1 and 2 (GPx1/2-DKO) develop mild to moderate ileocolitis around weaning. These DKO mice have a disease resembling human very-early-onset inflammatory bowel disease (VEOIBD), which is associated with mutations in NADPH oxidase genes. Drugs including dexamethasone ...

journal_title：Life sciences

authors： Chu FF,Esworthy RS,Shen B,Gao Q,Doroshow JH

更新日期：2019-12-15 00:00:00

abstract：:Intestinal mucosal capsaicin-sensitive afferent nerves mediate, in part, the mesenteric hyperemia after intraduodenal acidification. The hyperemia plays a role in protecting the duodenal mucosa against acid damage. We tested the hypothesis that bradykinin contributes to this protective hyperemia. A specific antagonist...

journal_title：Life sciences

authors： Leung FW,Iwata F,Kao J,Seno K,Itoh M,Leung JW

更新日期：2002-01-04 00:00:00

abstract：:This study was designed to investigate the effect of diabetic duration on serum concentrations of endogenous inhibitor of nitric oxide synthase N(G), N(G)-asymmetric dimethylarginine (ADMA) in patients and rats with diabetes, and to determine whether elevated endogenous ADMA is implicated in endothelial dysfunction or...

journal_title：Life sciences

authors： Xiong Y,Lei M,Fu S,Fu Y

更新日期：2005-05-27 00:00:00

abstract：:Insulin binding and 3-0-Methylglucose transport have been studied in erythrocyte- and reticulocyte-enriched fractions of blood cells in order to determine if the increased number of insulin binding sites in reticulocytes is associated with a glucose transport response to insulin. In these experiments rabbit reticulocy...

journal_title：Life sciences

authors： Albert SG

更新日期：1982-07-19 00:00:00

abstract：:Liver sections removed from phenobarbital induced rats 24 to 48 hours after a 2 hour exposure to 1.0% halothane with 10% oxygen and subjected to immunocytochemical treatment showed evidence of centrilobular damage as well as evidence of the production of a protein which has immunoreactivity with anti HSP 72 antibodies...

journal_title：Life sciences

authors： Van Dyke RA,Mostafapour S,Marsh HM,Li Y,Chopp M

更新日期：1992-01-01 00:00:00

abstract：:Cd2+ (0.4 mg/kg) administration to growing rats (45 +/- 5 g) intraperitoneally, daily for 30 days was found to decrease the activity of superoxide dismutase (SOD) in all the brain regions, except hippocampus. The concentrations of lipid peroxides were significantly elevated in the cerebellum, cerebral cortex, corpus s...

journal_title：Life sciences

authors： Shukla GS,Hussain T,Chandra SV

更新日期：1987-11-09 00:00:00

abstract：AIMS:The aim of the present study was to evaluate the oral resveratrol effects associated with diet and physical training changes on anthropometric and biochemical parameters. MAIN METHODS:25 individuals aged from 30 to 60 years old; with Body Mass Index (BMI) ≥ 30 kg/m2 were included in the study. Following the prima...

journal_title：Life sciences

authors： Batista-Jorge GC,Barcala-Jorge AS,Silveira MF,Lelis DF,Andrade JMO,de Paula AMB,Guimarães ALS,Santos SHS

更新日期：2020-09-01 00:00:00

abstract：:Groups of 35-day-old male C57BL/6 mice were stressed 1 hour per day by immobilization for 1, 2, 3, 5, 8, 11 or 14 consecutive days. Control groups were left undisturbed. The animals were then killed and body weight and the weights of the thymus, spleen and axillary lymph nodes determined. Chronic immobilization stress...

journal_title：Life sciences

authors： Domínguez-Gerpe L,Rey-Méndez M

更新日期：1997-01-01 00:00:00

abstract：:The endocannabinoids are endogenous agonists of the cannabinoid receptors and some members of the transient receptor potential, vanilloid type (TRPV), family of cation channels. Endocannabinoids along with their target receptors comprise a signaling system that is not well characterized. There have been many advances ...

journal_title：Life sciences

authors： McFarland MJ,Barker EL

更新日期：2005-08-19 00:00:00